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Leptosphaeria biglobosa Induced Resistance to *** in Brassica napus Involves Different Signalling Pathways

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Leptosphaeria biglobosa Induced Resistance to *** in Brassic...

黑胫病弱毒种和化学诱导剂诱导油菜对黑胫病抗性的比较研究

中国植物病理学会2005年学术年会暨植物病理学报创刊50周年纪念会

作者： Akinwunmi O.Latunde-Dada hans cools Bruce D.L.Fitt John.A.Lucas Rothamsted Research HarpendenHertfordshire AL5 2JQUK

Effects of pre-treatment of Brassica napus leaves with ascospores of L. biglobosa or chemical defence activators (acibenzolar-S-methyl (ASM) or menadione sodium bisulphate (MSB)) on local and systemic resistance to infection by ascospores of Leptosphaeria maculans (phoma stem canker) were studied in controlled environment and field experiments. In controlled environment experiments, pre-treatment of oilseed rape leaves (cv. Madrigal) with L. biglobosa, ASM or MSB delayed appearance of L. maculans phoma leaf spot lesions. These pre-treatments also decreased phoma leaf spot lesion area in both pre-treated (local effect) and untreated (systemic effect) leaves. In winter oilseed rape field experiments in 2002/2003 and 2003/2004 growing seasons, pre-treatment with L. biglobosa or ASM in October/November decreased not only number of phoma leaf spot lesions per leaf caused by L. maculans in autumn/winter, but also severity of phoma stem canker in the subsequent spring/summer. Effects were greater in 2002/2003, when natural L. maculans ascospore release began in September 2002, than in 2003/2004, when ascospore release began in December, following a period of dry weather in August/September 2003.

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科学通报 2007年第6期52卷 660-667页

作者：刘胜毅刘仁虎 Akinwunmi O.Latunde-Dada hans J.cools Simon J.Foster 黄永菊 Bruce D.L.Fitt Rothamsted Research HarpendenHertfordshire AL5 2JQUK 中国农业科学院油料作物研究所武汉430062 浙江省农业科学院杭州310021

油菜黑胫病是由弱毒种Leptosphaeria bigloaosa和强毒种***混合感染引起的油菜严重病害．本文比较研究了弱毒种预接种、化学诱导剂水杨酸类似物（acibenzolar-S-methyl）和维他命K3类似物（menadione sodium bisulphite）处理所诱导的... 详细信息

油菜黑胫病是由弱毒种Leptosphaeria bigloaosa和强毒种***混合感染引起的油菜严重病害．本文比较研究了弱毒种预接种、化学诱导剂水杨酸类似物（acibenzolar-S-methyl）和维他命K3类似物（menadione sodium bisulphite）处理所诱导的油菜对强毒种在抗性表型、组织细胞和RNA水平上的反应．诱导接种或化学处理后用强毒种接种．强毒种接种后8～21d，受诱导的植株其病斑扩展速度比水处理的对照显著降低，无论是受诱导的叶（局部效应）还是上部未诱导的叶（系统效应）均如此．强毒种接种后96h，观察到侵入叶组织的病原菌菌丝周围坏死的叶肉细胞，而在对照的植株上没有观测到．定量PCR分析表明，病害防御反应的标记基因PDF1．2，PR-1，NPR1，APX和CHB4在接种后0～96h的表达发生了变化．弱毒种预接种处理优先激活了茉莉酸，乙烯途径的基因表达，包括NPR1的诱导加强表达，这种效应不仅是局部的，而且是系统的．

关键词：化学诱导剂防御基因表达防御信号途径诱导的系统抗性油菜黑胫病

黑胫病弱毒种Leptosphaeria biglobosa通过不同的信号途径诱导油菜抗性

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黑胫病弱毒种Leptosphaeria biglobosa通过不同的信号途径诱导油...

Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

中国植物病理学第七届青年学术讨论会

作者：刘胜毅刘仁虎 Akinwunmi O Latunde-Dada hans cools Bruce D L Fitt John A Lucas 中国农业科学院油料作物研究所基因组与分子生物学研究室 Rothamsted Research HarpendenHertfordshire AL5 2JQUK Rothamsted Research HarpendenHertfordshire AL5 2JQUK Rothamsted Research HarpendenHertfordshire AL5 2JQUK Rothamsted Research HarpendenHertfordshire AL5 2JQUK Rothamsted Research HarpendenHertfordshire AL5 2JQUK

＜正＞油菜黑胫病是由两种类型病原引起的,分别为A型强致病株（***）和B型弱致病株,B型现命名为一个新种***。本试验研究了弱致病株诱导的针对强致病株的抗性及其分子信号途径。油菜叶分别用弱致病株子囊孢子预接种和及病害防御反应信... 详细信息

＜正＞油菜黑胫病是由两种类型病原引起的,分别为A型强致病株（***）和B型弱致病株,B型现命名为一个新种***。本试验研究了弱致病株诱导的针对强致病株的抗性及其分子信号途径。油菜叶分别用弱致病株子囊孢子预接种和及病害防御反应信号分子水杨酸类似物（acibenzolar-S-methyl,ASM）与维生素K3（menadione sodiumbisulphate,MSB）处理,然后挑战接种强致病株子囊孢子。在控制条件下的试验中,预接种和预处理均推

关键词：黑胫病诱导的系统抗性甘蓝型油菜病害防御反应基因

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam Felix Langerscheidt hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

黑胫病弱毒种Leptosphaeria biglobosa通过不同的信号途径诱导油菜抗性

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西北农林科技大学学报（自然科学版） 2005年第B08期33卷 257-257页

作者：刘胜毅刘仁虎 Akinwunmi O Latunde-Dada hans cools Huang Y J Bruce D L Fitt John A Lucas 中国农业科学院油料作物研究所基因组与分子生物学研究室湖北武汉430062 Rothamsted Research HarpendenHertfordshire AL5 2JQUK

油菜黑胫病是由两种类型病原引起的,分别为A型强致病株(***)和B型弱致病株,B型现命名为一个新种***.本试验研究了弱致病株诱导的针对强致病株的抗性及其分子信号途径.

关键词：黑胫病诱导的系统抗性甘蓝型油菜病害防御反应基因

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Removing trace oxygen to obtain truly intrinsic transport in organic semiconductors

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Science China Materials 2024年第5期67卷 1668-1669页

作者： hans Kleemann Dresden Integrated Center for Applied Physics and Photonic Materials Technische UniversitätDresdenGermany

Organic semiconductor is an emerging generation semiconductor material,which has a broad application prospect in the field of flexible and large-area *** now,tens of thousands of organic semiconductor molecules with diverse functions have been developed through elaborate molecular *** molecules are often classified into n-type and ptype,depending on whether the prevalent charge carriers are electrons or holes[1].

关键词： transport intrinsic moving

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Chitin synthesis inhibitors： old molecules and new developments

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Insect Science 2013年第2期20卷 121-138页

作者： hans Merzendorfer Department of Biology/Chemistry University of Osnabruck 49069 OsnabrEick Germany

Chitin is the most abundant natural aminopolysaccharide and serves as a structural component of extracellular matrices. It is found in fungal septa, spores, and cell walls, and in arthropod cuticles and peritrophic matrices, squid pens, mollusk shells, nematode egg shells, and some protozoan cyst walls. As prokaryotes, plants and vertebrates including humans do not produce chitin, its synthesis is considered as an attractive target site for fungicides, insecticides, and acaricides. Although no chitin synthesis inhibitor has been developed into a therapeutic drug to treat fungal infections in humans, a larger number of compounds have been successfully launched worldwide to combat arthropod pests in agriculture and forestry. This review summarizes the latest advances on the mode of action of chitin synthesis inhibitors with a special focus on those molecules that act on a postcatalytic step of chitin synthesis.

关键词： acaricide benzoylurea chitin synthesis inhibitor cuticle etoxazole,insecticide

THE GENERALIZED(NONLINEAR)POISSON PROBLEM:A DUAL VARIATIONAL APPROACH

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Acta Mechanica Sinica 1994年第3期10卷 227-236页

作者： hans Bufler Institute for Mechanics Stuttgart UniversityD-70550 StuttgartGermany

A series of problems in mechanics and physics are governed by the ordinary Poisson equation which demands linearity,isotropy,and material homo- *** this paper a generalization with respect to nonlinearity,anisotropy,and inhomogeneity is *** from the canonical basic equations in the primal and dual formulation respectively we derive systematically the corresponding generalized variational principles;under certain conditions they can be extended to so called complementary extremum principles allowing for global *** simplicity a restriction to two dimensional problems is made,including twice-connected domains.

关键词： Generalized Poisson problem dual and complementary variational principles