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World Journal of diabetes 2023年第11期14卷 1621-1631页

作者： Yi-Chen Guo hao-di cao Xiao-Fen Lian Pei-Xian Wu Fan Zhang Hua Zhang Dong-Hui Lu Department of Endocrinology Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Endocrinology Zhujiang Hospital of Southern Medical UniversityGuangzhou 510282Guangdong ProvinceChina

diabetes mellitus(DM)and obesity have become two of the most prevalent and challenging diseases worldwide,with increasing incidence and serious *** studies have shown that noncoding RNA(ncRNA)and epigenetic regulation play crucial roles in the pathogenesis of DM complicated by *** of the involvement of ncRNA and epigenetic regulation in the pathogenesis of diabetes with obesity has opened new avenues of *** these mechanisms with small molecules or RNA-based therapies may provide a more precise and effective approach to diabetes treatment than traditional *** this review,we discuss the molecular mechanisms of ncRNA and epigenetic regulation and their potential therapeutic targets,and the research prospects for DM complicated with obesity.

关键词： diabetes mellitus Obesity Noncoding RNA Epigenetic regulation Insulin resistance

Deciphering fungal metabolon coupling tandem inverse-electrondemand diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong di Man-Cheng Tang ding-Kang Chen Ming-Ming cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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高校硕士研究生就业多重困境探析——以S高校为例

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江苏商论 2025年第1期 130-134页

作者：曹迪张浩哲沈阳化工大学人文与艺术学院辽宁沈阳110142

社会工作硕士毕业生严峻的就业形势与社会工作从业人员的巨大缺口这一矛盾,深刻地影响着社会的稳定。为了解决这一矛盾,本文由小看大,基于S大学社工硕士毕业生,利用问卷调查的方式,探究择业就业取向。再利用访谈法,分析得出取向形成的原... 详细信息

社会工作硕士毕业生严峻的就业形势与社会工作从业人员的巨大缺口这一矛盾,深刻地影响着社会的稳定。为了解决这一矛盾,本文由小看大,基于S大学社工硕士毕业生,利用问卷调查的方式,探究择业就业取向。再利用访谈法,分析得出取向形成的原因,进而提出相应对策,使其选择社会相关工作。建设社工人才队伍,弥补人才缺口,增加就业,解决就业矛盾,是促进社会稳定的一个重要的问题。

关键词：社工硕士毕业生择业就业取向问卷调查对策建议

Advantage of selective production of green rusts for Sb(Ⅴ) removal in Fe(0) electrocoagulation

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Chinese Chemical Letters 2020年第10期31卷 2779-2783页

作者： di cao Meng Qiao Angzhen Li Jingwei hao Xu Zhao Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China China ENFI Engineering Corporation Beijing 100038China China Academy of Urban Planning and Design Beijing 100037China

The re moval efficiency of pollutants in Fe(O) electrocoagulation(EC) has been associated closely with the speciation of generated Fe(Ⅱ)/Fe(Ⅲ) oxides during this process,which is very complicated and can be affected by various *** this work,in-situ Raman,X-ray diffraction and some other techniques have been used to study the speciation of Fe under different conditions and to establish a relationship between Fe speciation and Sb(V) removal *** indicated that concentration of dissolved oxygen(DO)is a key factor influencing Fe(O) *** was found that green rusts(GRs) were formed and were then transformed into magnetite at lower DO concentration,and Sb(V) removal efficiency reached 99.9% after30 min of *** contrast,γ-FeOOH was formed at high DO concentration,and the removal efficiency of Sb(V) after 30 min of EC was only 72.8%.In the presence of sulfite and phosphate with low concentrations,GRs can be stabilized and benefit the removal of Sb(V).We believe this work will provide some new insights on the mechanism of Fe(O) EC and the effective removal of other pollutants during Fe(O)EC process.

