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magnetically actuated glaucoma drainage devicefor regulating intraocular pressure afterimplantation

microsystems & Nanoengineering 2023年第4期9卷 91-105页

作者： Inês C.F.Pereira Ralph J.S.van mechelen hans m.wyss Leonard Pinchuk Henny J.m.Beckers Jaap m.J.den Toonder microsystems Department of Mechanical EngineeringEindhoven University of Technology5600MB EindhovenThe Netherlands Institute for Complex molecular Systems(ICmS) Eindhoven University of Technology5600MB EindhovenThe Netherlands University Eye Clinic maastricht Maastricht University Medical Centre+(MUMC+)6202AZ MaastrichtThe Netherlands InnFocus Inc.a Santen CompanyMiamiFlorida 33186USA Ophthalmic Biophysics Center Bascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiamiFlorida 33136USA

The key risk factor for glaucoma is increased intraocular pressure (IOP). Glaucoma drainage devices implanted in theeye can reduce IOP and thus stop disease progression. However, most devices currently used in clinical practice arepassive and do not allow for postsurgical IOP control, which may result in serious complications such as hypotony (i.e.,excessively low IOP). To enable noninvasive IOP control, we demonstrate a novel, miniature glaucoma implant that willenable the repeated adjustment of the hydrodynamic resistance after implantation. This is achieved by integrating amagnetic microvalve containing a micropencil-shaped plug that is moved using an external magnet, thereby openingor closing fluidic channels. The microplug is made from biocompatible poly(styrene-block-isobutylene-block-styrene)(SIBS) containing iron microparticles. The complete implant consists of an SIBS drainage tube and a housing elementcontaining the microvalve and fabricated with hot embossing using femtosecond laser-machined glass molds. Usingin vitro and ex vivo microfluidic experiments, we demonstrate that when the microvalve is closed, it can providesufficient hydrodynamic resistance to overcome hypotony. Valve function is repeatable and stable over time. Due to itssmall size, our implant is a promising, safe, easy-to-implant, minimally invasive glaucoma surgery device.

关键词： enable implantation overcome

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The olfactory system of Pieris brassicae caterpllars:from receptors to glomeruli

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Insect Science 2024年第2期31卷 469-488页

作者： Qi Wang hans m.Smid marcel Dicke Alexander Haverkamp Laboratory of Entomology Wageningen University and ResearchWageningenthe Netherlands

Tolfactory system of adult lepidopterans is among the best described neuronal ***,comparatively little is known about the organization of the olfactory system in the larval stage of these ***,we explore the expression of olfactory receptors and the organization of olfactory sensory neurons in caterpillars of Pieris brassicae,a significant pest species in Europe and a well-studied species for its chemical *** describe the larval olfactory system in this species,we first analyzed the head transcriptome of third-instar larvae(L3)and identified 16 odorant receptors(ORs)including the OR coreceptor(Orco),13 ionotropic receptors(IRs),and 8 gustatory receptors(GRs).We then quantified the expression of these 16 ORs in different life stages,using qPCR,and found that the majority of ORs had significantly higher expression in the L4 stage than in the L3 and L5 stages,indicating that the larval olfactory system is not static throughout caterpillar *** an Orco-specific antibody,we identified all olfactory receptor neurons(ORNs)expressing the Orco protein in L3,L4,and L5 caterpillars and found a total of 34 Orco-positive ORNs,distributed among three sensilla on the *** number of Orco-positive ORNs did not differ among the three larval ***,we used retrograde axon tracing of the antennal nerve and identified a mean of 15 glomeruli in the larval antennal center(LAC),suggesting that the caterpillar olfactory system follows a similar design as the adult olfactory system,although with a lower numerical *** together,our results provide a detailed analysis of the larval olfactory neurons in P brassicae,highlighting both the differences as well as the commonalities with the adult olfactory *** findings contribute to a better understanding of the development of the olfactory system in insects and its life-stage-specific adaptations.

