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First immunohistochemical evidence of human tendon repair following stem cell injection: A case report and review of literature

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World Journal of Stem Cells 2021年第7期13卷 944-970页

作者： Eckhard Alt Ralf Rothoerl Matthias Hoppert hans-georg frank Tobias Wuerfel Christopher Alt Christoph Schmitz Chairman of the Board Isarklinikum MunichMunich 80331Germany Department of Spine Surgery Isarklinikum MunichMunich 80331Germany Department for Orthopedics and Trauma Surgery Isarklinikum MunichMunich 80331Germany Chair of Neuroanatomy Institute of AnatomyFaculty of MedicineLMU MunichMunich 80336Germany Director of Science and Research InGeneron GmbHMunich 80331Germany

BACKGROUND Current clinical treatment options for symptomatic,partial-thickness rotator cuff tear(sPTRCT)offer only limited potential for true tissue healing and improvement of clinical *** animal models,injections of adult stem cells isolated from adipose tissue into tendon injuries evidenced histological regeneration of tendon ***,it is unclear whether such beneficial effects could also be observed in a human tendon treated with fresh,uncultured,autologous,adipose derived regenerative cells(UA-ADRCs).A specific challenge in this regard is that UA-ADRCs cannot be labeled and,thus,not unequivocally identified in the host ***,histological regeneration of injured human tendons after injection of UA-ADRCs must be assessed using comprehensive,immunohistochemical and microscopic analysis of biopsies taken from the treated tendon a few weeks after injection of *** SUMMARY A 66-year-old patient suffered from sPTRCT affecting the right supraspinatus and infraspinatus tendon,caused by a bicycle *** day 18 post injury[day 16 post magnetic resonance imaging(MRI)examination]approximately 100 g of abdominal adipose tissue was harvested by liposuction,from which approximately 75×10^(6) UA-ADRCs were isolated within 2 ***,UA-ADRCs were injected(controlled by biplanar X-ray imaging)adjacent to the injured supraspinatus tendon immediately after *** fast clinical recovery,a follow-up MRI examination 2.5 mo post treatment indicated the need for open revision of the injured infraspinatus tendon,which had not been treated with *** this operation,a biopsy was taken from the supraspinatus tendon at the position of the injury.A comprehensive,immunohistochemical and microscopic analysis of the biopsy(comprising 13 antibodies)was indicative of newly formed tendon *** Injection of UA-ADRCs can result in regeneration of injured human tendons by formation of new tendon tissue.

关键词： Stem cells Partial-thickness rotator cuff tear Tendon regeneration Adipose derived regenerative cells Cell-based therapy at point of care Case report

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Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda Gonzalez Charlotte Nelson frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

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Does laser surface texturing really have a negative impact on the fatigue lifetime of mechanical components?

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Friction 2021年第6期9卷 1766-1775页

作者： Chia-Jui HSU Andreas STRATMANN Simon MEDINA georg JACOBS frank MÜCKLICH Carsten GACHOT Institute for Engineering Design and Product Development TU WienLehárgasse 6Campus GetreidemarktVienna 1060Austria Chair of Functional Materials Saarland UniversityCampus D3.3Saarbrücken 66123Germany AC2T Research GmbH Viktor-Kaplan-Straße 2/CWiener Neustadt 2700Austria Institute for Machine Elements and Systems Engineering RWTH AachenSchinkelstraße 10Aachen 52062Germany

Laser surface texturing(LST)has been proven to improve the tribological performance of machine *** micro-scale patterns manufactured by LST may act as lubricant reservoirs,thus supplying oil when encountering insufficient ***,not many studies have investigated the use of LST in the boundary lubrication regime,likely due to concerns of higher contact stresses that can occur with the increasing surface *** study aims to examine the influence of LST on the fatigue lifetime of thrust rolling bearings under boundary lubrication.A series of periodic patterns were produced on the thrust rolling bearings,using two geometrically different designs,namely cross and dimple *** oil ISO VG 100 mixed with 0.05 wt%P of zinc dialkyldithiophosphate(ZDDP)was *** bearings with cross patterns reduce the wear loss by two orders of *** patterns not only retain lubricant in the textured pockets but also enhance the formation of an anti-wear *** tribofilm generation may be improved by the higher contact stresses that occur when using the textured ***,in contrast to the negative concerns,the ball bearings with cross patterns were instead found to increase the fatigue life by a factor of three.

