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Colorectal cancer incidence and mortality:the current status,temporal trends and their attributable risk factors in 60 countries in 2000–2019

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Chinese Medical Journal 2021年第16期134卷 1941-1951页

作者： Bin Lu Na Li Chen-yu Luo Jie Cai Ming Lu yu-han zhang Hong-Da Chen Min Dai Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Cancer Prevention Hunan Cancer HospitalChangshaHunan 410006China Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China.

Background:Globally,colorectal cancer(CRC)imposes a substantial burden on healthcare systems and confers considerable medical *** aimed to evaluate the global and regional burden in epidemiological trends and factors associated with the incidence and mortality of ***:We used data from the GLOBOCAN database to estimate CRC incidence and mortality worldwide in 2020 and their association with the human development index(HDI).Trends of age-standardized rates of incidence and mortality in 60 countries(2000–2019)were evaluated by Joinpoint regression analysis using data of Global Burden of Disease *** association between exposure to country-level lifestyle,metabolic and socioeconomic factors obtained from the World Health Organization Global Health Observatory and World Bank DataBank data and CRC incidence and mortality was determined by multivariable linear ***:CRC incidence and mortality varied greatly in the 60 selected countries,and much higher incidence and mortality were observed in countries with higher HDIs,and vice *** 2000 to 2019,significant increases of incidence and mortality were observed for 33 countries(average annual percent changes[AAPCs],0.24–3.82)and 18 countries(AAPCs,0.41–2.22),respectively.A stronger increase in incidence was observed among males(AAPCs,0.36–4.54)and individuals<50 years(AAPCs,0.56–3.86).Notably,15 countries showed significant decreases in both incidence(AAPCs,0.24 to2.19)and mortality(AAPCs,0.84 to2.74).A significant increase of incidence among individuals<50 years was observed in 30 countries(AAPCs,0.28–3.62).Countries with higher incidence were more likely to have a higher prevalence of alcohol drinking,higher level of cholesterol level,higher level of unemployment,and a poorer healthcare ***:Some high-HDI countries showed decreasing trends in CRC incidence and mortality,whereas developing countries that previously had low disease burden showed significantly increas

关键词： Colorectal cancer burden Trend Incidence Mortality Risk factor GLOBOCAN Global Burden of Disease

The prediction of the peak width at half height in HPLC

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Chinese Journal of Chemistry 1991年第3期9卷 237-244页

作者： ZOU,han-Fa zhang,yu-Kui LU,Pei-Chang Dalian Chromatographic R.& D.Center of China Dalian Institute of Chemical Physics,Academia Sinica,Dalian 116011 Dalian Chromatographic R. & D. Center of China Dalian Institute of Chemical Physics Academia Sinica Dalian 116011

The prediction of the peak width at half height is an important aspect in the optimization of the chromatographic operating *** this paper,a linear relationship,between the peak widths at half height and the retention values with various isocratic elution is *** gradient elution,however,the relationship between the peak widths at half height and the so-called invented retention values that correspond to the mobile phase composition by eluting the solute from the column end is *** believe that there is almost the same band width at half height inside the column (in unit of length)for different *** peak width at half height in the chromatogram(in unit of time)is mainly determined by the capacity factor of the solute when it is eluted front the column *** larger the capacity factor of a solute eluted from the column end,the more slowly will be the solute eluted from the column end and the wider will be the peak width at half *** is possible to predict the peak width at half height in various isocratic and gradient elutions by using this linear relationship.

关键词： The prediction of the peak width at half height in HPLC

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城市公交区域调度双层优化方法研究

中国公路学报 2021年第6期34卷 196-204页

作者：慈玉生韩张宇吴丽娜哈尔滨工业大学交通科学与工程学院黑龙江哈尔滨150090 黑龙江工程学院汽车与交通工程学院黑龙江哈尔滨150050

为了实现区域公交行车计划编制优化,构建了一个以区域内乘客候车时间为上层目标、以车队规模为下层目标的双层规划模型。由于上、下层目标之间存在的互相影响关系,导致模型难以获取最优解,选择将下层目标转化为模型的约束条件从而实现... 详细信息

