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基于局部SURF与Kalman滤波的多机器人识别与跟踪

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燕山大学学报 2016年第5期40卷 426-430页

作者：李江昊韩立媛彭丹王绪全燕山大学信息科学与工程学院河北秦皇岛066004 燕山大学理学院河北秦皇岛066004

针对SURF匹配算法,提出一种局部特征匹配的思想,对场景中多个目标机器人进行识别与跟踪。在静态场景中,利用背景差法检测出场景中所有运动机器人,提取各个机器人的轮廓,通过轮廓获得每个机器人在图像中的区域,对每个小区域提取SURF特征... 详细信息

针对SURF匹配算法,提出一种局部特征匹配的思想,对场景中多个目标机器人进行识别与跟踪。在静态场景中,利用背景差法检测出场景中所有运动机器人,提取各个机器人的轮廓,通过轮廓获得每个机器人在图像中的区域,对每个小区域提取SURF特征点并与模板图像进行匹配,得到想要跟踪机器人的位置信息,最后通过Kalman滤波对机器人位置进行修正并跟踪。实验证明本算法在不降低匹配的准确性上有效提高了识别与跟踪的效率。

关键词： SURF 特征匹配背景差法 Kalman滤波

liraglutide protects against Aβ 25-35-induced impairment of spatial learning and memory in rats

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Liraglutide protects against Aβ 25-35-induced impairment of...

Anomaly monitoring and early warning of electric moped charging device with infrared image

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Wei-Na han,li yuan,Dong YANG,Zhao-Jun WANG,Xiao-Jie liU,Jin-Shun QI~* Department of Physiology,Shanxi Medical University,Taiyuan 030001,China

＜正＞Objective Alzheimer’s disease（AD） is a progressive neurodegenerative disorder which mainly manifests as severe impairments of learning and *** prominent pathological hallmark in AD patient’s brain is the presence of high density of senile plaques composed ofβ-amyloid peptide（Aβ）.Type 2 diabetes mellitus is a risk factor of AD,most likely linked to an impairment of insulin signaling in the ***,a novel long-lasting Glucagon-like peptide-1（GLP-1） analogue,facilitates insulin signaling and shows neuroprotective properties in vitro and in ***,it is still lack of behavioral evidence of the protection effect of liraglutide against Aβ-induced impairment of spatial *** The present study observed the effects of bilateral intrahippocampal injection of liraglutide on spatial learning and memory in the Morris water maze test and investigated the potential protective function of liraglutide against Aβ-induced memory ***（1） Bilateral intrahippocampal injection of Aβ25-35（4 nmol） resulted in a significant decline of spatial learning and memory;（2） liraglutide（5 nmol） alone slightly improved the learning and memory,but there is no significant differences compared with control groups;（3） Pretreatment with 0.5 nmol or 5 nmol,but not 0.05 nmol,liraglutide effectively reversed the impairment of spatial learning and memory induced by Aβ25-35;（4） All drugs used in the present experiments did not affect the vision and motor function of the *** Aβ25-35 could result in a significant decline of spatial learning and memory of rats and pretreatment with liraglutide could effectively prevent the impairment induced by neurotoxic Aβ***,these results suggest that insulin signaling in the brain maybe a new strategy to ameliorate learning and memory impairment in AD.

关键词： liraglutide amyloid-βprotein Morris water maze spatial learning and memory

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Optoelectronics Letters 2025年第3期 136-141页

作者： li Jiamin han Bo JIANG Mingshun School of Control Science and Engineering Shandong University

Potential high-temperature risks exist in heat-prone components of electric moped charging devices, such as sockets,interfaces, and controllers. Traditional detection methods have limitations in terms of real-time performance and monitoring scope. To address this, a temperature detection method based on infrared image processing has been proposed:utilizing the median filtering algorithm to denoise the original infrared image, then applying an image segmentation algorithm to divide the image.

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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： lifang Zhao Mingkai Zhang Qimeng li Xuemin Wang Jie Lu Ying han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Solar flare forecasting based on a Fusion Model

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Earth and Planetary Physics 2025年第1期9卷 171-181页

作者： YiYang li ShiYong Huang SiBo Xu ZhiGang yuan Kui Jiang QiYang Xiong RenTong lin School of Earth and Space Science Technology Hubei Luojia LaboratoryWuhan UniversityWuhan 430072China

Solar flare prediction is an important subject in the field of space *** learning technology has greatly promoted the development of this *** this study,we propose a novel solar flare forecasting model integrating Deep Residual Network(ResNet)and Support Vector Machine(SVM)for both≥C-class(C,M,and X classes)and≥M-class(M and X classes)*** collected samples of magnetograms from May 1,2010 to September 13,2018 from Space-weather Helioseismic and Magnetic Imager(HMI)Active Region Patches and then used a cross-validation method to obtain seven independent data *** then utilized five metrics to evaluate our fusion model,based on intermediate-output extracted by ResNet and SVM using the Gaussian kernel *** results show that the primary metric true skill statistics(TSS)achieves a value of 0.708±0.027 for≥C-class prediction,and of 0.758±0.042 for≥M-class prediction;these values indicate that our approach performs significantly better than those of previous *** metrics of our fusion model’s performance on the seven datasets indicate that the model is quite stable and robust,suggesting that fusion models that integrate an excellent baseline network with SVM can achieve improved performance in solar flare ***,we also discuss the performance impact of architectural innovation in our fusion model.

