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Total hip arthroplasty in patients with Paget's disease of bone: A systematic review

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World Journal of Orthopedics 2017年第4期8卷 357-363页

作者： Sammy A hanna Sebastian Dawson-Bowling Steven Millington Rej Bhumbra Pramod Achan Department of Trauma and Orthopaedic Surgery Royal London HospitalBarts Health NHS Trust

AIM To investigate the clinical and functional outcomes following total hip arthroplasty(THA) in patients with Paget's *** We carried out a systematic review of the literature to determine the functional outcome, complications and revision rates of THA in patients with Paget's disease. Eight studies involving 358 hips were reviewed. The mean age was 70.4 years and follow-up was 8.3 years. There were 247 cemented THAs(69%), 105 uncemented THAs(29%) and 6 hybrid THAs(2%). RESULTS All studies reported significant improvement in hip function following THA. There were 19 cases of aseptic loosening(5%) at a mean of 8.6 years. Three cases occurred in the uncemented cohort(3%) at a mean of 15.3 years and 16 cases developed in the cemented group(6%) at a mean of 7.5 years(P = 0.2052). There were 27 revisions in the 358 cases(8%) occurring at a mean of 7 years. Six revisions occurred in the uncemented cohort(6%) at a mean of 8.6 years and 21 in the cemented cohort(9%) at a mean of 6.5 years(P = 0.5117). CONCLUSION The findings support the use of THA in patients with Paget's disease hip arthropathy. The post-operative functional outcome is largely similar to other patients; however, the revision rate is higher with aseptic loosening being the most common reason for revision. Uncemented implants appear to be associated with a lower failure rate, however, there were no modern stem designs fixed using current generation cementing techniques used in the reported studies, and as such, caution is advised when drawing any conclusions.

关键词： Total hip arthroplasty Paget’s disease Revision Loosening Heterotopic ossification

Study on the Rural Electrification in Jordan

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Journal of Energy and Power Engineering 2012年第4期6卷 609-614页

作者： Ghassan hanna Halasa Electrical Engineering Department University of Jordan Amman 11942 Jordan

An investigation was conducted to install wind farm to supply electrical power to the village of Ras Munif, the highest elevation in Jordan. The village installed capacity load was found to be 500 kW. A 25 windmills, 20 kW each, forming the wind farm was found to be the best choice to supply the village with 100% of its needed power. The windmills will be spaced 50 meters along an unobstructed continuous wind flow location, along sloping sides of Ras Munif Mountain, alongside service road. The village load bus will be connected directly to both the output of wind farm inverter output bus and to the national grid bus. Both buses supply the needed power. The power flow was found to be supplied by the wind farm, except when the wind speed is low, the village load will be supplied partially or totally by the national grid bus.

关键词： Grid link loads power flow windmills electrical generation.

Insight into Cellulose Nanosizing for Advanced Electrochemical Energy Storage and Conversion:A Review

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Electrochemical Energy Reviews 2022年第3期5卷 42-70页

作者： Wenbin Kang Li Zeng Xingang Liu hanna He Xiaolong Li Wei Zhang Pooi See Lee Qi Wang Chuhong Zhang State Key Laboratory of Polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu 610065SichuanChina State Key Laboratory of Environment‑Friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Living in a world of heavy industrialization and confronted by the ever-deteriorating environment,the human race is now undertaking serious efforts to reach the target of carbon *** major step is to promote the development of sustainable electrochemical energy storage and conversion technologies based on green resources instead of the traditional nonreusable petroleum-based *** an almost inexhaustible bioresource,nanocellulose derived from natural biomass exhibits outstanding physiochemical properties that could be well leveraged to bring about numerous opportunities for electrochemical *** structure engineering,nanocellulose with a width of a few tens of nanometers and a length of up to micrometers could be *** drastic reduction in dimensions leads to superior mechanical,optical,and functional properties inaccessible to the bulky cellulose *** this review,different types of nanocellulose with distinctive physiochemical properties and their respective preparation methods are first *** is followed by a detailed and insightful analysis of the superiority and unprecedented performance gains that nanocellulose imparts to different electrochemical energy storage and conversion applications as a result of ***,we humbly put forward our perspectives on the problems regarding current studies as well as on the future research direction for nanocellulose-mediated electrochemical processes to enable practical *** review is intended as guidance to initiate cross-disciplinary research effort in this engaging field and help evoke inspiration to effect solutions to critical energy issues of the day.

