盘状红斑狼疮伴继发性淀粉样变性

作     者：Powell A.-M Albert S Bhogal B Black M.M 李政霄 

作者机构：Department of ImmunodermatopathologySt John's Institute of Dermatology St Thomas'Hospital LondonSE1 7EH United Kingdom 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第1期

页      面：36-37页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：盘状红斑狼疮 继发性淀粉样变 皮肤淀粉样变性 胶质小体 淀粉样 抗细胞角蛋白 角质形成细胞 上皮肿瘤 

摘      要：Background: Secondary localized cutaneous amyloidosis is a clinically unapparent phenomenon associated with various cutaneous pathologies, usually tumours of epidermal origin. The amyloid is thought to be derived from keratinocytes. Objec tives: To characterize the amyloid deposition observed incidentally within lesio nal biopsies from three patients with discoid lupus erythematosus (DLE), and ret rospectively to study the phenomenon within DLE skin samples. Methods: Localized amyloid deposition was observed in three cases of DLE by immunofluorescence stu dies, and these cases were further studied by histology and immunohistochemistry using amonoclonal anticytokeratin antibody. Retrospective histological review o f DLE tissue specimens archived over 12 months was performed to look for evidenc e of previously undetected amyloid. Results: Amyloid deposition was confirmed hi stologically in the three index cases by staining with Congo red and thioflavin T. Positive staining with an anticytokeratin antibody demonstrated the epidermal origin of the amyloid protein. Of the 18 archived cases reviewed amyloid was re trospectively detected in one sample. Conclusions: Secondary cutaneous amyloidos is of keratinocyte origin can be seen in DLE lesions. It may be a not infrequent occurrence and may remain under-reported. We discuss the possible role of dise ase chronicity and colloid body degradation in the pathogenesis of amyloidosis.