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Transcriptomic profile of human erythroleukemia cells in response to Sargassum fusiforme polysaccharide and its structure analysis

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Chinese Journal of Natural Medicines 2021年第10期19卷 784-795页

作者： DING hao-miao FU Rui-Jie XIE Ce WANG Cai-Sheng QIAN Guo-Ying College of Biological and Environmental Sciences Zhejiang Wanli UniversityNingbo 315100China School of Marine Sciences Ningbo UniversityNingbo 315211China

Sargassum fusiforme(***)has been used as an ingredient in Chinese herbal medicine for thousands of ***,there are a limited number of studies concerning its therapeutic *** performance gel permeation chromatography(HPGPC)analysis showed that the average molecular weight of the *** polysaccharide,SFPS 191212,is 43 *** 191212 is composed of mannose,rhamnose,galactose,xylose,glucose,and fucose(at a molar ratio:2.1:2.9:1.8:15.5:4.6:62.5)withα-andβ-*** present research evaluated the anti-tumor potential of the *** polysaccharide in human erythroleukemia(HEL)cells in *** explore the SFPS 191212’s apoptosis mechanism in HEL cells,transcriptome analysis was performed on HEL cells that were incubated with SFPS *** inhibitory effect of SFPS 191212 on HEL cell growth was also *** was found that SFPS 191212 inhibited HEL cell proliferation,reduced cell viability in a concentration-dependent manner,and induced an insignificant toxic effect on normal human embryonic lung(MRC-5)*** with the control group,transcriptome analysis identified a total of 598 differentially expressed genes(DEGs),including 243 up-regulated genes and 355 downregulated *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were performed on all DEGs,and 900 GO terms and 52 pathways were found to be significantly ***,23 DEGs were randomly selected and confirmed by quantitative real-time polymerase chain reaction(qRT-PCR).Moreover,SFPS 191212 down-regulated the PI3K/Akt signal transduction *** results provide a framework for understanding the effect of SFPS 191212 on cancer cells and can serve as a resource for delineating the anti-tumor mechanisms of ***.

关键词： Human erythroleukemia Polysaccharide Sargassum fusiforme Transcriptome

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Effect of Sargassum fusiforme polysaccharide on apoptosis and its possible mechanism in human erythroleukemia cells

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Chinese Journal of Natural Medicines 2020年第10期18卷 749-759页

作者： DING hao-miao CHEN Xue-Jia CHEN Hai-Min WANG Cai-Sheng QIAN Guo-Ying School of Marine Sciences Ningbo UniversityNingbo 315211China College of Biological and Environmental Sciences Zhejiang Wanli UniversityNingbo 315100China

This study aimed to investigate the effects of Sargassum fusiforme polysaccharide(SFPS I,II,and III)on the apoptosis and regulation of human erythroleukemia(HEL)*** effect of different doses of SFPS on HEL cell growth was detected using the Cell Counting Kit-8 method,and apoptosis was detected by Hoechst *** cycle distribution and apoptosis were detected using flow *** of the cell cycle gene,p53,antiapoptotic genes,Bcl-xL and Bcl-2,and pro-apoptotic genes,Bax,Bad,and Caspase-3,as well as the expression of the corresponding proteins,were detected using real-time quantitative polymerase chain reaction(qPCR)and Western *** results showed that SFPS Ⅱ and Ⅲ decreased HEL cell viability and induced HEL cell *** concentrations of SFPS(Ⅰ,Ⅱ,and Ⅲ)were detected that induced much less toxic effect in normal human embryonic lung(MRC-5)cells,and SFPS Ⅰ increased cell proliferation,indicating its favorable selectivity towards cancer *** mechanism by which SFPS induced apoptosis was also found to be related to the induction of cell cycle arrest in the G0/G1 phase and the increased expression of apoptosis-related genes and *** concluded that SFPS induces HEL cell apoptosis,possibly via activation of the Caspase pathway,providing the theoretical basis for the development of SFPS-based anti-tumor drug products.

关键词： Sargassum fusiforme Polysaccharides Human erythroleukemia(HEL cells) Apoptosis Cell cycle

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Learned Distributed Query Optimizer:Architecture and Challenges

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ZTE Communications 2024年第2期22卷 49-54页

作者： GAO Jun HAN Yinjun LIN Yang miao hao XU Mo Peking University Beijing 100871China ZTE Corporation Shenzhen 518057China

The query processing in distributed database management systems(DBMS)faces more challenges,such as more operators,and more factors in cost models and meta-data,than that in a single-node DMBS,in which query optimization is already an NP-hard *** query optimizers(mainly in the single-node DBMS)receive attention due to its capability to capture data distributions and flexible ways to avoid hard-craft rules in refinement and adaptation to new *** this paper,we focus on extensions of learned query optimizers to distributed ***,we propose one possible but general architecture of the learned query optimizer in the distributed context and highlight differences from the learned optimizer in the single-node *** addition,we discuss the challenges and possible solutions.

