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Influence of SCENIC recommendations on terminology used for histopathologic diagnosis of inflammatory bowel disease-associated dysplasia

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1375-1387页

作者： Yuan li hanlin l wang Department of Pathology and laboratory Medicine David Geffen School of MedicineUniversity of California at Los AngelesLos AngelesCA 90095United States Department of Pathology Molecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical ScienceBeijing 100730China

BACKGROUND Published in 2015,the International Consensus Recommendations on Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients(SCENIC)recommended abandoning the use of diagnostic term“dysplasia-associated lesion or mass(DAlM)”for polypoid dysplastic lesions detected in patients with inflammatory bowel disease(IBD).The aim of this study was to investigate whether this recommendation had any influence on diagnostic terminologies used by pathologists in their *** We retrospectively reviewed all pathology reports for surveillance colonoscopic biopsies from ulcerative colitis(UC)patients in our institution during 1/2012-12/2014(pre-SCENIC)and 1/2016-12/2018(post-SCENIC).These included 1203 biopsies from 901 UC patients during the pre-SCENIC period and 1273 biopsies from 977 UC patients during the post-SCENIC *** corresponding endoscopic findings and histopathologic diagnoses were *** indications for total colectomy for UC patients and corresponding histopathologic findings in colectomy specimens were also recorded and *** A total of 347 and 419 polyps/polypoid lesions were identified during the preSCENIC and post-SCENIC periods,among which 60 and 104 were dysplastic/adenomatous,*** polypoid dysplastic lesions were simply diagnosed as“adenoma”during the post-SCENIC period in comparison with the pre-SCENIC period(97.1%vs 65.0%;Plogy reports regarding the distinction between DAlM and sporadic adenoma was also significantly decreased during the post-SCENIC period(5.8%vs 38.3%;Plasia”was more consistently used for random biopsies during the post-SCENIC ***,the terms“sessile serrated adenoma/polyp”(SSA/P)and“serrated epithelial change”(SEC)were more consistently used for polypoid lesions and random biopsies,respectively,during the post-SCENIC period,althoug

关键词： Inflammatory bowel disease Ulcerative colitis Dysplasia Terminology SCENIC

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Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation

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World Journal of Gastroenterology 2016年第45期22卷 10071-10076页

作者： Keri E lunsford Adam S Bodzin Diego C Reino hanlin l wang Ronald W Busuttil The Pfleger liver Institute The Dumont-UCLA Liver Transplant Center Division of Liver and Pancreas Transplantation Department of Surgery David Geffen School of Medicine at UCLA University of California Los Angeles J.C Walter Jr. Center for Transplantation Sherrie and Alan Conover Center for Liver Disease and Transplantation Center for Transplantation Immunobiology Houston Methodist Hospital and Research Institute Department of Pathology and laboratory Medicine David Geffen School of Medicine at UCLA University of California Los Angeles

Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients.

关键词： Dietary supplements Fulminant hepatic failure Drug-induced liver injury liver transplantation Hyroxycitric acid Weight-loss supplements

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Fluorescent Double Network Hydrogels with Ionic Responsiveness and High Mechanical Properties for Visual Detection

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 487-496页

作者：郑湾 lIU lerong lü hanlin wang Yuhang lI Feihu ZHANG Yixuan 陈艳军 wang Yifeng School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

We developed a fluorescent double network hydrogel with ionic responsiveness and high mechanical properties for visual *** nanocomposite hydrogel of laponite and polyacrylamide serves as the first network,while the ionic cross-linked hydrogel of terbium ions and sodium alginate serves as the second *** double-network structure,the introduction of nanoparticles and the reversible ionic crosslinked interactions confer high mechanical properties to the *** ions are not only used as the ionic cross-linked points,but also used as green emitters to endow hydrogels with fluorescent *** the basis of the “antenna effect” of terbium ions and the ion exchange interaction,the fluorescence of the hydrogels can make selective responses to various ions(such as organic acid radical ions,transition metal ions) in aqueous solutions,which enables a convenient strategy for visual detection toward ***,the fluorescent double network hydrogel fabricated in this study is promising for use in the field of visual sensor detection.

关键词： visual detection ionic responsiveness fluorescent hydrogels double network hydrogels mechanical property

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Automated identification of steel weld defects,a convolutional neural network improved machine learning approach

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 294-308页

作者： Zhan SHU Ao WU Yuning SI hanlin DONG Dejiang wang Yifan lI School of Mechanics and Engineering Science Shanghai UniversityShanghai 200444China School of Civil Engineering Shanghai Normal UniversityShanghai 201418China Shanghai PinlanData Technology Co. Ltd.Shanghai 200072China

This paper proposes a machine-learning-based methodology to automatically classify different types of steel weld defects,including lack of the fusion,porosity,slag inclusion,and the qualified(no defects)*** methodology solves the shortcomings of existing detection methods,such as expensive equipment,complicated operation and inability to detect internal *** study first collected percussed data from welded steel members with or without weld ***,three methods,the Mel frequency cepstral coefficients,short-time Fourier transform(STFT),and continuous wavelet transform were implemented and compared to explore the most appropriate features for classification of weld *** and convolutional neural network-enhanced algorithms were used to classify,the extracted ***,experiments were designed and performed to validate the proposed *** showed that STFT achieved higher accuracies(up to 96.63%on average)in the weld status *** convolutional neural network-enhanced support vector machine(SVM)outperformed six other algorithms with an average accuracy of 95.8%.In addition,random forest and SVM were efficient approaches with a balanced trade-off between the accuracies and the computational efforts.