关键词： thrust rolling bearing laser surface texturing direct laser interference patterning zinc dialkyldithiophosphate(ZDDP) tribofilm

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近海应用中土壤-结构界面的亚塑性模型（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第8期19卷 624-637页

作者： hans Henning STUTZ frank WUTTKE Department of Engineering Aarhus University Institute of Geo-Science Kiel University

目的:研究一种使用连续的土壤模型模拟土壤-结构界面的新方法,并阐述这些模型增强土壤-结构相互作用的建模方法。创新点:1.基于先前的亚塑性模型,通过将晶粒间应变的概念融入模型公式来模拟循环载荷。2.整体性较好的模型具有更好、更精... 详细信息

目的:研究一种使用连续的土壤模型模拟土壤-结构界面的新方法,并阐述这些模型增强土壤-结构相互作用的建模方法。创新点:1.基于先前的亚塑性模型,通过将晶粒间应变的概念融入模型公式来模拟循环载荷。2.整体性较好的模型具有更好、更精确的模拟结果。方法:1.采用一种砂浆接触的力学方法,其中一个表面作为主面,另一个表面作为从属面。2.采用砂浆接触的力学方法并结合用户定义的子程序,对土壤-结构界面进行建模。3.基于先前的亚塑性模型,将晶粒间应变的概念融入模型公式来模拟循环载荷。结论:1.整体性较好的模型具有更好、更精确的模拟结果。2.本文提出的土壤-结构界面建模方法不仅提高了模拟结果,且在某些模拟中提高了数值收敛性。

关键词：亚塑性接触面循环荷载细颗粒和粗粒土

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Intrahepatic endometriosis as differential diagnosis: Case report and literature review

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World Journal of Gastroenterology 2013年第29期19卷 4818-4822页

作者： georg Fluegen frank Jankowiak Luisa Zacarias Foehrding Feride Kroepil Wolfram T Knoefel Stefan A Topp Department of Surgery (A) Heinrich-Heine-University and University Hospital Duesseldorf 40225 Duesseldorf Germany Institute of Pathology Heinrich-Heine-University and University Hospital Duesseldorf 40225 Duesseldorf Germany

Intrahepatic endometriosis is one of the rarest forms of atypical endometriosis; only eighteen cases have been reported in the English literature. We describe the case of a 32-year-old woman, who presented with persistent, non-cyclical upper right quadrant abdominal pain, a central liver cyst, and no history of endometriosis. Three years previous, she was diagnosed with an intrahepatic cyst. The lesion progressed and two laparoscopic deroofing-operations were performed, yet the diagnosis of intrahepatic endometriosis was never reached. She presented in our clinic with further progress of the cyst as well as obstruction of the intrahepatic biliary system. The magnetic resonance imaging showed a 9.5 cm × 12 cm, lobulated intrahepatic cyst. We performed an ultrasonic pericystectomy. Immunostaining confirmed intrahepatic endometriosis. Only one of the previously described eighteen patients with intrahepatic endometriosis presented with cyclical pain in the upper right abdominal quadrant accompanying menstruation. This lack of a "typical" clinic makes it challenging to diagnose extragonadal endometriosis without histopathology. A previous history of endometriosis was described in only twelve cases, thus the diagnosis of this condition should not be limited to patients with a known history of endometriosis. Six of 18 patients were postmenopausal, demonstrating this condition is not limited to women of reproductive age. A preoperative diagnosis was only reached in seven of the previously described cases, highlighting the importance of preoperative biopsies. Yet due to the potential adverse effects, a transhepatic biopsy must be discussed individually. Although rare, intrahepatic endometriosis should always be considered as a differential diagnosis in women with recurrent hepatic cysts, regardless of age or previous medical history. In such cases, histology is essential and a pericystectomy should be performed as standard of care.

关键词： Intrahepatic endometriosis Atypical endometriosis Extrapelvic endometriosis Hepatic cysts

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From basic properties to the Mott design of correlated delafossites

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npj Computational Materials 2021年第1期7卷 1084-1100页

作者： frank Lechermann European XFEL SchenefeldGermany Center for Computational Quantum Physics Flatiron InstituteNew YorkNYUSA

The natural-heterostructure concept realized in delafossites highlights these layered *** metallic,band-or Mott-insulating character may be associated with individual layers,inter-layer coupling still plays a decisive *** review the correlated electronic structure of PdCoO_(2),PdCrO_(2),and AgCrO_(2),showing that layer-entangled electronic states can deviate from standard classifications of interacting *** finding opens up possibilities for materials design in a subtle Mott-critical *** Hidden-Mott physics,correlation-induced semimetallicity,or Dirac/flat-band dispersions in a Mott background are emerging *** with achievements in the experimental preparation,this inaugurates an exciting research field in the arena of correlated materials.

