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Portal vein thrombosis and arterioportal shunts:Effects on tumor response after chemoembolization of hepatocellular carcinoma

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World j.urnal of Gastroenterology 2011年第10期17卷 1267-1275页

作者： Thomas j.Vogl Nour-Eldin Nour-Eldin Sally Emad-Eldin Nagy NN Naguib j.erg Troj.n hans Ackermann Omar Abdelaziz Institute for Diagnostic and Interventional Radiology Johan Wolfgang Goethe University Hospital Diagnostic and Interventional Radiology Department Cairo University Hospital

AIM: To evaluate the effect of portal vein thrombosis and arterioportal shunts on local tumor response in advanced cases of unresectable hepatocellular carcinoma treated by transarterial chemoembolization. METHODS: A retrospective study included 39 patients (mean age: 66.4 years, range: 45-79 years, SD: 7) with unresectable hepatocellular carcinoma (HCC) who were treated with repetitive transarterial chemoembolization (TACE) in the period between March 2006 and October 2009. The effect of portal vein thrombosis (PVT) (in 19 out of 39 patients), the presence of arterioportal shunt (APS) (in 7 out of 39), the underlying liver pathology,Child-Pugh score, initial tumor volume, number of tumors and tumor margin definition on imaging were correlated with the local tumor response after TACE. The initial and end therapy local tumor responses were evaluated according to the response evaluation criteria in solid tumors (RECIST) and magnetic resonance imaging volumetric measurements. RESULTS: The treatment protocols were well tolerated by all patients with no maj.r complications. Local tumor response for all patients according to RECIST criteria were partial response in one patient (2.6%), stable disease in 34 patients (87.1%), and progressive disease in 4 patients (10.2%). The MR volumetric measurements showed that the PVT, APS, underlying liver pathology and tumor margin definition were statistically significant prognostic factors for the local tumor response (P = 0.018, P = 0.008, P = 0.034 and P = 0.001, respectively). The overall 6-, 12- and 18-mo survival rates from the initial TACE were 79.5%, 37.5% and 21%, respectively. CONCLUSION: TACE may be exploited safely for palliative tumor control in patients with advanced unresectable HCC; however, tumor response is significantly affected by the presence or absence of PVT and APS.

关键词： Hepatocellular carcinoma Transarterialchemoembolization Portal Shunt Thrombosis

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Prevalence of refractive errors in Hungary reveals three-fold increase in myopia

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International j.urnal of Ophthalmology(English edition) 2022年第7期15卷 1174-1179页

作者： j.nos Németh TennóDaiki Gergely Dankovics István Barna hans Limburg Zoltán Zsolt Nagy Department of Ophthalmology Semmelweis UniversityBudapest 1085Hungary Comprehensive Health Test Program of Hungary Szentendre 2000Hungary Department of Media and Education Informatics Eötvös Loránd UniversityBudapest 1053Hungary 1st Department of Internal Medicine Semmelweis UniversityBudapest 1083Hungary Health Information Services Grootebroek 1613LCThe Netherlands

AIM:To examine the prevalence and composition of refractive errors in ***:Nationwide cross-sectional data collected between 2014 and 2019 were analysed from the Comprehensive Health Screening Program of Hungary,which provided spectacle dioptric power and autorefractometry data for 68227 people(35850 women and 32377 men).Their age distribution,18-99y,was similar to the national demographic ***:Of the total population,16.50%of the refractive errors exhibited hyperopia,40.05%emmetropia,and 43.45%*** was 3 times more frequent(58.7%)in younger ages(18-35y of age)compared to older age groups(19.4%of those 56-70y of age;P<0.001).High myopia showed a low prevalence(0.21%),and an increase parallel with ageing(r=0.716;P=0.009).CONCLUSION:Myopia is the most frequent refractive error in *** prevalence of myopia is especially increased,up to 2-3 times,in the younger age *** actions need to be taken to reduce the onset of myopia and its associated consequences.