关键词： distributed query processing query optimization learned query optimizer

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Risk factors for operative morbidity and mortality in gastric cancer patients undergoing total gastrectomy

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World Journal of Gastroenterology 2008年第42期14卷 6560-6563页

作者： Dao-Jun Gong hao-Feng miao Qi Bao Ming Jiang Li-Fang Zhang Xiao-Tao Tong Li Chen Department of Surgery Second Affiliated Hospital Zhejiang University College of Medicine Hangzhou 310009 Zhejiang Province China

AIM： To study the risk factors for morbidity and mortality following total gastrectomy. METHODS： We retrospectively reviewed the records of 125 consecutive patients who underwent total gastrectomy for gastric cancer at the Second Affiliated Hospital of Zhejiang University School of Medicine between January 2003 and March 2008. RESULTS： The overall morbidity rate was 20.8% （27 patients） and the mortality rate was 3.2% （4 patients）. Morbidity rates were higher in patients aged over 60 [odds ratio （OR） 4.23 （95% confidence interval （CI） 1.09 to 12.05）], with preoperative comorbidity [with vs without, OR 1.25 （95% CI 1.13 to 8.12）], when the combined resection was performed [combined resection vs total gastrectomy only, OR 2.67 （95% CI 1.58 to 5.06）]. CONCLUSION： Age, preoperative comorbidity and combined resection were with the rate of morbidity gastric cancer. independently associated after total gastrectomy for

关键词： Gastric cancer Total gastrectomy Morbidity Mortality Risk factor

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RNP STRUCTURE IN METAPHASE CHROMOSOMES OF Vicia faba

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Science China Chemistry 1989年第6期32卷 706-710,769-770页

作者：邢苗郝水 Department of Biology Northeast Normal University Changchun

The results of studies on ultrastructural and cytochemical features of metaphase chromosomes of Vicia faba are reported. In conventionally stained specimens are observed many electron-lucent compartments, in which exists an internal fibrillar-granular structure. When stained with the Bernhard’s technique, the internal structure is found to consist of ribonucleoprotein (RNP) fibrilsand granules that measure about 15 to 20 nmin diameter. In the transverse section of metaphase chromosomes, the RNP structures are distributed in both the central and the peripheral regions of chromatids. It is conceivable that this RNP structure constitutes a special component of chromosomes. The distribution of the RNP structure in a chromosome and some questions related to the chromosomal scaffold are discussed on the basis of these data.

关键词： chromosome RNP structure scaffold Vicia faba.

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Rehabilitation interventions for malnutrition in head and neck cancer patients: Current state and future directions

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Journal of Nutritional Oncology 2023年第2期8卷 71-78页

作者： hao-miao Zhang Li-Li Yu Department of Radiation Oncology Harbin Medical University Cancer HospitalHarbin 150081HeilongjiangChina

Head and neck cancer and the approaches used to treat it can cause symptoms such as mucositis,alteration or loss of taste,dysphagia,and xerostomia,whichmakes the incidence of malnutrition in head and neck cancer patients higher than in the general population of cancer *** in patients with head and neck cancer is associated with the occurrence of treatment-related adverse events,an increase in overall economic cost,a decline in quality of life,and a poor ***,rehabilitation interventions for malnutrition are necessary throughout the course of the ***,the importance of rehabilitation interventions for malnutrition in patients with head and neck cancer has not been fully recognized,and the optimal methods and timing of interventions are *** article provides an overview of rehabilitation interventions for malnutrition,including nutritional supplementation,exercise-based interventions,nutritional counseling and cognitive improvement,and drug therapy,and discusses their advantages and disadvantages as well as potential future directions.

关键词： Head and neck cancer Intervention Malnutrition Rehabilitation

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BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction

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Journal of Molecular Cell Biology 2017年第3期9卷 209-219页

作者： Qian Ba Xiaoguang Li Chao Huang Junyang Li Yijing Fu Peizhan Chen Juan Duan miao hao Yinghua Zhang Jingquan Li Chuanqi Sun hao Ying Haiyun Song Ruiwen Zhang Zhiyuan Shen Hui Wang School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Key' Laboratory of Food Safety Research institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Department of Pharmaceutical Sciences School of Pharmacy Texas Tech University Health Sciences Center Amarillo TX 79106 USA Rutgers Cancer Institute of New Jersey Department of Radiation Oncology of Robert Wood Johnson Medical School Rutgers The State University of NewJersey New Brunswick NJ 08903 USA

Extraribosomal functions of ribosomal proteins （RPs） have gained much attention for their implications in tumorigenesis and pro- gression. However, the regulations for transition between the ribosomal and extraribosomal functions of RPs are rarely reported. Herein, we identified a ribosomal protein S7-interacting partner, BCCIPβ, which modulates the functional conversion of S7. Through the N-terminal acidic domain, BCCIPβ interacts with the central basic region in S7 and regulates the extraribosomal dis- tribution of S7. BCCIPI~ deficiency abrogates the ribosomal accumulation but enhances the ribosome-free location of S7. This translocation further impairs protein synthesis and triggers ribosomal stress. Consequently, BCCIPβ deficiency suppresses the ribosomal function and initiates the extraribosomal function of S7, resulting in restriction of cell proliferation. Moreover, clinically relevant S7 mutations were found to dampen the interaction with BCCIPβ and facilitate the functional transition of S7. In conclu- sion, BCCIPβ, as a S7 modulator, contributes to the regulation of ribosomal and extraribosomai functions of S7 and has implica- tions in cell growth and tumor development.

