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Macrophages play a role in inflammatory transformation of colorectal cancer

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2013-2028页

作者： Lu Lu Yu-Jing Liu Pei-Qiu Cheng hu Dan han-Chen Xu guang Ji Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai Pudong New Area Hospital of Traditional Chinese Medicine Shanghai 200120China

Colorectal cancer(CRC)is one of the most common and fatal cancers worldwide,and it is also a typical inflammatory *** function of macrophages is very important in the tissue immune microenvironment during inflammatory and carcinogenic ***,we evaluated the function and mechanism of macrophages in intestinal physiology and in different pathological ***,the role of macrophages in the immune microenvironment of CRC and the influence of the intestinal population and hypoxic environment on macrophage function are *** addition,in the era of tumor immunotherapy,CRC currently has a limited response rate to immune checkpoint inhibitors,and we summarize potential therapeutic strategies for targeting tumorassociated macrophages.

关键词： Colorectal cancer Macrophages Inflammatory transformation Tumor microenvironment

Influence of original microstructure on the transformation behavior and mechanical properties of ultra-high-strength TRIP-aided steel

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International Journal of Minerals,Metallurgy and Materials 2015年第3期22卷 262-271页

作者： Hong-xiang Yin Ai-min Zhao Zheng-zhi Zhao Xiao Li Shuang-jiao Li han-jiang hu Wei-guang Xia Metallurgical Engineering Research Institute University of Science and Technology Beijing Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of Mechanics Chinese Academy of Sciences

The transformation behavior and tensile properties of an ultra-high-strength transformation-induced plasticity （TRIP） steel （***） were investigated by different heat treatments for automobile applications. The results show that F-TRIP steel, a tradi- tional TRIP steel containing as-cold-rolled ferfite and pearlite as the original microstructure, consists of equiaxed grains of intercritical ferrite surrounded by discrete particles of M/RA and B. In contrast, M-TRIP steel, a modified TRiP-aided steel with martensite as the original mi- crostlucture, containing full martensite as the original microstructure is comprised of lath-shaped grains of ferrite separated by lath-shaped martensite/retained austenite and bainite. Most of the austenite in F-TRIP steel is granular, while the austenite in M-TRIP steel is lath-shaped. The volume fraction of the retained austenite as well as its carbon content is lower in F-TRIP steel than in M-TRIP steel, and austenite grains in M-TRIP steel are much finer than those in F-TRIP steel. Therefore, M-TRIP steel was concluded to have a higher austenite stability, re- sulting in a lower transformation rate and consequently contributing to a higher elongation compared to F-TRIP steel. Work hardening be- havior is also discussed for both types of steel.

关键词： high strength steels transformation-induced plasticity phase transformations mechanical properties original microstructure work hardening

PhaseⅡstudy of induction chemotherapy followed by concurrent chemoradiotherapy with raltitrexed and cisplatin in locally advanced nasopharyngeal carcinoma

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Chinese Journal of Cancer Research 2020年第5期32卷 665-672页

作者： Yuan Wu Xueyan Wei Zilong Yuan Hongbin Xu Yanping Li Ying Li Liu hu guang han Yu Qian Desheng hu Department of Radiation Oncology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430071China Department of Radiology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430071China Department of Medical Oncology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430071China

Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be ***,a specific thymidylate synthase inhibitor with a convenient administration schedule,has an acceptable and manageable toxicity,and possesses radio-sensitizing *** investigate the efficacy and safety of raltitrexed and cisplatin induction chemotherapy and concurrent chemoradiotherapy(IC+CCRT)in patients with LA-NPC,a phaseⅡclinical study was ***:Sixty eligible patients with LA-NPC were enrolled into this study.A raltitrexed-cisplatin combination was used as part of an IC+CCRT ***-cisplatin IC was given once every 3 weeks(q3 w)for two cycles,followed by raltitrexed-cisplatin based CCRT q3 w for two ***-modulated radiotherapy(IMRT)was given for all enrolled ***:All patients were included in survival analysis according to the intent-to-treat *** objective response rate(ORR)3 months after treatment was 98%.The 2-year overall survival(OS)rate was 92%.The median relapse-free survival(RFS)time was 30.5[95%confidence interval(95%CI),28.4-32.3]*** 2-year RFS rate was 85%.The 2-year local failure-free survival(LFFS)rate was 97%and the 2-year distant metastasis-free survival(DMFS)rate was 88%.Acute toxicities were mostly grade 2 and 3 reactions in bone marrow suppression,gastrointestinal side effect and oropharyngeal *** two patients occurred grade 4 acute toxicities,one was bone marrow suppression and the other was dermatitis ***:The combination of raltitrexed and cisplatin has a comparable efficacy to those in standard firstline therapy.

关键词： Nasopharyngeal carcinoma raltitrexed cisplatin induction chemotherapy concurrent chemoradiotherapy

A new method for introduction ω-side chain of prostanoid using Barton radical reaction

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Chinese Chemical Letters 2009年第3期20卷 253-255页

作者： Yi hua Zeng guang Dian han Institute of Materia Medica Peking Union Medical College Chinese Academy Medical Sciences Beijing 100050 China

A new method for introduction to-side chain of prostanoid was described in this note. Starting from acid chloride （3）, via Barton radical reaction, a trans α,β-unsaturated ketone sython was introduced.