关键词： solar flare pace weather deep learning Fusion Model

1990-2019年中国卒中危险因素的归因负担及变化趋势

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中华疾病控制杂志 2022年第1期26卷 28-33,79页

作者：吴琼王晨冉赵燕韩丽媛刘世炜中国科学院大学宁波华美医院宁波315010 内蒙古医科大学公共卫生学院呼和浩特010059 中国疾病预防控制中心妇幼保健中心北京100081 中国疾病预防控制中心控烟办公室北京100050

目的分析1990-2019年中国卒中及其亚型的危险因素归因负担与变化趋势。方法利用2019年全球疾病负担研究开放数据,用人群归因分值(population attributable fraction, PAF)和伤残调整生命年(disability-adjusted life years, DALYs)探讨1... 详细信息

目的分析1990-2019年中国卒中及其亚型的危险因素归因负担与变化趋势。方法利用2019年全球疾病负担研究开放数据,用人群归因分值(population attributable fraction, PAF)和伤残调整生命年(disability-adjusted life years, DALYs)探讨1990-2019年中国卒中及其亚型的危险因素归因负担及变化趋势。结果卒中危险因素主要包括环境、行为和代谢三大类,因其亚型不同而有所不同。与蛛网膜下腔出血(subarachnoid hemorrhage, SAH)的15种危险因素(室外空气污染、高温、低温、铅暴露、室内空气污染、红肉摄入过多、高钠饮食、吸烟、吸二手烟、蔬菜摄入不足、水果摄入不足、纤维摄入不足、高BMI、高SBP、高FPG)相比,颅内出血(intracerebral hemorrhage, ICH)、缺血性卒中(ischemic stroke, IS)的危险因素还包括饮酒与肾功能不全,IS的危险因素还有低体力活动、全谷物摄入不足、高LDL-C。2019年,由IS、ICH、SAH导致的1 861.91、1 989.18、204.29万人年DALYs中,分别有68.91%、68.83%、66.35%归因于代谢因素,IS危险因素主要是高SBP(50.94%)、室外空气污染(26.81%)、高LDL-C(20.69%);ICH、SAH危险因素主要是高SBP(58.18%、58.01%)、室外空气污染(28.82%、30.09%)、高钠饮食(24.40%、25.11%)。1990-2019年,室外空气污染、高BMI、饮酒、红肉摄入过多导致的IS和ICH DALYs增幅较大,分别为410.46%、320.48%、277.03%、245.41%和168.93%、132.07%、60.01%、84.58%,而SAH仅因室外空气污染增加4.47%。结论导致卒中疾病负担的危险因素大多是可防可控的,因其亚型不同而有所不同,建议在考虑成本效益的情况下采取有针对性的干预措施。

关键词：卒中缺血性卒中颅内出血蛛网膜下腔出血疾病负担危险因素

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附睾特异蛋白与精子功能的研究进展

国际生殖健康／计划生育杂志 2011年第1期30卷 54-57页

作者：韩丽媛于和鸣国家人口计生委科学技术研究所北京100081 北京协和医学院研究生院

鉴定精子特异蛋白的目的是阐明其在生殖过程中的作用,将其作为有效调控的靶点。哺乳动物的精子在睾丸的曲细精管内生成后,虽然形态上已成为蝌蚪状,但并不具备运动和识别卵子并使其受精的能力。精子必须经过附睾内的加工才能成熟,即精子... 详细信息

鉴定精子特异蛋白的目的是阐明其在生殖过程中的作用,将其作为有效调控的靶点。哺乳动物的精子在睾丸的曲细精管内生成后,虽然形态上已成为蝌蚪状,但并不具备运动和识别卵子并使其受精的能力。精子必须经过附睾内的加工才能成熟,即精子的附睾成熟。该过程主要是修饰精子膜表面的蛋白,随着精子在附睾管腔中的运行,某些蛋白被移除或结合其上,还有经历糖基化或磷酸化等修饰。因此,对附睾中蛋白的鉴定研究,特别是附睾特异合成的蛋白,始终是揭示精子功能的重要切入点之一。综述近年对附睾特异蛋白参与精子成熟以及保护精子的较系统的研究。

关键词：精子附睾精子成熟附睾分泌蛋白质类

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胃癌与mTOR信号通路的相关性研究

世界复合医学 2017年第2期3卷 21-22,32页

作者：韩熙渊韩丽红包头医学院第二附属医院肝胆胰微创中心内蒙古包头014030 包头医学院基因诊断研究所内蒙古包头014060

目的研究胃癌与mTOR信号通路的相关性。方法选取2014年1月—2015年12月在包头医学院第二附属医院诊治的50例胃癌患者,采用免疫印迹技术及逆转录聚合酶链反应技术,就其癌旁胃组织及癌组织实施检测,另选取同期50例非胃癌患者,就其mTOR相... 详细信息

目的研究胃癌与mTOR信号通路的相关性。方法选取2014年1月—2015年12月在包头医学院第二附属医院诊治的50例胃癌患者,采用免疫印迹技术及逆转录聚合酶链反应技术,就其癌旁胃组织及癌组织实施检测,另选取同期50例非胃癌患者,就其mTOR相应表达状况予以检测;且对mTOR表达与临床参数关系予以分析。结果 mTOR在胃癌组织中的表达水平高于正常胃组织及癌旁胃组织,差异有统计学意义(P<0.05);mTOR mRNA在胃癌组织相应表达当中呈现为正相关,而其在正常胃组织及癌旁胃组织表达当中也呈现为正相关。mTOR mRNA在胃癌组织当中相应表达水平,则相关于有无淋巴结转移及病理分期等,而不相关于性别及肿瘤直径等。结论针对胃癌患者,mTOR信号通路在其组织当中特异性激活,而mTOR信号通路可能作用于胃癌的发生及发展。

关键词：胃癌 mTOR信号通路免疫印迹

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli yuan Tianjie Lyu ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell