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Self-therapeutic metal-based nanoparticles for treating inflammatory diseases

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Acta Pharmaceutica Sinica B 2023年第5期13卷 1847-1865页

作者： Ruifang Han Yu Xiao Qianqian Bai Chung hang Jonathan choi Department of Biomedical Engineering the Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

Inflammatory diseases are key contributors to high mortality globally and adversely affect the quality of *** treatments include corticosteroids or nonsteroidal anti-inflammatories that may cause systemic toxicity and biologics that may increase the risk of *** nanoparticles that bear not only the drug payload but also targeting ligands for delivery to inflammation sites at lowered systemic toxicity are established in the nanomedicine field,but their relatively large size often leads to systemic ***-based nanoparticles with intrinsic anti-inflammatory properties represent attractive *** are not only designed to be compact for crossing biological barriers(with the nanoparticle serving as a dual carrier and drug),but also support label-free tracking of their interactions with *** review commences with an outline of the common inflammatory diseases,inflammatory pathways involved,and conventional drug-loaded nanoparticles for ***,the review features the emerging applications of self-therapeutic metal-based nanoparticles(e.g.,gold,coper oxide,platinum,ceria,and zinc oxide)for managing inflammatory diseases in animals over the past three years,focusing on therapeutic outcomes and anti-inflammatory *** review concludes with an outlook on the biodistribution,long-term toxicity,and clinical translation of self-therapeutic metalbased nanoparticles.

关键词： Metal-based nanoparticles Inflammatory disease Self-therapeutic Nanomedicine Delivery Gold nanoparticles Clinical translation Reactive oxygen species

Do we have enough evidence for expanding the indications of ESD for EGC?

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World Journal of Gastroenterology 2011年第21期17卷 2597-2601页

作者： hang Lak Lee Chang Hwan choi Dae Young Cheung Department of Internal Medicine Hanyang University College of Medicine Department of Internal Medicine ChungAng University College of Medicine Division of Gastroenterology Department of Internal MedicineYeouido St.Mary's Hospitalthe Catholic University of Korea College of Medicine

Endoscopic submucosal dissection(ESD) is the most advanced and representative technique in the field of therapeutic endoscopy and has been used for the treatment of gastrointestinal neoplasms,including early gastric *** major difference and advantage of ESD compared to existing endoscopic resection techniques,such as endoscopic mucosal resection(EMR) and polypectomy,are the width and depth of the *** developed cutting devices,distal attachable endoscopic accessories,and an advanced electrosurgical unit have helped to overcome the limitations of therapeutic endoscopy in terms of lesion size,location,presence of fibrotic scarring,and accompanying *** a result,the indications for ESD have been expanded from the classical indication for EMR and polypectomy,and there is now support for a further expansion of ESD *** present,the most critical factor to consider in the decision of whether to perform ESD is the probability of unexpected lymph node *** guidelines for ESD are continually being updated and *** this review,we discuss the strengths and weaknesses of the expanded guidelines,based on evidence found in the literature.

关键词： Endoscopic submucosal dissection Endoscopic mucosal resection Early gastric cancer Indications

Structural and electrical properties of reactive magnetron sputtered yttrium-doped HfO_2 films

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Chinese Physics B 2018年第4期27卷 514-519页

作者： Yu Zhang Jun Xu Da-Yu Zhou hang-hang Wang Wen-Qi Lu Chi-Kyu choi Key Laboratory of Materials Modification by Laser Ion and Electron Beams Ministry of Education School of Physics Dalian University of Technology Dalian 116024 China School of Materials Science and Engineering Dalian University of Technology Dalian 116024 China Department of Physics Jeju National University Jeju 63243 Korea

Hafnium oxide thin films doped with different concentrations of yttrium are prepared on Si（100） substrates at room temperature using a reactive magnetron sputtering *** effects of Y content on the bonding structure,crystallographic structure,and electrical properties of Y-doped HfO2 films are *** x-ray photoelectron spectrum（XPS） indicates that the core level peak positions of Hf 4 f and O 1 s shift toward lower energy due to the structure change after Y *** depth profiling of XPS shows that the surface of the film is completely oxidized while the oxygen deficiency emerges after the stripping depths have *** x-ray diffraction and high resolution transmission electron microscopy（HRTEM） analyses reveal the evolution from monoclinic HfO2 phase towards stabilized cubic HfO2 phase and the preferred orientation of（111） appears with increasing Y content,while pure HfO2 shows the monoclinic phase *** leakage current and permittivity are determined as a function of the Y *** best combination of low leakage current of 10-7 A/cm^2 at 1 V and a highest permittivity value of 29 is achieved when the doping ratio of Y increases to 9 mol%.A correlation among Y content,phase evolution and electrical properties of Y-doped HfO2 ultra-thin film is investigated.

关键词： Y-doped HfO2 ultra-thin film high-k x-ray photoelectron spectrum

Food intolerance and skin prick test in treated and untreated irritable bowel syndrome

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World Journal of Gastroenterology 2006年第15期12卷 2382-2387页

作者： Dae-Won Jun Oh-Young Lee Ho-Joo Yoon seok-Hwa Lee hang-Lak Lee Ho-Soon choi Byung-Chul Yoon Min-Ho Lee Dong-Hoo Lee Sang-Hoen Cho Department of Internal Medicine College of Medicine Hanyang UniversitySeoulKorea Department of Food and Nutrition College of Human Ecology Hanyang UniversitySeoulKorea Department of Internal Medicine College of Medicine Seoul National UniversitySeoulSouth Korea

AIM： To correlate the clinical features of treated and untreated patients with irritable bowel syndrome （IBS） to the results of skin prick test （SPT） for food and inhalant allergens. METHODS： We recruited 105 subjects to form three different target groups： treated group （n=44） undergoing treatment for IBS, untreated group （n =31） meeting the Rome Ⅱ criteria without treatment for IBS, control group （n = 30） with no IBS symptoms. RESULTS： SPT results were different among the three groups in which SPT was positive in 17 （38.6%） treated patients, in 5 （16.1%） untreated patients and in 1 （3.3%） control （P〈0.01）. The number of positive SPTs was greater in the IBS group than in the control group （P〈 0.001）. The number of positive food SPTs was higher in the treated IBS group than in the untreated IBS group （P= 0.03）. CONCLUSION： Positive food SPT is higher in IBS patients than in controls.

关键词： Irritable bowel syndrome Skin prick test Food allergy

Memory Recently Retold： The Chinese Historical Writing of the Second Sino-Japanese War and World War II

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Sociology Study 2013年第9期3卷 697-706页

作者： choi Sze hang, Henry Jniversity of Hong Kong China

Memories regarding the history of the Second Sino-Japanese War （1931-1945） and World War il （1939-1945） have always been refreshed in the minds of contemporaries through the retelling of ＂historical war stories＂ in various forms including books, posters, films and other media presentations. However, these retellings are often criticised by some academics as distortion of historical facts. This is because many of the present generation of readers and audiences were not even born at the time the events happened. Thus, ＂historical facts＂ of this era are, in reality, very vague in people＇s minds and their ＂facts＂ are often simply a construction of frequently retold ＂historical war stories＂ mixed with imagination. This article will argue that even immediately after the end of both wars in 1945, fresh history memory was already distorted, with China being the main victim. Following the end of World War II, there was an extensive publication of books and periodicals about the war. However, through varied interpretations of primary sources and use of visual materials in different ways, various positions were created to suit specific needs for justification of China＇s desire to be part of the camp of world powers after 1945. Similar diverse positions were also used to make political arguments criticising both the Axis and Allied Powers for working toward different political ends.

关键词： Second Sino-Japanese War World War II history memory historical writing translation

Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma

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World Journal of Gastroenterology 2009年第18期15卷 2258-2264页

作者： Dongho choi Hyo Won Lee Kyung Yul Hur Jae Joon Kim Gyeong-Sin Park Si-Hyong Jang Young Soo Song Ki-seok Jang Seung Sam Paik Department of Surgery College of MedicineSoonchunhyang University140-743 SeoulSouth Korea Department of Surgery Chi Hang Hospital140-741 SeoulSouth Korea Department of Pathology College of MedicineCatholic University137-040 SeoulSouth Korea Department of Pathology College of MedicineHanyang University133-790 SeoulSouth Korea

AIM:To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon ***:Immunohistochemistry for CD133,CD24 and CD44 was performed on the tissue microarray of 523 colorectal *** records were reviewed and clinicopathological analysis was ***:In colorectal adenocarcinoma,128 of 523 cases(24.5%) were positive and 395 cases(75.5%) were negative for CD133 *** hundred and sixty-four of 523 cases(50.5%) were positive and 259 cases(49.5%) were negative for CD24 *** hundred and two of 523 cases(96%) were negative and 21 cases(4%) were positive for CD44 *** clinicopathological analysis,CD133 expression was present more in male patients(P = 0.002) and in advanced T stage cancer(P = 0.024).Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation(P = 0.006).Correlation between CD44 expression and clinicopathological factors was seen in the tumor size(P = 0.001).Survival was not significantly related to CD133,CD24 and CD44 ***:CD markers were related to invasiveness and differentiation of colorectal ***,CD expression was not closely related to survival.

关键词： CD133 CD24 CD44 Colon cancer stemcells Colorectal adenocarcinoma

Role of computed tomographic colonoscopy of postoperative surveillance in patient with gastric cancer

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World Journal of Gastroenterology 2007年第11期13卷 1646-1651页

作者： Dae Won Jun Oh Young Lee Hyun Chul Lim Sung Joon Kwon hang Lak Lee Byung Chul Yoon Ho Soon choi Joon Soo Hahm Min Ho Lee Dong Hoo Lee Department of Internal Medicine Hanyang University College of Medicine Seoul Korea Department of Radiology Hanyang University College of Medicine Seoul Korea Department of General Surgery Hanyang University College of Medicine Seoul Korea

AIM： TO examine the diagnostic yield of colorectal neoplasia at computed tomographic colonoscopy （CTC） as well as the feasibility of contrast enhanced CTC in patients with gastric cancer. METHODS： To examine the incidence of colon polyp we selected postoperative 188 gastric cancer patients, which we refer to as the ‘colon polyp survey group’. To examine the feasibility of CTC for early detection of colon cancer or advanced colon adenoma, we selected 47 gastric cancer patients （M：F 29：18, mean age 53.8 years）, which we call the ‘CT colonoscopy group’. All the 47 patients underwent successive CTC and colonoscopy on the same day. RESULTS： Totally 109 colon polyps were observed from 59 out of 188 gastric cancer patients, the inddence rate of colon polyps in gastric cancer patients being 31.4%. The sensitivity of CTC in detecting individuals with at least 1 lesion of any size was 57.1%, the specificity was 72.7%, the positive predictive value was 47.1%, and the negative predictive value was 71.9%. When the cutoff size was decreased to 6 mm, the sensitivity and specificity were 80.0% and 92.9%, respectively, with positive and negative predictive values of 57.1% and 97.5%, respectively. Only one patient was classified as false negative by virtual colonoscopy. CONCLUSION： The diagnostic yield of colorectal polyp was 31.4% in patients with gastric cancer, and contrast enhanced CTC is an acceptable tool for the detection of synchronous colorectal advanced adenoma and postoperative surveillance of gastric cancer patients.

关键词： Stomach cancer Colon cancer Computed tomocjraphic colonoscopy

Unknown origined massive osteolysis（Gorham’s disease） of the mandible

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Unknown origined massive osteolysis（Gorham’s disease） of ...

Chest wall metastasis from unknown primary site of hepatocellular carcinoma

The 9th Asian Congress of Oral and Maxillofacial Radiology

作者： In-Woo Park Jin-Woo Han hang-Moon choi Department of Oral and Maxillofacial Radiology College of DentistryGangneung-Wonju National University and Research Institute of Oral Science

＜正＞Aims:Gorham’s disease is a very rare condition,characterized by spontaneous and progressive bony destruction of unknown *** study presents a case of Gorham’s disease affecting the mandibular region. Methods:Th...

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World Journal of Gastroenterology 2006年第13期12卷 2139-2142页

作者： Yil Sik Hyun Ho Soon choi Joong Ho Bae Dae Won Jun hang Lak Lee Oh Young Lee Byung Chul Yoon Min Ho Lee Dong Hoo Lee Choon Shuk Kee Jung Ho Kang Moon Hyang Park Department of Internal Medicine Hanyang University College of Medicine SeoulKorea Department of Thoracic Surgery Hanyang University College of Medicine SeoulKorea Department of Pathology Hanyang University College of Medicine SeoulKorea

Previous reports of a solitary metastatic hepatocellular carcinoma have been rare. Because this tumor has a different treatment modality and prognosis, an accurate differential diagnosis is essential. Here we report a rare case of a solitary chest wall metastasis from unknown primary site of hepatocellular carcinoma. It involves a 51-year-old man who was admitted to our hospital because of a palpable left upper chest wall mass. The mass was resected and pathologic examination confirmed a diagnosis of metastatic hepatocellular carcinoma. Despite our investigation, no evidence was found that indicated the primary origin of the hepatocellular carcinoma. Four months later, the patient was admitted again because of spinal cord compression at the third and fourth thoracic vertebrae. Emergent decompressive laminectomy was performed and microscopic features revealed the same pathology as the initial chest wall mass resected 4 months earlier. After one year, a follow-up abdominal computed tomography （CT） still revealed no evidence of primary hepatocellular carcinoma.

关键词： Chest wall Hepatocellular carcinoma Metastasis