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Effect of Intrauterine Laser Therapy at the IVF Success Rate on Infertile patients with a History of IVF Failure: A pilot Non-Blinded Study

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Advances in Sexual Medicine 2024年第3期14卷 21-30页

作者： Fateme Hoseinzade Hatav Tehrani Shahriyar Mirshams Yasaman Zandi Mehran Michael hans Weber Department of physical Medicine and Rehabilitation Isfahan University of Medical Sciences Isfahan Iran Department of Obstetrics and Gynecology Isfahan University of Medical Sciences Isfahan Iran Department of physical Medicine and Rehabilitation Novin Comprehensive Physical Medicine Center Isfahan Iran Biomedical Engineering Center Dubai UAE International Society of Medical LASER Applications Lauenfoerde Germany

Backgrounds: While there’s developing proof aimed toward improving embryo implantation thru a focal point on great development, restrained studies have been performed on enhancing endometrial receptivity. Intrauterine Laser Therapy (LT) can be powerful in selling endometrial cell proliferation, therefore enhancing the achievement of assisted reproductive techniques (ART). The contemporary look at aimed to research the effectiveness of effective intrauterine lasers in growing endometrial thickness and the achievement of being pregnant rate. Materials and Methods: In the current clinical randomized trial (RTC) study, the infertile women (20 - 42 years old) referred to the infertility clinic in 2023-2024 who were candidates for IVF treatment with recurrent implantation failure (RIF) history were included. The patients were divided into two main groups: the intervention group;low level laser therapy (LLLT) after hormone administration) (n = 52) and the control group (hormone administration without LT) (n = 52). The IVF success rate and change in endometrial thickness before and after the LT were compared in groups. Results: There was a significant difference between groups (p Conclusion: It appears that the incorporation of Intrauterine LT in the realm of infertility could significantly impact as a novel supplementary treatment in improving endometrial receptivity and pregnancy rate.

关键词： Infertility IVF Implementation Intrauterine Low Level Laser Therapy

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Body Building on Diamonds

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Journal of Bionic Engineering 2009年第1期6卷 14-17页

作者： Andrei p. Sommer Tim Scharnweber hans-Joerg Fecht Institute of Micro and Nanomaterials University of UlmUlm 89081Germany Institute for Biological Interfaces Research Center KarlsruheKarlsruhe 76021Germany Institute for Nanotechnology Research Center Karlsruhe Karlsruhe 76021Germany

Whereas conservative therapies aim to stall the advance of disease,regenerative medicine strives to reverse *** capacity of most tissues to regenerate derives from stem cells,but there are a number of barriers which have to be circumvented before it will be possible to use stem-cell-based *** therapies,however,are expected to improve human health enormously, and knowledge gained from studying stem cells in culture and in model organisms is now laying the groundwork for a new era of regenerative *** of the most prominent methods to study stem cell differentiation is to let them to form embryoid *** favourable conditions any stem cell line will form embryoid ***,the mechanism of the formation of embryoid bodies is not very well understood,and to produce them in the laboratory is in no way trivial-an important technical barrier in stem cell ***,the embryoid body cultivation step has been successfully circumvented for the derivation of osteogenic cultures of embryonic stem *** we report on a simple and reusable system to cultivate embryoid bodies in extremely short *** method is inspired by the principles that lead to the establishment of the biomimetic triangle.

关键词： biomimetic triangle stem cells embryoid bodies nanobionics nanocrystalline diamond

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AtGGM2014, an Arabidopsis gene co-expression network for functional studies

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Science China(Life Sciences) 2015年第3期58卷 276-286页

作者： MA ShiSong BOHNERT hans J DINESH-KUMAR Savithramma p Department of plant Biology and the Genome Center College of Biological Sciences University of California Departments of plant Biology and of Crop Sciences University of Illinois at Urbana-Champaign