关键词： glomeruli larvae Lepidoptera odorant receptor olfactory receptor neurons sensilla

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Synthetic demand data generation for individual electricity consumers:Inpainting

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Energy and AI 2024年第1期15卷 36-43页

作者： Dascha Dobrovolskij hans-Georg Stark Universität Bremen Bibliothekstraβe 528359 BremenGermany Technische Hochschule Aschaffenburg Würzburger Straβe4563743 AschaffenburgGermany

In this contribution we deal with the problem of producing“reasonable”data,when considering recorded energy consumption data,which are at certain sections incomplete and/or *** task is important,when energy providers employ prediction models for expected energy consumption,which are based on past recorded consumption data,which then of course should be reliable and *** a related contribution Yilmaz(2022),GAN-based methods for producing such“artificial data”have been *** this contribution,we describe an alternative and complementary method based on signal inpainting,which has been successfully applied to audio processing Lieb and Stark(2018).After giving a short overview of the theory of proximity-based convex optimization,we describe and adapt an iterative inpainting scheme to our *** usefulness of this approach is demonstrated by analyzing real-world-data provided by a German energy supplier.

关键词： Time series missing data points Time-frequency analysis Convex optimization Douglas-Rachford-algorithm Gabor transform

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Pelleting and particle size reduction of corn increase net energy and digestibility of fiber,protein,and fat in corn-soybean meal diets fed to group-housed pigs

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1751-1760页

作者： Su A Lee Diego A.Rodriguez Chad B.Paulk hans H.Stein Department of Animal Sciences University of IllinoisUrbanaIL 61801USA Department of Grain Sciences and Industry Kansas State UniversityManhattanKS 66506USA

Background Reduction of the particle size of corn increases energy digestibility and concentrations of digestible and metabolizable *** may also reduce particle size of grain,but it is not known if there are interactions between particle size reduction and *** objective of this experiment was to test the hypothesis that particle size reduction and pelleting,separately or in combination,increase N balance,apparent total tract digestibility(ATTD)of fiber and fat,and net energy(NE)in corn-soybean meal diets fed to group-housed *** Six corn-soybean meal-based diets were used in a 3×2 factorial design with 3 particle sizes of corn(i.e.,700,500,or 300μm)and 2 diet forms(i.e.,meal or pelleted).Pigs were allowed ad libitum access to feed and ***-four castrated male pigs(initial weight:29.52 kg;standard diviation:1.40)were allotted to the 6 diets using a 6×6 Latin square design with 6 calorimeter chambers(i.e.,4 pigs/chamber)and 6 *** consumption and CO_(2)and CH_(4)productions were measured during fed and fasting states and fecal and urine samples were *** Regardless of particle size of corn,the ATTD of gross energy(GE),N,and acid-hydrolyzed ether extract(AEE),and the concentration of NE were greater(Pmeal *** of diet form,the ATTD of GE,N,and AEE,and the concentration of NE were increased(linear;Pmeal diets than in pelleted diets(interaction;Pmeal diets than in pelleted diets.

关键词： Corn Digestibility Feed technology Net energy Particle size Pelleting

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Prevention of thromboembolic events after radical prostatectomy in patients with hereditary thrombophilia due to a factor V Leiden mutation by multidisciplinary coagulation management

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Asian Journal of Urology 2024年第1期11卷 42-47页

作者： Randi m.Pose Sophie Knipper Jonas Ekrutt mara Kölker Pierre Tennstedt hans Heinzer Derya Tilki Florian Langer markus Graefen martini-Klinik Prostate Cancer Centre University Hospital Hamburg-EppendorfGermany Department of Urology University Hospital Hamburg-EppendorfGermany Department of Hematology and Oncology University Medical Centre Hamburg-EppendorfHamburgGermany