关键词： refractive errors myopia hyperopia emmetropia Hungary

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Problem Solving Solutions in Thermal Spray:HSE and Overspray

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有色金属（冶炼部分） 2008年第S1期 139-145页

作者： hans Keller j.achim Beczkowiak Stefan Zimmermann Benno Gries j.rgen Fischer H.C.Starck GmbH LaufenburgDeutschland H.C.Starck GmbH GoslarDeutschland

目前金属基材料的原材料成本对热喷涂涂层的经济性造成压力。特别是材料挥发和近期铼、钨、钴和镍基材料的价格增长,对各应用领域的许多涂层的经济性造成严重威胁。由于沉积效率的限制,喷涂中未沉积物问题变得越来越重要,不仅只是减少浪... 详细信息

目前金属基材料的原材料成本对热喷涂涂层的经济性造成压力。特别是材料挥发和近期铼、钨、钴和镍基材料的价格增长,对各应用领域的许多涂层的经济性造成严重威胁。由于沉积效率的限制,喷涂中未沉积物问题变得越来越重要,不仅只是减少浪费,还可以从材料自身价值角度去看。回收是解决这个问题的一个措施,特别是当废料中含有高价值金属时。欧洲执行的REACH(化学制品的注册、评估、授权)将会逐步强制淘汰标有有毒的材料和物质的使用。在热喷涂中使用这些有毒物质或使用热喷涂产品可能暂时是安全的,然而,从法律限制和从其他工业领域得到的指示表明,像WC-Co粉末这样的化学制品对人体有害。要想在将来的涂层工厂中保持竞争性,必须符合不断提高的更严格的环保和安全规程。

关键词：热喷涂粉末 WC-Co 健康和环保毒物学回收喷涂中未沉积物

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Economics and Performance of 10 Gb/s Metro Transport Over Mixed Fiber Plant of G.655 NZDF and G.652.C Zero Water-Peak Fibers

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光学学报 2003年第S1期23卷 717-718页

作者： hans-j.rg Thiele Santanu Das Raymond Boncek Lynn E. Nelson OFS 791 Holmdel-Keyport Road Holmdel NJ 07733OFS 19 Schoolhouse Road Somerset NJOFS 2000 Northeast Expressway Norcross GAOFS 791 Holmdel-Keyport Road Holmdel NJ 07733

Using lower-cost lasers, 30% savings are possible for 10-Gb/s uncompensated metro transmission over NZDF, compared to G.652 fiber. We present WDM transmission results for a mixed plant of NZDF rings interconnected to ... 详细信息

关键词： of or on as Economics and Performance of 10 Gb/s Metro Transport Over Mixed Fiber Plant of G.655 NZDF and G.652.C Zero Water-Peak Fibers dBm DML EML WDM

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Persistent elevation of fibrosis biomarker cartilage oligomeric matrix protein following hepatitis C virus eradication

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World j.urnal of Hepatology 2019年第3期11卷 330-334页

作者： Kristofer ANDréasson G?ran j.nsson Roger HesselstrAND hans Norrgren Section of Rheumatology Department of Clinical Sciences Lund Lund University Section of Infectious Diseases Department of Clinical Sciences Lund Lund University

Serum levels of cartilage oligomeric matrix protein(COMP) has been presented as a biomarker of liver fibrosis in several cross-sectional studies. COMP is also an essential mediator in carcinoma development and has also been associated with hepatocellular carcinoma. We present a prospective analysis of this biomarker in38 patients with chronic hepatitis C who were subj.ct to eradication therapy with direct acting antivirals. We confirm previous studies associating COMP elevation with liver cirrhosis. We also show how viral levels are correlated with COMP at baseline. In our prospective analysis, we report that successful eradication of hepatitis C results in improvement in liver stiffness and laboratory liver function tests at 1 year follow-up. In contrast, median COMP-levels remain unchanged during the study period. We conclude that the biomarker potential of COMP in the prospective evaluation of liver diseases, remains to be elucidated.

