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Neural Regeneration Research 2023年第1期18卷 135-136页

作者： Xiaorong Liu hao f.zhang Department of Biology Department of PsychologyProgram in Fundamental NeuroscienceUniversity of VirginiaCharlottesvilleVAUSA Department of Biomedical Engineering Northwestern UniversityEvanstonILUSA

Retinal ganglion cells(RGCs)receive synaptic inputs through their dendritic trees in the inner plexiform layer(IPL)and convey the visual information via their axons which form the optic nerve to the brain(Sanes and Masland,2015).In glaucoma,RGCs and their axons degenerate and die,leading to irreversible vision loss and eventually blindness if left untreated(Quigley,2016).

关键词： bundle visible eventually

Symmetrically dispersed spectroscopic singlemolecule localization microscopy

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Light(Science & Applications) 2020年第1期9卷 1154-1163页

作者： Ki-Hee Song Yang zhang Benjamin Brenner Cheng Sun hao f.zhang Department of Biomedical Engineering Northwestern University2145 Sheridan Rd.EvanstonIL 60208USA Department of Mechanical Engineering Northwestern University2145

Spectroscopic single-molecule localization microscopy(sSMLM)was used to achieve simultaneous imaging and spectral analysis of single molecules for the first *** sSMLM fundamentally suffers from a reduced photon budget because the photons from individual stochastic emissions are divided into spatial and spectral ***,both spatial localization and spectral analysis only use a portion of the total photons,leading to reduced precisions in both *** improve the spatial and spectral precisions,we present symmetrically dispersed sSMLM,or SDsSMLM,to fully utilize all photons from individual stochastic emissions in both spatial and spectral *** achieved 10-nm spatial and 0.8-nm spectral precisions at a total photon budget of *** with the existing sSMLM using a 1:3 splitting ratio between spatial and spectral channels,SDsSMLM improved the spatial and spectral precisions by 42% and 10%,respectively,under the same photon *** also demonstrated multicolour imaging of fixed cells and three-dimensional single-particle tracking using *** enables more precise spectroscopic single-molecule analysis in broader cell biology and material science applications.

关键词： dispersed spectroscopic stochastic

PHOTOACOUSTIC GENERATION Of fOCUSED QUASI-UNIPOLAR PRESSURE PULSES

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Journal of Innovative Optical Health Sciences 2010年第4期3卷 247-253页

作者： KONSTANTIN MASLOV hao f.zhang LIHONG V.WANG Optical Imaging Laboratory Department of Biomedical Engineering Washington University in St.Louis St.LouisMissouri 63130USA Department of Electrical Engineering and Computer Science University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201USA

The photoacoustic effect was employed to generate short-duration quasi-unipolar acoustic pressure pulses in both planar and spherically focused *** the focal region,the temporal profile of a pressure pulse can be approximated by the first derivative of the temporal profile near the front transducer surface,with a time-averaged value equal to *** approximation agreed with experimental results acquired from photoacoustic transducers with both rigid and free *** a free boundary,the acoustic pressure in the focal region is equal to the sum of a positive pressure that follows the spatial profile of the optical energy deposition in the medium and a negative pressure that follows the temporal profile of the laser pulse.

关键词： Photoacoustics optoacoustics ultrasound generation unipolar pulse

A standardized crush tool to produce consistent retinal ganglion cell damage in mice

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Neural Regeneration Research 2021年第7期16卷 1442-1443页

作者： Pedro Norat Jingyi Gao Sauson Soldozy hao f.zhang Xiaorong Liu Department of Biology University of VirginiaCharlottesvilleVAUSA Department of Neurological Surgery University of Virginia Health SystemCharlottesvilleVAUSA Department of Biomedical Engineering Northwestern UniversityEvanstonILUSA Department of Psychology University of VirginiaCharlottesvilleVAUSA

In the mammalian central ner vous system, neuronal loss induced by injuries or in neurodegenerative diseases is often irreversible(Quigley, 2016;Gan et al., 2018).following the disease insult, the surviving neurons may continue to lose their functionality because their axons degenerate and fail to maintain proper synaptic connections, and the underlying molecular and cellular mechanisms remain to be investigated(Raff et al., 2002;Bei et al., 2016;Quigley, 2016).

