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Diagnosis and treatment of benign multicystic peritoneal mesothelioma

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World Journal of Gastroenterology 2013年第39期19卷 6689-6692页

作者： Tian-Bao Wang Wei-Gang Dai Da-Wei Liu han-ping shi Wen-Guang Dong Department of Surgery the First Affiliated HospitalSun Yat-sen University Department of Pathology the First Affiliated HospitalSun Yat-sen University

Benign multicystic peritoneal mesothelioma(BMPM)is a rare cystic mesothelial lesion that occurs predominantly in reproductive aged women.A 56-year-old Caucasian male was admitted to our surgical department with a chief complaint of a painful mass in his right lower abdomen for almost 2 *** physical examination revealed a palpable painful *** tomography demonstrated an irregular,cystic tumor in his right lower *** was no obvious capsule or internal *** enhancement after intravenous administration of contrast was *** exploratory laparotomy was performed,and a multicystic tumor and adherent to the caecum was *** walls of the cysts were thin and smooth,filled with clear fluid,and very *** en bloc resection of the tumor,including appendix and caecum,was *** examination revealed multiple cysts lined with flattened simple epithelial cells,and the capsule walls of the cysts were composed of fibrous *** analysis documented positive expression of mesothelial cells and *** final diagnosis was *** patient was well at 6-mo *** is exceedingly rare lesion.A complete resection of the tumor is *** diagnosis of BMPM is based on pathological analysis.

关键词： Benign multicystic peritoneal mesothelioma Computed tomography Pathological analysis Diagnosis Resection

Cancer Prohibitor-Telomeric DNA Repair Pathways

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Journal of Nutritional Oncology 2018年第2期3卷 84-91页

作者： ping ping Jia han ping shi Departments of Gastrointestinal Surgery and Clinical Nutrition Beijing 100038China shijitan Hospital Department of OncologyCapital Medical University/Ninth Clinical Medical CollegePeking UniversityBeijing 100038China

Telomeres are DNA-protein structures that form protective caps at the end of eukaryotic chromosomes,safeguarding the chromosomes from degradation and maintaining the genomic *** DNA damage occurs,the cell will activate its repair system to fix the errors to prevent *** are three major molecular mechanisms of DNA repair:base excision repair(BER),nucleotide excision repair(NER),and mismatch repair(MMR).In this review article,we discuss the three canonical repair pathways at the telomeres and their functions in cancer prevention and therapy.

关键词： Telomeres Base excision repair Nucleotide excision repair Mismatch repair

Great News on Nutritional Oncology

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Journal of Nutritional Oncology 2016年第1期1卷 4-5页

作者： han ping shi

Cancer remains the leading cause of death worldwide. With the advances made in basic cancer research and clinical oncology,therearefivemajortherapiesformostcancersintheclinic,namelysurgery,cytotoxicchemotherapy,radiotherapy, precision therapy and immunotherapy. Although there is a trend of declining incidence and mortality for

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Early-onset and later-onset cancer:trends,risk factors,and prevention in Northern China

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Science China(Life Sciences) 2024年第9期67卷 1928-1940页

作者： Tong Liu Chen-An Liu Qing-Song Zhang Qi Zhang Yi-Ming Wang Meng-Meng Song shi-Qi Lin Li Deng Shou-Ling Wu han-ping shi Department of Gastrointestinal Surgery Department of Clinical NutritionBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China National Clinical Research Center for Geriatric Diseases Xuanwu HospitalCapital Medical UniversityBeijing 100053China Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038China Laboratory for Clinical Medicine Capital Medical UniversityBeijing 100038China Department of General Surgery Kailuan General HospitalTangshan 063000China Department of Genetics Yale School of MedicineNew Haven 06510USA Department of Hepatobiliary Surgery Kailuan General HospitalTangshan 063000China Cardiovascular Research Institute University of CaliforniaSan Francisco 94158USA Department of Cardiology Kailuan General HospitalTangshan 063000China

The characteristics of early-onset(onset age<50 years)and later-onset(onset age≥50 years)cancers differ *** novel risk factors for both types of cancer is crucial for increasing awareness of cancer prevention and for... 详细信息

The characteristics of early-onset(onset agehanges in incidence trends between these two specific types of cancer.

