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Biology of Hippo signaling pathway:Skeletal muscle development and beyond

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Journal of Integrative Agriculture 2024年第6期23卷 1825-1838页

作者： Shuqi qin Chaocheng Li Haiyan Lu Yulong feng Tao Guo Yusong Han Yongsheng Zhang Zhonglin Tang Xinjiang Characteristic Livestock Breeding and Reproduction Team College of Animal Science and TechnologyShihezi UniversityShihezi 832003China Lanzhou Veterinary Research Institute Chinese Academy of Agricultural SciencesLanzhou 730046China Kunpeng Institute of Modern Agriculture at Foshan Foshan 528226China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China

Global demand for farm animals and their meat products i.e.,pork,chicken and other livestock meat,is steadily *** the ongoing life science research and the rapid development of biotechnology,it is a great opportunity to develop advanced molecular breeding markers to efficiently improve animal meat production *** is an important study subject because of its crucial role in the regulation of organ *** recent years,with the increase of research on Hippo signaling pathway,the integrative application of multi-omics technologies such as genomics,transcriptomics,proteomics,and metabolomics can help promote the in-depth involvement of Hippo signaling pathway in skeletal muscle development *** Hippo signaling pathway plays a key role in many biological events,including cell division,cell migration,cell proliferation,cell differentiation,cell apoptosis,as well as cell adhesion,cell polarity,homeostasis,maintenance of the face of mechanical overload,*** influence on the development of skeletal muscle has important research value for enhancing the efficiency of animal husbandry *** this study,we traced the origin of the Hippo pathway,comprehensively sorted out all the functional factors found in the pathway,deeply analyzed the molecular mechanism of its function,and classified it from a novel perspective based on its main functional domain and mode of *** aim is to systematically explore its regulatory role throughout skeletal muscle *** specifically focus on the Hippo signaling pathway in embryonic stem cell development,muscle satellite cell fate determination,myogenesis,skeletal muscle meat production and organ size regulation,muscle hypertrophy and atrophy,muscle fiber formation and its transformation between different types,and *** roles in proliferation and regeneration are methodically summarized and analyzed *** summary and prospect of the Hippo signaling pathway within this a

关键词： Hippo skeletal muscle organ size myogenesis C2C12 livestock animals

Decomposition of pre-existing Au–P clusters induced in situ a-Fe grains uniformization in Fe–P-based nanocrystalline alloys

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Rare Metals 2024年第10期43卷 5242-5255页

作者： Min-hao Han Cheng Sun Guo-Guo Xi Yang Meng Qiang Luo Xue-Qian Yu Wen-feng Zhang hao Liu Hong-Jie Xu Tao Zhang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang University Laboratory of Functional Fiber Materials Institute of Bast Fiber CropsChinese Academy of Agricultural Science School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic MaterialsSoutheast University Institute for Advanced Materials North China Electric Power University Center for Advanced Analysis and Computational Science Zhengzhou University

In Fe-based amorphous-/nanocrystalline ribbons,the uniformization and refinement of a-Fe grains are key aspects for optimizing their soft magnetic and mechanical ***,the Fe–P–C–B nanocrystalline alloy system was selected for *** produced as-spun ribbons with pre-existing nanocrystals through melt-quenching and then obtained a well-distributed a-Fe nanocrystalline structure through annealing below the first crystallization onset temperature （633 K）resulting in excellent magnetic properties (saturation magnetization of 1.65 T and coercivity of 1.6 A·m-1)ultra-wide annealing temperature window （from 613 to 733 K）,and extremely high annealing stability （up to 480 min at 633 K）.Furthermore,we propose a new in situ two-step mechanism for the uniformization of a-Fe nanocrystals,which is separately induced by the decomposition of the Au–P clusters and the pre-existing a-Fe nanocrystals during *** work underscores the crucial significance of micro-alloying via metastable clusters primarily influenced by metal-phosphide interactions in the process of refining a-Fe ***,i introduces a new principle for optimizing the comprehensive properties of Fe-based amorphous/nanocrystalline alloys.

关键词： Fe-based nanocrystalline alloys In-situ nano-crystallization Micro-alloying Soft magnetic property

Community structure and species diversity dynamics of a subtropical evergreen broad-leaved forest in China:2005 to 2020

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Plant Diversity 2024年第1期46卷 70-77页

作者： Shi-Guang Wei Lin Li Kun-Dong Bai Zhi-feng Wen Jing-Gang Zhou qin Lin Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University) Ministry of EducationGuilin 541004GuangxiChina School of Life&Environmental Sciences Guilin University of Electronic TechnologyGuilin 541004GuangxiChina Guangxi Key Laboratory of Landscape Resources Conservation and Sustainable Utilization in Lijiang River Basin Guilin 541004GuangxiChina Key Laboratory of Vegetation Restoration and Management of South China Botanical Garden of Degraded Ecosystems Chinese Academy of SciencesGuangzhou 510650GuangdongChina Center of Plant Ecology Core Botanical GardensChinese Academy of SciencesGuangzhou 510650GuangdongChina

Here,we characterize the temporal and spatial dynamics of forest community structure and species diversity in a subtropical evergreen broad-leaved forest in *** found that community structure in this forest changed over a 15-year ***,renewal and death of common species was large,with the renewal of individuals mainly concentrated within a few populations,especially those of Aidia canthioides and Cryptocarya *** numbers of individual deaths for common species were concentrated in the small and mid-diameter *** spatial distribution of community species diversity fluctuated in each monitoring period,showing a more dispersed diversity after the 15-year study period,and the coefficient of variation on quadrats *** 2010,the death and renewal of the community and the spatial variation of species diversity were different compared to other survey *** weather may have affected species regeneration and community stability in our subtropical monsoon evergreen broad-leaved *** findings suggest that strengthening the monitoring and management of the forest community will help better understand the long-and short-term causes of dynamic fluctuations of community structure and species diversity,and reveal the factors that drive changes in community structure.

关键词： Community structure Death and renewal dynamics Species diversity dynamics South subtropical forest

The infection kinetics and transmission potential of two Guaico Culex viruses in Culex quinquefasciatus mosquitoes

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Virologica Sinica 2024年第2期39卷 228-234页

作者： Ru-Yi Chen Teng Zhao Jing-Jing Guo feng Zhu Na-Na Zhang Xiao-feng Li Hai-Tao Liu Fei Wang Yong-Qiang Deng Cheng-feng qin College of Bioscience and Bioengineering Jiangxi Agricultural UniversityNanchang330045China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMSBeijing100071China School of Life Sciences Southwest Forestry UniversityKunming650224China

Guaico Culex virus(GCXV)is a newly identified segmented Jingmenvirus from Culex *** in Central and South *** genome of GCXV is composed of four or five single-stranded positive RNA ***,the infection kinetics and transmission capability of GCXV in mosquitoes remain *** this study,we used reverse genetics to rescue two GCXVs(4S and 5S)that contained four and five RNA segments,respectively,in C6/36 *** in vitro characterization revealed that the two GCXVs exhibited comparable replication kinetics,protein expression and viral ***,GCXV RNAs were detected in the bodies,salivary glands,midguts and ovaries of Culex quinquefasciatus at 4–10 days after oral *** addition,two GCXVs can colonize *** eggs,resulting in positive rates of 15%–35%for the second gonotrophic *** conclusion,our results demonstrated that GCXVs with four or five RNA segments can be detected in *** eggs during the first and second gonotrophic cycles after oral infection.

关键词： Guaico Culex virus(GCXV) Jingmenvirus Culex quinquefasciatus Vertical transmission

Separation identification of a neural fuzzy Wiener–Hammerstein system using hybrid signals

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Frontiers of Information Technology & Electronic Engineering 2024年第6期25卷 856-868页

作者： feng LI hao YANG qingfeng CAO College of Electrical and Information Engineering Jiangsu University of TechnologyChangzhou 213001China College of Electrical Energy and Power EngineeringYangzhou UniversityYangzhou 225127China

A novel separation identification strategy for the neural fuzzy Wiener–Hammerstein system using hybrid signals is developed in this *** Wiener–Hammerstein system is described by a model consisting of two linear dynamic elements with a nonlinear static element in *** static nonlinear element is modeled by a neural fuzzy network(NFN)and the two linear dynamic elements are modeled by an autoregressive exogenous(ARX)model and an autoregressive(AR)model,*** the system input is Gaussian signals,the correlation technique is used to decouple the identification of the two linear dynamic elements from the nonlinear ***,based on the input and output of Gaussian signals,the correlation analysis technique is used to identify the input linear element and output linear element,which addresses the problem that the intermediate variable information cannot be measured in the identified Wiener–Hammerstein ***,a zero-pole match method is adopted to separate the parameters of the two linear ***,the recursive least-squares technique is used to identify the nonlinear element based on the input and output of random signals,which avoids the impact of output *** feasibility of the presented identification technique is demonstrated by an illustrative simulation example and a practical nonlinear *** results show that the proposed strategy can obtain higher identification precision than existing identification algorithms.

