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3-Dimensional Kinematic Comparison of Arm movements between an Individual with NGLY1 Deficiency and a Neurotypical Individual

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Case Reports in Clinical medicine 2024年第4期13卷 122-146页

作者： Charles S. Layne Christopher A. malaya Brock Futrell Dacia martinez Diaz Christian Alfaro hannah E. Gustafson Subhalakshmi Chandrasekaran Rhea m. Phatak Bernhard Suter Department of Health and Human Performance University of Houston Houston TX USA Center for Neuromotor and Biomechanics Research University of Houston Houston TX USA Center for Neuro Engineering and Cognitive Science University of Houston Houston TX USA Department of Computer Science and Engineering Texas A&M University College Station TX USA Blue Bird Circle Rett Center Texas Children&#8217s Hospital Houston TX USA Baylor College of medicine Houston TX USA

NGLY1 Deficiency is an ultra-rare autosomal recessively inherited disorder. Characteristic symptoms include among others, developmental delays, movement disorders, liver function abnormalities, seizures, and problems with tear formation. movements are hyperkinetic and may include dysmetric, choreo-athetoid, myoclonic and dystonic movement elements. To date, there have been no quantitative reports describing arm movements of individuals with NGLY1 Deficiency. This report provides quantitative information about a series of arm movements performed by an individual with NGLY1 Deficiency and an aged-matched neurotypical participant. Three categories of arm movements were tested: 1) open ended reaches without specific end point targets;2) goal-directed reaches that included grasping an object;3) picking up small objects from a table placed in front of the participants. Arm movement kinematics were obtained with a camera-based motion analysis system and “initiation” and “maintenance” phases were identified for each movement. The combination of the two phases was labeled as a “complete” movement. Three-dimensional analysis techniques were used to quantify the movements and included hand trajectory pathlength, joint motion area, as well as hand trajectory and joint jerk cost. These techniques were required to fully characterize the movements because the NGLY1 individual was unable to perform movements only in the primary plane of progression instead producing motion across all three planes of movement. The individual with NGLY1 Deficiency was unable to pick up objects from a table or effectively complete movements requiring crossing the midline. The successfully completed movements were analyzed using the above techniques and the results of the two participants were compared statistically. Almost all comparisons revealed significant differences between the two participants, with a notable exception of the 3D initiation area as a percentage of the complete movement. The stati

关键词： NGLY1 Deficiency Developmental Disorders Kinematics 3 Dimensional Analyses

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3m收购的脚环电子监视器公司给自己惹来了麻烦

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商业周刊（中文版） 2017年第11期 58-63页

作者： LAUREN ETTER hannah WHITAKER

在2012年，美国马萨诸塞州执法部门达成一项交易，与一家生产电子脚环的一流制造商签订了供货合同。这种脚环是一种小型全球定位系统（GPS）装置，

关键词：电子监视器公司收购全球定位系统马萨诸塞州执法部门供货合同

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Biofabrication and biomanufacturing in Ireland and the UK

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Bio-Design and manufacturing 2024年第6期7卷 825-856页

作者： Jack F.murphy martha Lavelle Lisa Asciak Ross Burdis hannah J.Levis Cosimo Ligorio Jamie mc Guire marlene Polleres Poppy O.Smith Lucinda Tullie Juan Uribe-Gomez Biqiong Chen Jonathan I.Dawson Julien E.Gautrot Nigel m.Hooper Daniel J.Kelly Vivian S.W.Li Alvaro mata Abhay Pandit James B.Phillips Wenmiao Shu molly m.Stevens Rachel L.Williams James P.K.Armstrong Yan Yan Shery Huang Department of Engineering University of CambridgeCambridge CB21PZUK Department of Translational Health Sciences Bristol Medical SchoolUniversity of BristolBristol BS13NYUK Department of Biomedical Engineering University of StrathclydeGlasgow G40NWUK Department of materials Institute of Biomedical EngineeringImperial College LondonLondon SW72AZUK Department of Bioengineering Institute of Biomedical EngineeringImperial College LondonLondon SW72AZUK Department of Eye and Vision Science Institute of Life Course and Medical SciencesUniversity of LiverpoolLiverpool L78TXUK Biodiscovery Institute University of NottinghamNottingham NG72RDUK Department of Chemical and Environmental Engineering University of NottinghamNottingham NG72RDUK Centre for Human Development Stem Cells and RegenerationHuman Development and HealthFaculty of MedicineUniversity of SouthamptonSouthampton S0166YDUK Division of Neuroscience School of Biological SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PTUK UCL Centre for Nerve Engineering Department of PharmacologyUCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK Stem Cell and Cancer Biology Laboratory The Francis Crick InstituteLondon NW11ATUK CÚRAm SFI Research Centre for Medical DevicesUniversity of GalwayGalway H91 W2TYIreland School of mechanical and Aerospace Engineering Queen’s University BelfastBelfast BT95AHUK School of Engineering and materials Science Queen Mary University of LondonLondon E14NSUK Geoffrey Jefferson Brain Research Centre Manchester Academic Health Science CentreNorthern Care Alliance and University of ManchesterManchester M139PLUK Trinity Centre for Biomedical Engineering Trinity Biomedical Sciences InstituteTrinity College DublinDublin 2Ireland Department of mechanical Manufacturing and Biomedical EngineeringSchool of EngineeringTrinity College DublinDublin 2Ireland Advanced materials and Bioengineering Research Centre(AmBER) Royal College of Surgeons in Ireland and T