关键词： cancer early-onset later-onset trend risk factor prevention

Ketogenic Therapy for Cancer

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Journal of Nutritional Oncology 2017年第3期2卷 114-121页

作者： han ping shi Ming Yong Miao Department of Gastrointestinal Surgery Department of Clinical NutritionBeijing Shijitan HospitalDepartement of OncologyCapital Medical UniversityBeijing 100038China Department of Biochemistry and Molecular Biology College of Basic Medical SciencesThe Navy Medical UniversityShanghai 200433China

Ketogenic diet(KD)has been used as a successful dietary administration for refractory epilepsy for about a ***,the efficacy of KD has become a hot topic in the field of *** an important therapeutic strategy,this dietary modulation can selectively inhibit tumor ***,some researchers dispute the efficacy,safety,feasibility and acceptability of *** paper reviewed the effects of KD on different cancer types and proposed the guideline for KD on clinical caner patients.

关键词： Ketogenic diet Cancer Metabolic modulation therapy Warburg effect

Investigating Factors Influencing the Stability of Enteral Nutritional Emulsions Designed for Cancer Patients

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Journal of Nutritional Oncology 2021年第3期6卷 140-148页

作者： Qin Qin Li Dan ping Hou Zhuang Ding Sangeeta Prakash Yu Ying Liu han ping shi Jun han Zheng ping Wang Institute of BioPharmaceutical Liaocheng UniversityLiaocheng252000ShandongChina Liaocheng High-tech Biotechnology Co. Ltd.Liaocheng 252000ShandongChina School of Agriculture&Food Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Gastrointestinal Surgery/Department of Clinical Nutrition Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objective A commercially available reference product was“re-engineered”and the target emulsion was formulated to contain the same energy density,as well as the same percentage of energy sources,as the reference *** particle size and distribution,polydispersity index(PDI),and zeta-potential of emulsions were measured as indices to analyse the quality of the *** The centrifugal stability(Ke)was examined as the main measure of the stability of the target *** parameters affecting the stability of emulsions were also determined,while the temperature was fixed at 30℃,shear speed at 3500 r/min,and shear time was 15 *** optimal quantity of emulsifier was also studied in the crude *** A relatively stable emulsion could be obtained by using PC-50 at a dosage of 2%as the emulsifier.A 2∶1 proportion of whey protein to casein,a 1∶1 proportion of maltodextrin(DE 10-15)to maltodextrin(DE 15-20)and medium chain triglyceride(MCT)in powder form were used to obtain the most desirable *** This study explored the critical parameters that influence the stability of a total nutrition enteral emulsion designed for cancer patients,providing useful information for further industrialisation of this and other emulsion products.

关键词： Food for Special Medical Purposes Enteral nutritional emulsion Emulsion stability Functional food,Cancer nutrition

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热处理对Mg-8Gd-2.5Nd-0.5Zr合金组织和力学性能的影响

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中国有色金属学报 2017年第1期27卷 82-88页

作者：蔚晓嘉刘邱祖韩世平太原理工大学机械工程学院太原030024

通过OM、XRD、TEM、SEM和电子拉力试验机等,研究了固溶和时效处理对Mg-8Gd-2.5Nd-0.5Zr(质量分数,%)合金显微组织和力学性能的影响。结果表明:合金铸态组织由α-Mg基体和含Mg5Gd相、Mg12Nd相的粗大枝晶组成,经过热处理后,合金中方块状... 详细信息

通过OM、XRD、TEM、SEM和电子拉力试验机等,研究了固溶和时效处理对Mg-8Gd-2.5Nd-0.5Zr(质量分数,%)合金显微组织和力学性能的影响。结果表明:合金铸态组织由α-Mg基体和含Mg5Gd相、Mg12Nd相的粗大枝晶组成,经过热处理后,合金中方块状颗粒相明显增多,且分布在晶界处;固溶时效态合金析出的纳米尺寸方块相可有效强化合金。时效态合金中β'析出相形态类似多个纺锤形相连接而成,相互之间的夹角呈120°,且具有周期结构。铸态、固溶态和时效态合金在不同状态下的室温拉伸强度分别为:189.3、201.4和251.1MPa。

