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Chinese Chemical Letters 2020年第2期31卷 501-504页

作者： Lin Liu Liying Yin hang bian Ning Zhang Department of Chemistry Northeast Normal UniversityChangchun 130024China School of Material Science and Engineering Jilin Jianzhu UniversityChangchun 130118China

A straightforward coassembly strategy was developed for the preparation of polymeric nanoparticles driving by the intermolecular hydrogen bond between neutral poly(2-methyl-2-oxaozline)(PMeOx),tannic acid(TA) and doxorubicin hydrochloride(Dox).The occurrence of the hydrogen-bonding amongst the different functionalities within the formed nanoparticles was verified by infrared(IR) spectroscopy.Scanning electron microscopy(SEM),dynamic light scattering(DLS),UV-vis absorption and photoluminescent measurements indicated the rapid formation of uniform and water dispersible/stable nanoparticles.The relative poor stability of PMeOx-TA-Dox in fetal bovine serum(FBS) solution enabled the rapid separation of Dox and PMeOx-TA,facilitating the release of Dox and its entrance into cellular nuclei as revealed by confocal laser scanning microscopy(CLSM).The presented strategy may provide an efficient alternative for the construction of multifunctional nanomedicines.

关键词： Polymeric nanoparticle Poly(2-oxazoline) Drug delivery Self-assembly Doxorubicin

Selective modification of two-dimensional MoS_2 nanosheets by polymer grafting

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Chinese Chemical Letters 2019年第2期30卷 311-313页

作者： hang bian Xuejian Zhang Dexin Huang Ning Zhang School of Material Science and Engineering Jilin Jianzhu University Key Laboratory of Synthetic Rubber Changchun Institute of Applied ChemistryChinese Academy of Sciences

As an emerging two-dimensional (2D) nanomaterial, single layer ora few layers of molybdenum disulfide (MoS_2) has drawn significant attention in the past decade. In the present work, we report a strategy in direct creating polymer brushes on MoS_2 surfaces via S—C bond in the presence of UV light. The modification of MoS_2 nanosheets can be achieved bilaterally or homolaterally by performing the UVgrafting polymerization on exfoliated MoS_2 nanosheets or a single layer of MoS_2 deposited on a silicon substrate. A series of vinyl monomers including methyl methacrylate (MMA), styrene (St) and 2-isopropenyl-2-oxazoline (IPOx) could be applied to this approach, leading to the formation of poly (methyl methacrylate) (PMMA), polystyrene (PS) and poly (2-isopropenyl-2-oxazoline) (PIPOx) brushes.AFM, IR, and XPS characterizations indicate the successful formation of homogeneous brush layers on MoS_2 surfaces. The polymer brushes modified MoS_2 may found potential applications in photo dynamic therapy and sensing technologies.

关键词： Molybdenum disulfide Polymer brushes SIPGP Surface modification S-C bond

Controlled synthesis of silver nanoparticles from polyoxometalates-immobilized poly(4-vinylpyridine) brushes

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Chinese Chemical Letters 2019年第5期30卷 1097-1099页

作者： hang bian Xuejian Zhang Hongkai Zhao Ning Zhang School of Material Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Department of Chemistry Northeast Normal UniversityChangchun 130024China

This contribution reports the immobilization of polyoxometalate(POM)into poly(4-vinyl pyridine)(P4 VP)brushes and the controlled reduction of silver ions,in-situ generating metal nanoparticles in the brushes.P4 VP brushes were straightforwardly created by UV-assisted photopolymerization of 4-vinyl pyridine(4VP)on silicon or glass substrates.Phosphotungstic acid(H3 PW12 O40),one of the most widely used Keggin-type POM was anchored onto these pyridine moieties through electrostatic interaction,leading to the P4 VP/POM hybrid brushes.The immobilized POM was further reduced to heteropolyblue,which could be used to generate silver nanoparticles in a controlled fashion.AFM,UV-vis and IR characterization indicate that P4 VP brushes not only provide an efficient platform in the controlled preparation of Ag nanoparticles,but also efficiently disperse and stabilize POM,thus preventing the aggregation of the generated Ag nanoparticles.

关键词： Polymer brushes Polyoxometalate Ag nanoparticles Grafting polymerization

Polymer brushes on hydrogen-terminated silicon substrates via stable Si--C bond

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Chinese Chemical Letters 2018年第1期29卷 171-174页

作者： hang bian Xiaozhe Dong Shanshan Chen Dewen Dong Ning Zhang School of Material Science and Engineering Jilin jianzhu University Changchun 130118 China Key Laboratory of Synthetic Rubber Changchun Institute of Applied ChemistryChinese Academy of Sciences Changchun 130022. China

We demonstrate a straightforward and efficient method for the creation of polymer brushes on hydrogen-terminated silicon substrates through the UV-induced photopoiymerization. The surface grafting polymerization is applicable to a series of monomers, allowing the direct formation of homogeneous polymer coatings ranging from hydrophilic poly（2-isopropenyl-2-oxazoline）（PIPOx）, amphiphilic poly（N-isopropyl acrylamide）（PNIPAM）, to hydrophobic polystyrene （PS） and poly（4- （1H,1H,2H,2H-perfiuorohexyl）oxymethylstyrene）（PPHMS） on Si（100） and Si（lll） surfaces via stable Si--C bonds. Polymerization kinetic investigation indicates a linear increase of polymer layer thickness with the polymerization time. Moreover, the as-prepared polymer brushes exhibit superior stability against basic conditions in contrast to those that were formed on silicon substrates via conventional Si--O--C bond.

关键词： Polymer brushesSilicon substratesSIPGPSurface wettabilitySurface functionalization

Synthesis, supramolecular structures and luminescent properties of quinacridone derivatives bearing carbazole groups

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Chinese Science Bulletin 2009年第10期54卷 1677-1684页

作者： ZHAO GuoLi FAN Yan HUO Cheng bian hang SONG WeiFeng Zhang JingYing WANG Yue State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 China

The syntheses of three carbazyl-containing quinacridone derivatives, N,N’-di((N-carbazyl)-n-butyl) quinacridone (DCBQA), N,N’-di((N-carbazyl)-n-hexyl)quinacridone (DCHQA) and N,N’-di((N-carbazyl)-n-octyl)quinacridone (DCOQA), are reported, and the photoluminescent (PL) characteristics are pre- sented. The single crystal X-ray structures of DCBQA, DCHQA and DCOQA are investigated. The crystal of DCBQA is characterized by intermolecular π…π interactions between quinacridone cores and carbazole moieties resulting in the formation of DCBQA molecule layer, in which every quinacridone core is surrounded by four carbazole groups. In DCHQA crystal, molecules assemble into two kinds of oriented columns based on intermolecular π…π interactions between quinacridone cores. The DCOQA crystal displays intermolecular CH…π and hydrogen bonding interactions feature. In DCOQA solid, every quinacridone core is sandwiched by two alkyl chains from two adjacent DCOQA molecules and simultaneously linked together with two other quinacridone cores by hydrogen bonding interactions. The PL spectra of the three compounds in solution exhibit concentration-dependent properties and their PL quantum causes decrease with the increasing concentration.

关键词：吖啶酮衍生物超分子结构发光性能合成咔唑氢键相互作用喹吖啶酮浓度依赖性

Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes

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Genes & Diseases 2024年第4期11卷 134-137页

作者： Shusheng Wang Yunji Liao Kaiyong Yang hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen Haiyang Yin Yantin bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng Yuan Jianwei Zhu Engineering Research Center of Cell and Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Jecho Laboratories Inc.FrederickMD 21704USA Jecho Institute Co. Ltd.Shanghai 200240China

The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic lives.Previous and recent studies indicate that monoclonal antibodies can be efficacious in preventing and treating SARSCoV-1 and SARS-CoV-2 infections.Using a phage display platform,we have identified dozens of monoclonal antibodies that bind to diverse epitope groups on the SARS-CoV-2 spike protein.Many of them bound to the receptor binding domain(RBD)and inhibited ACE2-RBD interaction.

关键词： antibodies inhibited monoclonal

The second natural gas hydrate production test in the South China Sea

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China Geology 2020年第2期3卷 197-209页

作者： Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong hang bian China Geological Survey Ministry of Natural ResourcesBeijing 100037China Guangzhou Marine Geological Survey China Geological SurveyMinistry of Natural ResourcesGuangzhou 510075China Institute of Exploration Techniques China Geological SurveyMinistry of Natural ResourcesLangfang 065000China Peking University Beijing 100871China CNPC Offshore Engineering Company Limited Beijing 100102China Oil and Gas Resources Survey China Geological SurveyMinistry of Natural ResourcesBeijing 100083China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 510000China

Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experim

关键词： Natural gas hydrates Second production test Horizontal well Reservoir stimulation Environmental impact NGH exploration trial engineering South China Sea

父母对子女消极情绪的反应方式量表(青少年版)的本土化修订

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中国临床心理学杂志 2024年第2期32卷 282-288页

作者：蒋柳青张航张明明边玉芳合肥师范学院教育与心理科学学院合肥230601 青少年心理健康与危机智能干预安徽省哲学社会科学重点实验室合肥230601 北京师范大学中国基础教育质量监测协同创新中心北京100875 北京师范大学儿童家庭教育研究中心北京100875 北京师范大学心理健康与教育研究所北京100875

目的:修订父母对子女消极情绪的反应方式量表(青少年版)(Coping with Children’s Negative Emotion Scale-Adolescents, CCNES-A),并检验其在我国青少年父母中的信效度及跨父母性别测量等值性。方法:对2008名青少年及其父母施测,采用... 详细信息

