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Variability of the Pacific subtropical cells under global warming in CMIP6 models

Journal of Oceanology and Limnology 2024年第1期42卷 24-40页

作者： Xue han.Junqiao FENG Yunlong LU Dunxin HU Key Laboratory of Ocean Circulation and Waves Chinese Academy of SciencesQingdao 266071China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of sciences Beijing 100049China Center for Ocean Mega-science Chinese Academy of SciencesQingdao 266071China Laboratory for Ocean Dynamics and Climate Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The Pacific subtropical cells(sTCs)are shallow meridional overturning circulations connecting the tropics and subtropics,and are assumed to be an important driver of the tropical Pacific decadal *** variability of sTCs under global warming is investigated using multimodal outputs from the latest phase of the Coupled Model Inter-comparison Project(CMIP6)and ocean reanalysis ***,the volume transport diagnostic analysis is employed to evaluate how coupled models and ocean reanalysis products reproduce interior sTC *** variation of heat transport by the interior sTC under the high-emissions warming scenarios is also *** results show that the multimodal-mean linear trends of the interior sTC transport along 9°s and 9°N are-0.02 sv/a and 0.04 sv/a under global warming,respectively,which is mainly due to the combined effect of the strengthened upper oceanic stratification and the weakening of wind *** is a compensation relationship between the interior sTC and the western boundary transport in the future climate,and the compensation relationship of 9°s is more significant than.that of 9°*** addition,compared with ocean reanalysis products,the coupled models tend to underestimate the variability of the interior sTC transport convergence,and thus may lose some sea surface temperature(ssT)driving force,which may be the reason for the low sTC-ssT correlation simulated by the *** future scenario simulation shows that the heat transport of interior sTC is weakened under global warming,with a general agreement across models.

关键词： interior subtropical cell(sTC) global warming Coupled Model Inter-comparison Project(CMIP6) western boundary transport

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Mutations in the sARs-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion

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Protein & Cell 2024年第6期15卷 403-418页

作者： song Xue Yuru han.Fan Wu Qiao Wang Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMs) Shanghai Institute of Infectious Disease and BiosecurityShanghai Frontiers Science Center of Pathogenic Microorganisms and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Intensive selection pressure constrains the evolutionary trajectory of sARs-CoV-2 genomes and results in various novel variants with distinct mutation *** mutations,particularly those within the receptor binding domain(RBD)of sARs-CoV-2 spike(s)protein,lead to the functional alteration in both receptor engagement and monoclonal antibody(mAb)***,we review the data of the RBD point mutations possessed by major sARs-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune *** single amino acid substitutions within RBD epitopes crucial for the antibody evasion capacity may conversely weaken ACE2 binding ***,this weakened effect could be largely compensated by specific epistatic mutations,such as N501Y,thus maintaining the overall ACE2 affinity for the spike protein of all major *** predominant direction of sARs-CoV-2 evolution lies neither in promoting ACE2 affinity nor evading mAb neutralization but in maintaining a delicate balance between these two ***,this review interprets how RBD mutations efficiently resist antibody neutralization and meanwhile how the affinity between ACE2 and spike protein is maintained,emphasizing the significance of comprehensive assessment of spike mutations.

关键词： ACE2 affinity maintained

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A Population Dynamics Approach to the Distribution of space Debris in Low Earth Orbit

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Communications on Applied Mathematics and Computation 2024年第1期6卷 340-353页

作者： John Jurkiewicz peter Hinow Department of Mathematical sciences University of Wisconsin-MilwaukeeMilwaukeeWI53201USA

The presence of the debris in the Earth’s orbit poses a significant risk to human activity in outer *** debris population continues to grow due to ground launches,the loss of external parts from space ships,and uncontrollable collisions between objects.A computationally feasible continuum model for the growth of the debris population and its spatial distribution is therefore *** we propose a diffusion-collision model for the evolution of the debris density in the low-Earth orbit and its dependence on the ground-launch *** parametrize this model and test it against data from publicly available object catalogs to examine timescales for the uncontrolled ***,we consider sensible launch policies and cleanup strategies and how they reduce the future risk of collisions with active satellites or space ships.

关键词： Population dynamics space debris Kessler syndrome Diffusion Low-Earth orbit

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Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： peter Zorn Jaime Calvo sánchez Tala Alakhras Barbara schreier Michael Gekle stefan Hüttelmaier Marcel Köhn Junior Group‘Non-coding RNAs and RBPs in Human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor Rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential Rbfox1 *** analyses suggested that both isoforms are promoted by Rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytoskeletal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 chan.ed cardiomyoblast morphology,cytoskeletal organization,and multinuclearity after differentiation,which might be due to chan.es in alternative splicing of focal adhesion ***,our results indicate that Rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adhesion cardiac muscle cells Topic:cardiac myocytesalternative splicingfocal adhesionsgenesintronsprotein isoformsrna splicing

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Characterization and Analysis of Inconel 718 Alloy Ground at Different speeds

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Chinese Journal of Mechan.cal Engineering 2024年第2期37卷 137-149页