关键词： irreversible maintain degenerate

SIMULTANEOUS IMAGING Of A lacZ-MARKED TUMOR AND MICROVASCULATURE MORPHOLOGY IN VIVO BY DUAL-WAVELENGTH PHOTOACOUSTIC MICROSCOPY

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Journal of Innovative Optical Health Sciences 2008年第2期1卷 207-215页

作者： LI LI hao f.zhang ROGER J.ZEMP KONSTANTIN MASLOV LIHONG V.WANG Optical Imaging Laboratory Department of Biomedical Engineering Washington University in St.Louis St.LouisMissouri 63130USA Department of Electrical Engineering University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201USA Department of Electrical and Computer Engineering University of Alberta EdmontonAlberta T6G2V4Canada

Photoacoustic molecular imaging,combined with the reporter-gene technique,can provide a valuable tool for cancer *** expression of the lacZ reporter gene can be imaged using photoacoustic imaging following the injection of X-gal,a colorimetric assay for the lacZ-encoded enzymeβ-***-wavelength photoacoustic microscopy was used to non-invasively image the detailed morphology of a lacZ-marked 9L gliosarcoma and its surrounding microvasculature simultaneously in vivo,with a superior resolution on the order of 10μ***-feeding vessels were found,and the expression level of lacZ in tumor was *** future development of new absorption-enhancing reporter-gene systems,we anticipate this strategy can lead to a better understanding of the role of tumor metabolism in cancer initiation,progression,and metastasis,and in its response to therapy.

关键词： Photoacoustic molecular imaging gene expression reporter gene

Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation

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Light(Science & Applications) 2015年第1期4卷 197-206页

作者： Ji Yi Wenzhong Liu Siyu Chen Vadim Backman Nader Sheibani Christine M.Sorenson Amani A.fawzi Robert A.Linsenmeier hao f.zhang Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA McPherson Eye Research Institute University of WisconsinMadisonWI 53705USA Department of Ophthalmology Northwestern UniversityChicago Illinois 60611USA Department of Neurobiology Northwestern UniversityEvanstonIL 60208USA

The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration,diabetic retinopathy,and *** visible light optical coherence tomography(vis-OCT),we demonstrated accurate and robust measurement of retinal oxygen metabolic rate(rMRO2)noninvasively in rat *** continuously monitored the regulatory response of oxygen consumption to a progressive hypoxic *** found that both oxygen delivery,and rMRO2 increased from the highly regulated retinal circulation(RC)under hypoxia,by 0.2860.08 μL min(^-1)(p,0.001),and 0.2060.04 μL min(^-1)(p,0.001)per 100 mmHg systemic pO2 reduction,*** increased oxygen extraction compensated for the deficient oxygen supply from the poorly regulated choroidal *** from an oxygen diffusion model based on previous oxygen electrode measurements corroborated our in vivo *** believe that vis-OCT has the potential to reveal the fundamental role of oxygen metabolism in various retinal diseases.

关键词： oxygen metabolism retinal circulation visible light optical coherence tomography

High-frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator

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Biomedical Engineering frontiers 2022年第1期3卷 348-355页

作者： Qiangzhou Rong Youngseop Lee Yuqi Tang Tri Vu Carlos Taboada Wenhan Zheng Jun Xia David A.Czaplewski hao f.zhang Cheng Sun Junjie Yao Department of Biomedical Engineering Duke UniversityDurhamNCUSA 27708 Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Optical&Ultrasonic Imaging Laboratory University at BuffaloNorth Campus BuffaloNY 14260USA Center for Nanoscale Materials Argonne National LaboratoryArgonneIL 60439USA

3D photoacoustic computed tomography(3D-PACT)has made great advances in volumetric imaging of biological tissues,with high spatial-temporal resolutions and large penetration *** development of 3D-PACT requires high-performance acoustic sensors with a small size,large detection bandwidth,and high *** this work,we present a new high-frequency 3D-PACT system that uses a microring resonator(MRR)as the acoustic *** MRR sensor has a size of 80μm in diameter and was fabricated using the nanoimprint lithography *** the MRR sensor,we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of~23 MHz,an imaging depth of~8 mm,a lateral resolution of 114μm,and an axial resolution of 57μ*** have demonstrated the 3D PACT’s performance on in vitro phantoms,ex vivo mouse brain,and in vivo mouse ear and *** MRR-based 3D-PACT system can be a promising tool for structural,functional,and molecular imaging of biological tissues at depths.