目的:修订父母对子女消极情绪的反应方式量表(青少年版)(Coping with Children’s Negative Emotion Scale-Adolescents, CCNES-A),并检验其在我国青少年父母中的信效度及跨父母性别测量等值性。方法:对2008名青少年及其父母施测,采用父母情绪调节困难量表和青少年情绪智力量表作为效标,一年后进行重测。结果:验证性因素分析结果支持原问卷的支持型和非支持型二阶结构,与西方样本结果不同,最小化在我国父母中属于支持型情绪社会化行为。CCNES-A支持型总分与父母情绪调节困难负相关,与青少年情绪智力正相关;非支持型总分与父母情绪调节困难正相关,与青少年情绪智力负相关。修订后量表信度较高且满足跨父母性别的严格等值性。结论:修订后CCNES-A是测量我国青少年父母情绪社会化行为的有效工具。

关键词：情绪社会化行为最小化青少年测量等值性

同方期刊数据库博看期刊评论

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多域整合治疗复杂原发性肺肉瘤样癌1例

中国肺癌杂志 2024年第2期27卷 157-160页

作者：霍小森邹珩董延妍李媛边灵杰李磊王洪武北京中医药大学东直门医院呼吸病中心北京101121

肺肉瘤样癌(pulmonary sarcomatoid carcinoma,PSC)是一类罕见的、恶性程度较高的肺部肿瘤,分为多形性癌、梭形细胞癌、巨细胞癌、癌肉瘤和肺母细胞瘤5种病理类型。PSC发病隐匿,临床症状和体征无特异性,与肿瘤生长和侵袭部位密切相关,... 详细信息

肺肉瘤样癌(pulmonary sarcomatoid carcinoma,PSC)是一类罕见的、恶性程度较高的肺部肿瘤,分为多形性癌、梭形细胞癌、巨细胞癌、癌肉瘤和肺母细胞瘤5种病理类型。PSC发病隐匿,临床症状和体征无特异性,与肿瘤生长和侵袭部位密切相关,可表现为刺激性咳嗽、痰中带血丝、呼吸困难或胸痛等。PSC易早期出现转移,多数患者就诊时已是局部进展期或晚期,中位生存时间为9个月。我呼吸病中心诊治1例致中央气道狭窄90%的原发性PSC患者;通过血管介入和气管镜下介入联合治疗的方法拯救了患者生命,延长了生存时间,术后随访19个月,效果满意,现报道如下,以供临床借鉴。

关键词：肺肉瘤样癌肺肿瘤中央气道狭窄

天然气水合物降压开采过程井周水合物的二次形成

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中国石油大学学报（自然科学版） 2022年第6期46卷 21-30页

作者：马超秦绪文孙金声余路李胜利王金堂毛文静边航陆程南方海洋科学与工程广东省实验室(广州) 广东广州511458 广州海洋地质调查局天然气水合物勘查开发国家工程研究中心广东广州511458 中国石油大学(华东)石油工程学院山东青岛266580 吉林大学建设工程学院吉林长春130061 中国地质大学(北京)能源学院北京100083 中国地质调查局油气资源调查中心北京100083

采用降压法开采天然气水合物,受分解吸热效应影响,地层温度降低区域的范围不断扩大。同时,生产井周水合物分解区受气体节流膨胀效应影响,温度降低现象更加显著,在一定的温、压条件下会出现水合物或冰形成,导致该区域内储层有效渗流通道... 详细信息

采用降压法开采天然气水合物,受分解吸热效应影响,地层温度降低区域的范围不断扩大。同时,生产井周水合物分解区受气体节流膨胀效应影响,温度降低现象更加显著,在一定的温、压条件下会出现水合物或冰形成,导致该区域内储层有效渗流通道被堵塞,渗流阻力升高,影响水合物分解气体的产出。通过自主研发的水合物分解区逆相变形成演化试验装置,模拟不同生产压差下水合物分解产出气体从分解前缘渗流至生产井筒这一过程,采集和计算试验过程中的储层温度、压力、饱和度等参数变化,探究分解区内影响冰与水合物二次形成的主控因素。结果表明:水合物分解气体在较大生产压差作用下受气体节流膨胀效应影响,会在生产井周5 m内引起温度下降,导致水合物二次形成;压差越大水合物二次形成的范围越向井壁缩小,且温度易降至0℃,形成冰堵,抑制气体产出;小压差情况下分解气供给小,造成分解前缘前部水合物二次形成区域范围大,但水合物二次形成量小;低渗透水合物储层气体流速低,气体节流膨胀效应减弱,水合物二次形成带窄。

关键词：降压开采试验模拟水合物分解水合物二次形成节流膨胀