Gene co-expression networks provide an important tool for systems biology studies. Using microarray data from the Array Express database, we constructed an Arabidopsis gene co-expression network, termed At GGM2014, based on the graphical Gaussian model, which contains 102,644 co-expression gene pairs among 18,068 genes. The network was grouped into 622 gene co-expression modules. These modules function in diverse house-keeping, cell cycle, development, hormone response, metabolism, and stress response pathways. We developed a tool to facilitate easy visualization of the expression patterns of these modules either in a tissue context or their regulation under different treatment conditions. The results indicate that at least six modules with tissue-specific expression pattern failed to record modular regulation under various stress conditions. This discrepancy could be best explained by the fact that experiments to study plant stress responses focused mainly on leaves and less on roots, and thus failed to recover specific regulation pattern in other tissues. Overall, the modular structures revealed by our network provide extensive information to generate testable hypotheses about diverse plant signaling pathways. At GGM2014 offers a constructive tool for plant systems biology studies.

关键词： Arabidopsis gene co-expression network graphical Gaussian model plant development stress response hormone response

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It is Time for a Change： opetri Dishes Weaken Cells

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Journal of Bionic Engineering 2012年第3期9卷 353-357页

作者： Andrei p. Sommer Mike Kh. Haddad hans-Joerg Fecht Institute of Micro and Nanomaterials University of Ulm 89081 Ulm Germany Institute for Nanotechnology Karlsruhe Institute for Technology 76344 Eggenstein-Leopoldshafen Germany

We wish to draw the attention to a potential deficiency in the biocompatibility of polystyrene cell culture dishes which is caused by a softening of the material under relevant culture conditions. The finding confirms the central hypothesis of our previous model study. In it we assumed a local increase in pH at the interface between the hydrophilic polymer and liquid. The finding is of considerable biological interest. polystyrene tissue culture dishes are now in use for 50 years. To the best of our knowledge their biocompatibility has never been challenged. Here we report the first experimental proof that exposure to water softens the surface of polystyrene petri dishes. We expect that our results will stimulate the development of a new generation of cell culture devices, including petri dishes and culture flasks, and the establishment of improved biomimetic settings for tissue engineering and stem cell research. New non-swelling biomaterials or nanocoatings designed to reduce the swelling of polymer ct, lture dishes could improve cell performance. The need for further study is clear.

关键词： petri dish polystyrene biomimetic triangle nanoindentation stem cells diamond

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The Top of the Biomimetic Triangle

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Journal of Bionic Engineering 2008年第2期5卷 91-94页

作者： Andrei p. Sommer Dan Zhu Matthias Wiora hans-Joerg Fecht Institute of Micro and Nanomaterials University of Ulm Ulm 89081 Germany Institute for Nanotechnology Forschungszentrum Karlsruhe Karlsruhe 76021 Germany

There is increasing observational evidence indicating that crystalline interfacial water layers play a central role in evolution and biology. For instance in cellular recognition processes, in particular during first contact events, where cells decide upon survival or entering apoptosis. Understanding water layers is thus crucial in biomedical engineering, specifically in the design of biomaterials inspired by biomimetic principles. Whereas there is ample experimental evidence for crystalline interfacial water layers on surfaces in air, their subaquatic presence could not be verified directly, so far. Analysing a polarity dependent asym- metry in the surface conductivity on hydrogenated nanocrystalline diamond, we show that crystalline interfacial water layers persist subaquatically. Nanoscopic interfacial water layers with an order different from that of bulk water have been identified at room temperature on both hydrophilic and hydrophobic model surfaces - in air and subaquatically. Their generalization and systematic inclusion into the catalogue of physical and chemical determinants of biocompatibility complete the biomimetic triangle.

关键词： biomimetic triangle crystalline interfacial water layers nanobionics diamond

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Do we really understand the role of the oesophagogastric junction in disease?