关键词： steel weld machine learning convolutional neural network weld defect detection classification task percussion

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Oriental Reed Warblers do not abandon Common Cuckoo chicks during prolonged nestling periods

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Avian Research 2024年第3期15卷 369-373页

作者： hanlin Yan Huahua Zhao Haixia luo longwu wang laikun Ma Wei liang Ministry of Education Key laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158China School of life Sciences Guizhou Normal UniversityGuiyang 550001China School of life Sciences Hebei UniversityBaoding 071002China Department of Biology and Food Science Hebei Normal University for Nationaliti

The Oriental Reed Warbler(Acrocephalus orientalis)is one of the most commonly used hosts for the parasitic Common Cuckoo(Cuculus canorus).However,as hosts that feed unrelated parasitic nestlings may suffer extra reproductive costs,they may be less willing to care for nestlings that have prolonged nestling *** test this hypothesis,the duration of feeding by Oriental Reed Warblers under natural conditions for their own nestlings was compared with the duration of feeding under natural conditions for Common Cuckoo nestlings and for artificially prolonged cuckoo *** results showed that Oriental Reed Warblers did not starve,drive away,or desert any of the nestlings in the experiment,and neither parent was left *** experimental study indicates that both Oriental Reed Warbler parents were willing to care for nestlings with a prolonged nestling period(up to 30 days,twice the average duration time that the Oriental Reed Warblers fed their own chicks in natural conditions).However,further experiments and observations are required in other host bird species to examine whether both parents or one of the parents may exhibit the behavior of abandoning nestlings with a prolonged nestling period.

关键词： Brood parasitism Common Cuckoo Deserted nestling Oriental Reed Warbler Prolonged nestling period

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A novel multi-channel porous structure facilitating mass transport towards highly efficient alkaline water electrolysis

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Journal of Energy Chemistry 2024年第6期93卷 511-518,I0013页

作者： Xinge Jiang Vasileios Kyriakou Chen Song Xianbin wang Sophie Costil Chunming Deng Taikai liu Tao Jiang hanlin liao Universitéde technologie de Belfort Montbéliard Centre national de la recherche scientifiqueLaboratoire Interdisciplinaire Carnot de BourgogneBelfort 90010France Department of Chemical Engineering Engineering and Technology Institute Groningen(ENTEG)University of GroningenGroningen 9747 AGThe Netherlands The Institute of New Materials Guangdong Academy of ScienceGuangzhou 510650GuangdongChina

An advantageous porous architecture of electrodes is pivotal in significantly enhancing alkaline water electrolysis(AWE)efficiency by optimizing the mass transport *** effect becomes even more pronounced when aiming to achieve elevated current ***,we employed a rapid and scalable laser texturing process to craft novel multi-channel porous ***,the obtained electrodes exhibit the lowest Tafel slope of 79 mV dec^(-1)(HER)and 49 mV dec^(-1)(OER).As anticipated,the alkaline electrolyzer(AEl)cell incorporating multi-channel porous electrodes(NP-lT30)exhibited a remarkable improvement in cell efficiency,with voltage drops(from 2.28 to 1.97 V)exceeding 300 mV under 1 A cm^(-1),compared to conventional perforated Ni plate *** enhancement mainly stemmed from the employed multi-channel porous structure,facilitating mass transport and bubble dynamics through an innovative convection mode,surpassing the traditional convection ***,the NP-lT30-based AEl cell demonstrated exceptional durability for 300 h under 1.0 A cm^(-2).This study underscores the capability of the novel multi-channel porous electrodes to expedite mass transport in practical AWE applications.

关键词： Alkaline water electrolysis Mass transport Bubble dynamics Innovative convection mode Multi-channel porous structure

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Clinical management of a rare melanoma case arising from congenital melanocytic nevus

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Genes & Diseases 2024年第3期11卷 79-82页

作者： Ruixin Jiang Yan wang Xuhui Ma Xinyang Xuanyuan Yanjie Zhang Bin Jiang Weizhen Zhang hanlin Zeng Department of Oncology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 201900China Department of Oncology The Third People's Hospital of ZhengzhouZhengzhouHenan 450000China Department of Oral&Maxillofacial-Head and Neck Oncology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Shanghai Institute of Precision Medicine Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai200125China Department of Dermatology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China

Congenital melanocytic nevi(CMNs)are skin lesions characterized by benign melanocytic proliferations and present at birth or shortly *** and giant CMNs,with a projected adult size≥20 cm and 40 cm in diameter respectively,are more likely to develop into malignant *** most cases,melanoma arising from congenital melanocytic nevus(CMN)is particularly aggressive.

关键词： melanoma congenital melan

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Spatiotemporal Variability and Environmental Controls of Temperature Sensitivity of Ecosystem Respiration across the Tibetan Plateau

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Advances in Atmospheric Sciences 2024年第9期41卷 1821-1842页

作者： Danrui SHENG Xianhong MENG Shaoying wang Zhaoguo lI lunyu SHANG Hao CHEN lin ZHAO Mingshan DENG hanlin NIU Pengfei XU Xiaohu WEN Key laboratory of land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Zoige Plateau Wetlands Ecosystem Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Key laboratory of Ecological Safety and Sustainable Development in Arid lands Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Warming-induced carbon loss via ecosystem respiration(R_(e))is probably intensifying in the alpine grassland ecosystem of the Tibetan Plateau owing to more accelerated warming and the higher temperature sensitivity of R_(e)(Q_(10)).However,little is known about the patterns and controlling factors of Q_(10)on the plateau,impeding the comprehension of the intensity of terrestrial carbon-climate feedbacks for these sensitive and vulnerable ***,we synthesized and analyzed multiyear observations from 14 sites to systematically compare the spatiotemporal variations of Q_(10)values in diverse climate zones and ecosystems,and further explore the relationships between Q_(10)and environmental ***,structural equation modeling was utilized to identify the direct and indirect factors predicting Q_(10)values during the annual,growing,and non-growing *** results indicated that the estimated Q_(10)values were strongly dependent on temperature,generally,with the average Q_(10)during different time periods increasing with air temperature and soil temperature at different measurement depths(5 cm,10 cm,20 cm).The Q_(10)values differentiated among ecosystems and climatic zones,with warming-induced Q_(10)declines being stronger in colder regions than elsewhere based on spatial *** was the most cardinal factor in predicting annual Q_(10)values,significantly and positively correlated with Q_(10).Soil temperature(Ts)was identified as the other powerful predictor for Q_(10),and the negative Q_(10)-Ts relationship demonstrates a larger terrestrial carbon loss potentiality in colder than in warmer regions in response to global *** that the interpretations of the effect of soil moisture on Q_(10)were complicated,reflected in a significant positive relationship between Q_(10)and soil moisture during the growing season and a strong quadratic correlation between the two during the annual and non-growing *** findings are conducive to imp

关键词： carbon cycle eddy covariance measurements ecosystem respiration Q_(10)value Tibetan Plateau climate change

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Intrinsic and scattering attenuations of the Sichuan-Yunnan region in China from S coda waves

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Earthquake Science 2024年第1期37卷 51-66页

作者： Tian li lei Zhang Xiaodong Song Qincai wang Xinyu Jiang Jinchuan Zhang hanlin Chen SinoProbe laboratory School of Earth and Space SciencesPeking UniversityBeijing 100871China Hebei Hongshan National Observatory on Thick Sediments and Seismic Hazards Peking UniversityBeijing 100871China Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China Earthquake Agency of Jiangsu Province Nanjing 210014China

Seismic attenuation is a fundamental property of the Earth's *** structure for the complicated geological structures with strong seismicity in the Sichuan-Yunnan region is poorly *** this study,we collected 108,399 waveforms of 11,517 local small earthquakes with magnitudes between 1.5 and 3.5 from January 2014 to September 2021 in the Sichuan-Yunnan region and its adjacent *** employed an envelope inversion technique for separating the intrinsic and scattering attenuations of the S coda wave,and obtained the intrinsic and scattering attenuation structures for frequencies between 0.25 and 8.00 *** attenuation structures correlate well with the geological units,and some major faults mark the attenuation variations where historic large earthquakes have *** regional average attenuation shows a negative frequency *** average scattering attenuation has a faster descending rate than the average intrinsic attenuation,and is dominant at low frequencies,while at high frequencies the average intrinsic attenuation is *** lateral variation in the intrinsic attenuation is consistent with the variation in heat flow,the scattering attenuation may be related to the scatter distribution and *** total attenuation is consistent with the previous studies in this region,and the separate intrinsic and scattering attenuation may be useful in understanding regional tectonics and important in earthquake prevention and disaster reduction.

关键词： Intrinsic attenuation scattering attenuation Sichuan-Yunnan region

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OptoGPT: A foundation model for inverse design in optical multilayer thin film structures

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Opto-Electronic Advances 2024年第7期7卷 4-16页

作者： Taigao Ma Haozhu wang l.Jay Guo Department of Physics University of MichiganAnn ArborMichigan 48109USA Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMichigan 48109USA

Optical multilayer thin film structures have been widely used in numerous photonic ***,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design targets,or are difficult to suit for different types of structures,e.g.,designing for different materials at each *** methods also cannot accommodate versatile design situations under different angles and *** addition,how to benefit practical fabrications and manufacturing has not been extensively considered *** this work,we introduce OptoGPT(Opto Generative Pretrained Transformer),a decoder-only transformer,to solve all these drawbacks and issues simultaneously.

关键词： multilayer thin film structure inverse design foundation models deep learning structural color

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