为了实现区域公交行车计划编制优化,构建了一个以区域内乘客候车时间为上层目标、以车队规模为下层目标的双层规划模型。由于上、下层目标之间存在的互相影响关系,导致模型难以获取最优解,选择将下层目标转化为模型的约束条件从而实现对模型的简便求解。对于车队规模的取值,提出了一种基于逆差函数的车队规模搜寻算法。进一步地,为了建立车队规模的约束条件,提出了3类核算时间点,并引入逻辑变量表征发车方案的选择,通过对核算时间点所对应的逆差函数值进行约束从而保证当前的发车方案能够满足既定的车队规模要求。在车队规模取值及约束条件确定的基础上,对模型进行求解即可得到不同车队规模取值情况下所对应的换乘时间表现最佳的发车方案。为了验证模型及求解思路的可行性,以哈尔滨市部分公交线路为例进行验证。结果表明:候车时间最优方案较初始方案能减少换乘时间10.3%,车队规模最优方案能减少初始车队规模15.2%;模型计算结果相当于为公交运营企业提供了可选择方案的效果边界,公交运营方可以通过结合预期的运营目标和实际公交规模选取最佳的发车方案,从而提高实际调度水平和运营效果。

关键词：交通工程公交行车计划双层规划模型车队规模约束条件逆差函数

Head-to-head comparison of the test performance of selfadministered qualitative vs. laboratory-based quantitative fecal immunochemical tests in detecting colorectal neoplasm

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Chinese Medical Journal 2021年第11期134卷 1335-1344页

作者： Ming Lu yu-han zhang Bin Lu Jie Cai Cheng-Cheng Liu Hong-Da Chen Min Dai Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Background:Fecal immunochemical tests(FITs)are the most widely used non-invasive tests in colorectal cancer(CRC)***,evidence about the direct comparison of the test performance of the self-administered qualitative a laboratory-based quantitative FITs in a CRC screening setting is ***:Based on a CRC screening trial(TARGET-C),we included 3144 pre-colonoscopy fecal samples,including 24 CRCs,230 advanced adenomas,622 non-advanced adenomas,and 2268 participants without significant findings at *** selfadministered qualitative FITs(Pupu tube)with positivity thresholds of 8.0,14.4,or 20.8 mg hemoglobin(Hb)/g preset by the manufacturer and one laboratory-based quantitative FIT(OC-Sensor)with a positivity threshold of 20 mg Hb/g recommended by the manufacturer were tested by trained staff in the central *** diagnostic performance of the FITs for detecting colorectal neoplasms was compared in the different scenarios using the preset and adjusted thresholds(for the quantitative FIT).Results:At the thresholds preset by the manufacturers,apart from the qualitative FIT-3,significantly higher sensitivities for detecting advanced adenoma were observed for the qualitative FIT-1(33.9%[95%CI:28.7–39.4%])and qualitative FIT-2(22.2%[95%CI:17.7–27.2%])compared to the quantitative FIT(11.7%[95%CI:8.4–15.8%]),while at a cost of significantly lower ***,such difference was not observed for detecting *** scenarios of adjusting the positivity thresholds of the quantitative FIT to yield comparable specificity or comparable positivity rate to the three qualitative FITs accordingly,there were no significant differences in terms of sensitivity,specificity,positive/negative predictive values and positive/negative likelihood ratios for detecting CRC or advanced adenoma between the two types of FITs,which was further evidenced in ROC ***:Although the self-administered qualitative and the laboratory-based quantitat

关键词： Fecal immunochemical test Test performance Colorectal neoplasm Screening

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang Chao Wang yunhong zhang Hong Liu yu zhang Lin han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

Calculation of Photonuclear Data for 180,182,183,184,186W

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中国核科技报告 1998年第S4期 93-95页

作者： han Yinlu yu Baosheng zhang Jingshang (China Nuclear Data Center, CIAE)

Based on available experimental data of neutron and photonuclear reaction, a set of neutron optical potential parameter and giant resonance parameters of γ for W were obtained. The photonuclear reaction data for180,1... 详细信息

关键词： Calculation of Photonuclear Data for data

Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

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World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： han-Chen Min Chun-Yan zhang Fang-yu Wang Xiao-Hui yu Shan-Hong Tang Hong-Wu Zhu Ya-Gang Zhao Ji-Luo Liu Jian Wang Jing-han Guo Xiao-Mei zhang yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