Objective:To examine the perioperative impact of factor V Leiden mutation on thromboembolic events'risk in radical prostatectomy(RP)*** an incidence of about 5%,factor V Leiden mutation is the most common hereditary hypercoagulability among Caucasians and rarer in *** increased risk of thromboembolic events is three-to seven-fold in heterozygous and to 80-fold in homozygous ***:Within our prospectively collected database,we analysed 33006 prostate cancer patients treated with RP between December 2001 and December *** those,patients with factor V Leiden mutation were *** patients received individualised recommendation of haemostaseologists for perioperative *** complications(deep vein thrombosis and pulmonary embolism)were assessed during hospital stay,as well as according to patient reported outcomes within the first 3 months after ***:Overall,85(0.3%)patients with known factor V Leiden mutation were *** age was 65(interquartile range:61-68)*** was at least one thrombosis in 53(62.4%)patients and 31(36.5%)patients had at least one embolic event in their medical history before *** all 85 patients with factor V Leiden mutation,we experienced no thromboembolic complications within the first 3 months after ***:In our cohort of patients with factor V Leiden mutation,no thromboembolic events were observed after RP with an individualised perioperative coagulation management *** may reassure patients with this hereditary condition who are counselled for RP.

关键词： Prostatecancer Prostatectomy Factor V Leiden mutation Thromboembolism Thrombophilia

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Functional characterization,structural basis,and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3746-3759页

作者： Zilong Wang Xueqing Du Guo Ye Haotian Wang Yizhan Liu Chenrui Liu Fudong Li hansÅgren Yang Zhou Junhao Li Chao He De-An Guo min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Anhui Key Laboratory of modern Biomanufacturing and School of Life Sciences Anhui UniversityHefei 230601China National Science Center for Physical Sciences at microscale Division of molecular&Cell Biophysics and School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Physics and Astronomy Uppsala UniversityUppsala SE-75120Sweden School of Pharmacy Jinan UniversityGuangzhou 510632China Shanghai Research Center for modernization of Traditional Chinese medicine Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Glycosylation is an important post-modification reaction in plant secondary metabolism,and contributes to structural diversity of bioactive natural *** plants,glycosylation is usually catalyzed by *** 2′-O-glycosides are rare ***,no UGTs have been reported,thus far,to specifically catalyze 2′-O-glycosylation of *** this work,UGT71AP2 was identified from the medicinal plant Scutellaria baicalensis as the first flavonoid 2′-*** could preferentially transfer a glycosyl moiety to 2′-hydroxy of at least nine flavonoids to yield six new *** of the 2′-O-glycosides showed noticeable inhibitory activities against cyclooxygenase *** crystal structure of UGT71AP2(2.15Å)was solved,and mechanisms of its regio-selectivity was interpreted by pKa calculations,molecular docking,mD simulation,mm/GBSA binding free energy,Qm/mm,and hydrogen‒deuterium exchange mass spectrometry *** structure-guided rational design,we obtained the L138T/V179D/m180T mutant with remarkably enhanced regio-selectivity(the ratio of 7-O-glycosylation byproducts decreased from 48%to 4%)and catalytic efficiency of 2′-O-glycosylation(kcat/Km,0.23 L/(s·μmol),12-fold higher than the native).moreover,UGT71AP2 also possesses moderate UDP-dependent de-glycosylation activity,and is a dual function *** work provides an efficient biocatalyst and sets a good example for protein engineering to optimize enzyme catalytic features through rational design.

关键词： Glycosyltransferase Regio-selectivity Crystal structure De-glycosylation Catalytic mechanisms

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1992年兰德斯(m=7.5)和大熊(m=6.5)地震前的地震平静

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世界地震译丛 1995年第5期26卷 1-16页

作者： S.Wiemer m.wyss 刘新美国家地震局地球物理研究所

1992年6月28日的兰德斯地震之前,位于靠近震中北面约11×23×15km体积内曾出现地震活动率下降75％。此异常从1988年1月开始,直至主震发生持续了4.5年,其中包含了各种大小震级的地震。位于震中南面的一个更小的体积(7×14×15 km),从1989... 详细信息