关键词： Hepatitis C Chronic Cartilage oligomeric matrix protein Fibrosis

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Guided Folding of Life’s Proteins in Integrate Cells with Holographic Memory and GM-Biophysical Steering

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Open j.urnal of Biophysics 2018年第3期8卷 117-154页

作者： Dirk K. F. Meij.r hans j. H. Geesink University of Groningen Groningen The Netherlands Biophysics Group Loon op Zand The Netherlands

The current geometric and thermodynamic approaches in protein folding studies do not provide a definite solution to understanding mechanisms of folding of biological proteins. A maj.r problem is that the protein is first synthesized as a linear molecule that subsequently must reach its native configuration in an extremely short time. Hydrophobicity-hydrophilicity models and random search mechanism cannot explain folding to the 3-D functional form in less than 1 second, as it occurs in the intact cell. We propose an integral approach, based on the embedding of proteins in the whole cellular context under the postulate: a life protein is never alone. In this concept the protein molecule is influenced by various long and short distance force fields of nature such as coherent electromagnetic waves and zero-point energy. In particular, the role of solitons is reviewed in relation to a novel GM-scale biophysical principle, revealed by us. This recent finding of a set of discrete EM frequency bands, that either promote or endanger life conditions, could be a key in further studies directed at the morphogenetic aspects of protein folding in a biological evolutionary context. In addition, an alternative hypothesis is presented in which each individual cell may store integral 3-D information holographically at the virtual border of a 4-D hypersphere that surrounds each living cell, providing a field receptive memory structure that is instrumental in guiding the folding process towards coherently oscillating protein networks that are crucial for cell survival.

关键词： Protein Folding Coherent Wave Pattern Electromagnetic Fields Solitons Harmonics Cellular Automata Quantum Mechanics

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鄂尔多斯盆地志留-泥盆纪和侏罗纪热事件——伊利石K-Ar年龄证据

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地质学报 1996年第2期70卷 186-194页

作者：赵孟为 hans Ahrendt Klaus Wemmer hans-j.rgen Behr 格丁根大学地质与岩石圈动力学研究所

利用伊利石K-Ar测年法,结合伊利石结晶度分析,首次在鄂尔多斯盆地确定出两期不同时代热事件。晚三叠世和晚二叠世<0.2μm粒级的岩石样品的K-Ar年龄(159-173Ma)反映了与燕山运动有关的伊利石化年龄,指示有一期中侏罗世的热事件;其<2μm... 详细信息

利用伊利石K-Ar测年法,结合伊利石结晶度分析,首次在鄂尔多斯盆地确定出两期不同时代热事件。晚三叠世和晚二叠世<0.2μm粒级的岩石样品的K-Ar年龄(159-173Ma)反映了与燕山运动有关的伊利石化年龄,指示有一期中侏罗世的热事件;其<2μm粒级的K-Ar年龄(210-308Ma)则被解释为碎屑物和自生伊利石的混合年龄。中寒武世<0.2μm和<2μm粒级的岩石样品K-Ar年龄(368Ma与419Ma)对应于北秦岭加里东褶皱带变质作用与最早期花岗岩侵入的时代(380-420Ma),表明在志留-泥盆纪发生了一期热事件。

关键词：伊利石 K-Ar测年法志留纪热事件鄂尔多斯盆地

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等通道转角挤压Al-Mg-Si铝合金的动态时效特性和力学性能

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材料研究学报 2016年第10期30卷 721-730页

作者：刘满平韦江涛李毅超江家威姜奎 hans j.Roven 江苏大学材料科学与工程学院江苏省高端结构材料重点实验室镇江212013 挪威科技大学材料科学与工程学院挪威特隆赫姆7491

在不同温度对固溶处理后的6061铝合金进行等通道转角挤压(ECAP),以实现动态时效处理。采用X射线衍射(XRD)、差示扫描量热法(DSC)、透射电镜(TEM)及拉伸测试,研究了6061 Al-Mg-Si铝合金的动态时效行为和力学性能。DSC分析结果表明,合金在... 详细信息