Effect of Different Irrigation Methods on Dissolved Organic Carbon and Microbial Biomass Carbon in the Greenhouse Soil

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Agricultural Sciences in China 2010年第8期9卷 1175-1182页

作者： han Lin,zhang yu-long,JIN Shuo,WANG Jiao,WEI Yan-yan,CUI Ning and WEI Wei College of Land and Environmental Sciences,Shenyang Agricultural University/Liaoning Key Laboratory of Agricultural Resources and Environment,Shenyang 110161,P.R.China [a] College of Land and Environmental Sciences Shenyang Agricultural University/Liaoning Key Laboratory of Agricultural Resources and Environment Shenyang 110161 P.R.China

The objective of this study was to investigate the contents and distribution of dissolved organic carbon （DOC） and microbial biomass carbon （MBC） at 0-100 cm soil depth under three irrigation treatments, viz., subsurface, drip and furrow irrigation in the greenhouse soil. The soil samples were collected at different depths （0-100 cm）, and the contents of soil total organic carbon （TOC）, DOC and MBC were analysed. The experiment was conducted for 10 yr, during which period the application of fertilizers and crop management practices were kept identical. The results showed that the contents of TOC, DOC and MBC were significantly affected by different irrigation regimes, decreased with the increase of soil depth. TOC at 0-10 and 80-100 cm soil depths followed the order of furrow irrigation 〉 subsurface irrigation 〉 drip irrigation, whereas at the depth of 10-80 cm followed the order of subsurface irrigation 〉 furrow irrigation 〉 drip irrigation. DOC and MBC contents at 0-100 cm soil depths followed the order of furrow irrigation 〉 drip irrigation 〉 subsurface irrigation, and drip irrigation 〉 furrow irrigation 〉 subsurface irrigation, respectively. The ratios of DOC and MBC to TOC accounted for 4.98-12.87% and 1.48-2.82%, respectively, which were the highest in the drip irrigation treatment, followed were in the furrow irrigation treatment, and the lowest in subsurface irrigation treatment. There were significant positive correlations among the contents of DOC, MBC and TOC in all irrigation treatments. The furrow irrigation facilitated the accumulation of TOC and DOC, while drip irrigation increased the MBC. The content of TOC and the ratios of DOC to TOC were the lowest in subsurface irrigation treatment.

关键词： greenhouse irrigation methods total organic carbon dissolved organic carbon microbial biomass carbon

Bibliometric analysis of soil phosphate solubilizing microorganisms research using VOSviewer

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Life Research 2024年第1期7卷 10-15页

作者： Xian-yuan Du Dan-dan Li Qiang-wei Wang han-yu zhang Yang Yang State Key Laboratory of Petroleum Pollutants Control China National Petroleum Corporation Research Institute of Safety and Environment TechnologyBeijing 102206China Department of Municipal and Environmental Engineering Hebei University of ArchitectureZhangjiakou 075000China College of Biological Science and Technology Shenyang Agricultural UniversityShenyang 110866China

Phosphorus-solubilizing microbes play key roles in improving phosphorus availability and in alleviating phosphorus nutrient limitation in soils. However, we did not have a comprehensive understanding of the overall research progress and development trend of phosphorus solubilizing microorganisms. In this study, we obtain documents from the Web of Science (WOS) core collection between 2002 and 2022, and a comprehensive review of the progress of global research on soil phosphate solubilizing microorganisms was conducted by using the VOSviewer bibliometric analysis tool. The results showed an increasing trend in the number of published articles from 2002 to 2022. India, accounting for 28% of the total number of published articles, became the most productive country. However, Canada was the country with the highest average citation frequency of articles. Chinese Academy of Sciences (CAS) was the greatest contributor with the most publications. Among the published journals, Frontiers in Microbiology, Applied Soil Ecology and Plant and Soil were the top three core journals in this field. Based on the keyword analysis, the assessment of the mechanisms between phosphorus solubilizing microbes and the soil carbon cycles with the different management practices became the new research trend among the scientific communities. These findings would provide an important reference value for future in-depth research on soil phosphate solubilizing microorganisms.

关键词： soil phosphate solubilizing microorganisms bibliometrics VOSviewe