关键词： Iron electrocoagulation Antimony Green rusts Sodium sulfite Phosphate

Constructing Pr-doped CoOOH catalytic sites for efficient electrooxidation of 5-hydroxymethylfurfural

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Journal of Energy Chemistry 2025年第1期 234-244页

作者： Botao Fan hao Zhang Bang Gu Feng Qiu Qiue cao Wenhao Fang School of Chemical Science and Technology Yunnan University National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University

Electrocatalytic conversion of renewable biomass is emerging as a promising route for sustainable chemical production;hence it urgently calls for developing efficient electrocatalysts with low potentials and high current ***,a Pr-doped Co（OH）2hexagonal sheet （Pr/Co=1/9,in mole） is synthesized by electrodeposition as highly performant catalyst for 5-hydroxymethylfurfural （HMF） oxidation reaction（HMFOR） to produce 2,5-furandicarboxylic acid （FDCA）.This novel and low-cost catalyst possesses a rather low onset potential of 1.05 V （***） and requires only 1.10 V （***） to reach a current density of 10 mA cm-2for HMFOR,significantly outperforming Co（OH）2benchmark (i.e.,210 mV higher to reach10 m A cm-2).The origin of Pr promotion effect as well as the evolution of CoOOH catalytic sites and HMFOR process has been deeply elucidated by physical characterizations,kinetic experiments,in situ electrochemical techniques,and theoretical *** unique Pr-ameliorated CoOOH active centers enable 100%conversion of HMF,99.6%selectivity of FDCA,and 99.7%Faraday efficiency,with a superior cycling durability toward *** can be one of the most outstanding results for Co-based HMFOR catalysts to date in the *** this work can help open up new horizons for constructing novel and efficient Co-based electrocatalysts by the utilization of lanthanide elements.

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SOME SEMI-BENT FUNCTIONS WITH POLYNOMIAL TRACE FORM

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Journal of Systems Science & Complexity 2014年第4期27卷 777-784页

作者： CHEN hao cao Xiwang Department of Math Nanjing University of Aeronautics and Aeronautics

This paper is devoted to the study of semi-bent functions with several parameters flexible on the finite field *** functions defined on F2n of the form f（r）ab（x） =Trn1（axr（2m-1））＋Tr41（bx（2n-1）/5） and the form g（rs）abcd（x）=Trn1（axr（2m-1））＋Tr41（bx（2n-1）/5）＋Trn1（cx（2m-1）1/2＋1）＋Trn1（dx（2m-1）s＋1） where n = 2m,m = 2（mod 4）,a,c ∈ F2n,and b ∈ F（16）,d ∈ F2,are investigated in constructing new classes of semi-bent *** characteristic sums such as Kloosterman sums and Weil sums are employed to determine whether the above functions are semi-bent or not.

关键词： Boolean function dickson polynomial exponential sum Kloosterman sum semi-bentfunction Walsh-Hadamard transformation Weil sum.

Experimental Study of the Influence of Flow Passage Subtle Variation on Mixed-flow Pump Performance

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Chinese Journal of Mechanical Engineering 2014年第3期27卷 615-621页

作者： BING hao cao Shuliang State Key Laboratory of Hydroscience and Engineering Tsinghua University

In the mixed-flow pump design, the shape of the flow passage can directly affect the flow capacity and the internal flow, thus influencing hydraulic performance, cavitation performance and operation stability of the mixed-flow pump. However, there is currently a lack of experimental research on the influence mechanism. Therefore, in order to analyze the effects of subtle variations of the flow passage on the mixed-flow pump performance, the frustum cone surface of the end part of inlet contraction flow passage of the mixed-flow pump is processed into a cylindrical surface and a test rig is built to carry out the hydraulic performance experiment. In this experiment, parameters, such as the head, the efficiency, and the shaft power, are measured, and the pressure fluctuation and the noise signal are also collected. The research results suggest that after processing the inlet flow passage, the head of the mixed-flow pump significantly goes down; the best efficiency of the mixed-flow pump drops by approximately 1.5%, the efficiency decreases more significantly under the large flow rate; the shaft power slightly increases under the large flow rate, slightly decreases under the small flow rate. In addition, the pressure fluctuation amplitudes on both the impeller inlet and the diffuser outlet increase significantly with more drastic pressure fluctuations and significantly lower stability of the internal flow of the mixed-flow pump. At the same time, the noise dramatically increases. Overall speaking, the subtle variation of the inlet flow passage leads to a significant change of the mixed-flow pump performance, thus suggesting a special attention to the optimization of flow passage. This paper investigates the influence of the flow passage variation on the mixed-flow pump performance by experiment, which will benefit the optimal design of the flow passage of the mixed-flow pump.

关键词： mixed-flow pumps flow passage hydraulic performance pressure fluctuation model test

Influence of zinc state on the catalyst properties of Zn/HZSM-5 zeolite in 1-hexene aromatization and cyclohexane dehydrogenation

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Chinese Journal of Chemical Engineering 2022年第3期35卷 124-134页

作者： di Gao Yibo Zhi Liyuan cao Liang Zhao Jinsen Gao Chunming Xu Mingzhi Ma Pengfei hao State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing 102249China Hebei Jingzhi Technology Company Limited Cangzhou 061000China

Rational design of Zn-containing HZSM-5 zeolite(Zn/HZSM-5)with high reactivity and excellent aromatization performance for olefin aromatization is crucially *** develop a new and uncomplicated method to synthesize Zn/HZSM-5(IMX/Z5)with superior aromatization performance in the *** to incipient wetness impregnation(IMP/Z5)and mechanical mixing(MIX/Z5),the asprepared IMX/Z5 presents a higher amount of surface ZnOH^(+)species(2.87%)while keeping identical bulk zinc *** a result,more surface ZnOH^(+)favor both the aromatization of 1-hexene and cyclohexane *** the two olefin aromatization pathways(hydrogen transfer and dehydrogenation),it is the first time found both the hydrogen transfer ability and the dehydrogenation ability increase linearly with the amount of surface ZnOH^(+)species while keeping identical bulk zinc *** believe that the linear relationships are essential to design next generation olefin aromatization catalysts.

关键词： Zinc state Catalyst Catalysis Hydrogen transfer Dehydrogenation Moleclar sieves

An Improved RPL Algorithm for Low-Power and Lossy Networks

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China Communications 2023年第1期20卷 140-152页

作者： Yanan cao hao Yuan Tianjin Key Laboratory of Wireless Mobile Communications and Power Transmission Tianjin Normal UniversityTianjin 300387China Chinese People’s Liberation Army Unit 61846 Zhuozhou 07250China

The routing protocol for low-power and lossy networks(RPL),standardized by Internet Engineering Task Force(IETF),is mainly designed to use for Low-power and Lossy Networks(LLNs).To solve the problems of several important routing metrics are not evaluated,the optimal path may contain long single hop links,lack of scientific multi-routing metrics evaluation method and mechanism to balance the parent child number(especially the parent with one hop away from root),this paper proposes an improved RPL algorithm for LLN(I-RPL).First of all,we propose the evaluated routing metrics:child number of parent,candidate parent number,hop count,ETX and energy consumption ***,we improve the path ETX calculation method to avoid selecting optimal path containing long single hop *** we design a novel lexical method to synthetically evaluate candidate ***,based on the evaluation results of candidate parents,we design a novel objective function and a new calculation node rank method which can also be used for selecting the optimal ***,evaluation results show that I-RPL outperforms ETXOF and several other improvements in terms of packet delivery ratio,latency,etc.

关键词： routing protocol RPL routing metric lexical method objective function

Readout electronics of a prototype spectrometer for measuring low-energy ions in solar wind plasma

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Nuclear Science and Techniques 2016年第6期27卷 130-136页

作者： di Yang Zhe cao Xi Qin Xin-Jun hao Shu-Bin Liu Chang-Qing Feng Qi An State Key Laboratory of Particle Detection and Electronics(IHEP-USTC) Hefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China division of Space Physics University of Science andTechnology of ChinaHefei 230026China CAS Key Laboratory of Geospace Environment Hefei 230026China

Readout electronics is developed for a prototype spectrometer for in situ measurement of low-energy ions of30 e V/e–20 ke V/e in the solar wind plasma.A low-noise preamplifier/discriminator(A111F) is employed for each channel to process the signal from micro-channel plate(MCP) detectors.A high-voltage(HV) supply solution based on a HV module and a HV optocoupler is adopted to generate a fast sweeping HV and a fixed *** to limitation of telemetry bandwidth in space communication,an algorithm is implemented in an FPGA(field programmable gate array) to compress the raw *** results show that the electronics achieves a 1 MHz event rate and a large input dynamic range of 95 p C.A slew rate of 0.8 V/ls and an integral nonlinearity of 0.7-LSB for the sweeping HV,and a precision of less than 0.8 % for the fixed HV are obtained.A vacuum beam test shows an energy resolution of 12 ± 0.7 % full width at half maximum(FWHM) is achieved,and noise counts are less than10/sec,indicating that the performance meets the physical requirement.

关键词：低能离子等离子体原位测量电子学光谱仪太阳风读出原型