Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation

作     者：Keri E Lunsford Adam S Bodzin Diego C Reino Hanlin L Wang Ronald W Busuttil 

作者机构：The Pfleger Liver Institute The Dumont-UCLA Liver Transplant Center Division of Liver and Pancreas Transplantation Department of Surgery David Geffen School of Medicine at UCLA University of California Los Angeles J.C Walter Jr. Center for Transplantation Sherrie and Alan Conover Center for Liver Disease and Transplantation Center for Transplantation Immunobiology Houston Methodist Hospital and Research Institute Department of Pathology and Laboratory Medicine David Geffen School of Medicine at UCLA University of California Los Angeles 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2016年第22卷第45期

页      面：10071-10076页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100215[医学-康复医学与理疗学] 10[医学] 

主　　题：Dietary supplements Fulminant hepatic failure Drug-induced liver injury Liver transplantation Hyroxycitric acid Weight-loss supplements 

摘      要：Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients.