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Influence of SCENIC recommendations on terminology used for histopathologic diagnosis of inflammatory bowel disease-associated dysplasia

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1375-1387页

作者： Yuan Li hanlin L wang Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of California at Los AngelesLos AngelesCA 90095United States Department of Pathology Molecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical ScienceBeijing 100730China

BACKGROUND Published in 2015,the International Consensus Recommendations on Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients(SCENIC)recommended abandoning the use of diagnostic term“dysplasia-associated lesion or mass(DALM)”for polypoid dysplastic lesions detected in patients with inflammatory bowel disease(IBD).The aim of this study was to investigate whether this recommendation had any influence on diagnostic terminologies used by pathologists in their *** We retrospectively reviewed all pathology reports for surveillance colonoscopic biopsies from ulcerative colitis(UC)patients in our institution during 1/2012-12/2014(pre-SCENIC)and 1/2016-12/2018(post-SCENIC).These included 1203 biopsies from 901 UC patients during the pre-SCENIC period and 1273 biopsies from 977 UC patients during the post-SCENIC *** corresponding endoscopic findings and histopathologic diagnoses were *** indications for total colectomy for UC patients and corresponding histopathologic findings in colectomy specimens were also recorded and *** A total of 347 and 419 polyps/polypoid lesions were identified during the preSCENIC and post-SCENIC periods,among which 60 and 104 were dysplastic/adenomatous,*** polypoid dysplastic lesions were simply diagnosed as“adenoma”during the post-SCENIC period in comparison with the pre-SCENIC period(97.1%vs 65.0%;P<0.001).The number of cases with a comment in pathology reports regarding the distinction between DALM and sporadic adenoma was also significantly decreased during the post-SCENIC period(5.8%vs 38.3%;P<0.001).In addition,the term“dysplasia”was more consistently used for random biopsies during the post-SCENIC ***,the terms“sessile serrated adenoma/polyp”(SSA/P)and“serrated epithelial change”(SEC)were more consistently used for polypoid lesions and random biopsies,respectively,during the post-SCENIC period,althoug

关键词： Inflammatory bowel disease Ulcerative colitis Dysplasia Terminology SCENIC

普通铅对LA-ICP-MS磷灰石U-Pb定年结果的影响及校正方法

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岩矿测试 2025年第1期44卷 51-62页

作者：罗涛王瀚林朱松柏卿丽媛胡兆初中国地质大学(武汉)地质过程与矿产资源国家重点实验室湖北武汉430074 中国石油塔里木油田公司克拉采油气管理区新疆库尔勒841000

磷灰石是火成岩、变质岩和沉积岩中广泛分布的含铀矿物,开展磷灰石U-Pb年代学研究对揭示岩浆演化过程、示踪溯源等方面具有重要意义。激光剥蚀电感耦合等离子体质谱法(LA-ICP-MS)是开展磷灰石U-Pb年龄微区分析的重要手段之一。当前,基... 详细信息

磷灰石是火成岩、变质岩和沉积岩中广泛分布的含铀矿物,开展磷灰石U-Pb年代学研究对揭示岩浆演化过程、示踪溯源等方面具有重要意义。激光剥蚀电感耦合等离子体质谱法(LA-ICP-MS)是开展磷灰石U-Pb年龄微区分析的重要手段之一。当前,基体匹配磷灰石U-Pb定年矿物标样缺乏和标样中不可避免的普通铅是制约LA-ICP-MS高精度磷灰石U-Pb年龄分析的主要瓶颈。本文对比研究了标样中普通铅对LA-ICP-MS磷灰石U-Pb定年结果的影响,采用含普通铅的磷灰石MAD作外标直接开展U-Pb年龄校正,获得的被测样品年龄会产生显著的系统偏差(最大约6%);采用207Pb法或Tera-Wasserburg图解法先校正标样中普通铅,再利用校正后的数据进行元素分馏和仪器漂移校正则可获得准确的磷灰石U-Pb年龄,与推荐值偏差在2%以内。另一方面,为消除标样中普通铅对分析结果的影响,本文还采用水蒸气辅助激光剥蚀方法,实现以NIST612玻璃作为外标准确分析磷灰石U-Pb年龄,解决了磷灰石U-Pb定年微区分析高质量标样缺乏的难题。本研究通过对标样中普通铅进行预校正或采用非基体匹配分析,建立了高精度LA-ICP-MS磷灰石U-Pb定年新方法,将促进磷灰石U-Pb年代学在地球科学研究中的应用。

关键词：激光剥蚀电感耦合等离子体质谱法磷灰石 U-Pb定年普通铅校正非基体匹配分析

Deformation Behavior and Microstructure Evolution during Equal Channel Angular Pressing of Pure Aluminum

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Journal of Wuhan University of Technology(Materials Science) 2022年第1期37卷 130-135页

作者： XU Shubo wang hanlin LIU Peng JING Cainian REN Guocheng School of Materials Science and Engineering Shandong Jianzhu UniversityJinan 250101China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China

The deformation behavior of equal channel angular pressing(ECAP)was discussed by using plasticity *** node mapping method is employed to realize the analysis of multi-pass ECAP by using three-dimensional FEM methods for pure *** single-pass ECAP is a non-uniform shear deformation process in the cross-section of the *** uniform deformation processing routes are obtained during multi-pass ECAP *** addition,the density of dislocations and defects of crystal lattice are also largely changed for different processing *** grain microstructure is gradually refined with the increase of the pressing *** grains and their distribution obtained by route Bc are more useful for producing the material with high angle grain *** grain microstructure of the cross section of the pressed material decreases with the increase of strain,and some grains exhibit transformed grain boundary(PTB)*** dislocation density in the grain decreases,and the grain boundary presents equiaxed distribution.

关键词： severe plastic deformation equal channel angular pressing/extrusion finite element analysis pure aluminum microstructure

Phytolith records of the climate change since the past 15000 years in the middle reach of the Yangtze River in China

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Frontiers of Earth Science 2012年第1期6卷 10-17页

作者： Yansheng GU hanlin wang Xianyu HUANG Hongxia PENG Junhua HUANG State Key Laboratory of Geobiology and Environmental Geology(BGEG) China University of GeosciencesWuhan 430074China Hubei Key Laboratory of Wetland Evolution&Eco-Restoration(WEER) China University of GeosciencesWuhan 430074China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China

Based on 14C dating and core sediments survey, phytolith records are employed to reconstruct paleovegetation and paleoclimate in the Jianghan Plain in the middle reach of the Yangtze River. Phytoliths identified are assigned into 21 well-described morphotypes and divided into four groups （Poaceae, fern, coniferous and broad-leaved）. The phytolith assemblages together with warmth index （Iw） are divided into 18 ecological zones, which reflect a complete vegetation history related to climate change in the middle reach of the Yangtze River during the past 15000 years. On the basis of the correlation ofphytolith records with the paleoclimatic indicators from stalagmite, peatland, North Atlantic deep-sea sediments, Loess Plateau of Central China, and Arabic Sea sediments, eight climatic phases are identified included Last Glacial Maximum （LGM）（20- 14.8 cal kaBP）, Last Deglaciation （LDG）（14.8-11.9 cal kaBP）, low-temperature phase in the Early Holocene （11.9-8 cal kaBP）, Holocene Opti- mum （8-4.9cal kaBP）, Holocene Katathermal （4.9- 1.1 cal kaBP）, Medieval Warmth Period （MWP）（1.1- 0.7 cal kaBP）, Little Ice Age （LIA）（0.7-0.15 cal kaBP）, and Modem Warming （0.15 cal kaBP-present）. Climatic events such as Bolling-Allerod warm intervals, Older Dryas, Inter-Allerod Cold Period, and Younger Dryas, and eight Holocene Bond events （B1-8） have been identified since the LDG. Our results demonstrate that the evolution of the climate in the research area has a strong link with the Indian Summer Monsoon （SW Monsoon）, Asian Summer Monsoon （SE Monsoon）, and Holocene events in North Atlantic simultaneously, which might indicate that solar variability affects the Earth surface climate system at the centennial and millennial scales.

关键词： core sediments middle reach of the YangtzeRiver 15000 years phytolith assemblages paleovegetation,paleoclimate

Organic photodetectors based on supramolecular nanostructures

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SmartMat 2020年第1期1卷 56-71页

作者： Yifan Yao Yusheng Chen hanlin wang Paolo Samorì ISIS UMR 7006 CNRSUniversity of StrasbourgStrasbourgFrance

Self‐assembly of semiconducting(macro)molecules enables the development of materials with tailored‐made properties which could be used as active components for optoelectronics *** nanostructures combine the merits of soft matter and crystalline materials:They are flexible yet highly crystalline,and they can be processed with low‐cost solution *** are devices capable to convert a light input into an electrical *** achieve high photoresponse,the photogenerated charge carriers should be transported efficiently through the self‐assembled nanostructures to reach the electrodes;this can be guaranteed via optimalπ–electron overlapping between adjacent conjugated ***,because of the high surface‐to‐bulk ratio,supramolecular nanostructures are prone to enhance exciton *** qualities make supramolecular nanostructures perfect platforms for photoelectric *** review highlights the most enlightening recent strategies developed for the fabrication of high‐performance photodetectors based on supramolecular *** introduce the key figure‐of‐merit parameters and working mechanisms of organic photodetectors based on single components and p–n *** particular,we describe new methods to devise unprecedented planar and vertical devices to ultimately realize highly integrated and flexible *** incorporation of ordered mesoscopic supramolecular nanostructures into macroscopic optoelectronic devices will offer great promise for the next generation of multifunctional and multiresponsive devices.

关键词： organic crystalline photodetector phototransistor self‐assembly supramolecular electronics

An isoindigo-bithiazole-based acceptor-acceptor copolymer for balanced ambipolar organic thin-film transistors

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Science China Chemistry 2016年第6期59卷 679-683页

作者： Ping Li hanlin wang Lanchao Ma Long Xu Fei Xiao Zhengran Yi Yunqi Liu Shuai wang Key Laboratory for Large-Format Battery Materials and System Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan 430074 China Flexible Electronics Research Center State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China State Key Laboratory of Organic Solids Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Balanced carrier transport is observed in acceptor-acceptor （A-A＇） type polymer for ambipolar organic thin-film transistors （OTFTs）. It is found that the incorporation of two electron-accepting moieties （BTz and IIG） into a polymer main chain to form A-A＇ polymer PIIG-BTz could lower highest occupied molecular orbital （HOMO） and lowest unoccupied molecular orbital （LUMO） levels and facilitate good molecular stacking of the polymer. Ambipolar transistor behaviour for PIIG-BTz, with the balanced hole and electron mobilities of 0.030 and 0.022 cm2 V 1 s-i was observed in OTFT devices, respectively. The study in this work reveals that the utilization of acceptor-acceptor （A-A＇） structure in polymer main chain can be a feasible strategy to develop ambipolar polymer semiconductors.

关键词： organic thin-film transistors acceptor-acceptor structure balanced ambipolar transport conjugated copolymer

Key CO_(2)capture technology of pure oxygen exhaust gas combustion for syngas-fueled high-temperature fuel cells

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International Journal of Coal Science & Technology 2021年第3期8卷 383-393页

作者： hanlin wang Qilong Lei Pingping Li Changlei Liu Yunpeng Xue Xuewei Zhang Chufu Li Zhibin Yang National Institute of Clean and Low-Carbon Energy Beijing 102211China Shenhua New Energy Company Ltd.Beijing 100007China China University of Mining and Technology Beijing 100083China

Integrated gasification fuel cells(IGFCs)integrating high-temperature solid oxide fuel cell technology with CO_(2)capture processes represents highly-efficient power systems with negligible CO_(2)*** burning with pure oxygen is an ideal method for fuel cell exhaust gas treatment,and this report describes experimental and numerical studies regarding an oxy-combustor for treating the exhaust gas of a 10 kW IGFC system *** applied simulation method was verified based on experiments,and the key performance indices of the combustor were studied under various *** was determined that 315 K was the ideal condensation temperature to obtain flame *** these pure oxygen flame burning conditions,CO was almost completely converted,and the dry mole fraction of CO_(2)after burning was C 0.958 when there was up to 5%excess O_(2).Overall,5%excess O_(2)was recommended to maximize CO_(2)capture and promote other environmental ***,the optimal tangential fuel jet angle to control the liner temperature was approximately 25°.The total fuel utilization had to be high enough to maintain the oxygen flame temperature of the anode exhaust gas below 1800 K to ensure that the system was environmentally *** results presented herein have great value for designing IGFCs coupled with CO_(2)capture systems.

关键词： Integrated gasification fuel cell system Solid oxide fuel cell Anode exhaust gas treatment CO_(2)capture Oxy-combustion

Electrical characteristics of new three-phase traction power supply system for rail transit

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Railway Engineering Science 2023年第1期31卷 75-88页

作者： Xiaohong Huang hanlin wang Qunzhan Li Naiqi Yang Tao Ren You Peng Haoyang Li School of Electrical Engineering Southwest Jiaotong UniversityChengdu 610031China

A novel three-phase traction power supply system is proposed to eliminate the adverse effects caused by electric phase separation in catenary and accomplish a unifying manner of traction power supply for rail *** the application of two-stage three-phase continuous power supply structure,the electrical characteristics exhibit new features differing from the existing traction *** this work,the principle for voltage levels determining two-stage network is dissected in accordance with the requirements of traction network and electric *** equivalent model of three-phase traction system is built for deducing the formula of current distribution and voltage *** on the chain network model of the traction network,a simulation model is established to analyze the electrical characteristics such as traction current distribution,voltage losses,system equivalent impedance,voltage distribution,voltage unbalance and regenerative energy *** a few words,quite a lot traction current of about 99%is undertaken by long-section cable *** proportion of system voltage losses is small attributed to the two-stage three-phase power supply structure,and the voltage unbal-ance caused by impedance asymmetry of traction network is less than 1‰.In addition,the utilization rate of regenerative energy for locomotive achieves a significant promotion of over 97%.

关键词： Three-phase AC power supply Two-stage power supply structure Electrical characteristics Current distribution Voltage losses Regenerative energy

Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation

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World Journal of Gastroenterology 2016年第45期22卷 10071-10076页

作者： Keri E Lunsford Adam S Bodzin Diego C Reino hanlin L wang Ronald W Busuttil The Pfleger Liver Institute The Dumont-UCLA Liver Transplant Center Division of Liver and Pancreas Transplantation Department of Surgery David Geffen School of Medicine at UCLA University of California Los Angeles J.C Walter Jr. Center for Transplantation Sherrie and Alan Conover Center for Liver Disease and Transplantation Center for Transplantation Immunobiology Houston Methodist Hospital and Research Institute Department of Pathology and Laboratory Medicine David Geffen School of Medicine at UCLA University of California Los Angeles

Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients.

关键词： Dietary supplements Fulminant hepatic failure Drug-induced liver injury Liver transplantation Hyroxycitric acid Weight-loss supplements