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Green a.d Susta.na.le Chemistry 2011年第3期1卷 92-97页

作者： Ka.a. Usef Sa.ek a.dula.iz a.na.ja. Ra.a.a. a.med Mekheimer Na.r Ka.el mohamed haney a. mohamed 不详

a.green, simple a.d highly efficient synthesis of N,N-dia.ylsubstituted forma.idines ha. been developed employs rea.tion of triethylorthoforma.e (TEO) with a.oma.ic a.ines ca.a.yzed by cerium (IV) a.monium nitra.e (Ca.) in wa.er a. a.bient tempera.ure. This method offers the a.va.ta.es of proceeding under environmenta.ly friendly technique with high yields a.d simplicity either in conducting the rea.tion or ha.dling the products.

关键词： Ca. Triethylorthoforma.e a.oma.ic a.ines Wa.er a.bient Tempera.ure

a. Enha.ced Lung Ca.cer Detection a.proa.h Using Dua.-Model Deep Lea.ning Technique

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 835-867页

作者： Suma.a.mohamed Elha.sa. Sa.d mohamed Da.wish Sa.eh Mesba. Elka.fa. Depa.tment of Informa.ion Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria21526Egypt College of Computing a.d Informa.ion Technology Arab Academy for ScienceTechnology and Maritime TransportAlexandriaP.O.Box 1029Egypt

Lung ca.cer continues to be a.lea.ing ca.se of ca.cer-rela.ed dea.hs worldwide,empha.izing the critica. need for improved dia.nostic *** detection of lung tumors significa.tly increa.es the cha.ces of successful trea.ment a.d ***,current dia.nostic methods often fa.l to detect tumors a. a. ea.ly sta.e or to a.cura.ely pinpoint their loca.ion within the lung ***-model deep lea.ning technologies for lung ca.cer detection,while beneficia.,ca.not ca.ture the full ra.ge of fea.ures present in medica. ima.ing da.a.lea.ing to incomplete or ina.cura.e ***,it ma. not be robust enough to ha.dle the wide va.ia.ility in medica. ima.es due to different ima.ing conditions,pa.ient a.a.omy,a.d tumor *** overcome these disa.va.ta.es,dua.-model or multi-model a.proa.hes ca. be *** resea.ch focuses on enha.cing the detection of lung ca.cer by utilizing a.combina.ion of two lea.ning models:a.Convolutiona. Neura. Network(CNN)for ca.egoriza.ion a.d the You Only Look Once(YOLOv8)a.chitecture for rea.-time identifica.ion a.d pinpointing of *** a.toma.ica.ly lea.n to extra.t hiera.chica. fea.ures from ra. ima.e da.a.ca.turing pa.terns such a. edges,textures,a.d complex structures tha. a.e crucia. for identifying lung ***8 incorpora.es multisca.e fea.ure extra.tion,ena.ling the detection of tumors of va.ying sizes a.d sca.es within a.single *** is pa.ticula.ly beneficia. for identifying sma.l or irregula.ly sha.ed tumors tha. ma. be cha.lenging to ***,through the utiliza.ion of cutting-edge da.a.a.gmenta.ion methods,such a. Deep Convolutiona. Genera.ive a.versa.ia. Networks(DCGa.),the suggested a.proa.h ca. ha.dle the issue of limited da.a.a.d boost the models’a.ility to lea.n from diverse a.d comprehensive *** combined method not only improved a.cura.y a.d loca.iza.ion but a.so ensured efficient rea.-time processing,which is crucia. for pra.tica. clinica. a.plica.i

关键词： Lung ca.cer detection dua.-model deep lea.ning technique da.a.a.gmenta.ion CNN YOLOv8

Effects of P301L-Ta. on post-tra.sla.iona. modifica.ions of microtubules in huma. iPSC-derived cortica. neurons a.d Ta. tra.sgenic mice

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2348-2360页

作者： mohamed a.hya. a. Ka.ba.i Christoph Köhler Ha.s Zempel Institute of Huma. Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecula. Medicine Cologne(CMMC) University of CologneCologneGermany Center a.a.omy Department ⅡMedical FacultyUniversity of CologneCologneGermany

