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Elucidating the molecular basis of ATP-induced cell death in breast cancer: Construction of a robust prognostic model

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World Journal of Clinical Oncology 2024年第2期15卷 208-242页

作者： hao-Ling zhang Sandai Doblin Zhong-Wen zhang Zhi-Jing Song Babu Dinesh Yasser Tabana DahhamSabbar Saad Mowaffaq Adam Ahmed Adam Yong Wang Wei Wang hao-long zhang Sen Wu Rui Zhao Barakat Khaled Department of Biomedical Sciences Advanced Medical and Dental InstituteUniversiti Sains MalaysiaPenang 13200Malaysia School of Public Health Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Clinical College of Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmonton AB T6G 2E1Canada Department of Science University of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA 92182United States Department of Pathology Center Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina College of Acupuncture-moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Universiti Sains Malaysia Advanced Medical and Dental InstitutePenang 13200Malaysia Department of Biomedical Science Universiti Sains MalaysiaPenang 13200Malaysia

BACKGROUND Breast cancer is a multifaceted and formidable disease with profound public health *** demise mechanisms play a pivotal role in breast cancer pathogenesis,with ATP-triggered cell death attracting mounting interest for its unique specificity and potential therapeutic *** To investigate the impact of ATP-induced cell death(AICD)on breast cancer,enhancing our understanding of its *** The foundational genes orchestrating AICD mechanisms were extracted from the literature,underpinning the establishment of a prognostic ***,a microRNA(miRNA)prognostic model was constructed that mirrored the gene-based prognostic *** between high-and low-risk cohorts within mRNA and miRNA characteristic models were scrutinized,with the aim of delineating common influence mechanisms,substantiated through enrichment analysis and immune infiltration *** The mRNA prognostic model in this study encompassed four specific mRNAs:P2X purinoceptor 4,pannexin 1,caspase 7,and cyclin *** miRNA prognostic model integrated four pivotal miRNAs:hsa-miR-615-3p,hsa-miR-519b-3p,hsa-miR-342-3p,and hsa-miR-324-3p.B cells,CD4+T cells,CD8+T cells,endothelial cells,and macrophages exhibited inverse correlations with risk scores across all breast cancer ***,Kyoto Encyclopedia of Genes and Genomes analysis revealed that genes differentially expressed in response to mRNA risk scores significantly enriched 25 signaling pathways,while miRNA risk scores significantly enriched 29 signaling pathways,with 16 pathways being jointly *** Of paramount significance,distinct mRNA and miRNA signature models were devised tailored to AICD,both potentially autonomous prognostic *** study's elucidation of the molecular underpinnings of AICD in breast cancer enhances the arsenal of potential therapeutic tools,offering an unparalleled window for innovative ***,this paper revea

关键词： ATP-induced cell death mRNA miRNA Prognostic model Breast cancer

Fabrication of corrosion inhibiting microcapsules functional coating and their high-efficiency corrosion resistance

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Rare Metals 2024年第2期43卷 842-848页

作者： hao-Ran Yun Lu Lu Xue-long hao Xing-Xiang zhang School of Material Science and Engineering Tiangong UniversityTianjin300387China National Center of Analysis and Testing for Nonferrous Metals and Electronic Materials General Research Institute for Nonferrous MetalsBeijing100088China Guobiao(Beijing)Testing&Certification Co. Ltd.Beijing101407China

Benzotriazole(BTA)was loaded into calcium carbonate microsphere shell by self-assembly method and a new type of high-efficiency corrosion inhibiting microcapsules(CIMs)were fabricated,which were added and dispersed into epoxy resin coating to obtain a new corrosion resistance functional *** corrosion inhibition effect of benzotriazole on aluminum alloy matrix was verified by polarization curve *** effectiveness of the CIMs and their loading capacity on inhibitor were evaluated by scanning electron microscope,laser confocal Raman spectroscopy together with thermogravimetric analysis.

