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The expression of MAPK signaling pathways in conjunctivochalasis

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1801-1806页

作者： Yuan-Ling Jia Xiao-Jing Liu hang wen Yue-Ping Zhan Min-Hong Xiang Department of Ophthalmology Putuo Hospital Shanghai University of Traditional Chinese Medicine

This study investigated the potential role of MAPK signaling pathways in conjunctivochalasis(CCH). Twenty loose conjunctival biopsy samples from 20 CCH and 15 conjunctival biopsy samples from 15 normal controls(CON) were collected. The conjunctival fibroblasts were cultured in vitro. Immunofluorescence, ELISA, Western blot and reverse transcription-polymerase chain reaction(RT-PCR) were used. Our results showed that the expression of p-ERK, p-JNK, and p-p38 in CCH conjunctiva was significantly higher than that in CON group. The expression of p38 MAPK, JNK, and ERK proteins in CCH fibroblasts was significantly higher than that in CON group. The total expression of MAPK m RNA in CCH fibroblasts was significantly higher than that in CON group. The activated forms of p38 MAPK, JNK, and ERK proteins and m RNAs might up-regulate the expression of MMPs in CCH loose conjunctival tissue and fibroblasts, causing the degradation of collagen fibers and elastic fibers and promoting the occurrence of CCH. Our results deepen the understanding of CCH pathological mechanism.

关键词： ERK JNK p38 MAPK conjunctivochalasis phosphorylation level

Subtotal colonic bypass plus colostomy with antiperistaltic cecoproctostomy for the treatment of slow transit constipation in an aged population:A retrospective control study

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World Journal of Gastroenterology 2018年第23期24卷 2491-2500页

作者： Yang Yang Yong-Li Cao wen-hang Wang Yuan-Yao Zhang Nan Zhao Dong Wei Institute of Anal-Colorectal Surgery No.150 Central Hospital of PLA

AIM To compare the efficacy,improved quality of life,and prognosis in patients undergoing either subtotal colonic bypass with antiperistaltic cecoproctostomy(SCBAC) or subtotal colonic bypass plus colostomy with antiperistaltic cecoproctostomy(SCBCAC) for the treatment of slow transit *** Between October 2010 and October 2014,aged patients with slow transit constipation who were hospitalized and underwent laparoscopic surgery in our institute weredivided into two groups: the bypass group,15 patients underwent SCBAC,and the bypass plus colostomy group,14 patients underwent SCBCAC. The following preoperative and postoperative clinical data were collected: gender,age,body mass index,operative time,first flatus time,length of hospital stay,bowel movements(BMs),Wexner fecal incontinence scale,Wexner constipation scale(WCS),gastrointestinal quality of life index(GIQLI),numerical rating scale for pain intensity(NRS),abdominal bloating score(ABS),and ClavienDindo classification of surgical complications(CD) before surgery and at 3,6,12,and 24 mo after *** All patients successfully underwent laparoscopic surgery without open surgery conversion or surgeryrelated death. The operative time and blood loss were significantly less in the bypass group than in the bypass plus colostomy group(P = 0.007). No significant differences were observed in first flatus time,length of hospital stay,or complications with CD > 1 between the two groups. No patients had fecal incontinence after surgery. At 3,6,and 12 mo after surgery,the number of BMs was significantly less in the bypass plus colostomy group than in the bypass group. The parameters at 3,6,12,and 24 mo after surgery in both groups significantly improved compared with the preoperative conditions(P < 0.05),except NRS at 3,6 mo after surgery in both groups,ABS at 12,24 mo after surgery and NRS at 12,24 mo after surgery in the bypass group. WCS,GIQLI,NRS,and ABS significantly improved in the bypass plus col

关键词： Subtotal colonic bypass plus colostomy with antiperistaltic cecoproctostomy Subtotal colonic bypass with antiperistaltic cecoproctostomy Minimally invasive surgery for treatment of constipation Clinical efficacy Slow transit constipation in an aged population

Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice

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Bioactive Materials 2023年第11期29卷 85-97页

作者： Lu Yu hang wen Chang Liu Chen Wang Huaxin Yu Kaiyue Zhang Qingsheng Han Yue Liu Zhongchao Han Zongjin Li Na Liu School of Medicine Nankai UniversityTianjin300071China Key Laboratory of Bioactive Materials Ministry of EducationCollege of Life Sciences Nankai UniversityTianjin300071China Institute of Stem Cells Health-Biotech(Tianjin)Stem Cell Research Institute Co.LtdTianjin301700China