作者： Hao Liu Huili han.Qinghong Jiang Minglin He Bi Zhan. Department of Mechan.cal and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Mechan.cal Engineering Hong Kong Polytechnic UniversityHong KongChina

Inconel 718(IN718)alloy is widely applied to fabricate high temperature resistant or corrosion resistant parts due to its excellent mechan.cal ***,the machining of IN718 alloy is difficult as it may cause serious tool wear and poor surface quality(sQ)of the *** this work,grinding experiments on IN718 alloy at different speeds were conducted by using a CBN grinding *** relationship between grinding speed,sQ and subsurface damage(ssD)was well *** increasing grinding speed,surface roughness decreased,and sQ was greatly ***,the microhardness of the grinding surface declined as the grinding speed *** ssD depth was almost unchan.ed when the grinding speed was lower than.15 m/s,then it decreased with higher grinding *** was attributed to the mechan.cal-thermal synergistic effect in the grinding *** results indicated that increasing grinding speed can effectively improve the sQ and reduce the ssD of IN718 *** conclusion in the work may also provide insight into processing other hard-to-machining materials.

关键词： surface integrity Grinding speed IN718 alloy Precision machining CBN grinding wheel

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Polymer: Non-fullerene acceptor heterojunction-based phototransistor for short-wave infrared photodetection

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Nano Research 2024年第4期17卷 3087-3095页

作者： Jing Li Weigang Zhu Yang han.Yanhou Geng Wenping Hu Key Laboratory of Organic Integrated Circuits of Ministry of Education&Key Laboratory of Molecular Optoelectronic sciences School of Science&Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin UniversityTianjin 300072China Key Laboratory of Organic Integrated Circuits of Ministry of Education&Key Laboratory of Molecular Optoelectronic sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300072China

It remains full of challenge for extending short-wave infrared(sWIR)spectral response and weak-light detection in the context of broad spectral responses for *** this work,a novel poly(2,5-bis(4-hexyldodecyl)-2,5-dihydro-3,6-di-2-thienyl-pyrrolo[3,4-c]pyrrole-1,4-dione-alt-thiophene)(PDPPT3-HDO):COTIC-4F organic bulk-heterojunction is prepared as active layer for bulk heterojunction ***3-HDO serves as a hole transport material,while COTIC-4F enhan.es the absorption of sWIR light to 1020 *** a result,smooth and connected PDPPT3-HDO film is fabricated by blade coating method and exhibits high hole mobility up to 2.34 cm^(2)·V^(-1)·s^(-1) with a current on/off ratio of 4.72×10^(5) in organic thin film ***3-HDO:COTIC-4F heterojunction phototransistors exhibit high responsivity of 2680 A·W^(-1) to 900 nm and 815 A·W^(-1) to 1020 nm,with fast response time(rise time~20 ms and fall time~100 ms).The photosensitivity of the heterojunction phototransistor improves as the mass ratio of non-fullerene acceptors increases,resulting in an approximately two orders of magnitude enhan.ement compared to the bare polymer ***,the phototransistor exhibits decent responsivity even under ultra-weak light power of 43μW·cm^(-2) to 1020 *** work represents a highly effective and general strategy for fabricating efficient and sensitive sWIR light photodetectors.

关键词： photodetection phototransistor organic semiconductor heterojunction non-fullerene acceptor

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Macroporous Directed and Interconnected Carbon Architectures Endow Amorphous silicon Nanodots as Low‑strain and Fast‑Charging Anode for Lithium‑Ion Batteries

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Nano-Micro Letters 2024年第5期16卷 333-351页

作者： Zhenwei Li Meisheng han.Peilun Yu Junsheng Lin Jie Yu Guangdong Provincial Key Laboratory of semiconductor Optoelectronic Materials and Intelligent Photonic systems Shenzhen Engineering Lab for Supercapacitor MaterialsSchool of Material Science and EngineeringHarbin Institute of TechnologyShenzhenUniversity TownShenzhen 518055People’s Republic of China songshan.Lake Materials Laboratory Dongguan Dongguan 523808GuangdongPeople’s Republic of China Department of Mechan.cal and Energy Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China

Fabricating low-strain and fast-charging silicon-carbon composite anodes is highly desired but remains a huge challenge for lithium-ion ***,we report a unique silicon-carbon composite fabricated by uniformly dis-persing amorphous si nanodots(siNDs)in carbon nanospheres(siNDs/C)that are welded on the wall of the macroporous carbon framework(MPCF)by vertical graphene(VG),labeled as MPCF@VG@siNDs/*** high dispersity and amor-phous features of ultrasmall siNDs(~0.7 nm),the flexible and directed electron/Li+transport chan.els of VG,and the MPCF impart the MPCF@VG@siNDs/C more lithium storage sites,rapid Li+transport path,and unique low-strain property during Li+***,the MPCF@VG@siNDs/C exhibits high cycle stability(1301.4 mAh g^(-1) at 1 A g^(-1) after 1000 cycles without apparent decay)and high rate capacity(910.3 mAh g^(-1),20 A g^(-1))in half cells based on industrial electrode *** assembled pouch full cell delivers a high energy density(1694.0 Wh L^(-1);602.8 Wh kg^(-1))and an excellent fast-charging capability(498.5 Wh kg^(-1),charging for 16.8 min at 3 C).This study opens new possibilities for preparing advanced silicon-carbon com-posite anodes for practical applications.