关键词： corrosion coating resistance

Novel cellular therapies for hepatobiliary malignancies

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 450-454页

作者： Jing-Nan Xue Yan-Yu Wang Yun-Chao Wang Nan zhang long-hao zhang Zheng-Hui Lu Li-Jin Zhao Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Hepatobiliary and Pancreatic Surgery Affiliated Hospital of Zunyi Medical UniversityZunyi 563000China Hepatobiliary and Pancreatic Surgery Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000China

Background:The mortalities of hepatobiliary malignancies are *** the failure of conventional chemotherapy and unsatisfactory outcome of molecular targeted drugs,immune-based therapy has become a new focus of research in hepatobiliary cancers *** sources:We performed a Pub Med search with relevant articles published up to May 2022 and the following keywords:cellular immunotherapy,hepatobiliary cancer,antigen receptor T cell therapy,and receptor-engineered T *** of clinical trials was obtained from https://***/.Results:Cell therapies for hepatobiliary malignancies are at early stage of *** current review showed that cellular therapies are safe and feasible in *** findings provide an important platform for future lager scale clinical trials on immunotherapy in patients with hepatobiliary ***:With the continuous advances of cellular immunotherapy,the combination of cellular immunotherapy with surgery,chemotherapy and radiotherapy will be new therapeutic strategies for patients with hepatobiliary cancer.

关键词： Cellular therapy Chimeric antigen receptor T cell therapy Receptor-engineered T cell Hepatobiliary malignancy

Graded Heterojunction Improves Wide-Bandgap Perovskite for Highly Efficient 4-Terminal Perovskite/Silicon Tandem Solar Cells

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Research 2024年第2期2023卷 181-190页

作者： Wenming Chai Lindong Li Weidong Zhu Dazheng Chen long Zhou He Xi Jincheng zhang Chunfu zhang Yue hao State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology&Shaanxi Joint Key Laboratory of Graphene School of MicroelectronicsXidian UniversityXi'anShaanxi 710071China Xi'an Baoxin Solar Technology Co. Ltd.Xi'an710071China

Wide-bandgap(WBG)perovskite solar cells(PSCs)are essential for highly efficient and stable silicon/perovskite tandem solar *** this study,we adopted a synthetic strategy with lead thiocyanate(Pb(SCN)_(2))additive and methylammonium chloride(MACl)posttreatment to enhance the crystallinity and improve the interface of WBG perovskite films with a bandgap of 1.68 *** excessive PbI_(2)was formed at grain boundaries and converted into MAPbI_(3-x)Cl_(x)perovskites,which are utilized to form the graded heterojunction(GHJ)and compressive *** is beneficial for passivating nonradiative recombination defects,suppressing halide phase segregation,and facilitating carrier ***,the device with GHJ delivered a champion efficiency of 20.30%and superior stability in ambient air and under 85℃.Finally,we achieved a recorded efficiency of 30.91%for 4-terminal WBG perovskite/TOPCon tandem silicon solar *** findings demonstrate a promising approach for fabricating efficient and stable WBG PSCs through the formation of GHJ.

关键词： perovskite Graded Highly

Targeted regeneration and upcycling of spent graphite by defect‐driven tin nucleation

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Carbon Energy 2024年第4期6卷 91-103页

作者： Zhiheng Cheng Zhiling Luo hao zhang Wuxing zhang Wang Gao Yang zhang long Qie Yonggang Yao Yunhui Huang Kun Kelvin Fu State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhanChina Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationDepartment of Materials Science and EngineeringJilin UniversityChangchunChina Electronic Materials Research Laboratory(Key Lab of Education Ministry) School of Electronic and Information Engineeringand Instrumental Analysis CenterXi'an Jiaotong UniversityXi'anChina Department of Mechanical Engineering University of DelawareNewarkUSA

