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Dynamic energy system modeling using hybrid physics-based and machinelearning encoder–decoder models

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Energy and AI 2022年第3期9卷 128-138页

作者： Derek machalek Jake Tuttle Klas Andersson Kody m.powell Department of Chemical Engineering University of UtahSalt Lake CityUTUnited States of America Taber International LLCUnited States of America Department of Space Earthand EnvironmentUniversity of ChalmersGothenburgSweden Department of mechanical Engineering University of UtahSalt Lake CityUTUnited States of America

Three model configurations are presented for multi-step time series predictions of the heat absorbed by thewater and steam in a thermal power plant. The models predict over horizons of 2, 4, and 6 steps into thefuture, where each step is a 5-minute increment. The evaluated models are a pure machine learning model, anovel hybrid machine learning and physics-based model, and the hybrid model with an incomplete dataset. Thehybrid model deconstructs the machine learning into individual boiler heat absorption units: economizer, waterwall, superheater, and reheater. Each configuration uses a gated recurrent unit (GRU) or a GRU-based encoder–decoder as the deep learning architecture. mean squared error is used to evaluate the models compared totarget values. The encoder–decoder architecture is over 11% more accurate than the GRU only models. Thehybrid model with the incomplete dataset highlights the importance of the manipulated variables to the *** hybrid model, compared to the pure machine learning model, is over 10% more accurate on averageover 20 iterations of each model. Automatic differentiation is applied to the hybrid model to perform a localsensitivity analysis to identify the most impactful of the 72 manipulated variables on the heat absorbed in theboiler. The models and sensitivity analyses are used in a discussion about optimizing the thermal power plant.

关键词： Hybrid model Encoder-decoder Time series Automatic differentiation Thermal power plant

Coordinated AR and microRNA regulation in prostate cancer

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Asian Journal of Urology 2020年第3期7卷 233-250页

作者： Ieva Eringyte Joanna N.Zamarbide Losada Sue m.powell Charlotte L.Bevan Claire E.Fletcher Imperial Centre for Translational and Experimental medicine Department of Surgery and CancerImperial College LondonHammersmith HospitalLondonUnited Kingdom

The androgen receptor(AR)remains a key driver of prostate cancer(PCa)progression,even in the advanced castrate-resistant stage,where testicular androgens are *** is therefore of critical importance to understand the molecular mechanisms governing its activity and regulation during prostate ***(miRs)are small w22 nt noncoding RNAs that regulate target gene,often through association with 30 untranslated regions(30UTRs)of *** display dysregulation during cancer progression,can function as oncogenes or tumour suppressors,and are increasingly recognised as targets or regulators of hormonal ***,understanding factors which modulate miRs synthesis is *** is increasing evidence for complex and dynamic bi-directional cross-talk between the multi-step miR biogenesis cascade and the AR signalling axis in *** review summarises the wealth of mechanisms by which miRs are regulated by AR,and conversely,how miRs impact AR’s transcriptional activity,including that of AR splice *** addition,we assess the implications of the convergence of these pathways on the clinical employment of miRs as PCa biomarkers and therapeutic targets.

关键词： microRNA Androgen receptor Androgen Prostate cancer Hormone Non-coding RNA

mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity

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Bone Research 2020年第4期8卷 393-405页

作者： Xin Yi Laura E.Wright Gabriel m.Pagnotti Gunes Uzer Katherine m.powell Joseph m.Wallace Uma Sankar Clinton T.Rubin Khalid mohammad Theresa A.Guise William R.Thompson Department of Physical Therapy School of Health and Rehabilitation SciencesIndiana UniversityIndianapolisIN 46202USA Department of medicine Division of EndocrinologySchool of MedicineIndiana UniversityIndianapolisIN 46202USA Department of mechanical and Biomedical Engineering Boise State UniversityBoiseID 83725USA Department of Biomedical Engineering Purdue School of Engineering and TechnologyPurdue UniversityIndianapolisIN 46202USA Department of Anatomy&Cell Biology Indiana UniversityIndianapolisIN 46202USA Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA

Exercise benefits the musculoskeletal system and reduces the effects of *** effects of exercise are multifactorial,where metabolic changes and tissue adaptation influence *** signals,a principal component of exercise,are anabolic to the musculoskeletal system and restrict cancer *** examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of ***-magnitude,high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration(LIV).LIV decreased matrix invasion and impaired secretion of osteolytic factors PTHLH,IL-11,and ***,paracrine signals from mechanically stimulated cancer cells,reduced osteoclast differentiation and resorptive *** the nucleus by knockdown of SUN1 and SUN2 impaired LIV-mediated suppression of invasion and osteolytic factor *** increased cell stiffness;an effect dependent on the LINC *** data show that mechanical vibration reduces the metastatic potential of human breast cancer cells,where the nucleus serves as a mechanosensory apparatus to alter cell structure and intercellular signaling.

关键词： invasion impaired skeletal

Color change in a marine isopod is adaptive in reducing predation

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Current Zoology 2015年第4期61卷 739-748页

作者： Kristin m. HULTGREN hannah mITTELSTAEDT Department of Biology Seattle University 901 12^th ave. Seattle WA 98122

Although background matching is a common form of camouflage across a wide diversity of animals, there has been surprisingly little experimental work testing the fitness consequences of this camouflage strategy, especially in marine ecosystems. In this study, we tested whether color camouflage enhances survival of the intertidal marine isopod Pentidotea （Idotea） wosnesenskii, quantified patterns of camouflage in different algal habitats, and examined how algal diet affected color change and growth using laboratory assays. In the field, isopods collected from two differently colored algal habitats （the brown alga Fucus distichus and the red alga Odonthaliafloccosa） matched the color of their respective algal habitats, and also differed significantly in body size： smaller red isopods were found on red algae, while larger brown isopods were found on brown algae. Predation ex- periments demonstrated these color differences had fitness benefits： brown isopods that matched their brown algae habitats sur- vived at higher rates than red unmatched isopods. Surprisingly, despite the propensity of isopods to match their algal habitats, algal diet had no effect on color change in color change experiments. Instead, isopods in all treatments turned browner, matching the color of the algal habitat that many isopods are found on as adults. In summary, our data supported our hypothesis that back- ground matching serves an adaptive function in reducing predation, with important evolutionary implications for explaining the wide variation in color change mechanisms in idoteid isopods [Current Zoology 61 （4）： 739-748, 2015].

关键词： Isopod Pentidotea wosnesenskii. Camouflage Crypsis Background matching Color change

A seed and soil model of loneliness in Alzheimer's disease

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Neural Regeneration Research 2024年第12期19卷 2575-2576页

作者： hannah L.Apostolou Ian m.mcDonough Department of Psychology The University of AlabamaTuscaloosaALUSA Department of Psychology Binghamton UniversityBinghamtonNYUSA

Loneliness is classically defined as a result of perceiving a discrepancy between the desired quantity and quality of one's social life and actual social relationships(Perlman and Peplau,1984).Lifespan research has indicated older adults are among the highest risk for experiencing loneliness because their social network size decreases more frequently than that of younger adults.

关键词： Alzheimer younger soil

Effect of salinity and acidity on bioleaching activity of mesophilic and extremely thermophilic bacteria

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中国有色金属学会会刊：英文版 2008年第3期18卷 714-721页

作者： H.DEVECI m.A.JORDAN N.powell I.ALP Department of mining Engineering Karadeniz Technical UniversityTrabzon 61080Turkey Camborne School of mines UECTremough CampusPenrynCornwallTR109EZUK

The effects of bacterial strain, salinity and pH on the bioleaching of a complex ore using mesophilic and extremely thermophilic bacteria were investigated and the statistical analysis of the results was performed using ERGUN’s test. The extreme thermophiles were shown to display superior kinetics of dissolution of zinc compared with the mesophiles as confirmed by the statistical analysis. Bioleaching performance of the extreme thermophiles is found to improve in response to the increase in acidity (pH from 2.0 to 1.0) whilst the activity of the mesophiles is adversely affected by decreasing pH. Statistical analysis of the bioleaching data indicates that the effect of pH is insignificant in the range of pH 1.0-1.2 for the extreme thermophiles and pH 1.4-2.0 for the mesophiles. Salinity is shown to have a suppressing effect on the mesophiles. However, the extreme thermophiles appear to be halophilic in character as they could operate efficiently under saline conditions (1%-4%Cl- (w/v)).