As we navigate the transition from the Fourth to the Fifth Industrial Revolution,the emerging fields of biomanufacturing and biofabrication are transforming life sciences and *** sectors are benefiting from a synergy of synthetic and engineering biology,sustainable manufacturing,and integrated design *** techniques such as 3D bioprinting,tissue engineering,directed assembly,and self-assembly are instrumental in creating biomimetic scaffolds,tissues,organoids,medical devices,and biohybrid *** field of biofabrication in the United Kingdom and Ireland is emerging as a pivotal force in bioscience and healthcare,propelled by cutting-edge research and *** on the production of biologically functional products for use in drug delivery,in vitro models,and tissue engineering,research institutions across these regions are dedicated to innovating healthcare solutions that adhere to ethical standards while prioritising sustainability,affordability,and healthcare system benefits.

关键词： Bioprinting Drug delivery Biomaterials Tissue engineering Sustainability Biohybrid

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Flow of Eyring-powell liquid due to oscillatory stretchable curved sheet with modified Fourier and Fick’s model

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Applied mathematics and mechanics(English Edition) 2021年第10期42卷 1461-1478页

作者： m.ImRAN Z.ABBAS m.NAVEED Department of mathematics The Islamia University of BahawalpurBahawalpur 63100Pakistan Department of mathematics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan 64200Pakistan

This study deals with the features of the mass and heat transport mechanism by adopting a modified version of Fourier and Fick’s model known as the CattaneoChristov double diffusive *** time-dependent magnetohydrodynamic(mHD)flow of the Eyring-powell liquid across an oscillatory stretchable curved sheet in the presence of Fourier and Fick’s model is *** acquired set of flow equations is transformed into the form of nonlinear partial differential equations(PDEs)by applying appropriate similarity variables.A convergent series solution to the developed nonlinear equations is accomplished with the help of an analytical approach,i.e.,the homotopy analysis method(HAm).The consequences of diverse parameters,including the dimensionless Eyringpowell liquid parameter,the radius of curvature,the Schmidt/Prandtl numbers,the ratio of the oscillatory frequency of the sheet to its stretchable rate constant,the mass and thermal relaxation variables involved in the flow,and the heat and mass properties,are displayed through graphs and *** is noted from this study that the amplitude of the pressure distribution rises for the high parametric values of the Eyring-powell parameter.

关键词： oscillatory stretchable curved surface magnetohydrodynamic(mHD) Eyring-powell liquid Cattaneo-Christov double diffusion analytical technique

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Ability of community-based prostate cancer screening to target an appropriate and underserved population

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World Journal of methodology 2015年第2期5卷 10-12页

作者： Jared moss Eric Heidel Jason Johnson Chase powell Erin Dittrich Susan Rawn Paul D Terry mitchell Goldman W Bedford Waters Wesley m White Division of Urologic Surgery the University of Tennessee Medical Center Department of Surgery the University of Tennessee Medical Center Departments of Public Health and Surgery the University of Tennessee

Screening is not universally beneficial due to over-and under-diagnosis,and false positives that beget additionaltesting and associated adverse events and *** examined data from all men who participated in a mass community prostate cancer screening between may 2009 and September *** data contained information regarding patient demographics,family history of prostate cancer,lower urinary tract symptoms,prior history of prostate cancer,most recent digital rectal examination,and the presence of an established relationship with a *** American Urological Association screening recommendations were then applied to determine the appropriateness of our outreach effort.A total of 438 men(mean age 66.5 years) underwent screening.A total of 106(24.2%) patients in our study met contemporary criteria for *** these men,the vast majority was well educated,well insured,and well informed about the need for prostate cancer *** on these data,mass community-based prostate cancer screening does not appear to identify and screen at-risk *** efforts at mass screening should more carefully target men most likely to benefit.

