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Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C

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Cellular & Molecular Immunology 2017年第12期14卷 986-996页

作者： Philipp Blüm Joachim Pircher Monika Merkle Thomas Czermak Andrea Ribeiro hanna mannell Florian Krötz Alexander Hennrich Michael Spannagl Simone Köppel Erik Gaitzsch Markus Wörnle Medizinische Klinik und Poliklinik IV InnenstadtKlinikum der Universität München80336 MünchenGermany Walter Brendel Centre of Experimental Medicine and Munich Heart Alliance Ludwig Maximilians University München80336 MünchenGermany Medizinische Klinik und Poliklinik I Klinikum der Universität München80336 MünchenGermany Abteilung für Transfusionsmedizin Zelltherapeutika und HämostaseologieKlinikum der Universität München80336 MünchenGermany

Hepatitis C virus(HCV)infection is a major problem *** is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is ***:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in *** procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet *** addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HMC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as *** protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HMC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HMC but not in *** vivo,protein C inhibits poly(I:C)-induced arteriolar ***,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral ***,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection.

关键词： hepatitis C thrombosis toll-like receptor 3

Estimation of actual carbon dioxide removal in burned forests using satellite data:A case study in South Korea

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Journal of Mountain Science 2023年第4期20卷 1051-1060页

作者： hanna LEE Gihong KIM Institute for Disaster Prevention Gangneung-Wonju National UniversityGangneung25457South Korea Department of Civil Engineering Gangneung-Wonju National UniversityGangneung25457South Korea

With the increasing impact of climate change,carbon emissions and removals have become major *** are major carbon pools,and forest fires are an essential part of the carbon *** study introduces a model for estimating the detailed actual CO_(2)removal in burned forests using burn severity and tree *** CO_(2)removal was estimated from empirical yield tables without using the standard carbon removal provided by the national *** primary CO_(2)calculation method followed the guidelines of the International Panel on Climate *** burn severity was mapped using Sentinel-2 multispectral instrument data,and the survivability of each forest type was estimated according to burn *** survivability was applied to the pre-fire CO_(2)removal of each forest to estimate post-fire CO_(2)*** our case study,the burned forest area was 1,034 ha,and the CO_(2)removal before the fire was 8,615.3t/*** the fire,removal decreased by 81.2%to 1,618.4 t/*** particular,the decrease in coniferous forests was high,more than 86%.The lack of survivability data on burned trees was a major limitation of our *** accumulating field monitoring data of post-fire forests will be necessary for future research and could serve as a reference for devising immediate countermeasures against forest fires.

关键词： Forest fire CO_(2)removal Carbon emission Tree survivability Remote sensing Satellite data

Heat of absorption of CO_2 in aqueous N,N-diethylethanolamine+ N-methyl-1,3-propanediamine solutions at 313 K

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Chinese Journal of Chemical Engineering 2019年第3期27卷 628-633页

作者： Katarzyna Sobala hanna Kierzkowska-Pawlak Lodz University of Technology Faculty of Process and Environmental Engineering

Differential heat of absorption of CO_2 in aqueous solutions of N,N-diethylethanolamine(DEEA) and activated DEEA solutions up to a total concentration of 2 mol·L^(-1) was measured as a function of CO_2 loading at 313.15 K using a reaction calorimeter. In order to analyze the performance of N-methyl-1,3-propanediamine(MAPA)as an activator, DEEA blended solutions containing 0.05, 0.1 and 0.2 mol·L^(-1) MAPA were studied. The heat of CO_2 absorption in single DEEA solutions was unaffected by changing the DEEA concentration in the range of(0.5–2) mol·L^(-1). On the other hand, increasing the concentration of MAPA in aqueous amine mixtures of(DEEA + MAPA) raised the heat of absorption.

关键词： CO2 capture Differential heat of absorption N,N-diethylethanolamine N-methyl-1,3-propanediamine Amine blends

Oscillating-grid turbulence at large strokes: Revisiting the equation of Hopfinger and Toly

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Journal of Hydrodynamics 2016年第3期28卷 473-481页

作者： wan hanna melini wan mohtar Department of Civil and Structural Engineering Faculty Engineering and Built Environment Universiti Kebangsaan Malaysia Bandar BaruBangi 43600 Selangor Malaysia

A quasi-isotropic, quasi-homogeneous turbulence generated by an oscillating-grid, spatially decays according to power law of u ∝ Z-nM , where u is the root mean square （rms） horizontal velocity, Z is the vertical distance from the grid and nu = 1. However, the findings of Nokes and Yi indicate that as the stroke of oscillation increases, the power law n u= 1 and does not follow the established decay law equation of Hopfinger. This paper investigates the characteristics of the turbulence that are generated using larger strokes S/M = 1.6 and 2 and compares with that obtained using a S/M = 0.8, which is the stroke used when the equation was developed. Measurements of the grid-generated turbulence in a water tank were taken using particle image velocimetry （PIV）. The results showed that the homogeneity occurred at distance beyond 2.5 mesh spacings away from the grid midplane, independent of the stroke and the frequency of oscillation. Within this region, the turbulent kinetic energy distribution was quasi-homogeneous, and the secondary mean flow is negligible. The statistical characteristics of the measured turbulence confirmed that although nu decreases as stroke increases, the grid-turbulence generated at S/M = 1.6 and 2 obeys the universal decay law.