Aging is a degenerative process that leads to tissue dysfunction and *** stem cells(ESCs)have great therapeutic potential for age-related diseases due to their capacity for self-renewal and ***,the use of ESCs in clinical treatment is limited by immune rejection,tumourigenicity and ethical ***-derived extracellular vesicles(EVs)may provide therapeutic effects that are comparable to those of ESCs while avoiding unwanted ***,we fully evaluate the role of ESC-EVs in rejuvenation in vitro and in *** RNA sequencing(RNA-Seq)and microRNA sequencing(miRNA-Seq)screening,we found that miR-15b-5p and miR-290a-5p were highly enriched in ESC-EVs,and induced rejuvenation by silencing the Ccn2-mediated AKT/mTOR *** results demonstrate that miR-15b-5p and miR-290a-5p function as potent activators of rejuvenation mediated by *** rejuvenating effect of ESC-EVs was further investigated in vivo by injection into aged *** results showed that ESC-EVs successfully ameliorated the pathological age-related phenotypes and rescued the transcriptome profile of aged *** findings demonstrate that ESC-EVs treatment can rejuvenate senescence both in vitro and in vivo and suggest the therapeutic potential of ESC-EVs as a novel cell-free alternative to ESCs for age-related diseases.

关键词： treatment aging finding

INVESTIGATION OF CABIN NOISE REDUCTION IN THE Y12

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Chinese Journal of Aeronautics 1992年第4期 277-283页

作者： Yao Qi-hang,Huang wen-chao,Ma Xiao-jun(Aircraft Strength Research Institute,Xi’an,China

Over 14 dB(A) in the highest cabin noise levels of the propeller—driven Y12 aircraftwas reduced from the untreated ***,its interior higher noise environment hasbeen improved preliminarily *** paper deals with the noise control measuresapplied to the Y12 *** includes mainly the application of honeycomb sandwich stiffenedpanels,dynamic absorbers,damping treatments,window acoustic design andreplacement of the window and door closure *** results of cabin noise levels inflight measurements are given for both acoustic pre-and aft-treated on the 4-th Y12 *** of the flight results shows that the noise control measures are *** weight of the noise control package is about 0.8% of the total gross take-off weightof the aircraft.

关键词： aircraft hasbeen gross honeycomb NOISE interior closure preliminarily sandwich listed

Idiopathic membranous nephropathy complicated with malignant hypertension:a case report

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Chinese Medical Journal 2007年第15期120卷 1369-1371页

作者： TAO Jian-ling LI hang wen Yu-bing LI Xue-wang Department of Nephrology Peking Union Medical College Hospital Peking Union Medical College ＆ Chinese Academy of Medical Sciences Beijing 100730 China

Membranous nephropathy （MN） is the most common cause of nephrotic syndrome in adults. Its insidious onset and progression often hinder timely renal biopsy and early diagnosis delaying treatment while worsening prognosis. The complication of malignant hypertension （MHT） is rarely seen in idiopathic MN. To provide a better understanding of the disease we report a case of idiopathic MN diagnosed by biopsy six years after onset.

关键词： glomerulonephritis, membranous hypertension, malignant

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粟酒裂殖酵母菌对环境压力响应的研究进展

生态学杂志 2011年第8期30卷 1845-1850页

作者：文航黄艺北京大学环境科学与工程学院北京100871 北京大学环境模拟与污染控制国家重点联合实验室北京100871

粟酒裂殖酵母菌(Schizosaccharomyces pombe)是一种重要的模式生物,被广泛运用于细胞周期控制、染色体分离、基因沉默、线粒体来源论和减数分裂的研究。由于粟酒裂殖酵母与人类进化的亲缘关系较近,因此近年来其被运用于对非自然环境压... 详细信息

粟酒裂殖酵母菌(Schizosaccharomyces pombe)是一种重要的模式生物,被广泛运用于细胞周期控制、染色体分离、基因沉默、线粒体来源论和减数分裂的研究。由于粟酒裂殖酵母与人类进化的亲缘关系较近,因此近年来其被运用于对非自然环境压力的研究中。大多数压力会直接或间接引起粟酒裂殖酵母的活性氧压力。本文从基因组、蛋白质组和整体细胞结构上概述了粟酒裂殖酵母的基本特征,重点探讨了粟酒裂殖酵母在物理辐射、氧化物、重金属和激素类化合物等环境压力下的响应研究进展,分析了不同环境压力下粟酒裂殖酵母响应途径以及可能涉及的组分,并对该模式生物该如何更好地应用于环境评价领域进行了展望。