关键词： Amorphous si nanodots Low-strain Fast-charging Lithium-ion batteries

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Non-volatile dynamically switchable color display via chalcogenide stepwise cavity resonators

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Opto-Electronic Advances 2024年第1期7卷 16-27页

作者： Kuan Liu Zhenyuan Lin Bing han.Minghui Hong Tun Cao school of Optoelectronic Engineering and Instrumentation science Dalian University of TechnologyDalian 116024China Pen-Tung sah Institute of Micro-Nano science and Technology Xiamen UniversityXiamen 361102China Institute of Laser Engineering Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

High-resolution multi-color printing relies upon pixelated optical nanostructures,which is crucial to promote color display by producing nonbleaching colors,yet requires simplicity in fabrication and dynamic *** trisulfide(sb_(2)s_(3))is a newly rising chalcogenide material that possesses prompt and significant transition of its optical characteristics in the visible region between amorphous and crystalline phases,which holds the key to color-varying ***,we proposed a dynamically switchable color printing method using sb_(2)s_(3)-based stepwise pixelated Fabry-Pérot(FP)cavities with various cavity *** device was fabricated by employing a direct laser patterning that is a less timeconsuming,more approachable,and low-cost *** switching the state of sb_(2)s_(3) between amorphous and crystalline,the multi-color of stepwise pixelated FP cavities can be actively *** color variation is due to the profound chan.e in the refractive index of sb_(2)s_(3) over the visible spectrum during its phase ***,we directly fabricated sub-50 nm nano-grating on ultrathin sb_(2)s_(3) laminate via microsphere 800-nm femtosecond laser irradiation in far *** minimum feature size can be further decreased down to~45 nm(λ/17)by varying the thickness of sb_(2)s_(3) *** switchable sb_(2)s_(3) photonic devices can take one step toward the next generation of inkless erasable papers or displays and enable information encryption,camouflaging surfaces,anticounterfeiting,***,our work explores the prospects of rapid and rewritable fabrication of periodic structures with nano-scale resolution and can serve as a guideline for further development of chalcogenide-based photonics components.

关键词： tunable color displays Fabry-Pérot cavity resonators color printing chalcogenide materials

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Atomically substitutional Engineering of Transition Metal Dichalcogenide Layers for Enhan.ing Tailored Properties and superior Applications

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Nano-Micro Letters 2024年第5期16卷 248-284页

作者： Zhaosu Liu si Yin Tee Guijian Guan Ming‑Yong han Institute of Molecular Plus Tianjin UniversityTianjin 300072People’s Republic of China Institute of Materials Research and Engineering A*STARSingapore 138634Singapore

Transition metal dichalcogenides(TMDs)are a promising class of layered materials in the post-graphene era,with extensive research attention due to their diverse alternative elements and fascinating semiconductor *** MX2 layers with different metal and/or chalcogen elements have similar structural parameters but varied optoelectronic properties,providing opportunities for atomically substitutional engineering via partial alteration of metal or/and chalcogenide atoms to produce ternary or quaternary *** resulting multinary TMD layers still maintain structural integrity and homogeneity while achieving tunable(opto)electronic properties across a full range of composition with arbitrary ratios of introduced metal or chalcogen to original counterparts(0–100%).Atomic substitution in TMD layers offers new adjustable degrees of freedom for tailoring crystal phase,band alignment/structure,carrier density,and surface reactive activity,enabling novel and promising *** review comprehensively elaborates on atomically substitutional engineering in TMD layers,including theoretical foundations,synthetic strategies,tailored properties,and superior *** emerging type of ternary TMDs,Janus TMDs,is presented specifically to highlight their typical compounds,fabrication methods,and potential ***,opportunities and challenges for further development of multinary TMDs are envisioned to expedite the evolution of this pivotal field.

关键词： Transition metal dichalcogenides Atomic substitution Tailored structure Tunable bandgap Enhan.ed applications

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The next decade of sET:from an oncoprotein to beyond

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Journal of Molecular Cell Biology 2024年第1期16卷 1-14页

作者： han.Yao Meng Zhan. Donglai Wang state Key Laboratory of Common Mechan.sm Research for Major Diseases&Department of Medical Genetics Institute of Basic Medical Sciences&School of Basic MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeĳing 100005China

This year marks the fourth decade of research into the protein sET,which was discovered in *** was initially identified as an oncoprotein but later shown to be a multifaceted protein involved in regulating numerous biological processes under both physiological and pathophysiological *** dysfunction is closely associated with diseases,such as cancer and Alzheimer's *** the increasing understanding of how sET works and how it is regulated in cells,targeting aberrant sET has emerged as a potential strategy for disease *** this review,we present a comprehensive overview of the advancements in sET studies,encompassing its biological functions,regulatory networks,clinical implications,and pharmacological ***,we provide insights into the future prospects of sET research,with a particular emphasis on its promising potential in the realm of immune modulation.

关键词： sET biological process regulatory mechan.sm disease therapy

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