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The prognostic value of collateral circulation in coronary chronic total occlusion underwent percutaneous coronary intervention

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Journal of Geriatric Cardiology 2024年第2期21卷 232-241页

作者： Xiao-Ying HU Wei-Xian YANG Chang-Dong GUAN Li-Hua xie Ke-Fei DOU Yong-Jian WU Jin-qing YUAN Jie QIAN Yue-Jin YANG Shu-Bin QIAO Lei SONG Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center for Cardiovascular Diseases BeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND The prognostic value of coronary collateral circulation(CC)in patients undergoing chronic total occlusion(CTO)percutaneous coronary intervention(PCI)is *** purpose of the study was to assess the prognostic value of current two CC grading systems and their association with long-term outcomes in patients with CTO underwent *** We consecutively enrolled patients with single-vessel CTO underwent PCI between January 2010 and *** patients were categorized into well-developed or poor-developed collaterals group according to angiographic Werner's CC(grade 2 *** 0–1)or Rentrop(grade 3 *** 0–2)grading *** primary endpoint was 5-year cardiac *** Of 2452 enrolled patients,the overall technical success rate was 74.1%.Well-developed collaterals were present in686 patients(28.0%)defined by Werner's CC grade 2,and in 1145 patients(46.7%)by Rentrop grade *** to Werner's CC grading system,patients with well-developed collaterals had a lower rate of 5-year cardiac death compared with those with poordeveloped collaterals(1.6%vs.3.3%,P=0.02),those with suboptimal recanalization was associated with higher rate of 5-year cardiac death compared with optimal recanalization(4.7%vs.0.8%,P=0.01)and failure patients(4.7%vs.1.6%,P=0.12).However,the similar effect was not shown in Rentrop grading *** In patients with the single-vessel CTO underwent PCI,well-developed collaterals by Werner's CC definition were associated with lower rate of 5-year cardiac ***'s CC grading system had a greater prognostic value than Rentrop grading system in patients with CTO underwent PCI.

关键词： coronary collateral occlusion

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Highly efficient discovery of the covalent Minhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches

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Food Science and Human Wellness 2024年

作者： Guang-hao Zhu Ya-Ni Zhang Sheng-Lan Qi Jian-Rong Xu Yuan Xiong Zhao-Qin Zhang Xi-Xiang Chen Yuan-Yuan xie Xiao-qing Guan Wei-Dong Zhang Wei Liu Guang-Bo Ge Shanghai Frontiers Science Center of TCM Chemical Biology， Institute of Interdisciplinary Integrative Medicine Research， Shanghai University of Traditional Chinese Medicine Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

The main proteases (Mpros) are hydrolases playing essential roles in the replication of β-coronaviruses including SARS-CoV-2. Herein， a highly efficient strategy was developed for discovering the Mproinactivators from crude plant extract integrating target-based biochemical assay and chemoproteomic approaches. Firstly， Pu-erh tea was found to potently suppress SARS-CoV-2 Mproin a time-dependent manner. Next， global chemical analysis coupling with peptide-modification profiling were used to identify the cysteine-modified constituents in Pu-erh tea. The results suggested that seven constituents in Pu-erh tea could modify SARS-CoV-2 Mpro， which turned out that epigallocatechin， gallocatechin and gallic acid were the most efficacious Mproinactivators. Further investigations demonstrated that epigallocatechin and gallocatechin could inactivate SARS-CoV-2 Mprovia blocking the formation of the homodimers. Collectively， this work proposed a novel and practical strategy for highly efficient discovery of time-dependent inhibitors of SARS-CoV-2 Mprofrom plant extracts， while three constituents in Pu-erh tea have emerged as robust SARS-CoV-2 Mproinactivators.

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大型耙吸挖泥船结构设计要点

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船海工程 2024年第1期53卷 82-86页

作者：荆海东杨青谢昊中国船舶及海洋工程设计研究院上海200011

为实现大型耙吸挖泥船结构设计安全、合理、可靠,以某大型耙吸挖泥船为例,分析大型耙吸挖泥船结构设计特点,从结构设计、强度评估、疲劳评估和振动评估等角度论证其设计要点,通过对泥舱结构设计分析,给出泥舱设计的关键节点,对关键节点... 详细信息

为实现大型耙吸挖泥船结构设计安全、合理、可靠,以某大型耙吸挖泥船为例,分析大型耙吸挖泥船结构设计特点,从结构设计、强度评估、疲劳评估和振动评估等角度论证其设计要点,通过对泥舱结构设计分析,给出泥舱设计的关键节点,对关键节点进行强度分析和疲劳分析,结果表明,该船局部关键区域应力水平较高,低周疲劳在关键区域的疲劳中占据主要地位,建立三维有限元模型计算挖泥船固有频率,对比该大型耙吸挖泥船激励频率与固有频率,结果表明,船体总振动固有频率通常可以避开激励频率,生活楼固有频率与激励频率较为接近。

关键词：大型耙吸挖泥船结构设计中剖面设计关键区域强度评估疲劳评估振动控制

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Single-cell profiling of the pig cecum at various developmental stages

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Zoological Research 2024年第1期45卷 55-68页

作者： Yan-Yuan Xiao qing Zhang Fei Huang Lin Rao Tian-Xiong Yao Si-Yu Yang Lei xie Xiao-Xiao Zou Li-Ping Cai Jia-Wen Yang Bin Yang Lu-Sheng Huang National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangJiangxi 330045China

The gastrointestinal tract is essential for food digestion,nutrient absorption,waste elimination,and microbial ***-cell transcriptome profiling of the intestinal tract has greatly enriched our understanding of cellular diversity,functional heterogeneity,and their importance in intestinal tract development and *** such profiling has been extensively conducted in humans and mice,the single-cell gene expression landscape of the pig cecum remains ***,single-cell RNA sequencing was performed on 45572 cells obtained from seven cecal samples in pigs at four different developmental stages(days(D)30,42,150,and 730).Analysis revealed 12 major cell types and 38 subtypes,as well as their distinctive genes,transcription factors,and regulons,many of which were conserved in *** increase in the relative proportions of CD8^(+)T and Granzyme A(low expression)natural killer T cells(GZMA^(low)NKT)cells and a decrease in the relative proportions of epithelial stem cells,Tregs,RHEX^(+)T cells,and plasmacytoid dendritic cells(pDCs)were noted across the developmental ***,the post-weaning period exhibited an up-regulation in mitochondrial genes,COX2 and ND2,as well as genes involved in immune activation in multiple cell ***-cell crosstalk analysis indicated that IBP6^(+)fibroblasts were the main signal senders at D30,whereas IBP6^(−)fibroblasts assumed this role at the other *** cells established interactions with epithelial cells and IBP6^(+)fibroblasts in the D730 cecum through mediation of GZMA-F2RL1/F2RL2 *** study provides valuable insights into cellular heterogeneity and function in the pig cecum at different development stages.

关键词： Single-cell RNA-seq Cecum Bama Xiang pigs Various developmental stages Cellular heterogeneity

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How can we establish animal models of HIV-associated lymphoma?

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Animal Models and Experimental Medicine 2024年第4期7卷 484-496页

作者： qing Xiao Liuyue Zhai Xiaomei Zhang Yi Liu Jun Li Xiaoqing xie Guofa Xu Sanxiu He Huihui Fu Yifeng Tang Fujie Zhang Yao Liu Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Department of Hematology-OncologyChongqing University Cancer HospitalChongqingChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina

Human immunodeficiency virus(HIV)infection is strongly associated with a height-ened incidence of *** mirror the natural course of human HIV infection,animal models have been *** models serve as valuable tools to inves-tigate disease pathobiology,assess antiretroviral and immunomodulatory drugs,ex-plore viral reservoirs,and develop eradication ***,there are currently no validated in vivo models of HIV-associated lymphoma(HAL),hampering progress in this crucial domain,and scant attention has been given to developing animal models dedicated to studying HAL,despite their pivotal role in advancing *** re-view provides a comprehensive overview of the existing animal models of HAL,which may enhance our understanding of the underlying pathogenesis and approaches for malignancies linked to HIV infection.