关键词： Wiener-Hammerstein system Neural fuzzy network Correlation analysis technique Hybrid signals Separation identification

Perforated gastric ulcer causing mediastinal emphysema: A case report

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World Journal of Clinical Cases 2024年第4期12卷 859-864页

作者： Zhi-Cheng Dai Xun-Wu Gui feng-He Yang hao-Yuan Zhang Wen-feng Zhang Department of General Surgery Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina Department of Medical Imaging Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina

BACKGROUND Mediastinal emphysema is a condition in which air enters the mediastinum between the connective tissue spaces within the pleura for a variety of *** can be spontaneous or secondary to chest trauma,esophageal perforation,medi-cally induced factors,*** common symptoms are chest pain,tightness in the chest,and respiratory *** mediastinal emphysema patients have mild symptoms,but severe mediastinal emphysema can cause respiratory and circulatory failure,resulting in serious *** SUMMARY A 75-year-old man,living alone,presented with sudden onset of severe epigastric pain with chest tightness after drinking *** to the remoteness of his residence and lack of neighbors,the patient was found by his nephew and brought to the hospital the next morning after the disease *** tomography(CT)showed free gas in the abdominal cavity,mediastinal emph-ysema,and subcutaneous *** gastrointestinal angiography showed that the esophageal mucosa was intact and the gastric antrum was ***,we chose to perform open gastric perforation repair on the patient under thoracic epidural anesthesia combined with intravenous *** operative incision of the muscle layer of the patient's abdominal wall was made,and a large amount of subperitoneal gas was *** a continued incision of the peritoneum revealed the presence of a perforation of approx-imately 0.5 cm in the gastric antrum,which we repaired after pathological ***,the patient received high-flow oxygen and cough *** CT was performed on the first and sixth postoperative days,and the mediastinal and subcutaneous gas was gradually *** After gastric perforation,a large amount of free gas in the abdominal cavity can reach the mediastinum through the loose connective tissue at the esophageal hiatus of the diaphragm,and upper gastrointestinal angiography can clarify the site of *** pat

关键词： Gastric ulcer Perforated Mediastinal emphysema Case report

Engineering Shewanella-re duce d graphene oxide aerogel biohybrid to efficiently synthesize Au nanoparticles

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Journal of Materials Science & Technology 2024年第1期168卷 50-61页

作者： Baocai Zhang Shulin Shao Huan Yu Qijing Liu Sicheng Shi qingyuan Wu Zijie Wu Yiyu feng Yifei Wang Xi Sun Deguang Wu feng Li hao Song Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China School of Materials Science and Engineering Tianjin UniversityTianjin 300350China College of Biological Engineering Tianjin Agricultural UniversityTianjin 300384China Department of Brewing Engineering Moutai InstituteLuban AveRenhuai 564507China

Biosynthesizing Au nanoparticles(AuNPs)from gold-bearing scraps provides a sustainable method to meet the urgent demand for ***,it remains challenging to efficiently biosynthesize AuNPs of which the diameter is less than 10 nm from a trace amount of Au^(3+)concentration at the level of tens ***,we constructed an exoelectrogenic cell(eCell)-conductive reduced-graphene-oxide aero-gel(rGA)biohybrid by assembling Shewanella sp.S1(SS1)as living biocatalyst and rGA as conductive ad-sorbent,in which Au^(3+)at trace concentrations would be enriched by the adsorption of rGA and reduced to AuNPs through the extracellular electron transfer(EET)of *** regulate the size of the synthe-sized AuNPs to 10 nm,the strain SS1 was engineered to enhance its EET,resulting in strain RS2(pYYD-P tac-ribADEHC&pHG13-P_(bad)-omcC in SS1).Strain RS2 was further assembled with rGA to construct the RS2-rGA biohybrid,which could synthesize AuNPs with the size of 7.62±2.82 nm from 60 ppm Au^(3+)*** eCell-rGA biohybrid integrated Au^(3+)adsorption and reduction,which enabled AuNPs biosyn-thesis from a trace amount of Au^(3+).Thus,the required Au^(3+)ions concentration was reduced by one or two orders of magnitude compared with conventional methods of AuNPs *** work devel-oped an AuNPs size regulation technology via engineering eCell’s EET with synthetic biology methods,providing a feasible approach to synthesize AuNPs with controllable size from trace level of gold ions.