关键词：粟酒裂殖酵母菌环境压力核心环境压力响应特定环境压力响应

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基于自适应控制时域参数的电压协调控制

电力系统自动化 2015年第18期39卷 37-42页

作者：张文张岩褚晓东王亮电网智能化调度与控制教育部重点实验室山东大学山东省济南市250061 国网山东省电力公司电力科学研究院山东省济南市250002 山东电力调度控制中心山东省济南市250001

模型预测控制方法中的控制时域参数通常离线确定,且在优化过程中保持恒定,影响了其在电压协调控制问题中的优化控制效果。针对上述问题,提出了一种基于自适应控制时域参数的电压协调控制策略。基于轨迹灵敏度量化分析了节点电压对于备... 详细信息

模型预测控制方法中的控制时域参数通常离线确定,且在优化过程中保持恒定,影响了其在电压协调控制问题中的优化控制效果。针对上述问题,提出了一种基于自适应控制时域参数的电压协调控制策略。基于轨迹灵敏度量化分析了节点电压对于备选控制的响应特性。在控制调节速率的约束下,通过电压响应特性评估当前优化步数下电压的累计最大恢复值,建立极限调压能力指标。在每个采样周期初始时刻,根据预测电压轨迹和极限调压能力指标确定控制时域参数,在滚动优化过程中自适应调整,可减少计算量和耗时,加快故障后电压恢复速度和优化过程的收敛。新英格兰39节点系统的仿真结果验证了所提出方法的有效性。

关键词：自适应控制时域参数模型预测控制电压协调控制中长期电压稳定

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基于模糊聚类算法的多配送中心选址优化方法

东南大学学报（自然科学版） 2012年第5期42卷 1006-1011页

作者：毛海军王勇杭文于航何杰东南大学交通学院南京210096 哈尔滨工业大学管理学院哈尔滨150001

为了优化二级设施物流网络中多配送中心的选址操作,提取了影响配送中心选址的主要因素,建立了一种综合评价指标体系.首先,将语言变量值用三角模糊数表示,对备选配送中心进行综合评价;然后,采用区间数优度函数法将二级准则指标集成到一... 详细信息

为了优化二级设施物流网络中多配送中心的选址操作,提取了影响配送中心选址的主要因素,建立了一种综合评价指标体系.首先,将语言变量值用三角模糊数表示,对备选配送中心进行综合评价;然后,采用区间数优度函数法将二级准则指标集成到一级准则指标上,以集成后的方案评价指标值作为模糊聚类算法的输入进行聚类操作,并设计了聚类有效性指标以用于判断聚类结果合理性;最后,应用TOPSIS方法对各类内的备选址进行排序,以确定选址位置及数量.实例验证表明,当隶属度数值取0.740 2时,得到最小的聚类有效性指标为2.43.依据该操作可将备选配送中心分成4类进行逐类选址,选址结果合理且较其他方法更具有优越性.因此,该方法能够更有效地解决多配送中心选址问题.

关键词：物流网络多配送中心三角模糊数模糊聚类算法

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线路无间隙避雷器的发展趋势

电瓷避雷器 2010年第2期 48-50页

作者：杭文安徽淮南供电公司安徽淮南232007

安装线路避雷器已公认为线路防雷的有效措施。线路避雷器的产品结构包括有间隙避雷器及无间隙带脱离器的避雷器,指出了线路有间隙避雷器在绝缘配合、放电特性上存在一定问题。介绍了多家公司开发的线路无间隙(带脱离器)避雷器的安装结构... 详细信息

安装线路避雷器已公认为线路防雷的有效措施。线路避雷器的产品结构包括有间隙避雷器及无间隙带脱离器的避雷器,指出了线路有间隙避雷器在绝缘配合、放电特性上存在一定问题。介绍了多家公司开发的线路无间隙(带脱离器)避雷器的安装结构,其降低过电压效果明显,并且线路无间隙避雷器必须是免维护的。

关键词：线路避雷器无间隙免维护