The Efficacy of a Formula Food for Preventing Postoperative Recurrence in a Tumor Dormancy Model

作     者：Jie Zhang Zhe Wen Chen Ming Yong Miao Han Ping Shi 

作者机构：Department of Respiratory Diseasesthe Affiliated Huai’an Hospital of Xuzhou Medical UniversityHuai’an 223002China The Second Affiliated HospitalWenzhou Medical UniversityWenzhou 325000China Department of Biochemistry and Molecular BiologyNaval Military Medical UniversityShanghai 200433China Department of Gastrointestinal Surgery/Clinical Nutrition Beijing Shijitan Hospital/Capital Medical University Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition/Department of Oncology Capital Medical UniversityBeijing 100038China 

出 版 物：《Journal of Nutritional Oncology》 (肿瘤营养学杂志（英文）)

年 卷 期：2019年第4卷第4期

页      面：180-186页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Wushen Immune regulation Tumor dormancy Postoperative recurrence 

摘      要：Objective To establish a lung cancer dormancy mouse model and verify the effects of Wushen(WS),a formula food,on postoperative *** We established a Lewis cell tumor dormancy model system that definitively links surgery and the subsequent wound-healing response to the outgrowth of lung cancer *** used this model to observe the effects of WS on the postoperative recurrence and the nutritional status of the ***,the immunocyte subtypes and cytokine levels in the serum and spleens of mice were detected by flow cytometry and *** The recurrence rate in the WS group was obviously lower than that in the control *** increased the body weights and serum albumin levels of the *** levels of NK,Gr1+CD11b+CD3+CD8+and CD3+CD4+T cells in the spleens of mice in the WS group were also *** with the control group,the levels of CD4+IFN-γ+,CD4+IL-2 and CD4+/IL-10+in the spleens of mice in the WS group were *** also seemed to decrease the levels of IL-6 and TNF-α,but the decrease was not *** The postoperative lung cancer recurrence model was successfully *** inhibited postoperative recurrence,apparently by regulating the level of immune cell subtypes and cytokines in the serum and spleen.