1992年6月28日的兰德斯地震之前,位于靠近震中北面约11×23×15km体积内曾出现地震活动率下降75％。此异常从1988年1月开始,直至主震发生持续了4.5年,其中包含了各种大小震级的地震。位于震中南面的一个更小的体积(7×14×15 km),从1989年11月开始地震活动率减小75％。同一天发生的大熊地震之前地震活动率下降了100％,这是在围绕震源的一个约13×22×15 km的体积内出现的。在背景期的9年内该体积内包含了192个m≥1.6的地震,但是从1990年12月至1992年6月27日的1.6年内没有一个地震发生。表征这些地震活动率变化的标准偏差z值是很高的,分别为6.3和12.3,说明这些异常是唯一的,在有效性上没有被南加州地震目录(117°06′W至115°40′W和33°45N′至35°10′N)检验到的其它地震活动率的减小所超过。1992年4月23日m=6.1约书亚特里地震的附近地区没有发现地震活动率有变化。根据震级图象和频度-震级分析,我们的结论是,这两个平静异常不可能是由于震级标度的偏移或压缩所致,我们认为它们是前兆异常。这个分析是借助兰德斯地区的已除去群发事件的地震目录,用0.2和0.1校正值(1985年8月和1990年5月)对两个有怀疑的震级偏移进行了修正。我们用新的显示技术将地震活动率作为时间和空间的函数对它的稳定性和变化情形进行了研究。通过对每一时间间隔以及点(纬度、经度)周围的密集网格的范围把地震活动率变化绘制成z值图,则这种计算机程序使活动率变化程度的光滑等值线图作为一个几乎连续的序列而提供出来。因此任何异常,不论人为的还是实际的,都可以精确地确定出来。

关键词：地震前兆震级地震活动性兰德斯地区

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Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den Berg Alexander Kurilshikov Dasha V.Zhernakova Ranko Gacesa Shixian Hu Esteban A.Lopera-maya Alexandra Zhernakova Lifelines Cohort Study Vincent E.de meijer Serena Sanna Robin P.F.Dullaart hans Blokzijl Eleonora A.m.Festen Jingyuan Fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(mAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(mRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University medical Center Groningen(UmCG)Genetics Lifelines Initiative(UGLI).meta-analysis of GWASs of mRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCm1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,Tm6SF2,and *** of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between mRI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel mRI-PDFF genetic signals(CREB3L1 and GCm1)were replicated in the FLI *** identified two novel genes for mRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between mRI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content mAFLD Genome-wide association study Fatty liver index magnetic resonance imaging proton density fat fraction

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Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest Ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik J.Persson magnus Ekstrom Sean P.Healey Zhiqiang Yang Johan Holmgren Eva Lindberg Kenneth Nystrom Emanuele Papucci Patrik Ulvdal hans OleØrka Erik Næsset Zhengyang Hou Håkan Olsson Ronald E.mcRoberts Department of Forest Resource management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of Environmental Sciences and Natural Resource management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of ministry of Education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias model-based inference Design-based inference

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7.2级地震的四种前兆现象及其与多次主破裂的关系

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地震地质译丛 1984年第5期 56-57页

作者： m.wyss 张鸣冈

1975年 m=7.2地震时,夏威夷南岸地带地壳破裂45公里以上。自1868年本区最后一次同样大小地震发生以来,引起这次主震的应力便逐步积累起来。尽管这种应力积累是基拉韦厄火山区和其裂谷带所致,地震却不是一种与岩浆活动有关的火山地震,而... 详细信息

1975年 m=7.2地震时,夏威夷南岸地带地壳破裂45公里以上。自1868年本区最后一次同样大小地震发生以来,引起这次主震的应力便逐步积累起来。尽管这种应力积累是基拉韦厄火山区和其裂谷带所致,地震却不是一种与岩浆活动有关的火山地震,而是百余年来应力积聚造成这一脆性地壳破裂事件。详细研究震源区地球物理和大地测量资料清楚地证明存在下述前兆现象:地震活动率降低40%;主震前约4年 P 波走时延迟0.2秒;大地测量法观测到的应受释放开始于主破裂前1年至4年。此外,m;=3.5+0.5地震的平均应力降显然在

关键词：主震应力降地震应变阶跃震源参数前兆现象震源体主破裂

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