关键词： oscillating-grid turbulence large strokes decay power law

Strong internal resonance in a nonlinear, asymmetric microbeam resonator

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Microsystems & Nanoengineering 2021年第1期7卷 117-131页

作者： Keivan Asadi Junghoon Yeom hanna Cho Department of Mechanical and Aerospace Engineering The Ohio State UniversityColumbusOH 43210USA Department of Mechanical Engineering Michigan State UniversityEast LansingMI 48824USA

Exploiting nonlinear characteristics in micro/nanosystems has been a subject of increasing interest in the last *** others,vigorous intermodal coupling through internal resonance(IR)has drawn much attention because it can suggest new strategies to steer energy within a micro/nanomechanical ***,a challenge in utilizing IR in practical applications is imposing the required frequency commensurability between vibrational modes of a nonlinear micro/***,we experimentally and analytically investigate the 1:2 and 2:1 IR in a clamped–clamped beam resonator to provide insights into the detailed mechanism of *** is demonstrated that the intermodal coupling between the second and third flexural modes in an asymmetric structure(e.g.,nonprismatic beam)provides an optimal condition to easily implement a strong IR with high energy transfer to the internally resonated *** this case,the quadratic coupling between these flexural modes,originating from the stretching effect,is the dominant nonlinear mechanism over other types of geometric *** design strategies proposed in this paper can be integrated into a typical micro/nanoelectromechanical system(M/NEMS)via a simple modification of the geometric parameters of resonators,and thus,we expect this study to stimulate further research and boost paradigm-shifting applications exploring the various benefits of IR in micro/nanosystems.

关键词： nonlinear asymmetric clamped

Nanomechanical Characterization of Bone Quality Depending on Tissue Age via Bimodal Atomic Force Microscopy

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Nanomanufacturing and Metrology 2023年第4期6卷 24-34页

作者： Jinha Kwon hanna Cho Department of Mechanical and Aerospace Engineering The Ohio State UniversityColumbusOH 43210USA

Characterization of bone quality during the healing process is crucial for successful implantation procedures and patient *** this study,a bone implant specimen that underwent a 4-week healing period was *** atomic force microscopy(AFM)was employed to simultaneously obtain the morphology and elastic modulus maps of the newly formed and pre-existing bone regions within the *** indicate that the new bone matrix possessed lower miner-alization levels and presented larger,uneven mineral grains,exhibiting the attributes of a woven *** the other hand,the old bone matrix exhibited a more uniform and mineralized structure,which is characteristic of lamellar *** new bone had a lower overall elastic modulus than the old *** AFM further confrmed that the new bone displayed three regions comprising unmineralized,partially mineralized,and fully matured sections,which indicate a turbulent change in its ***,the old bone exhibited two sections comprising partially mineralized and matured bone parts,which denote the fnal phase of *** study provides valuable insights into the morphological and nanome-chanical diferences between the old and new bone matrixes and presents a novel approach to investigate bone quality at diferent phases of the bone-healing process.

关键词： Bone quality Atomic force microscopy Bimodal AFM Nanomechanical characterization Bone tissue age Woven bone Lamellar bone

Impact of rotavirus vaccine implementation on Israeli children:a comparison between pre-and post-vaccination era

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World Journal of Pediatrics 2022年第6期18卷 417-425页

作者： Hussein Zaitoon Shaden hanna Ellen Bamberger Department of Pediatrics Bnai Zion Medical CenterThe Ruth and Bruce Rappaport Faculty of MedicineTechnion-Israel Institute of Technology47 Golomb St.31048HaifaIsrael The Ruth and Bruce Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifaIsrael

Background Worldwide rotavirus vaccination has resulted in a substantial decrease in rotavirus-induced severe gastroenteritis and related hospitalizations among ***,the characterization of patients warranting hospitalization needs to be further *** purpose of the study is to compare the clinical and laboratory features of children hospitalized with acute rotavirus infection before and after the introduction of routine *** This is a retrospective observational *** were pediatric patients who presented to the Bnai Zion Medical Center pediatric emergency department and were diagnosed with rotavirus acute gastroenteritis between 2017 and *** During the pre-vaccination period(2007–2009),114 infants and young children(median age:14 months,range:1–72 months;59 male,55 female)were hospitalized for rotavirus-induced acute gastroenteritis with a rate of 11.71 positive rotavirus tests per 1000 emergency room *** the post-vaccination period(2012–2019),168 infants and young children(median age:17 months,range:0–84 months;90 male,78 female)were hospitalized with a rate of 4.18 positive rotavirus tests per 1000 emergency room *** were no statistical differences between the two groups in gender,breast-feeding rates and sibling(s).The proportion of cases with moderate-to-severe dehydration was higher in the post-vaccination children than in the pre-vaccination *** Rates of rotavirus-attributed acute gastroenteritis hospitalizations declined from the pre-to the post-vaccination *** rates of dehydration were found in the post-vaccination *** surveillance is warranted to better understand the implications of the vaccine.

关键词： Acute gastroenteritis Booster dose Hospitalization Rotavirus Vaccination

Modulators affecting the immune dialogue between human immune and colon cancer cells

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World Journal of Gastrointestinal Oncology 2014年第5期6卷 129-138页

作者： Meir Djaldetti hanna Bessler The Laboratory for Immunology and Hematology Research Rabin Medical Center Hasharon Hospital The Sackler School of Medicine Tel-Aviv University

The link between chronic inflammation and colorectal cancer has been well established. The events proceeding along tumorigenesis are complicated and involve cells activated at the cancer microenvironment, tumor infiltrating polymorphonuclears, immune cells including lymphocyte subtypes and peripheral blood mononuclear cells(PBMC), as well as tumor-associated macrophages. The immune cells generate inflammatory cytokines, several of them playing a crucial role in tumorigenesis. Additional factors, such as gene expression regulated by cytokines, assembling of tumor growth- and transforming factors, accelerated angiogenesis, delayed apoptosis, contribute all to initiation, development and migration of tumor cells. Oxygen radical species originating from the inflammatory area promote cell mutation and cancer proliferation. Tumor cells may over-express pro-inflammatory mediators that in turn activate immune cells for inflammatory cytokines production. Consequently, an immune dialogue emerges between immune and cancer cells orchestrated through a number of activated molecular pathways. Cytokines, encompassing migration inhibitory factor, transforming growth factor beta 1, tumor necrosisfactor-α, Interleukin(IL)-6, IL-10, IL-12, IL-17, IL-23 have been reported to be involved in human cancer development. Some cytokines, namely IL-5, IL-6, IL-10, IL-22 and growth factors promote tumor development and metastasis, and inhibit apoptosis via activation of signal transducer activator transcription-3 transcription factor. Colon cancer environment comprises mesenchymal, endothelial and immune cells. Assessment of the interaction between components in the tumor environment and malignant cells requires a reconsideration of a few topics elucidating the role of chronic inflammation in carcinogenesis, the function of the immune cells expressed by inflammatory cytokine production, the immunomodulation of cancer cells and the existence of a cross-talk between immune and malignant cells lea

关键词： Cytokines Immune dialogue Colon cancer Peripheral blood mononuclear cells Cross-talk

3D X-ray microscopy with a CsPbBr3 nanowire scintillator

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Nano Research 2023年第1期16卷 1084-1089页

作者： hanna Dierks Zhaojun Zhang Nils Lamers Jesper Wallentin Lund University Synchrotron Radiation Research and NanoLundBox 118SE-22100 LundSweden

X-ray microscopy is an essential imaging method in many scientific fields,which can be extended to three-dimensional(3D)using ***,metal halide perovskite(MHP)nanomaterials have become a promising candidate for X-ray scintillators,due to their high light yield,high spatial resolution,and easy *** requires many projections and therefore scintillators with excellent *** is challenging for MHPs,which often suffer from fast degradation under X-ray irradiation and ambient ***,we demonstrate that MHP scintillators of CsPbBr3 nanowires(diameter:60 nm,length:5–9μm)grown in anodized aluminum oxide(CsPbBr3 NW/AAO)have sufficient stability for X-ray micro-tomography.A tomogram was taken with a Cu X-ray source over 41 h(dose 4.2 Gyair).During this period the scintillator brightness fluctuated less than 5%,which enabled a successful reconstruction.A long-term study with 2 weeks of continuous X-ray exposure(37.5 Gyair)showed less than 14%fluctuations in brightness and no long-term degradation,despite variations in the ambient relative humidity from 7.4%RH to 34.2%*** resolution was stable at(180±20)lp·mm−1,i.e.,about 2.8 *** demonstrates that CsPbBr3 NW/AAO scintillators are promising candidates for high resolution X-ray imaging detectors.

关键词： tomography perovskites scintillators X-ray imaging micrometer spatial resolution