关键词：细菌生物浸取盐度 pH 硫化物

Tattoos as a window to the psyche:How talking about skin art can inform psychiatric practice

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World Journal of Psychiatry 2017年第3期7卷 148-158页

作者： hannah Roggenkamp Andrew Nicholls Joseph m Pierre mental Illness Research Education and Clinical CenterVA Puget Sound Healthcare System VA Greater Los Angeles Healthcare System Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA

Tattooing the skin as a means of personal expression is a ritualized practice that has been around for centuries across many different ***,the symbolic meaning of tattoos has evolved over time and is highly individualized,from both the internal perspective of the wearer and the external perspective of an *** modern Western societies through the 1970 s,tattoos represented a cultural taboo,typically associated with those outside of the mainstream such as soldiers,incarcerated criminals,gang members,and others belonging to marginalized and counter-cultural *** paper aims to review the more recent epidemiology of tattoos in Western culture in order to establish that tattooing has become a mainstream *** then review psychological and psychiatric aspects of tattoos,with a goal of revising outmoded stigmas about tattooing and helping clinicians working with tattooed patients to facilitate an exploration of the personal meaning of skin art and *** suggest that as a kind of augmentation of the physical exam,looking at and talking to patients about their tattoos can provide a valuable window into the psyche,informing clinical practice.

关键词： Tattoos military psychiatry Deviance Skin art Psychopathology Psychology

Paleoecological Response of Corals to the End-Triassic mass Extinction： An Integrational Analysis

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Journal of Earth Science 2018年第4期29卷 879-885页

作者： George D Stanley Jr hannah m E Shepherd Autumn J Robinson University of montana Paleontology Center Missoula MT 59812 USA

The end-Triassic （also Triassic-Jurassic） mass extinction severely affected life on planet Earth 200 million years ago. Paleoclimate change triggered by the volcanic eruptions of the Central Atlantic magmatic Province （CAmP） caused a great loss of marine biodiversity, among which 96% coral genera were get lost. However, there is precious little detail on the paleoecology and growth forms lost between the latest Triassic extinction and the Early Jurassic recovery. Here a new pilot study was conducted by analyzing corallite integration levels among corals from the latest Triassic and Early Jurassic times. Integration levels in corals from the Late Triassic and Early Jurassic were determined through both the Paleobiology Database as well as from a comprehensive museum collection of fossil corals. Results suggest that in addition to a major loss of diversity following the end-Triassic mass extinction, there also was a significant loss of highly integrated corals as clearly evidenced by the coral data from the Early Jurassic. This confirms our hypothesis of paleoecological selectivity for corals following the end-Triassic mass extinction. This study highlights the importance of assigning sim- ple to advanced paleoecological characters with integration levels, which opens a useful approach to understanding of mass extinction and the dynamics of the recovery.

关键词： coral loss integration level end-Triassic mass extinction paleoecology

Crosslinking of viral nanoparticles with “clickable” fluorescent crosslinkers at the interface

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Science China Chemistry 2010年第6期53卷 1287-1293,1459页

作者： KAUR Gagandeep BARNHILL hannah Department of Chemistry and Biochemistry and Nanocenter University of South Carolina

Cu (I) catalyzed alkyne-azide cycloaddition (CuAAC) reaction,a typical "click" reaction,is one of the modular synthetic approaches which has been broadly used in various organic syntheses,medicinal chemistry,materials development and bioconjugation *** have for the first time synthesized two dialkyne derivatized fluorescent crosslinkers which could be applied to crosslink two biomolecules using CuAAC *** yellow mosaic virus,a plant virus with unique structural and chemical properties,was used as a prototypical scaffold to form a 2D single layer at the interface of two immiscible liquids and crosslinked with these two linkers by the CuAAC *** crosslinking,the fluorescence of both linkers diminished,likely due to the distortion of the polymethylene backbone,which therefore could be used to indicate the completion of the reaction.

关键词： pickering emulsion crosslinking nanoparticles CuAAC reaction click chemistry interfacial assembly