关键词： resonator lithography resolution

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功能光学成像——从单分子到人眼

光学与光电技术 2020年第5期18卷 1-4页

作者：张浩美国西北大学生物医学工程系美国埃文斯顿82930

超分辨定位成像打破了衍射极限,使得光学成像系统的分辨率可以达到20-50 nm。传统的超分辨定位成像无法获取荧光分子的光谱信息,因此,研发了一种基于光栅的光谱光子定位超分辨成像技术(SPLM),能够同时获取单个分子的空间位置信息和光谱... 详细信息

超分辨定位成像打破了衍射极限,使得光学成像系统的分辨率可以达到20-50 nm。传统的超分辨定位成像无法获取荧光分子的光谱信息,因此,研发了一种基于光栅的光谱光子定位超分辨成像技术(SPLM),能够同时获取单个分子的空间位置信息和光谱信息。SPLM可以用于多分子超分辨成像,并且能够分辨发射光谱高度重叠的荧光标记物。此外,针对常用的光学诊断技术OCT,研发了一种可见光OCT(Vis-OCT),弥补了传统OCT无法用于氧代谢成像的缺陷,并将该技术用于致盲性疾病的研究。

关键词：超分辨成像光谱光子定位成像光学相干断层扫描技术氧代谢成像致盲性疾病

Preparation of Low Ratio Magnesium Ccement by Acid Leaching Treatment of Boron Mud

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 120-129页

作者： YANG Mei zhang Mingzhe CHEN hao School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China School of Physical Science and Technology Shenyang Normal UniversityShenyang 110168China

The effects of liquid-solid ratio and reaction time on the leaching rate of magnesium at room temperature were investigated,as well as the effects of the molar ratio of MgO/MgCl_(2),the amount of water added,and the amount of acid-impregnated slag dosed on the compressive strength and water resistance of *** results showed that the magnesium element in the boron mud could be maximally leached under the conditions of 1:1 concentration of hydrochloric acid at room temperature,liquid-solid ratio of 2.5 mL·g^(-1),and reaction time of 5 h,and the main products were amorphous SiO_(2) as well as a small amount of magnesium olivine which had not been completely *** LR-MOC prepared using the acid-soaked mixture could reach a softening coefficient of 0.85 for 28 d of water immersion when the molar ratio of MgO/MgCl_(2) was 2.2,the amount of water added was 0 g,and the acid-soaked slag dosing was 40 wt%,which also led to an appreciable late-strength,with an increase of 19.4%in compressive strength at 28 d compared to that at 7 *** previous studies,LR-MOC prepared in this way has a final strength phase that is not the more easily hydrolysed 3-phase but the lath-like *** this phenomenon,we analyzed the mechanism and found that,during the acid leaching process,a part of amorphous SiO_(2) dissolved in the acid leaching solution formed a silica sol,in which Mg^(2+)played a bridging role to make the silica sol more *** the addition and hydrolysis of MgO,the silica sol gel coagulation slows down,providing a capping layer to inhibit the hydrolysis of the 5-phase crystals and providing some strength after *** amorphous SiO_(2) in the other part of the acid-impregnated slag generated M-S-H gel with Mg^(2+)and OH-,which synergised with the dense structure composed of interlocking crystals to improve the water resistance of LR-MOC.

关键词： boron mud magnesium chloride-oxygen cement acid immersion water resistance silica sol

Optimizing battery deployment: Aging trajectory prediction enabling homogenous performance grouping

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Journal of Energy Chemistry 2025年第1期100卷 565-577页

作者： Shuquan Wang feng Gao Zhan Ma hao Tian Yusen zhang School of Control Science and Engineering Shandong University Key Lab of Power System Intelligent Dispatch and Control of Ministry of Education Shandong University

As battery deployments in electric vehicles and energy storage systems grow, ensuring homogeneous performance across units is crucial. We propose a multi-derivative imaging fusion(MDIf) model, employing advanced imaging and machine learning to predict battery aging trajectories from minimal initial data, thus facilitating effective performance grouping before deployment. Utilizing a derivative strategy and Gramian Angular Difference field for dimensional enhancement, the MDIf model uncovers subtle predictive features from discharge curve data after only ten cycles. The architecture includes a parallel convolutional neural network with lateral connections to enhance feature integration and *** on a self-developed dataset, the model achieves an average root-mean-square error of 0.047 Ah and an average mean absolute percentage error of 1.60%, demonstrating high precision and *** robustness is further validated through transfer learning on two publicly available datasets, adapting with minimal retraining. This approach significantly reduces the testing cycles required, lowering both time and costs associated with battery testing. By enabling precise battery behavior predictions with limited data, the MDIf model optimizes battery utilization and deployment strategies, enhancing system efficiency and sustainability.

关键词： Lithium-ion battery Battery prognostics fusion model Convolutional neural network Transfer learning