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World Journal of Gastroenterology 2009年第2期15卷 144-150页

作者： Barry p McMahon Blair A Jobe John E pandolfino hans Gregersen Department of Medical physics & Clinical Engineering Adelaide & Meath Hospital Tallaght Dublin 24 Ireland Associate professor of Surgery Director of Esophageal Diagnostics & Therapeutic Endoscopy Heart Lung and Esophageal Surgery Institute University of Pittsburgh Medical Centre Shadyside Medical Building Suite 715 Pittsburgh PA 15232 United States Division of Gastroenterology Northwestern Memorial University Hospital 676 N. St. Clair St. Suite 1400 Chicago IL 60611 United States professor of Biomechanics Director of Research Mech-Sense Aalborg Hospital Science and Innovation Centre Sφndre Skovvej 15 9000 Aalborg Denmark

The role of the oesophago-gastric junction (OGJ) in gastro-oesophageal reflux disease is still not completely understood, and there is no clinically used method to assess the OGJ function in patients. Only indirect methods such as pH studies are carried out. The OGJ acts a valve controlling the flow of solids, liquids and gases between the oesophagus and the stomach. Manometry can determine if a sphincter is toned or relaxed; but, it cannot confirm that the sphincter region is actually open. Distension is a new technique for measuring function in the OGJ. By measuring the cross-sectional area through the narrow region in the junction during distension of a catheter mounted bag, much more information on the opening and closing patterns of the junction can be determined. This technique has already been demonstrated to show changes in the OGJ after surgical treatments for reflux disease. New measurement ideas around the concept of distending the OGJ offer new hope that a clinically useable test for compliance at the junction can be developed and could potentially help in determining appropriate therapy.

关键词： Achalasia Distensibility Impedance planimetry Intraluminal impedance manometry Oesophago-gastric junction

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Evidence for the polyphyly of Encoelia and Encoelioideae with reconsideration of respective families in Leotiomycetes

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Fungal Diversity 2017年第1期82卷 183-219页

作者： Kadri pärtel hans-Otto Baral Heidi Tamm Kadri põldmaa Institute of Ecology and Earth Sciences University of TartuLai 40EE-51005 TartuEstonia Mycological Collections Institute of Agricultural and Environmental SciencesEstonian University of Life SciencesTartuEstonia Blaihofstraße 42 72074 TübingenGermany

This study focuses on the genus Encoelia and the subfamily Encoelioideae in the morphologically and ecologically diverse *** 28S and 18S rDNA as well as tef1,rpb1 and rpb2 were sequenced for 70 *** analyses revealed Encoelia and Encoelioideae to be highly polyphyletic,with species distributed among eight major *** fascicularis and *** belonged to Sclerotiniaceae and were combined in a new genus,*** comprised *** and Dencoeliopsis johnstonii,both accepted in *** type of Encoelia,***,was closely related to species of Velutarina,Cenangiopsis and *** species together with members of Hemiphacidiaceae formed a clade conforming to the emended concept of Cenangiaceae,introduced *** resurrected family,Cordieritidaceae,comprised ***,*** and species of Ameghiniella,Cordierites,Diplocarpa and Ionomidotis,characterised by inamyloid asci and a positive ionomidotic *** glauca showed closest affinities with Chlorociboria species in Chlorociboriaceae.A new genus,Xeropilidium,with sporodochial and pycnidial synanamorphs,was described for the distinct encoelioid member of the Chaetomellaceae,previously known as *** and ecological synapomorphies were distinguished from convergent characters to delimit monophyletic taxa including encoelioid *** of public sequences from various biological samples in ITS rDNA analyses allowed identification of sequenced organisms at species,genus,or family level and added information on the ecology of seversal *** of Cenangiaceae appeared to be widespread as *** of encoelioid genera in Chaetomellaceae and Sclerotiniaceae added xylicolous saprotrophs to these families.