关键词： Nanocellulose Nanosizing Electrochemistry Energy storage Energy conversion Deformable devices

The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman David Han Colin hanna David Baron Ashim Gupta Shan Kazmi Jag Khalsa Debasis Bagchi Thomas McLaughlin Rajendra D. Badgaiyan Edward J. Modestino Drew Edwards Catherine A. Dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine Paul R. Carney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos Division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA Division of Personalized Interventions Peak Logic Del Mar CA USA Division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA Division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Psychiatry Harvard School of Medicine Cambridge MA USA Department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA Department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA Department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA Department of Family Medicine Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANDAS CANS Genetic Addiction Risk Testing (GARS) Pro-Dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

Sustainable Energy Potential in the Egyptian Residential Sector

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Journal of Environmental Science and Engineering(B) 2013年第6期2卷 374-382页

作者： George Bassili hanna Housing and Building National Research Center Cairo 12311 Egypt

This paper presents an overview of sustainable energy investment potential in the Egyptian Residential Building sector. It demonstrates an analysis of the problems that faces the residential sector, house hold consumption and overview of the building construction, energy and renovation. The paper summaries the Egyptian EE （energy efficiency） policies and measures and the possibility to uses and finance that face EE and RE （renewable energy） policies to overcome the Barriers to enhance the Egyptian economy specially in the residential sector.

关键词： Energy investment residential buildings energy efficiency renewable energy.

Eccentric exercise-induced muscle weakness abolishes sex differences in fatigability during sustained submaximal isometric contractions

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运动与健康科学(英文) 2023年第4期12卷 523-533页

作者： hanna L.Jodoin Avery Hinks Olivia P.Roussel Vincenzo S.Contento Brian H.Dalton Geoffrey A.Power Department of Human Health and Nutritional Sciences College of Biological SciencesUniversity of GuelphGuelphON N1G 2W1Canada School of Health and Exercise Science University of British ColumbiaKelownaBC V1V 1V7Canada

Background:Females are typically less fatigable than males during sustained isometric contractions at lower isometric contraction *** sex difference in fatigability becomes more variable during higher intensity isometric and dynamic *** less fatiguing than isometric or concentric contractions,eccentric contractions induce greater and longer lasting impairments in force ***,it is not clear how muscle weakness influences fatigability in males and females during sustained isometric ***:We investigated the effects of eccentric exercise-induced muscle weakness on time to task failure(TTF)during a sustained submaximal isometric contraction in young(18-30 years)healthy males(n=9)and females(n=10).Participants performed a sustained isometric contraction of the dorsiflexors at 35°plantar flexion by matching a 30%maximal voluntary contraction(MVC)torque target until task failure(i.e.,falling below 5%of their target torque for>2 s).The same sustained isometric contraction was repeated 30 min after 150 maximal eccentric *** and antagonist activation were assessed using surface electromyography over the tibialis anterior and soleus muscles,***:Males were~41%stronger than *** eccentric exercise both males and females experienced an~20%decline in maximal voliuntary contraction *** was-34%longer in females than males prior to eccentic exercise-induced muscle ***,following eccentric exercise-induced muscle weakness,this sex-related difference was abolished,with both groups having an"45%shorter ***,there was~100%greater antagonist activation in the female group during the sustained isometric contraction following exercise-induced weakness as compared to the ***:This increase in antagonist activation disadvantaged females by decreasing their TTF,resulting in a blunting of their typical fatigability advantage over males.

关键词： Fatigue Isometric Sex Time to task failure Weakness

Assessment of Castor Plant (Ricinus communis L.) Tolerance to Heavy Metal Stress-A Review

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 453-472页

作者： Akwasi Yeboah Jiannong Lu Ting Yang Yuzhen Shi hanna Amoanimaa-Dede Kwadwo Gyapong Agyenim Boateng Xuegui Yin Department of Crop Breeding and Genetics College of Agricultural SciencesGuangdong Ocean UniversityZhanjiang524088China The National Engineering Laboratory for Crop Molecular Breeding MARA Key Laboratory of Soybean Biology(Beijing)Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing100081China

Increased urbanization and industrialization have greatly contributed to the emission of higher amount of heavy metals such as cadmium,nickel,and lead into the *** metals are non-biodegradable and toxic,causing much effects on plants and by extension to animals and humans,which have become a major global *** inherent ability of plants to resist heavy metal toxicity seems to be the most sustainable and cost-effective *** plant is widely studied due to its tolerance to the effects of heavy metal contaminated soils,owing to its large biomass content and high accumulating *** plants to some extent can tolerate elevated levels of heavy metals through several developed mechanisms,such as activation of antioxidant enzymes,exclusion,accumulation of proline,compartmentalization,organic acid exudation,and *** studies have identified some stress-responsive to aid the tolerance of heavy metals in *** caused by heavy metal toxicity affects seedling growth,biomass,photosynthetic pigments,protein level,and nutrient uptake of castor *** response of castor,however,to these stresses differs among cultivars,metal type and concentration,and time of metal *** review aims to summarize the physiological responses and various defense mechanisms of castor to tolerate and eradicate heavy metal toxicity and some stress-responsive genes identified at transcriptional and posttranscriptional levels that confer metal tolerance in this plant.

关键词： Castor metal stress biomass proline tolerance

Antibacterial Activity and Structure-Activity Relationships of Schiff Bases on Staphylococcus aureus by Microcalorimetry

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Wuhan University Journal of Natural Sciences 2010年第1期15卷 71-77页

作者： HOU hanna ZHU Juncheng QI Zude ZHOU Bo LI Meiying LIU Yi College of Chemistry and Molecular Sciences/State Key Laboratory of Virology Wuhan University Wuhan 430072 Hubei China Department of Chemistry Hubei University of Education Wmhan 430205 Hubei China

The growth of Staphylococcus aureus under the action of six kinds of Schiff bases（A,B,C,D,E,F） was studied by means of microcalorimetry. Growth constant k and inhibition ratio I were calculated. Also,the antibacterial activity,the action characteristics and the structure-activity relationships of the compounds on S. aureus were analyzed. Results indicate that B,F show good antibacterial activity（IC50：293.6 mg · L-1 and 307.8 mg · L-1） ,D,E show moderate antibacterial activity（IC50：966.3 mg · L-1 and 1 126.7 mg · L-1） ,and A,C just show weak antibacterial activity（IC50 〉1 200 mg · L-1） . The I-c curves mainly present a straight line shape for B,D,E and F,but an inverse ＂S＂ shape for A and C. Structure-activity relationships analysis suggests that the species and position of the substituents determine the antibacterial activity of these Schiff bases,and the charge density distribution is one of the most important influencing factors.

关键词： Schiff bases Staphylococcus aureus microcalorimetry antibacterial activity structure-activity relationships

电子吸入药物监测装置在慢性阻塞性肺疾病和支气管哮喘管理中的应用进展

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数字医学与健康 2024年第1期2卷 45-49页

作者：乌汗娜牛宏涛于涛张雨诗李雪昕杨汀北京大学中日友好临床医学院北京100029 国家呼吸医学中心呼吸和共病全国重点实验室国家呼吸疾病临床研究中心中国医学科学院呼吸病学研究院中日友好医院呼吸与危重症医学科中日友好医院呼吸中心北京100029 中国医学科学院北京协和医学院北京100730 中日友好医院急诊科北京100029

吸入类药物是慢性阻塞性肺疾病和支气管哮喘的主要药物治疗方案,但患者对吸入装置的低依从性及不规范使用,成为治疗效果不佳的主要原因。为解决这一矛盾,近来陆续出现了利用吸人药物电子监测装置提高患者用药依从性和规范性的产品及研... 详细信息

吸入类药物是慢性阻塞性肺疾病和支气管哮喘的主要药物治疗方案,但患者对吸入装置的低依从性及不规范使用,成为治疗效果不佳的主要原因。为解决这一矛盾,近来陆续出现了利用吸人药物电子监测装置提高患者用药依从性和规范性的产品及研究。本文从电子吸人药物监测装置的功能及其对用药依从性、疾病控制的影响等三个方面进行概述,为慢性呼吸道疾病吸入用药的规范管理提供参考。

关键词：慢性阻塞性肺疾病支气管哮喘吸入治疗依从性数字疗法