关键词： Prostate cancer Screening Outcomes Prostate specifc antigen Community health

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顶尖公司:科学家才思与成长的“孵化器”——《科学》职业2016年度生物技术和制药产业“最佳雇主”

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科学新闻 2018年第2期 79-83页

作者： Kendall powell 崔敏

提及驱动性创新、鼓励专业发展以及尊重员工工作生活界限时,正值蓬勃发展期的生物技术和制药公司都有着共同的理念。由于科研人员们寻求用生物学而非化学的方法解决更多尚未被满足的医学需求,药物的发现便是科研人员创造力的一个转折点... 详细信息

提及驱动性创新、鼓励专业发展以及尊重员工工作生活界限时,正值蓬勃发展期的生物技术和制药公司都有着共同的理念。由于科研人员们寻求用生物学而非化学的方法解决更多尚未被满足的医学需求,药物的发现便是科研人员创造力的一个转折点:这些药物包含更复杂的抗体疗法,但也囊括了信使核糖核酸(m RNA)的药物,用设计药物、超负荷T细胞对抗癌症的免疫肿瘤学疗法,以及真正个性化的药物,比如攻击单个

关键词：诺和诺德研究人员最佳雇主摩德纳员工忠诚度

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“斯比伯爵”号战列舰的覆灭

“斯比伯爵”号战列舰的覆灭

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作者：迈克尔·鲍威尔(m. powell)

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盘状红斑狼疮伴继发性淀粉样变性

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 36-37页

作者： powell A.-m Albert S Bhogal B Black m.m 李政霄 Department of Immunodermatopathology St John's Institute of Dermatology St Thomas'Hospital LondonSE1 7EH United Kingdom

Background: Secondary localized cutaneous amyloidosis is a clinically unapparent phenomenon associated with various cutaneous pathologies, usually tumours of epidermal origin. The amyloid is thought to be derived from keratinocytes. Objec tives: To characterize the amyloid deposition observed incidentally within lesio nal biopsies from three patients with discoid lupus erythematosus (DLE), and ret rospectively to study the phenomenon within DLE skin samples. methods: Localized amyloid deposition was observed in three cases of DLE by immunofluorescence stu dies, and these cases were further studied by histology and immunohistochemistry using amonoclonal anticytokeratin antibody. Retrospective histological review o f DLE tissue specimens archived over 12 months was performed to look for evidenc e of previously undetected amyloid. Results: Amyloid deposition was confirmed hi stologically in the three index cases by staining with Congo red and thioflavin T. Positive staining with an anticytokeratin antibody demonstrated the epidermal origin of the amyloid protein. Of the 18 archived cases reviewed amyloid was re trospectively detected in one sample. Conclusions: Secondary cutaneous amyloidos is of keratinocyte origin can be seen in DLE lesions. It may be a not infrequent occurrence and may remain under-reported. We discuss the possible role of dise ase chronicity and colloid body degradation in the pathogenesis of amyloidosis.

关键词：盘状红斑狼疮继发性淀粉样变皮肤淀粉样变性胶质小体淀粉样抗细胞角蛋白角质形成细胞上皮肿瘤

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Axisymmetric powell-Eyring fluid flow with convective boundary condition: optimal analysis

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Applied mathematics and mechanics(English Edition) 2016年第7期37卷 919-928页

作者： T.HAYAT S.mAKHDOOm m.AWAIS S.SALEEm m.m.RASHIDI Department of mathematics Quaid-i-Azam University Department of mathematics COMSATS Institute of Information Technology Department of mathematics Statistics and Physics Qatar University Shanghai Key Lab of Vehicle Aerodynamics and Vehicle Thermal management Systems Tongji University

The effects of axisymmetric flow of a powell-Eyring fluid over an impermeable radially stretching surface are presented. Characteristics of the heat transfer process are analyzed with a more realistic condition named the convective boundary condition. Governing equations for the flow problem are derived by the boundary layer approximations. The modeled highly coupled partial differential system is converted into a system of ordinary differential equations with acceptable similarity transformations. The convergent series solutions for the resulting system are constructed and analyzed. Optimal values are obtained and presented in a numerical form using an optimal homotopy analysis method （OHAm）. The rheological characteristics of different parameters of the velocity and temperature profiles are presented graphically. Tabular variations of the skin friction coefficient and the Nusselt number are also calculated. It is observed that the temperature distribution shows opposite behavior for Prandtl and Biot numbers. Furthermore, the rate of heating/cooling is higher for both the Prandtl and Biot numbers.

关键词： axisymmetric flow optimal homotopy analysis method (OHAm) analysis,convective boundary condition

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541m高处的安全——美国新世贸中心尖顶施工安装保护措施

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现代职业安全 2013年第11期 99-101页

作者： hannah Addison 王梦蓉

具有历史意义的541 m高度,使位于美国纽约市的新世贸中心不仅成为西半球最高的摩天大楼,也成为了美国人的骄傲和坚韧的象征。由斯基德摩尔家族的大卫·查尔兹、欧文斯和美林共同设计的这栋面积为24万1 548 m2的建筑物内既有办公区、观景... 详细信息

具有历史意义的541 m高度,使位于美国纽约市的新世贸中心不仅成为西半球最高的摩天大楼,也成为了美国人的骄傲和坚韧的象征。由斯基德摩尔家族的大卫·查尔兹、欧文斯和美林共同设计的这栋面积为24万1 548 m2的建筑物内既有办公区、观景台,也有世界级的餐厅及广播天线设施。新世贸中心投入运行后,将会有成千上万的人在其中工作。

关键词：世贸中心美国人保护措施施工安装安全历史意义摩天大楼技术人员

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