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Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich hao-tian wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

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Effects of chromium on the microstructure and hot ductility of Nb-microalloyed steel

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International Journal of Minerals,Metallurgy and Materials 2021年第6期28卷 1011-1021页

作者： Yang Liu Yan-hui Sun hao-tian wu Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China

It is well-known that the surface quality of the niobium microalloy profiled billet directly affects the comprehensive mechanical properties of the *** effects of chromium on theγ/αphase transformation and high-temperature mechanical properties of Nb-microalloyed steel were studied by Gleeble tensile and high-temperature in-situ observation *** indicated that the starting temperature of the γ→αphase transformation decreases with increasing Cr *** hot ductility of Nb-microalloyed steel is improved by adding 0.12wt% *** atoms inhibit the diffusion of carbon atoms,which reduces the thickness of grain boundary *** number fractions of high-angle grain boundaries increase with increasing chromium *** particular,the proportion is up to 48.7% when the Cr content is 0.12wt%.The high-angle grain boundaries hinder the crack propagation and improve the ductility of Nb-microalloyed steel.

关键词： phase transformation hot ductility chromium high-angle grain boundaries grain boundary ferrite

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Solidification structure simulation and casting process optimization of GCr15 bloom alloy

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China Foundry 2022年第1期19卷 63-74页

作者： Jie Li hao-tian wu Yang Liu Yan-hui Sun Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China

Based on the solidification heat transfer model and CAFÉmodel,the solidification structure of GCr15 bloom alloy was *** nail shooting and acid etching experiments,the solidification models were *** secondary dendrite arm spacing(SDAS)model of GCr15 was obtained by simulation calculation and metallographic *** the increase of casting speed,the SDAS,equiaxed crystal ratio(ECR)and average grain size *** the rise of superheat,the SDAS increases in the 20-70 mm of thickness and decreases in the 80-160 mm of *** ECR decreases and the average grain size increases with the increase of *** the increase of specific water flow,both the SDAS and ECR *** minimum average grain size is obtained when the specific water flow is 0.20 L·kg^(-1).The central carbon segregation index is reduced from 1.11 to 1.075.

关键词： numerical simulation continuous casting equiaxed crystal ratio secondary dendrite arm spacing carbon segregation

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Preparation and properties of flame-retardant rubber composites based on steel slag filler

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Journal of Iron and Steel Research International 2023年第7期30卷 1334-1341页

作者： Wei-cheng Xu Wei-cheng Zheng Ling Zhao hao-tian wu Yu-xi wu Hai-li Li hao Zhang Hong-ming Long Key Laboratory of Metallurgical Emission Reduction and Comprehensive Utilization of Resources Ministry of EducationAnhui University of TechnologyMa’anshan 243002AnhuiChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243032AnhuiChina School of Civil Engineering Anhui University of TechnologyMa’anshan 243032AnhuiChina

Ultrafine steel slag powder(shield powder)was prepared by grinding ordinary steel slag with a functional *** a substitute for aluminum hydroxide,the shield powder was combined with rubber to prepare flame-retardant *** tests showed that the incorporation of shield powder enhances the crosslinkage of the composite and speeds up the curing *** gaseous products formed in the pyrolysis process are mainly *** and combustion tests revealed that the introduction of shield powder improves flame-retardant performance without sacrificing mechanical ***,the optimum substitution ratio of shield powder for aluminum hydroxide is 50.0%.In this case,the composite has the highest degree of graphitization and exhibits excellent flame-retardant performance.

关键词： Steel slag Rubber Surface modification Solid waste utilization Flame-retardant composite

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Preparation of Self-limiting Heating Cables with Excellent Processability, Mechanical Properties and PTC Effect via Thermal and Electrical Treatments

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Chinese Journal of Polymer Science 2024年第4期42卷 511-520页

作者： tian-hao Yang Tong wu Qiang Fu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu610065China

Polymer/conductive filler composites have been widely used for the preparation of self-limiting heating cables with the positive temperature coefficient (PTC) effect. The control of conductive filler distribution and network in polymer matrix is the most critical for performance of PTC materials. In order to compensate for the destruction of the filler network structure caused by strong shearing during processing, an excessive conductive filler content is usually added into the polymer matrix, which in turn sacrifices its processability and mechanical properties. In this work, a facile post-treatment of the as-extruded cable, including thermal and electrical treatment to produce high-density polyethylene (HDPE)/carbon black (CB) cable with excellent PTC effect, is developed. It is found for the as-extruded sample, the strong shearing makes the CB particles disperse uniformly in HDPE matrix, and 25 wt% CB is needed for the formation of conductive paths. For the thermal-treated sample, a gradually aggregated CB filler structure is observed, which leads to the improvement of PTC effect and the notable reduction of CB content to 20 wt%. It is very interesting to see that for the sample with combined thermal and electrical treatment, CB particles are agglomerated and oriented along the electric field direction to create substantial conductive paths, which leads to a further decrease of CB content down to 15 wt%. In this way, self-limiting heating cables with excellent processability, mechanical properties and PTC effect have simultaneously been achieved.