关键词： Au nanoparticles Exoelectrogenic cell(e-Cell) Shewanella Synthesis biology Extracellular electron transfer Reduced graphene oxide aerogel

Precipitation evolution and properties of Cu-15Ni-8Sn alloys via Al microalloying during ageing

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Rare Metals 2024年第10期43卷 5216-5228页

作者： Wei Luo Li-Jun Peng Xu-Jun Mi hao-feng Xie Yi-Cheng Cao Shu-Hui Huang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.Ltd. GRIMAT Engineering Institute Co. Ltd. General Research Institute for Nonferrous Metals School of Materials Science and Engineering South China University of Technology

Studies have shown that microalloying Cu-Ni-Sn alloys using Al inhibits discontinuous precipitation reactions;however,the mechanism has not been investigated ***,this study explored the properties and precipitation evolution of Cu-15Ni-8Sn alloys without and with 1 wt%Al（Cu-15Ni-8Sn-1Al） during ageing at 500℃ through X-ray diffraction （XRD）,scanning electron microscopy and high-angle annular dark-field scanning transmission electron *** results revealed that in Cu-15Ni-8Sn alloy,DO22ordering first occurred after spinodal decomposition,subsequently transitioning to an L12ordering phase,during which the discontinuous precipitates gradually nucleated at the grain boundaries and formed *** alloy hardness increased sharply with ordering and then decreased rapidly after reaching its peak value,due to the dominance of the discontinuous precipitation ***,the DO22ordered phase did not appear during the ageing of Cu-15Ni-8Sn-1Al alloy,and a Ni3(Alx,Sn1-x) intermetallic compound with L12structure was formed,consuming Ni and Sn atoms,thereby significantly suppressing the discontinuous precipitation reaction and improving the stability during prolonged *** tensile strength （yield strength） of Cu-15Ni-8Sn and Cu-15Ni-8Sn-1Al alloys at peak hardness were 855 （755） and 936 MPa （892 MPa）,respectively,and their main strengthening mechanisms were solid solution strengthening and precipitation *** addition of 1 wt% Al effectively improved the precipitation strengthening effect of Cu-Ni-Sn alloys but severely decreased the ductility.

关键词： Al addition Cu-15Ni-8Sn Precipitation sequence Strengthening mechanism

Robust tantalum tuned perovskite oxygen electrode for reversible protonic ceramic electrochemical cells

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Rare Metals 2024年第7期43卷 3055-3065页

作者： Yu-Shi feng Yu Shen Fang Wang Chuan Tian qin-Yi Hu Qian Duan Jing-Wei Li Di Bao School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China Zhongshan Institute of Changchun University of Science and Technology Zhongshan528437China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China Key Laboratory of Preparation and Applications of Environmental Friendly Materials Ministry of EducationJilin Normal UniversityChangchun 130103China

Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward the sustainable hydrogen production and ***,enhancement of their activity and stability remains ***,we develop the Ta-regulated BaCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrode(Ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abundant oxygen defects and achieve the simultaneous enhancement in the electrocatalytic activity and stability toward ORR and ***-fabricated R-PCEC with(Ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrode performs high power density of 1.47 W·cm^(-2)at 650℃in fuel cell mode,and the current density is up to-2.11 A·cm^(-2)at 1.4 V at 650℃in electrolysis mode,as well as the good stability in both the fuel cell and electrolysis ***,the cell also demonstrates a stable cycling operation between fuel cell and electrolysis mode,suggesting a great potential of BCFT10 as oxygen electrode material for R-PCECs.

关键词： Reversible protonic ceramic electrochemical cells Perovskite oxide Oxygen electrode Ta element doping Oxygen defects