关键词： materials metallic showing

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Magnesium research in Canada:Highlights of the last two decades

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Journal of Magnesium and Alloys 2023年第10期11卷 3484-3510页

作者： frank Czerwinski Natural Resources Canada CanmetMATERIALSHamiltonONCanada

The highlights of major Canadian research projects of last two decades that aimed at advancing applications of magnesium and its alloys,being at the heart of lightweighting and ecological sustainability, are outlined. The research at universities, government laboratories, and other dedicated institutions, funded primarily through federal programs, was accompanied by strong activities of the industrial sector involved in designing and building the machinery for magnesium processing and production of components from magnesium alloys. The overall research directions matched the global trends of overcoming the key challenges that prevent magnesium alloys to play the major role in large-scale applications. Among industrially oriented projects the processing technologies in liquid, semisolid and solid states such as casting, twin roll casting, injection molding, rolling, extrusion, forging, and joining techniques were frequently pursued. Although the fundamental research aimed at understanding of a variety of magnesium behaviors and structural peculiarities up to nano and atomic levels, its essence spread around the inherently poor formability and high reactivity at room and elevated temperatures, including the ignition/flammability *** recent years, a shift in research interests was observed and novel directions emerged such as magnesium air batteries, biodegradable alloys, additive manufacturing, and magnesium-rich high entropy alloys. The volume of data gathered in this report may constitute a base for specifically oriented assessments, analyses, and drawing conclusions.

关键词： Magnesium Magnesium alloys Processing technologies Canadian research projects

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Sealing of the hepatic resection area using fibrin glue reduces significant amount of postoperative drain fluid

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World Journal of Gastroenterology 2005年第38期11卷 5984-5987页

作者： frank Eder frank Meyer Gerd Nestler Zuhir Halloul hans Lippert Department of Surgery

AIM: To investigate whether the routine use of fibrin glue applied onto the hepatic resection area can diminish postoperative volume of bloody or biliary fluids drained via intraoperatively placed perihepatic tubes and can thus lower the complication ***: Two groups of consecutive patients with a comparable spectrum of recent hepatic resections were compared: (1) 13 patients who underwent application of fibrin glue immediately after resection of liver parenchyma;(2) 12 patients who did not. Volumes of postoperative drainage fluid were determined in 4-h intervals through 24 h indicating the intervention caused bloody and biliary ***: Through the first 8 h postoperatively, there was a tendency of higher amounts of fluids in patients with no additional application of fibrin glue while through the following intervals, a significant increase of drainage volumes was documented in comparison with the first two 4-h intervals, e.g., after 12 h, 149.6 mL +/-110 mL vs 63.2 mL +/-78 mL. Using fibrin glue, postoperative fluid amounts were significantly lower through the postoperative observation period of 24 h (851 mL +/-715 mL vs 315 mL +/-305 mL).CONCLUSION: For hepatic resections, the use of fibrin glue appears to be advantageous in terms of a significant decrease of surgically associated segregation of blood or bile out of the resection area. This might result in a better outcome.

关键词： Fibrin glue Hepatic resection

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Ultra-broadband access enabled by fiber optics(Invited Paper)

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Chinese Optics Letters 2016年第12期14卷 17-20页

作者： frank Effenberger Futurewei Technologies Bridgewater NJ 08807 USA

The advent of low loss optical fiber has consistently led us to the ultra-broadband era, where bandwidths exceeding 1 Gb/s are commonplace. This Review reviews the early history of fiber access, pointing out some of the lasting design choices and signature features of fiber access. The progress of the various passive optical network technologies is also reviewed, and some views regarding the future trends of fiber in the access.

关键词： broadband consistently optics pointing signature lasting exceeding deployment bandwidth enabled

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Solid-pseudopapillary tumor of the pancreatic tail

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World Journal of Gastroenterology 2005年第26期11卷 4117-4119页

作者： frank Eder hans-Ulrich Schulz Christoph R(o|¨)cken hans Lippert Department of General Surgery Department of General Surgery Otto-von-Guericke-University Medical Faculty Leipziger StraBe 44 Magdeburg D-39120 Germany Institute of Pathology Otto-von-Guericke-University Medical Faculty Leipziger Str. 44 Magdeburg D-39120 Germany

We report a case of the rare solid-pseudopapillary tumor of the pancreas. In contrast to other pancreatic tumors,the solid-pseudopapillary tumor has a favorable *** 60-year-old female patient we report on here was treated by left pancreatic resection combined with splenectomy for a non-metastasizing tumor of the pancreas. A solid-pseudopapillary tumor was found on histology. The patient had no signs of metastases at *** a microscopically invasive tumor growth is assumed,oncologically curative resection should be preferred vs the less radical enucleation. The rare solid-pseudopapillary tumor of the pancreas has a good prognosis after successful oncological resection.

关键词： Pancreas Solid-pseudopapillary tumor

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