关键词： Self-limiting heating cables Positive temperature coefficient Thermal treatment Electrical treatment

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Effects of traditional Chinese exercises and general aerobic exercises on older adults with sleep disorders: A systematic review and meta-analysis

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Journal of Integrative Medicine 2021年第6期19卷 493-502页

作者： Yang-hao-tian wu Wen-bo He Yin-yan Gao Xue-mei Han School of Public Health Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

Background:Sleep disorders are common in older adults and have a negative influence on their physical and mental *** aerobic exercises(GAEs)have long been used in the treatment of sleep disorders as a non-pharmacological ***,there is no consensus on the efficacy of traditional Chinese exercises(TCEs)for treating sleep disorders in older adults and the difference between TCEs and ***:This study assessed the effects of TCEs and GAEs on the sleep quality of older adults and the differences between these two *** strategy:Pub Med,Embase,Cochrane Library,Web of Science,China Biology Medicine disc,China National Knowledge Infrastructure,China Science Journal Database and Wanfang Data were searched from their inception to August *** criteria:Randomized controlled trials(RCTs)that evaluated the effects of TCEs and GAEs on older adults with sleep disorders were *** extraction and analysis:Data were extracted by two researchers working *** risk bias of included studies was assessed using the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 and the quality of evidence was assessed using the Grades of Recommendation,Assessment,Development and Evaluation *** Pittsburgh Sleep Quality Index(PSQI)was used to estimate sleep ***-analyses were performed to assess the total PSQI score of the exercise intervention as the primary outcome,and the scores of subjective sleep quality,sleep latency,sleep duration,habitual sleep efficiency,sleep disturbance,use of sleep medication and daytime dysfunction were assessed as secondary ***,sensitivity,and meta-regression analyses were conducted to assess the contribution of covariables to ***:A total of 22 RCTs(including 1747 participants)were included in the *** results indicated that TCEs(weighted mean difference[WMD]=-2.14,95%confidence interval[CI][-2.82,-1.46],P<0.001;heterogeneity:

关键词： Traditional Chinese exercise General aerobic exercise Older adults Sleep quality Tai Chi Meta-analysis

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Theoretical research into low-voltage Na_(2)TiSiO_(5)anode for lithium-ion battery

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Rare Metals 2022年第10期41卷 3412-3420页

作者： Shu Zhao tian-hao wu Di He Zi-He Zhang Bo-Ya Wang Li-Hang Wang Hai-Jun Yu Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing100124China Key Laboratory of Advanced Functional Materials Beijing University of TechnologyMinistry of EducationBeijing100124China

Na_(2)TiSiO_(5)(NTSO)is a low-cost Li-ion battery anode with great application potential,such as the tetragonal NTSO(T-NTSO)with a high capacity and a low *** addition to the tetragonal structure,NTSO has two other ***,the basic understanding of the structure,ion insertion and transport mechanisms of these new materials is still ***,we present a combined experimental and computational investigation of the tetragonal and orthorhombic NTSO to reveal the intrinsic mechanism leading to the superior electrochemical performance of *** determined that the insertion site with a flexible Ti^(4+)/Ti^(3+)redox pair is critical for Li+insertion *** large number of such flexible sites in the T-NTSO results in a higher capacity and higher ionic conductivity than those of orthorhombic *** understanding of intrinsic properties will accelerate the development and utilization of titanosilicates as the next generation low-voltage anode of Li-ion battery.

关键词： Lithium-ion batteries Anode materials Titanosilicates First-principles calculations Flexible redox pair

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A new interacting capillary bundle model on the multiphase flow in micropores of tight rocks

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Petroleum Science 2024年第2期21卷 1099-1112页

作者： Wen-Quan Deng tian-Bo Liang Wen-Zhong Wang hao Liu Jun-Lin wu Fu-Jian Zhou National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China