Ta. is a.microtubule-a.socia.ed protein tha. promotes microtubule a.sembly a.d sta.ility in the *** is missorted a.d a.grega.ed in a. a.ra. of disea.es known a. *** a.e essentia. for neurona. function a.d regula.ed via.a.complex set of post-tra.sla.iona. modifica.ions,cha.ges of which a.fect microtubule sta.ility a.d dyna.ics,microtubule intera.tion with other proteins a.d cellula. structures,a.d media.e recruitment of microtubule-severing *** impa.rment of microtubule dyna.ics ca.ses neurona. dysfunction,we hypothesize cognitive impa.rment in huma. disea.e to be impa.ted by impa.rment of microtubule *** therefore a.med to study the effects of a.disea.e-ca.sing muta.ion of Ta.(P301L)on the levels a.d loca.iza.ion of microtubule post-tra.sla.iona. modifica.ions indica.ive of microtubule sta.ility a.d dyna.ics,to a.sess whether P301L-Ta. ca.ses sta.ility-cha.ging modifica.ions to *** investiga.e Ta. loca.iza.ion,phosphoryla.ion,a.d effects on tubulin post-tra.sla.iona. modifica.ions,we expressed wild-type or P301L-Ta. in huma. Ma.T-KO induced pluripotent stem cell-derived neurons(i Neurons)a.d studied Ta. in neurons in the hippoca.pus of mice tra.sgenic for huma. P301L-Ta.(p R5 mice).Huma. neurons expressing the longest Ta. isoform(2N4R)with the P301L muta.ion showed increa.ed Ta. phosphoryla.ion a. the a.8,but not the p-Ser-262 epitope,a.d increa.ed polygluta.yla.ion a.d a.etyla.ion of microtubules compa.ed with endogenous Ta.-expressing neurons.P301L-Ta. showed pronounced soma.odendritic presence,but a.so successful a.ona. enrichment a.d a.simila. a.odendritic distribution compa.a.le to exogenously expressed 2N4R-wildtype-Ta..P301L-Ta.-expressing hippoca.pa. neurons in tra.sgenic mice showed prominent missorting a.d ta.opa.hy-typica. a.8-phosphoryla.ion of Ta. a.d increa.ed polygluta.yla.ion,but reduced a.etyla.ion,of microtubules compa.ed with non-tra.sgenic *** sum,P301L-Ta. results in cha.ges in micr

关键词： huma. induced pluripotent stem cell microtubules P301L pR5 mice Ta. ta.opa.hy tubulin code

Structura., electronic, a.d optica. studies of cha.cogenides sta.nite Cu2CdSnX4（X=S, Se, a.d Te）: insights from the DFT study

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Optoelectronics Letters 2025年第2期21卷 69-76页

作者： Ja.a. GUERROUM mohamed a.-Ha.Ta. Lhoucine MOUDOU Kha.id Ra.Ma.I Youssef La.HTIOUI Oma. Ba.JOU La.ora.ory of Engineering in Chemistry a.d Physics of Ma.ter Faculty of Sciences and Technics Sultan Moulay Slimane University Ecole Norma.e Supérieure Mohammed V University in Rabat College of Gra.ua.e Studies University of South Africa

In this pa.er,we ha.e ca.cula.ed the structura.,electronic,a.d optica. properties of cha.cogenide sta.nite Cu2CdSnX4（X=S,Se,Te） *** ca.cula.ions a.e ba.ed on the density functiona. theory （DFT） method a.d a.e performed using the Ca.bridge sequentia. tota. energy pa.ka.e （Ca.TEP） code included in the Biovia.Ma.eria. Studio 20 *** optica. properties ha.e been studied in a.doma.n tha. extends energetica.ly from 10 meV to 40 *** results show tha. Cu2CdSnX4（X=S,Se,Te） sta.nite exhibits a.sorption in the visible region,the refra.tive index decrea.es with increa.ing energy,a.d the refra.tive index va.ues a.e n=3.2,3.73 a.d 3.75 for Cu2CdSnS4,Cu2CdSnSe4a.d Cu2CdSnTe4,*** show a.so high conductivity,which implies tha. this ma.eria. is promising for sola. *** results a.gue in fa.or of the use of these ma.eria.s in va.ious potentia. *** density of sta.e,ba.d structures,a.d structura. properties of Cu2CdSnX4（X=S,Se,a.d Te） sta.nite a.e a.so studied in this work.

关键词： Refra.tive index

Dyna.ic Intera.tion a.a.ysis of Coupled a.ia.-Torsiona.-La.era. Mecha.ica. Vibra.ions in Rota.y Drilling Systems

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Structura. Dura.ility & Hea.th Monitoring 2025年第1期19卷 77-103页

作者： Sa.rina.Medda. Sid a.med Ta.jer a.delha.im Idir Kong Fa. Tee mohamed Zinela.idine Doghma.e Ma.jid Kidouche a.plied a.toma.ion La.ora.ory Faculty of Hydrocarbons and ChemistryUniversity of BoumerdesBoumerdes35000Algeria Institute of Electrica. a.d Electronic Engineering(IGEE) University of BoumerdesBoumerdes35000Algeria La.ora.ory of the Electrifica.ion of Industria. Enterprises University of BoumerdesBoumerdes35000Algeria Electrica. Engineering Depa.tment Mohamed Boudiaf University of M’silaM’sila28000Algeria Depa.tment of Civil a.d Environmenta. Engineering King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Interdisciplina.y Resea.ch Center for Construction a.d Building Ma.eria.s King Fahd University of Petroleum&Minerals(KFUPM)Dhahran31261Saudi Arabia

Ma.nta.ning the integrity a.d longevity of structures is essentia. in ma.y industries,such a. a.rospa.e,nuclea.,a.d *** a.hieve the cost-effectiveness of la.ge-sca.e systems in petroleum drilling,a.strong empha.is on structura. dura.ility a.d monitoring is *** study focuses on the mecha.ica. vibra.ions tha. occur in rota.y drilling systems,which ha.e a.substa.tia. impa.t on the structura. integrity of drilling *** study speciﬁca.ly investiga.es a.ia.,torsiona.,a.d la.era. vibra.ions,which might lea. to nega.ive consequences such a. bit-bounce,cha.tic whirling,a.d high-frequency *** events not only hinder the efﬁciency of drilling but a.so lea. to exha.stion a.d ha.m to the system’s components since they a.e difﬁcult to be detected a.d controlled in rea. *** study investiga.es the dyna.ic intera.tions of these vibra.ions,speciﬁca.ly in their high-frequency modes,usingﬁeld da.a.obta.ned from mea.urement while ***ﬁndings ha.e demonstra.ed the effect of strong coupling between the high-frequency modes of these vibra.ions on drilling sys-tem *** obta.ned results highlight the importa.ce of considering the interconnected impa.ts of these vibra.ions when designing a.d implementing robust control ***,integra.ing these compo-nents ca. increa.e the dura.ility of drill bits a.d drill strings,a. well a. improve the a.ility to monitor a.d detect ***,by exploiting theseﬁndings,the a.sessment of structura. resilience in rota.y drilling systems ca. be ***,the study demonstra.es the ca.a.ity of structura. hea.th monitoring to improve the qua.ity,dependa.ility,a.d efﬁciency of rota.y drilling systems in the petroleum industry.

关键词： Rota.y drilling systems mecha.ica. vibra.ions structura. dura.ility dyna.ic intera.tion a.a.ysis ﬁeld da.a.a.a.ysis

The impa.t of a.pha.fetoprotein(a.P),child-turcotte-pugh(CTP)score a.d disea.e sta.ing on the surviva. of hepa.ocellula. ca.cinoma.HCC)pa.ients:a.retrospective cohort from single oncology center

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Oncology Resea.ch 2025年第1期33卷 149-160页

作者： Na.SER MULLa.YOUSEF Ka.IB a.IM M.a.MUGHa.SI DUa. S.a.KHa.a. mohamed MOSa.D Sa.IR T.a.FOTIH Ra.a. a.a.FI Depa.tment of Interna. Medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Depa.tment of Ra.iology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Depa.tment of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Depa.tment of Endemic a.d Infectious Disea.es Suez Canal UniversityIsmailia41522Egypt King Sa.ma. bin a.dula.iz Medica. City Madinah42311Saudi Arabia Prince Moha.med Bin a.dula.iz Hospita. Madinah41511Saudi Arabia

Ba.kground:Hepa.ocellula. ca.cinoma.HCC)is the most common ca.se of ca.cer-rela.ed dea.h in Sa.di *** study a.med to investiga.e the pa.terns of HCC a.d the effect of TNM sta.ing,a.fa.fetoprotein(a.P),a.d Child-Turcotte Pugh(CTP)on pa.ients’overa.l surviva.(OS).Methods:a.retrospective a.a.ysis wa. conducted on 43 HCC pa.ients a. a.single oncology center in Sa.di a.a.ia.from 2015 to *** pa.ients ha. to fulfill one of the following criteria.(a.a.liver lesion reported a. definitive HCC on dyna.ic ima.ing a.d/or(b)a.biopsy-confirmed ***:The mea. pa.ient a.e of a.l HCC ca.es wa. 66.8 with a.ma.e-to-fema.e ra.io of 3.3:*** pa.ients were stra.ified into two groups:vira. HCC(n=22,51%)a.d non-vira. HCC(n=21,49%).a.ong vira.-HCC pa.ients,55%were due to HBV a.d 45%due to *** wa. dia.nosed in 79%of *** a.d sex did not significa.tly sta.istica.ly differ in OS a.ong vira. a.d non-vira. HCC pa.ients(p-va.ue>0.05).a.out 65%of pa.ients ha. tumor size>5 cm during the dia.nosis,with a.significa.t sta.istica. difference in OS(p-va.ue=0.027).a.P wa.>400 ng/ml in 45%of the *** wa. a.sta.istica.ly significa.t difference in the OS in terms of a.P levels(p-va.ue=0.021).a.sta.istica.ly significa.t difference wa. a.so observed between the CTP score a.d OS(p-va.ue=0.02).CTP cla.s B ha. the longest *** wa. the most common trea.ment provided to HCC pa.ients followed by sora.enib *** wa. a.significa.t sta.istica. difference in OS a.ong vira. a.d non-vira. HCC pa.ients(p-va.ue=0.008).Conclusions:The most common predictors for OS were the underlying ca.se of HCC,a.P,a.d tumor *** ha.ing non-vira. etiology,a.tumor size>5 cm,a. a.P>400 ng/mL,a.d a.CTP score cla.s C were a.l nega.ively a.socia.ed with OS.

关键词： Hepa.ocellula. ca.cinoma Pa.tern a.pha.fetoprotein(a.P) Child-turcotte-pugh Progression free surviva.

Sma.l hea. shock protein B8:from cell functions to its involvement in disea.es a.d potentia. thera.eutic a.plica.ions

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2872-2886页

作者： Ma.ta.Chierichetti Ricca.do Cristofa.i Va.eria.Crippa.Veronica.Ferra.i Ma.ta.Cozzi Elena.Ca.a.otto Pa.la.Pra.a.giore La.ra.Corna.gia.Guglielmo Pa.elli a.i mohamed Ma.gherita.Piccolella.Ma.ia.ita.Ga.bia.i Pa.la.Rusmini Ba.ba.a.Tedesco a.gelo Poletti La.ora.ory of Experimenta. Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Hea. shock protein fa.ily B(sma.l)member 8(HSPB8)is a.22 kDa.ubiquitously expressed protein belonging to the fa.ily of sma.l hea. shock ***8 is involved in va.ious cellula. mecha.isms ma.nly rela.ed to proteotoxic stress response a.d in other processes such a. infla.ma.ion,cell division,a.d ***8 binds misfolded clients to prevent their a.grega.ion by a.sisting protein refolding or degra.a.ion through cha.erone-a.sisted selective *** line with this function,the pro-degra.a.ive a.tivity of HSPB8 ha. been found protective in severa. neurodegenera.ive a.d neuromuscula. disea.es cha.a.terized by protein misfolding a.d *** ca.cer,HSPB8 ha. a.dua. role being ca.a.le of exerting either a.pro-or a. a.ti-tumora. a.tivity depending on the pa.hwa.s a.d fa.tors expressed by the model of ca.cer under ***,HSPB8 exerts a.protective function in different disea.es by modula.ing the infla.ma.ory response,which cha.a.terizes not only neurodegenera.ive disea.es,but a.so other chronic or a.ute conditions a.fecting the nervous system,such a. multiple sclerosis a.d intra.erebella. *** note,HSPB8 modula.ion ma. represent a.thera.eutic a.proa.h in other neurologica. conditions tha. develop a. a.seconda.y consequence of other *** is the ca.e of cognitive impa.rment rela.ed to dia.etes mellitus,in which HSPB8 exerts a.protective a.tivity by a.suring mitochondria. *** review a.ms to summa.ize the diverse a.d multiple functions of HSPB8 in different pa.hologica. conditions,focusing on the beneficia. effects of its ***-ba.ed a.d a.terna.ive thera.eutic a.proa.hes ta.geting HSPB8 a.d its regula.ed pa.hwa.s will be discussed,empha.izing how new stra.egies for cell a.d tissue-specific delivery represent a. a.enue to a.va.ce in disea.e trea.ments.

关键词： a.grega.ion a.topha.y ca.cer cha.erone cha.erone-a.sisted selective a.topha.y cognitive impa.rment HSPB8 neuroinfla.ma.ion neuromuscula. disea.es thera.y

Enta.glement a.d Its Dyna.ics with a.omic Sponta.eous Deca.

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Chinese Physics Letters 2008年第7期25卷 2492-2495页

作者： H. a. Hessia. a.-B. a. mohamed Fa.ulty of Science Assiut University Assiut Egypt

The a.omic deca. for a.two-level a.om intera.ting with a.single mode of electroma.netic tield is considered. For a.chosen initia. sta.e, the exa.t solution of the ma.ter equa.ion is found. Therefore, effect of the a.omic da.ping on enta.glement （purity loss）, degree of enta.glement by the nega.ivity, mutua. informa.ion a.d a.omic coherence through the ma.ter equa.ion a.e studied.

关键词： the power-la. exponents precipita.ion dura.ive a.rupt precipita.ion cha.ge

Risk ba.ed security a.sessment of power system using genera.ized regression neura. network with fea.ure extra.tion

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Journa. of Centra. South University 2013年第2期20卷 466-479页

作者： M. Ma.sa.ek a. mohamed College of Engineering Universiti Tenaga Nasional Fa.ulty of Engineering a.d Built Environment Universiti Kebangsaan Malaysia

a.comprehensive risk ba.ed security a.sessment which includes low volta.e, line overloa. a.d volta.e colla.se wa. presented using a.rela.ively new neura. network technique ca.led a. the genera.ized regression neura. network (GRNN) with incorpora.ion of fea.ure extra.tion method using principle component a.a.ysis. In the risk ba.ed security a.sessment formula.ion, the fa.lure ra.e a.socia.ed to wea.her condition of ea.h line wa. used to compute the proba.ility of line outa.e for a.given wea.her condition a.d the extent of security viola.ion wa. represented by a.severity function. For low volta.e a.d line overloa., continuous severity function wa. considered due to its a.ility to zoom in into the effect of nea. viola.ing contingency. New severity function for volta.e colla.se using the volta.e colla.se prediction index wa. proposed. To reduce the computa.iona. burden, a.new contingency screening method wa. proposed using the risk fa.tor so a. to select the critica. line outa.es. The risk ba.ed security a.sessment method using GRNN wa. implemented on a.la.ge sca.e 87-bus power system a.d the results show tha. the risk prediction results obta.ned using GRNN with the incorpora.ion of principa. component a.a.ysis give better performa.ce in terms of a.cura.y.

关键词： genera.ized regression neura. network line overloa. low volta.e principle component a.a.ysis risk index volta.ecolla.se

Observer-ba.ed a.a.tive Fuzzy Control for a.Cla.s of Nonlinea. Time-dela. Systems

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Interna.iona. Journa. of a.toma.ion a.d computing 2013年第4期10卷 275-280页

作者： Ha.sa. a. Yousef mohamed Ha.dy Depa.tment of Electrica. a.d Computer Engineering College of Engineering Sultan Qaboos University Depa.tment of Industria. Electronics a.d Control Engineering Faculty of Electronic Engineering Menofia University

a. observer-ba.ed a.a.tive fuzzy control is presented for a.cla.s of nonlinea. systems with unknown time dela.s. The sta.e observer is first designed, a.d then the controller is designed via.the a.a.tive fuzzy control method ba.ed on the observed sta.es. Both the designed observer a.d controller a.e independent of time dela.s. Using a. a.propria.e Lya.unov-Kra.ovskii functiona., the uncerta.nty of the unknown time dela. is compensa.ed, a.d then the fuzzy logic system in Ma.da.i type is utilized to a.proxima.e the unknown nonlinea. functions. Ba.ed on the Lya.unov sta.ility theory, the constructed observer-ba.ed controller a.d the closed-loop system a.e proved to be a.ymptotica.ly sta.le. The designed control la. is independent of the time dela.s a.d ha. a.simple form with only one a.a.tive pa.a.eter vector, which is to be upda.ed on-line. Simula.ion results a.e presented to demonstra.e the effectiveness of the proposed a.proa.h.

关键词： Observer a.a.tive fuzzy control nonlinea. systems time dela. sta.ility.