关键词： Acid chloride N-Hydroxy-2-thiopyridine Barton ester ω-Side chain of prostanoid

Competitive analysis of online inventory problem with interrelated prices

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Applied Mathematics(A Journal of Chinese Universities) 2017年第2期32卷 237-252页

作者： han Shu-guang GUO Jiu-ling ZhanG Lu-ping hu Jue-liang JIANG Yi-wei ZHOU Di-wei Department of Mathematics Zhejiang Sci-Tech University School of Computing Engineering and Mathematics University of Brighton

This paper investigates the online inventory problem with interrelated prices in which a decision of when and how much to replenish must be made in an online fashion even without concrete knowledge of future prices. Four new online models with different price corre- lations are proposed in this paper, which are the linear-decrease model, the log-decrease model, the logarithmic model and the exponential model. For the first two models, the online algo- rithms are developed, and as the performance measure of online algorithm, the upper and lower bounds of competitive ratios of the algorithms are derived respectively. For the exponential and logarithmic models, the online algorithms are proposed by the solution of linear programming and the corresponding competitive ratios are analyzed, respectively. Additionally, the algorithm designed for the exponential model is optimal, and the algorithm for the logarithmic model is optimal only under some certain conditions. Moreover, some numerical examples illustrate that the algorithms based on the dprice-conservative strategy are more suitable when the purchase price fluctuates relatively flat.

关键词： online inventory problem interrelated prices competitive analysis.

Product Data Model for Performance-driven Design

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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1112-1122页

作者： guang-Zhong hu Xin-Jian Xu Shou-Ne Xiao guang-Wu Yang Fan Pu School of Mechanical Engineering Sichuan University of Science and Engineering State Key Laboratory of Traction Power Southwest Jiaotong University

When designing large-sized complex machinery products, the design focus is always on the overall per- formance; however, there exist no design theory and method based on performance driven. In view of the defi- ciency of the existing design theory, according to the performance features of complex mechanical products, the performance indices are introduced into the traditional design theory of ＂Requirement-Function-Structure＂ to construct a new five-domain design theory of ＂Client Requirement-Function-Performance-Structure-Design Parameter＂. To support design practice based on this new theory, a product data model is established by using per- formance indices and the mapping relationship between them and the other four domains. When the product data model is applied to high-speed train design and combining the existing research result and relevant standards, the corresponding data model and its structure involving five domains of high-speed trains are established, which can provide technical support for studying the relationships between typical performance indices and design parame- ters and the fast achievement of a high-speed train scheme design. The five domains provide a reference for the design specification and evaluation criteria of high speed train and a new idea for the train＇s parameter design.

关键词： Complex product design Performance driven Data model Mapping relationship High-speed train

FAMILIES OF p-ARY SEQUENCES WITH LOW CORRELATION AND LARGE LINEAR COMPLEXITY

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Journal of Systems Science & Complexity 2014年第6期27卷 1305-1319页

作者： CAI han ZENG Xiangyong hu Lei Faculty of Mathematics and Statistics Hubei University State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of Sciences

This paper generalizes a method of generating shift sequences in the interleaved construction proposed by *** the new shift sequences,some new families of p-ary sequences with desired properties can be obtained.A lowe... 详细信息

关键词： Auto-correlation cross-correlation linear complexity low correlation p-ary sequence.

Dynamic behaviors of rockslides subjected to brittle failure of locked segments

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Journal of Mountain Science 2023年第2期20卷 532-541页

作者： hu Kai ZHAO Xiao-yan ZhanG guang-ze Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China China Railway Eryuan Engineering Group Co. LtdChengdu 610031China

Locked segments are recognized as a critical role that controls the stability of rock slopes but remain an unclear and challenging problem with respect to their role incorporated into the failure *** order to study the effect of the locked segments on the initial failure process of rockslides,thirty-six groups of locked segment specimens with three different lithologies were prepared,direct shear tests were carried out to obtain the accelerations caused by brittle failure of the locked segment *** results showed that the maximum accelerations caused by the brittle failure of locked segment specimens was 2.91 g in the horizontal direction,and 3.18 g in the vertical *** took the Wangjiayan rockslide in 2008 Wenchuan earthquake as an example,the critical balance condition of the sliding mass under combined effect of gravity and accelerations induced by brittle failure of locked segment was analyzed,which indicated that the initial failure process of the Wangjiayan rockslides was notably influenced by the existence of the locked *** departure acceleration and direction of the Wangjiayan rockslide were *** study results can provide a new insight into the understanding of the initial failure mechanism of rockslides with locked segments.

关键词： Rockslides Rockfalls Locked segment Direct shear test Initial failure mechanism Sudden departure Brittle failure

Advanced Sensors Towards Ubiquitous Power Internet of Things

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 871-890页

作者： Jinliang He Zhifei han Jun hu Department of Electrical Engineering Tsinghua UniversityBeijing 100084China IEEE CSEE

The ubiquitous power Internet of Things(UPIoT)uses modern information technology and advanced communication technologies to realize interconnection and human-computer interaction in all aspects of the power *** has the characteristics of comprehensive state perception and efficient information processing,and has broad application prospects for transformation of the energy *** fundamental facility of the UPIoT is the sensor-based information *** using advanced sensors,Wireless Sensor Networks(WSNs),and advanced data processing technologies,Internet of Things can be realized in the power *** this paper,a framework of WSNs based on advanced sensors towards UPIoT is *** addition,the most advanced sensors for UPIoT purposes are reviewed,along with an explanation of how the sensor data obtained in UPIoT is utilized in various scenarios.

关键词： Advanced sensors ubiquitous power Internet of Things wireless sensor networks