Surfactants are widely used in the fracturing fluid to enhance the imbibition and thus the oil recovery rate. However, current numerical models cannot capture the physics behind capillary imbibition during the wettability alteration by surfactants. Although the interacting capillary bundle(ICB) model shows potential in characterizing imbibition rates in different pores during wettability alteration, the existing ICB models neglect the influence of wettability and viscosity ratio on the imbibition behavior, making it difficult to accurately describe the oil-water imbibition behavior within the porous media. In this work,a new ICB mathematical model is established by introducing pressure balance without assuming the position of the leading front to comprehensively describe the imbibition behavior in a porous medium under different conditions, including gas-liquid spontaneous imbibition and oil-water *** the pore size distribution of a tight rock is known, this new model can predict the changes of water saturation during the displacement process in the tight rock, and also determine the imbibition rate in pores of different sizes. The water saturation profiles obtained from the new model are validated against the waterflooding simulation results from the CMG, while the imbibition rates calculated by the model are validated against the experimental observations of gas-liquid spontaneous imbibition. The good match above indicates the newly proposed model can show the water saturation profile at a macroscopic scale while capture the underlying physics of the multiphase flow in a porous medium at a microscopic scale. Simulation results obtained from this model indicate that both wettability and viscosity ratio can affect the sequence of fluid imbibition into pores of different sizes during the multiphase flow, where less-viscous wetting fluid is preferentially imbibed into larger pores while more-viscous wetting fluid tends to be imbibed into smaller pores. Fur

关键词： Imbibition Multiphase flow Tight rock Interacting capillary bundle model Wettability

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Enhanced UAV Pursuit-Evasion Using Boids Modelling:A Synergistic Integration of Bird Swarm Intelligence and DRL

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Computers, Materials & Continua 2024年第9期80卷 3523-3553页

作者： Weiqiang Jin Xingwu tian Bohang Shi Biao Zhao Haibin Duan hao wu School of Information and Communications Engineering Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an710049China China Academy of Electronics and Information Technology China Electronics Technology Group Corporation(CETC)Beijing100041China Department ofAutomatic Control School of Automation Science and Electrical EngineeringBeihangUniversityBeijing100191China

TheUAV pursuit-evasion problem focuses on the efficient tracking and capture of evading targets using unmanned aerial vehicles(UAVs),which is pivotal in public safety applications,particularly in scenarios involving intrusion monitoring and *** address the challenges of data acquisition,real-world deployment,and the limited intelligence of existing algorithms in UAV pursuit-evasion tasks,we propose an innovative swarm intelligencebased UAV pursuit-evasion control framework,namely“Boids Model-based DRL Approach for Pursuit and Escape”(Boids-PE),which synergizes the strengths of swarm intelligence from bio-inspired algorithms and deep reinforcement learning(DRL).The Boids model,which simulates collective behavior through three fundamental rules,separation,alignment,and cohesion,is adopted in our *** integrating Boids model with the Apollonian Circles algorithm,significant improvements are achieved in capturing UAVs against simple evasion *** further enhance decision-making precision,we incorporate a DRL algorithm to facilitate more accurate strategic *** also leverage self-play training to continuously optimize the performance of pursuit *** experimental evaluation,we meticulously designed both one-on-one and multi-to-one pursuit-evasion scenarios,customizing the state space,action space,and reward function models for each *** simulations,supported by the PyBullet physics engine,validate the effectiveness of our proposed *** overall results demonstrate that Boids-PE significantly enhance the efficiency and reliability of UAV pursuit-evasion tasks,providing a practical and robust solution for the real-world application of UAV pursuit-evasion missions.

关键词： UAV pursuit-evasion swarm intelligence algorithm Boids model deep reinforcement learning self-play training

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Buildingcrystal structures ofconjugatedpolymersthrough X-ray diffraction and molecular modeling

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SmartMat 2021年第3期2卷 378-387页

作者： Ze-Fan Yao Qi-Yi Li hao-tian wu Yi-Fan Ding Zi-Yuan Wang Yang Lu Jie-Yu Wang Jian Pei Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter of Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijingChina

Crystal structure of conjugated molecules and polymers is fundamentally critical to understand their multilevel microstructures,carrier transport,and diverse ***,to determine the crystal structure of conjugated polymers is a significant challenge,mainly due to the poor crystallinity,weak diffraction,and instability under high-energy ***,we build the possible crystal structures of eight typical conjugated polymers,covering several widely used molecular segments in organic *** model the packing structures of these seed polymers based on synchrotron X-ray diffractions and molecular *** crystal structures provide a new platform to predict the packing structures of more related polymer systems,extending the molecular *** on this polymer crystal structure database,the multiscale microstructures and charge transport properties of conjugated polymers can be predicted before *** study sets up a polymer crystal structure database to eliminate the current trial-and-error approaches and accelerating the design of high-performance conjugated polymers.

关键词： charge transport conjugated polymers crystal structure molecular modeling

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