关键词： animal model HIV-associated lymphoma(HAL) human immunodeficiency virus(HIV) immunodeficient mice primate model

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All-silicon low-loss THz temporal differentiator based on microring waveguide resonator platform

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Light(Advanced Manufacturing) 2024年第2期5卷 14-23页

作者： Yunjie Rui Shuyu Zhou Xuecou Tu Xu Yan Bingnan Yan Chen Zhang Ziyao Ye Huilin Zhang Jingya xie qing-Yuan Zhao La-Bao Zhang Xiao-qing Jia Huabing Wang Lin Kang Jian Chen Peiheng Wu Research Institute of Superconductor Electronics(RISE) School of Electronic Science and EngineeringNanjing UniversityNanjingJiangsu 210023China Hefei National Laboratory Hefei 230088China Purple Mountain Laboratories NanjingJiangsu 211111China Terahertz Technology Innovation Research Institute Shanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai200093China

Microring resonators have been widely used in passive optical devices such as wavelength division multiplexers,differentiators,and *** on terahertz(THz)components has been accelerated by these photonics *** and integrated time-domain differentiators that enable low-loss,high-speed THz signal processing are necessary for THz *** this study,an on-chip THz temporal differentiator based on all-silicon photonic technology was *** device primarily consisted of a microring waveguide resonator and was packaged with standard waveguide *** performed time-domain differentiation on input signals at a frequency of 405.45 GHz with an insertion loss of 2.5 dB and a working bandwidth of 0.36 *** periodic waveforms could be handled by this *** device could work as an edge detector,which detected step-like edges in high-speed input signals through differential *** development holds significant promise for future THz data processing technologies and THz communication systems.

关键词： Silicon photonics Whispering gallery mode resonator THz silicon waveguide

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Publication trends of Leber congenital amaurosis researches:a bibliometric study during 2002-2022

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1501-1509页

作者： Xiao-Xu Huang Yi-Min Wang Min-Yue xie Yi-qing Sun Xiao-Huan Zhao Yu-Hong Chen Jie-Qiong Chen Si-Yang Han Min-Wen Zhou Xiao-Dong Sun Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China National Clinical Research Center for Eye Disease Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghai 200030China Beijing Tongren Hospital Capital Medical UniversityBeijing 100054China Eberly College of Science Penn State UniversityUniversity Park 16802-1503United States

AIM:To analyze the changes in scientific output relating to Leber congenital amaurosis(LCA)and forecast the study trends in this ***:All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science(WOS)*** analyzed the quantity(number of publications),quality(citation and H-index)and development trends(relative research interest,RRI)of published LCA research over the last two ***,VOSviewer software was applied to define the co-occurrence network of keywords in this ***:A total of 2158 publications were ultimately *** found that the focus on LCA kept rising and peaked in 2015 and 2018,which is consistent with the development trend of gene *** USA has contributed most to this field with 1162 publications,56674 citations and the highest H-index value(116).The keywords analysis was divided into five clusters to show the hotspots in the field of LCA,namely mechanism-related,genotype-related,local phenotype-related,system phenotype-related,and *** also identified gene therapy and antiretinal degeneration therapy as a major focus in recent ***:Our study illustrates historical research process and future development trends in LCA *** may help to guide the orientation for further clinical diagnosis,treatment and scientific research.

关键词： VOSviewer bibliometrics Leber congenital amaurosis gene therapy hotpots

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Ⅱ型亚历山大病一例

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中国现代神经疾病杂志 2024年第6期24卷 502-506页

作者：袁于青占青青谢亮南昌大学第二附属医院神经内科、江西省神经系统肿瘤及脑血管疾病重点实验室、江西省神经医学重点实验室、南昌大学神经科学研究所 330006

先证者男性,50岁。因右下肢无力6个月,加重伴左下肢无力2个月,于2021年5月10日至我院就诊。2020年11月无明显诱因出现右下肢无力,尚可行走和上下楼梯,行走百米后需稍作休息,易疲劳,偶有饮水呛咳,无肢体麻木,无头痛头晕,无恶心不适,未予... 详细信息