关键词： BCCIPβ ribosomal protein S7 translation ribosomal stress tumor suppressor

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Bottom-following control for an underactuated unmanned undersea vehicle using integral-terminal sliding mode control

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Journal of Central South University 2015年第11期22卷 4193-4204页

作者：严浙平于浩淼李本银 College of Automation Harbin Engineering University

The bottom-following problem of an underactuated unmanned undersea vehicle(UUV) is addressed. A robust nonlinear controller is developed by using integral-terminal sliding mode control(ITSMC), which can exponentially drive an UUV onto a predefined path at a constant forward speed. The kinematic error equations are first derived in the Serret-Frenet frame. Using the line of sight(LOS) method, Lyapunov's direct technique and tracking differentiator, the guidance law is established. Then, the kinematic controller, the guidance law, is expanded to cope with vehicle dynamics by resorting to introduce two integral-terminal sliding surfaces. Robustness to parameter perturbation is addressed by incorporating the reaching laws associated with the upper bound of the parameter perturbation. The proposed control law can guarantee that all error signals globally exponentially converge to the origin. Finally, a series of numerical simulation results are presented and discussed. In these simulations, wave, constant unknown ocean currents(for the purposes of the controller) and the parameter perturbation are added to illustrate the robustness and effectiveness of the bottom-following control scheme.

关键词： underactuated unmanned undersea vehicle integral-t

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Diving control of underactuated unmanned undersea vehicle using integral-fast terminal sliding mode control

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Journal of Central South University 2016年第5期23卷 1085-1094页

作者：严浙平于浩淼侯恕萍 College of Automation Harbin Engineering University College of Mechanical and Electrical Engineering Harbin Engineering University

The problem of diving control for an underactuated unmanned undersea vehicle(UUV) considering the presence of parameters perturbations and wave disturbances was *** vertical motion of an UUV was divided into two noninteracting subsystems for surge velocity control and *** stabilize the vertical motion system,the surge velocity and the depth control controllers were proposed using backstepping technology and an integral-fast terminal sliding mode control(IFTSMC).It is proven that the proposed control scheme can guarantee that all the error signals in the whole closed-loop system globally converge to the sliding surface in finite time and asymptotically converge to the origin along the sliding *** a unified control parameters for different motion states,a series of numerical simulation results illustrate the effectiveness of the above designed control scheme,which also shows strong robustness against parameters perturbations and wave disturbances.

关键词： integral-fast terminal sliding mode control depth control underactuated unmanned undersea vehicle

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Lumped-equivalent circuit model for multi-stage cascaded magnetoelectric dual-tunable bandpass filter

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Chinese Physics B 2015年第10期24卷 481-490页

作者：张秋实朱锋杰周浩淼 College of Information Engineering China Jiliang University

A lumped-equivalent circuit model of a novel magnetoelectric tunable bandpass filter, which is realized in the form of multi-stage cascading between a plurality of magnetoelectric laminates, is established in this paper for convenient *** multi-stage cascaded filter is degraded to the coupling microstrip filter with only one magnetoelectric laminate and then compared with the existing experiment results. The comparison reveals that the insertion loss curves predicted by the degraded circuit model are in good agreement with the experiment results and the predicted results of the electromagnetic field simulation, thus the validity of the model is verified. The model is then degraded to the two-stage cascaded magnetoelectric filter with two magnetoelectric laminates. It is revealed that if the applied external bias magnetic or electric fields on the two magnetoelectric laminates are identical, then the passband of the filter will drift under the changed external field; that is to say, the filter has the characteristics of external magnetic field tunability and electric field tunability. If the applied external bias magnetic or electric fields on two magnetoelectric laminates are different, then the passband will disappear so that the switching characteristic is achieved. When the same magnetic fields are applied to the laminates, the passband bandwidth of the two-stage cascaded magnetoelectric filter with two magnetoelectric laminates becomes nearly doubled in comparison with the passband filter which contains only one magnetoelectric laminate. The bandpass effect is also improved obviously. This research will provide a theoretical basis for the design, preparation, and application of a new high performance magnetoelectric tunable microwave device.

关键词： microwave magnetoelectric effect lumped-equivalent circuit magnetoelectric tunable microwave device multi-stage cascaded filter

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