关键词： Environmental sequencing Fungicolous ascomycetes Helotiaceae Lichenicolous fungi Forest pathogens Taxonomy

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Between Scylla and Charybdis:The role of the human immune system in the pathogenesis of hepatitis C

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World Journal of Gastroenterology 2013年第44期19卷 7852-7866页

作者： Ulrich Spengler hans Dieter Nischalke Jacob Nattermann Christian p Strassburg Department of Internal Medicine 1 University of Bonn 53105 Bonn Germany

Hepatitis C virus(HCV)frequently elicits only mild immune responses so that it can often establish chronic *** this case HCV antigens persist and continue to stimulate the immune *** persistence then leads to profound changes in the infected host’s immune responsiveness,and eventually contributes to the pathology of chronic *** topic highlight summarizes changes associated with chronic hepatitis C concerning innate immunity(interferons,natural killer cells),adaptive immune responses(immunoglobulins,T cells,and mechanisms of immune regulation(regulatory T cells).Our overview clarifies that a strong anti-HCV immune response is frequently associated with acute severe tissue *** chronic hepatitis C,however,the effector arms of the immune system either become refractory to activation or take over regulatory *** together these changes in immunity may lead to persistent liver damage and ***,effector arms of the immune system will not only be considered with respect to antiviral defence but also as pivotal mechanisms of inflammation,necrosis and progression to ***,avoiding Scylla-a strong,sustained antiviral immune response with inital tissue damage-takes the infected host to virus-triggered immunopathology,which ultimately leads to cirrhosis and liver cancerthe realm of Charybdis.

关键词： Natural killer cells CD4+ T helper cells Regulatory T cells Interferon Hepatitis C Hepatic stellate cells Hepatocytes Immunoglobulin Retinoic acid inducible gene-I Toll like receptors

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Round robin using the depth of penetration test method on an armour grade alumina

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Defence Technology（防务技术） 2019年第6期15卷 829-836页

作者： Erik p.Carton Bernt B.Johnsen Dennis-Bo Rahbek hans Broos Almar Snippe TNO P.O.Box 45NL-2280 AA Rijswijkthe Netherlands Norwegian Defence Research Establishment(FFI) P.O.Box 25NO-2027 KjellerNorway

The depth of penetration(DOp)method is a well-known ballistic test method for characterisation and ranking of ceramic armour *** ceramic tile is bonded to a backing material of semi-infinite thickness,and the penetration depth of the projectile gives a measure of the performance of the *** is,however,an inherent variability in the results from this test *** this work,the accuracy and the variability of the DOp method has been investigated in a round robin *** ballistic test centres took part in the exercise.A test protocol was developed,in which the threat type(projectile and impact conditions)and a procedure on how to prepare the targets were *** targets consisted of alumina tiles of two different thicknesses that were bonded to polycarbonate backing *** different 7.62 mm armour piercing projectiles were employed;one with a hard steel core and one with a tungsten carbide *** projectiles and the other materials all came from single material batches in order to avoid batch-to-batch variations in material *** materials were distributed between the ballistic test *** test results of the different ballistic test facilities were collected and *** was not a lot of variation between the average DOp values obtained at each laboratory,but the variation in penetration depth between shots was *** consequence of this variation may be less confidence in the test results,and a statistical method was used to evaluate the required number of tests that are sufficient to obtain an average result with high *** most cases,the required number of tests is much higher than what is practically *** work was conducted as part of the European Defence Agency-project CERAMBALL.

关键词： Ballistics Depth of penetration Test method Armour Ceramic Statistics

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The Dichotomy Between Traces on d-sets Г in R^n and the Density of D(R^n\Г) in Function Spaces

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Acta Mathematica Sinica,English Series 2008年第4期24卷 539-554页

作者： hans TRIEBEL Mathematisches Institut Fakultt fr Mathematik und InformatikFriedrich-Schiller-Universitt JenaD-07737 JenaGermany

A space Apq^s （R^n） with A ： B or A = F and s ∈R, 0 〈 p, q 〈 ∞ either has a trace in Lp（Г）, where Г is a compact d-set in R^n with 0 〈 d 〈 n, or D（R^n／Г） is dense in it. Related dichotomy numbers are ... 详细信息

A space Apq^s （R^n） with A ： B or A = F and s ∈R, 0 〈 p, q 〈 ∞ either has a trace in Lp（Г）, where Г is a compact d-set in R^n with 0 〈 d 〈 n, or D（R^n／Г） is dense in it. Related dichotomy numbers are introduced and calculated.

关键词： function spaces d-sets fractals traces

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