The recycling of spent batteries has become increasingly important owing to their wide applications,abundant raw material supply,and sustainable *** with the degraded cathode,spent anode graphite often has a relatively intact structure with few defects after long ***,most spent graphite is simply burned or discarded due to its limited value and inferior performance on using conventional recycling methods that are complex,have low efficiency,and fail in performance ***,we propose a fast,efficient,and“intelligent”strategy to regenerate and upcycle spent graphite based on defect‐driven targeted *** Sn as a nanoscale healant,we used rapid heating(~50 ms)to enable dynamic Sn droplets to automatically nucleate around the surface defects on the graphite upon cooling owing to strong binding to the defects(~5.84 eV/atom),thus simultaneously achieving Sn dispersion and graphite *** a result,the regenerated graphite showed enhanced capacity and cycle stability(458.9 mAh g^(−1) at 0.2 A g^(−1) after 100 cycles),superior to those of commercial *** from the self‐adaption of Sn dispersion,spent graphite with different degrees of defects can be regenerated to similar structures and *** analysis indicates that targeted regeneration and upcycling have significantly lower energy consumption(~99%reduction)and near‐zero CO_(2) emission,and yield much higher profit than hydrometallurgy,which opens a new avenue for direct upcycling of spend graphite in an efficient,green,and profitable manner for sustainable battery manufacture.

关键词： battery recycling spent graphite targeted regeneration upcycling graphite

Novel wood-plastic composite fabricated via modified steel slag:Preparation,mechanical and flammability properties

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2110-2120页

作者： Ling Zhao Kai Zhao Zhenwei Shen Yifan Wang Xiaojie Xia hao zhang Hongming long School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243032China School of Civil Engineering and Architecture Anhui University of TechnologyMa’anshan 243032China School of Materials Science and Engineering Anhui University of TechnologyMa’anshan 243032China Key Laboratory of Metallurgical Emission Reduction and Resources Recycling(Anhui University of Technology) Ministry of EducationMa’anshan 243002China

A novel method was developed to enhance the utilization rate of steel slag(SS).Through treatment of SS with phosphoric acid and aminopropyl triethoxysilane(KH550),we obtained modified SS(MSS),which was used to prepare MSS/wood-plastic composites(MSS/WPCs)by replacing talcum powder(TP).The composites were fabricated through melting blending and hot *** mechanical and combustion properties,which comprise heat release,smoke release,and thermal stability,were systematically *** can improve the mechanical strength of the composites through grafting reactions between wood powder and ***,MSS/WPC#50(16wt%MSS)with an MSS-to-TP mass ratio of 1:1 exhibited optimal comprehensive *** with those of WPC#0 without MSS,the tensile,flexural,and impact strengths of MSS/WPC#50 were increased by 18.5%,12.8%,and 18.0%,***,the MSS/WPC#50 sample achieved the highest limited oxygen index of 22.5%,the highest vertical burning rating at the V-1 level,and the lowest horizontal burning rate at 44.2 mm/*** formation of a dense and stable char layer led to improved thermal stability and a considerable reduction in heat and smoke releases of MSS/WPC#***,the partial replacement of TP with MSS slightly compromised the mechanical and flame-retardant properties,possibly due to the weak grafting caused by SS powder *** findings suggest the suitability of MSS/WPCs for high-value-added applications as decorative panels indoors or outdoors.

关键词： modified steel slag wood–plastic composites preparation method mechanical property flame retardant

Enhancing SAEAs with unevaluated solutions:a case study of relation model for expensive optimization

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Science China(Information Sciences) 2024年第2期67卷 41-58页

作者： hao hao Xiaoqun zhang Aimin ZHOU Institute of Natural Sciences Shanghai Jiao Tong University Shanghai Frontiers Science Center of Molecule Intelligent Syntheses School of Computer Science and Technology East China Normal University