在不同温度对固溶处理后的6061铝合金进行等通道转角挤压(ECAP),以实现动态时效处理。采用X射线衍射(XRD)、差示扫描量热法(DSC)、透射电镜(TEM)及拉伸测试,研究了6061 Al-Mg-Si铝合金的动态时效行为和力学性能。DSC分析结果表明,合金在ECAP过程中发生动态时效析出。XRD,DSC和TEM的分析结果均表明,合金在动态时效过程中生成了大量的位错和β″析出相。在不同温度进行ECAP动态时效,制备出几种高韧性(均匀伸长率大于10%)和高强度兼备的6061铝合金。ECAP动态时效铝合金的最高抗拉强度和屈服强度,分别为450 MPa和425 MPa。ECAP铝合金的高强高韧,可归因于ECAP后极细的β''析出相和高密度位错的交互作用。

关键词：金属材料等通道转角挤压大塑性变形 Al-Mg-Si铝合金动态时效力学性能强韧性

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Large-eddy simulation of wind-blown sand under unstable atmospheric boundary layer

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Science Bulletin 2022年第14期67卷 1421-1424,M0003页

作者： Panli He j.e Zhang hans j.Herrmann Ning Huang Key Laboratory of Mechanics on Disaster and Environment in Western China Lanzhou UniversityLanzhou 730000China College of Civil Engineering and Mechanics Lanzhou UniversityLanzhou 730000China Department 403 Rocket Force University of EngineeringXi’an 710025China Laboratoire de Physique et Mécanique des Milieux Hétérogènes École Supérieure de Physique et de Chimie Industrielles de la Ville de ParisParis 75005France Departamento de Física Universidade do CearáFortaleza 60020-181Brazil

Atmospheric turbulence which induced by wind shear and/or convection is non-uniform anisotropic flows of high Reynolds and Rayleigh number[1].According to the mechanism of turbulence generation,atmospheric boundary-layer stratification can be classified into neutral,unstable(convective)and stable[2].Observations show that sandstorms and wind-blown sand mostly occur under unstable stratifications from afternoon to early evening[3].As the surface absorbs the solar radiation,the surface temperature increases and vertical convection develops,which enhances the momentum exchange between the upper and lower layers and hence increases the near surface wind speed and shear stress[4].

关键词：大涡模拟剪切应力风沙运动风沙流大气边界层输沙率线性关系对流速度

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Tribology of enzymatically degraded cartilage mimicking early osteoarthritis

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Friction 2023年第9期11卷 1724-1740页

作者： Ke REN Miguel Alej.ndro REINA MAHECHA Maike HÜBNER Zhiwei CUI hans j.KAPER Hugo C.VAN DER VEEN Prashant K.SHARMA Department of Biomedical Engineering University Medical Centre GroningenUniversity of GroningenGroningen 9713AVthe Netherlands Department of Mechanical Engineering Eindhoven University of TechnologyEindhoven 5600MBthe Netherlands Department of Orthopedic Surgery University Medical Centre GroningenUniversity of GroningenGroningen 9700RBthe Netherlands

Healthy cartilage is a water-filled super lubricious *** type II provides it structural stability,and proteoglycans absorb water to keep the cartilage in a swollen condition,providing it the ability to creep and provide weeping ***(OA)is a degenerative and debilitating disorder of diarthrodial j.ints,where articular cartilage damage originates from enzymatic degradation and mechanical damage(wear).The obj.ctive of this research is to observe the level of cartilage damage present in knee arthroplasty patients and to understand the friction and creep behavior of enzymatically degraded bovine cartilage in ***(Lat)and medial(Med)condylar cartilages from OA patients undergoing total knee arthroplasty showed signs of enzymatic degradation and mechanical *** cartilages were exposed to collagenase III and chondroitinase ABC to degrade collagen and proteoglycans,*** loss of proteoglycans or collagen network and morphological changes were observed through histology and the atomic force microscope(AFM),respectively.A significant effect on creep due to enzymatic treatment was not *** the enzymatic treatment was found to significantly decrease the coefficient of friction(COF)at 4 N,while higher COF was shown from chondroitinase ABC degraded cartilage at 40 *** III treatment leads to the release of intact proteoglycans at the sliding interface,while chondroitinase ABC treatment leads to the loss of chondroitin sulfate(CS)from the *** ABC-digested bovine cartilage mimicked patient samples the best because of the similar distributions of proteoglycans,collagen network,and friction behavior.

关键词： lubrication cartilage boundary lubrication osteoarthritis(OA)

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