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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei Zhu lingfeng Zeng Zhen Zhang Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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Melanin/polydopamine-based nanomaterials for biomedical applications

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Science China Chemistry 2019年第2期62卷 162-188页

作者： Chao Qi Lian-Hua Fu han Xu Tian-Fu Wang Jing lin peng Huang Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Carson International Cancer Center Laboratory of Evolutionary Theranostics School of Biomedical Engineering Health Science Center Shenzhen University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering Shenzhen University

The natural melanin is one kind of ubiquitous biological pigments, which is produced in melanosomes and widely distributed in living organisms. The synthetic melanin, often known as polydopamine(PDA), has similar chemical compositions and physical properties to natural melanin. In recent years, both natural melanin and PDA have aroused increased research interests in biomedical fields owing to their inherent biocompatibility, antioxidant activity, free-radical scavenging, metal ion chelation,strong near-infrared absorption and high photothermal conversion efficiency. Inspired by these fascinating properties, melanin and PDA have been widely used as building blocks for the construction of multifunctional nanoplatforms for various biomedical applications. This review focuses on the state-of-the-art progress in melanin/PDA-based nanomaterials, which covers from their preparation methods to biomedical applications including bioimaging, treatment, theranostics, antibacterial, UV/radiation protection, biosensor and tissue engineering. Moreover, the current trends and the future prospects of melanin/PDA-based nanomaterials are also discussed.

关键词： melanin polydopamine nanomaterials biomedical applications

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Effect of seepage on soil arching effect in deep shield tunnel

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Underground Space 2023年第5期12卷 218-233页

作者： Xu Song Fan-Yan Meng Ren-peng Chen han-lin Wang Huai-Na Wu Research Center for Advanced Underground Space Technologies of Hunan University Changsha 410082China Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan UniversityChangsha 410082China College of Civil Engineering Hunan UniversityChangsha 410082China

Shield tunneling and post-tunneling steady seepage are accompanied by stress and displacement variations,which could induce and influence the soil arching *** there are many studies on the tunneling-induced soil arching effect,the research about the effect of seepage on soil arching effect is extremely *** this study,a numerical model is firstly established and verified by field ***,a series of numerical models,whose simulation method of steady seepage is verified by adopting the conformal mapping technique,are established to study the soil arching evolution of deep-buried tunneling and post-construction steady *** results indicate that seepage leads to an increase in effective vertical stress,which is consistent with the existing *** seepage weakens the soil arching effect resulting in the height of the arch zone reducing from 2.38D(D is the tunnel diameter)to *** seepage leads to the further development of ground consolidation settlement,but the differential displacement in the soil mass *** ground reaction curve in the steady seepage condition shows a bigger value than that after *** is reasonable to control the ground loss ratio in the range of 0.5–1.0%,which can minimize overburden pressure with moderate ground deformation.

关键词： Soil arching effect Steady seepage Numerical simulation Deep shield tunnel Stress change

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Blockchain-Based GNSS Spoofing Detection for Multiple UAV Systems

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Journal of Communications and Information Networks 2019年第2期4卷 81-88页

作者： Rui han lin Bai Jianwei Liu peng Chen School of Cyber Science and Technology Beihang UniversityBeijing 100191China Blockchain Research Center School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 101408China Laboratory Shenzhen 518000China

With the rapid growth of unmanned aerial vehicle(UAV),there is now an increasing interest in the security of UAV *** exist various attacks which have threatened the security of UAV systems,in terms of the global navigation satellite system(GNSS)*** of multiple UAVs,the flying ad hoc networks(FANET)have been studied to extend the employment and coverage of UAV *** on the connectivity and information interaction of FANET,in this article,the blockchain technology is applied to detect GNSS signal attacks for UAV *** particular,we first introduce an overview of the GNSS security of UAV systems and the principles for blockchain *** on the principles,a logical architecture is proposed,where blockchain is taken into consideration for GNSS spoofing *** analysis verifies that the proposed GNSS spoofing detection system can be used ***,several challenges in blockchain are discussed,including security,cost,and regulation.

关键词： unmanned aerial vehicle blockchain GNSS spoofing

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Alternative splicing of a carboxyl/choline esterase gene enhances the fenpropathrin tolerance of Tetranychus cinnabarinus

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Insect Science 2023年第5期30卷 1255-1266页

作者： peng Wei Xinying Zeng Haonan han Yiqing Yang Youjun Zhang lin He Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqingChina Academy of Agricultural Sciences Southwest UniversityChongqingChina National Citrus Engineering Research Center Southwest UniversityChongqingChina Department of Plant Protection Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijingChina

Detoxification plays a crucial role in agricultural pests to withstand pesticides,and cytochrome P450s,carboxyl/choline esterases(CCEs),and glutathione-S-transferases are the main proteins responsible for their detoxification *** activity of CCEs can be upregulated,downregulated,or modified by ***,few studies have examined the role of alternative splicing in altering the properties of *** identified 2 variants of TcCCE23 in Tetranychus cinnabarinus:a long version(CCE23-V1)and a short version that is 18 nucleotides shorter than CCE23-V1(CCE23-V2).Whether splicing affects the activity of TcCCE23 remains *** of CCE23-V2 in fenpropathrin-resistant *** revealed that splicing affected the detoxification of fenpropathrin by *** mortality of mites was significantly higher when the expression of CCE23-V2 was knocked down(43.2%±3.3%)via injection of CCE23-dsRNA(double-stranded RNA)compared with the control group injected with green fluorescent protein-dsRNA under fenpropathrin exposure;however,the downregulation of CCE23-V1(61.3%±6.3%)by CCE23-small interfering RNA had no such effect,indicating CCE23-V2 plays a greater role in xenobiotic metabolism than *** tolerance of flies overexpressing CCE23-V2 to fenpropathrin(50%lethal dose[LD_(50)]=19.47μg/g)was significantly higher than that of Gal4/UAS-CCE23-V1 transgenic flies(LD_(50)=13.11μg/g).Molecular docking analysis showed that splicing opened a“gate”that enlarges the substrate binding cavity of CCE23-V2,might enhance the ability of CCE23-V2 to harbor fenpropathrin *** findings suggest that splicing might enhance the detoxifying capability of ***,our data improve the understanding of the diversity and complexity of the mechanisms underlying the regulation of CCEs.

关键词： alternative splicing carboxyl/choline esterase(CCE) detoxification function pyrethroid pests

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Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min Yi Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

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Evolution of research on climate risk insurance:A bibliometric analysis from 1975 to 2022

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Advances in Climate Change Research 2023年第4期14卷 592-604页

作者： Yang-han lin Li-Jun WANG Xin-Yang SHI Min-peng CHEN School of Agricultural Economics and Rural Development Renmin University of ChinaBeijing 100872China School of Environment and Natural Resources Renmin University of ChinaBeijing 100872China School of International Studies Renmin University of ChinaBeijing 100872China

Insurance against climate risk is essential for mitigating the adverse effects of climate ***,theoretical consensus regarding climate risk insurance remains elusive,and the implementation of climate insurance policies varies markedly between countries owing to various *** study conducted bibliometric analysis of 1082 relevant publications(1975–2022)to determine the theoretical basis,evolution of research hotspots,and methodologies associated with climate risk *** insurance publications are growing at an average annual rate of 8.9%,with more than 2333 authors from 1103 organizations in 78 countries publishing on the *** the basis of milestones of global climate change assessment,i.e.,the publication of the Fourth and Fifth Assessment Reports of the Intergovernmental Panel on Climate Change,climate insurance research can be divided into three major *** the start-up phase(1975–2007),research schemes examined the feasibilities and potentials of the National Flood Insurance Program in the United States,and the socioeconomic implications of transferring climate risk through *** methodologies used in these studies were relatively simple owing to lack of comprehensive *** on flood insurance increased rapidly during the development phase(2008–2014),with increasing emphasis on the possibility of developing a flood insurance market in the *** utilized catastrophe modeling and probabilistic approaches to estimate natural disaster losses and financial *** boom phase(2015–2022)involved more research on the affordability of climate risk insurance given income *** topic of climate insurance and the scope of its impact have developed global and interdisciplinary characteristics in terms of journal,sector,and disciplinary *** the future,a trend might develop whereby big data will be combined with artificial intelligence and machine learning to design and implement index insu

关键词： Climate risk insurance Climate change Bibliometric analysis Adaptation Network analysis

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A new car-following model with driver's anticipation effect of traffic interruption probability

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Chinese Physics B 2020年第8期29卷 349-354页

作者： Guang-han peng College of Physical Science and Technology Guangxi Normal UniversityGuilin 541004China

Traffic interruption phenomena frequently occur with the number of vehicles *** investigate the effect of the traffic interruption probability on traffic flow,a new optimal velocity model is constructed by considering the driver anticipation term in the interruption case for car-following ***,the effect of driver anticipation in the interruption case is investigated via linear stability ***,the MKdV equation is obtained concerning the effect of driver anticipation in the interruption ***,numerical simulation states that the driver anticipation term in the interruption case contributes to the stability of traffic flow.

关键词： traffic flow interruption probability optimal velocity model numerical simulation

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Big data-driven automatic generation of ship route planning in complex maritime environments

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Acta Oceanologica Sinica 2020年第8期39卷 113-120页

作者： peng han Xiaoxia Yang Administrative Center for China’s Agenda 21 Beijing 100038China College of Earth Science Chengdu University of TechnologyChengdu 610059China

With the rapid development of the global economy, maritime transportation has become much more convenient due to large capacities and low freight. However, this means the sea lanes are becoming more and more crowded,leading to high probabilities of marine accidents in complex maritime environments. According to relevant historical statistics, a large number of accidents have happened in water areas that lack high precision navigation data, which can be utilized to enhance navigation safety. The purpose of this work was to carry out ship route planning automatically, by mining historical big automatic identification system(AIS) data. It is well-known that experiential navigation information hidden in maritime big data could be automatically extracted using advanced data mining techniques;assisting in the generation of safe and reliable ship planning routes for complex maritime environments. In this paper, a novel method is proposed to construct a big data-driven framework for generating ship planning routes automatically, under varying navigation conditions. The method performs density-based spatial clustering of applications with noise first on a large number of ship trajectories to form different trajectory vector clusters. Then, it iteratively calculates its centerline in the trajectory vector cluster, and constructs the waterway network from the node-arc topology relationship among these centerlines. The generation of shipping route could be based on the waterway network and conducted by rasterizing the marine environment risks for the sea area not covered by the waterway network. Numerous experiments have been conducted on different AIS data sets in different water areas, and the experimental results have demonstrated the effectiveness of the framework of the ship route planning proposed in this paper.

关键词： ship route planning AIS big data trajectory data mining electronic chart

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