Surrogate-assisted evolutionary algorithms(SAEAs) hold significant importance in resolving expensive optimization problems. Extensive efforts have been devoted to improving the efficiency of SAEAs through the development of proficient model-assisted solution selection methods, which, however, first requires generating high-quality solutions. The fundamental paradigm of evaluating a limited number of solutions in each generation within SAEAs reduces the variance of adjacent populations, thereby affecting the quality of offspring solutions. This is a frequently encountered issue yet receives little attention. To address the issue, this paper presents a framework using unevaluated solutions to enhance the efficiency of *** surrogate model is employed to identify high-quality solutions for the direct generation of new solutions without evaluation. To ensure dependable selection, we have introduced two tailored relation models to select the optimal solution and the unevaluated population. A comprehensive experimental analysis is performed on two test suites, which showcases the superiority of the relation model over regression and classification models in the solution selection phase. Furthermore, the surrogate-selected unevaluated solutions with high potential have been shown to enhance the efficiency of the algorithm significantly.

关键词： expensive optimization unevaluated solutions relation model surrogate-assisted evolutionary algorithm

Learning the imaging mechanism directly from optical microscopy observations

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Photonics Research 2024年第1期12卷 7-26页

作者： ZE-hao WANG long-KUN SHAN TONG-TIAN WENG TIAN-long CHEN XIANG-DONG CHEN zhang-YANG WANG GUANG-CAN GUO FANG-WEN SUN CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China University of Texas at Austin AustinTexas 78705USA Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

The optical microscopy image plays an important role in scientific research through the direct visualization of the nanoworld,where the imaging mechanism is described as the convolution of the point spread function(PSF)and *** on a priori knowledge of the PSF or equivalent PSF,it is possible to achieve more precise exploration of the ***,it is an outstanding challenge to directly extract the PSF from microscopy ***,with the help of self-supervised learning,we propose a physics-informed masked autoencoder(PiMAE)that enables a learnable estimation of the PSF and emitters directly from the raw microscopy *** demonstrate our method in synthetic data and real-world experiments with significant accuracy and noise *** outperforms DeepSTORM and the Richardson–Lucy algorithm in synthetic data tasks with an average improvement of 19.6%and 50.7%(35 tasks),respectively,as measured by the normalized root mean square error(NRMSE)*** is achieved without prior knowledge of the PSF,in contrast to the supervised approach used by DeepSTORM and the known PSF assumption in the Richardson–Lucy *** method,PiMAE,provides a feasible scheme for achieving the hidden imaging mechanism in optical microscopy and has the potential to learn hidden mechanisms in many more systems.

关键词： optical emitter mechanism

Frequency Domain Fatigue Evaluation on SCR Girth-Weld Based on Structural Stress

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China Ocean Engineering 2024年第2期38卷 255-270页

作者： zhang long Zhao Tian-feng College of Safety and Ocean Engineering China University of Petroleum(Beijing)Beijing 102249China

The Steel Catenary Riser(SCR)is a vital component for transporting oil and gas from the seabed to the floating *** harsh environmental conditions and complex platform motion make the SCR’s girth-weld prone to fatigue *** structural stress fatigue theory and Master S-N curve method provide accurate predictions for the fatigue damage on the welded joints,which demonstrate significant potential and compatibility in multi-axial and random fatigue ***,we propose a new frequency fatigue model subjected to welded joints of SCR under multiaxial stress,which fully integrates the mesh-insensitive structural stress and frequency domain random process and transforms the conventional welding fatigue technique of SCR into a spectrum analysis technique utilizing structural ***,a full-scale FE model of SCR with welds is established to obtain the modal structural stress of the girth weld and the frequency response function(FRF)of modal coordinate,and a biaxial fatigue evaluation about the girth weld of the SCR can be achieved by taking the effects of multi-load correlation and pipe-soil interaction into *** research results indicate that the frequency-domain fatigue results are aligned with the time-domain results,meeting the fatigue evaluation requirements of the SCR.

关键词： SCR girth weld random vibration self(cross)power spectrum structural stress method biaxial fatigue damage