先证者男性,50岁。因右下肢无力6个月,加重伴左下肢无力2个月,于2021年5月10日至我院就诊。2020年11月无明显诱因出现右下肢无力,尚可行走和上下楼梯,行走百米后需稍作休息,易疲劳,偶有饮水呛咳,无肢体麻木,无头痛头晕,无恶心不适,未予重视。2021年3月右下肢无力感加重,行走费力,有拖曳感,逐渐出现左下肢无力,双手持笔不稳,2021年3月27日至外院就诊,头部MRI显示延髓萎缩、纤细(图1a),考虑“脊髓损伤”可能,未予药物治疗。2021年5月上述症状加重,并伴有头晕、共济失调、言语不清,为求进一步诊治至我院神经内科就诊,门诊以“多系统萎缩?炎性脱髓鞘性病变(待排)”收入院。先证者自发病以来,食欲尚可,日间精神尚可;睡眠较差,主要表现为睡眠维持困难和易醒,一般10~20 min可入睡,但睡眠维持困难,夜间因小便间断觉醒3~4次,醒后难以入睡,持续10余年;便秘7~8年,且呈进行性加重;自发病以来体重下降约10 kg。

关键词： Alexander病神经胶质原纤维酸性蛋白质基因突变延髓萎缩磁共振波谱学病例报告

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基于非靶向代谢组学的沙枣花、叶片和幼枝的挥发性成分分析

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植物生理学报 2024年第2期60卷 363-376页

作者：解庆刘志红山西农业大学林学院山西晋中030801

本文运用顶空固相微萃取-气相色谱-质谱联用技术(HS-SPME-GC-MS)研究了不同发育阶段沙枣花(花蕾、全开和凋谢)、叶片和幼枝的挥发性成分,并采用主成分分析(PCA)、正交偏最小二乘法判别分析(OPLS-DA)等方法筛选出差异代谢物。结果表明,... 详细信息

本文运用顶空固相微萃取-气相色谱-质谱联用技术(HS-SPME-GC-MS)研究了不同发育阶段沙枣花(花蕾、全开和凋谢)、叶片和幼枝的挥发性成分,并采用主成分分析(PCA)、正交偏最小二乘法判别分析(OPLS-DA)等方法筛选出差异代谢物。结果表明,沙枣挥发油以酯类、烃类、醇类和醛类物质为主,主要成分为肉桂酸乙酯、β-罗勒烯和4-己烯-1-醇乙酸酯等。代谢组学分析共筛选出17种差异代谢物。其中沙枣花蕾中的特征成分为α-橙花叔醇、反式-2-己烯醇、十一醛和β-罗勒烯;沙枣花全开时的特征成分为肉桂酸乙酯和安息香酸乙酯;凋谢后沙枣花的特征成分为癸醛、庚醛、植酮和2-甲基丁酸乙酯;沙枣叶片的特征成分为4-己烯-1-醇乙酸酯和叶醇而沙枣幼枝的特征成分为壬醛、顺式-3-己烯基异戊酸酯、苯乙醇和3-己烯-1-醇。沙枣花、叶片和幼枝挥发性成分的代谢组学分析,可为沙枣精油的综合开发利用提供一定理论依据。

关键词：沙枣挥发性成分顶空固相微萃取气相色谱-质谱联用非靶向代谢组学

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Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

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Current Medical Science 2024年第1期44卷 121-133页

作者： Ting-ting WEI Wen XU Bo TU Wan-xue ZHANG Xin-xin YANG Yiguo ZHOU Shan-shan ZHANG Jun-lian YANG Ming-zhu xie Juan DU Wei-wei CHEN qing-bin LU Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Infectious Disease The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityBeijing 100191China Department of Health Policy and Management School of Public HealthPeking UniversityBeijing 100191China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains *** the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were *** In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had *** samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted *** Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and *** metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid *** sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI *** and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

关键词： human adenovirus metabonomic lipids pneumonia upper respiratory tract infection

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