关键词： Mg-8Gd-2.5Nd-0.5Zr合金热处理显微组织力学性能

Comparison of the Prevalence and Characteristics Between EWGSOP1-and EWGSOP2-defined Sarcopenia in Patients with Colorectal Cancer

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Journal of Nutritional Oncology 2020年第1期5卷 14-21页

作者： Feng Min Zhang Zhen Yu han ping shi Cheng Le Zhuang Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200072China Department of Clinical Nutrition/Gastrointestinal Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Gastrointestinal Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China

Background Sarcopenia,as diagnosed by the former EWGSOP1 guidelines,was prevalent in cancer *** aim of this study was to examine the diagnostic capabilities of the previous and current guidelines,and to compare the clinicopathological features between patients diagnosed using the algorithms comprising the EWGSOP1 and EWGSOP2 *** We conducted a study including colorectal cancer patients from July 2014 to July *** skeletal muscle mass,muscle attenuation,handgrip strength,and 6-meter usual gait speed were prospectively measured to define sarcopenia once patients were *** Of a total of 840 patients,160(19.0%)patients were diagnosed with sarcopenia based on the EWGSOP1 and 241(28.7%)patients were diagnosed based on the *** numbers of patients diagnosed with sarcopenia and severe sarcopenia were much higher when the EWGSOP2 guidelines were used(160 vs.241 and 74 vs.140,respectively).The patients with EWGSOP2-defined sarcopenia showed a lower plasma albumin concentration(37.4 vs.36.4,P=0.039)but higher BMI(21.01 vs.22.22,Phan the patient diagnosed based on the EWGSOP1 *** The diagnosis of sarcopenia based on screening using the EWGSOP1 and EWGSOP2 guidelines differs considerably,at least in patients with colorectal *** addition,the patients with EWGSOP2-diagnosed sarcopenia also showed a trend toward a lower plasma albumin level and higher BMI.

关键词： Sarcopenia Colorectal cancer EWGSOP EWGSOP2 Prevalence

The Efficacy of a Formula Food for Preventing Postoperative Recurrence in a Tumor Dormancy Model

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Journal of Nutritional Oncology 2019年第4期4卷 180-186页

作者： Jie Zhang Zhe Wen Chen Ming Yong Miao han ping shi Department of Respiratory Diseases the Affiliated Huai’an Hospital of Xuzhou Medical UniversityHuai’an 223002China The Second Affiliated Hospital Wenzhou Medical UniversityWenzhou 325000China Department of Biochemistry and Molecular Biology Naval Military Medical UniversityShanghai 200433China Department of Gastrointestinal Surgery/Clinical Nutrition Beijing shijitan Hospital/Capital Medical University Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition/Department of Oncology Capital Medical University Beijing 100038China

Objective To establish a lung cancer dormancy mouse model and verify the effects of Wushen(WS),a formula food,on postoperative *** We established a Lewis cell tumor dormancy model system that definitively links surgery and the subsequent wound-healing response to the outgrowth of lung cancer *** used this model to observe the effects of WS on the postoperative recurrence and the nutritional status of the ***,the immunocyte subtypes and cytokine levels in the serum and spleens of mice were detected by flow cytometry and *** The recurrence rate in the WS group was obviously lower than that in the control *** increased the body weights and serum albumin levels of the *** levels of NK,Gr1+CD11b+CD3+CD8+and CD3+CD4+T cells in the spleens of mice in the WS group were also *** with the control group,the levels of CD4+IFN-γ+,CD4+IL-2 and CD4+/IL-10+in the spleens of mice in the WS group were *** also seemed to decrease the levels of IL-6 and TNF-α,but the decrease was not *** The postoperative lung cancer recurrence model was successfully *** inhibited postoperative recurrence,apparently by regulating the level of immune cell subtypes and cytokines in the serum and spleen.

关键词： Wushen Immune regulation Tumor dormancy Postoperative recurrence