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Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress

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World Journal of Diabetes 2025年第1期16卷 91-103页

作者： Zhi-Min Lin han-Yuan Gao Shu-han shi Yue-Ting Li Department of Nephrology The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Mizagliflozin(MIZ)is a specific inhibitor of sodium-glucose cotransport protein 1(SGLT1)originally developed as a medication for *** To explore the impact of MIZ on diabetic nephropathy(DN).METHODS Diabetic mice were created using db/db *** were administered either a low dose(0.5 mg/kg)or a high dose(1.0 mg/kg)of the SGLT1 inhibitor MIZ via stomach gavage for 8 ***,mesangial cells(MCs)were isolated and subjected to high glucose conditions in culture to assess the effects of MIZ on *** The results showed that low doses of MIZ significantly reduced albuminuria to a level comparable to that achieved with high doses in db/db *** doses of MIZ led to a substantial increase in body weight in mice,along with decreased blood glucose levels and food ***,the intervention with high-dose MIZ notably decreased the expression of extracellular matrix genes,such as collagen type 1 alpha 1 mRNA *** the expression of SGLT1 increased after exposure to high glucose,it decreased following treatment with ***,MIZ intervention was more effective in improving lactate dehydrogenase levels in MCs induced by high glucose compared to *** also significantly elevated levels of antioxidant enzymes superoxide dismutase,catalase,and glutathione,while reducing malondialdehyde *** These findings indicate that MIZ can ameliorate DN by inhibiting SGLT1,inflammation,and oxidative stress.

关键词： Mizagliflozin Sodium-glucose cotransport protein 1 Diabetic nephropathy Mesangial cells

AlN precipitation during steel solidification using CA model

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Journal of Iron and Steel Research International 2022年第11期29卷 1789-1799页

作者： Lei Cui Yi-han shi Xiang-ning Meng Key Laboratory for Ecological Metallurgy of Multi-Metallic Ores Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

Based on the principles of metal solidification and cellular automaton(CA),as well as AlN precipitation thermodynamics and kinetics,a CA model of interdendritic AlN precipitation was established by coupling a large-size mesh describing the dendrite growth of Fe-C-Al-N alloys and a small-size mesh representing AlN precipitation based on transient chemical *** results of single dendrite growth stimulated by this model were compared with the Lipton-Glicksman-Kurz solution to verify the correctness of the matrix dendrite growth *** AlN morphology and dimensions obtained from the CA model simulations are following the experimental *** presence of equiaxed dendrite in the computational domain results in a significant coarsening of the columnar dendrite and a uniform solute distribution around them,and the AlN solid phase fraction *** of AlN precipitation at different wetting angles were also performed,and it was found that the solid phase fraction of AlN decreased with the increase in wetting ***,it is confirmed that the established model is an effective method to simulate interdendritic AlN precipitation.

关键词： Metal solidification Cellular automaton Wetting angle AlN precipitation Dendrite growth

Metal Oxide/Nitrogen-Doped Carbon Catalysts Enables Highly Effi cient CO_(2) Electroreduction

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Transactions of Tianjin University 2021年第3期27卷 269-277页

作者： han shi Yingying Cheng Peng Kang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300354China

The metal oxide/nitrogen-doped carbon(NC)compounds zirconium oxide/NC(ZrO_(2)/NC)and cerium oxide/NC(CeO_(2)/NC)were synthesized via the pyrolysis of polyaniline on the metal oxide *** characterization of the ZrO_(2)/NC and CeO_(2)/NC catalysts showed more active CO_(2) reduction reaction activity than that of NC catalyst without metal *** chromatography analysis revealed that CO and H_(2)were the primary products,and no liquid-phase products were detected via proton nuclear magnetic resonance spectroscopy or high-performance liquid *** maximum Faraday effi ciency of ZrO_(2)/NC reached 90%at−0.73 V(***),with the current density of CO at 5.5 mA/cm^(2);this Faraday effi ciency value was higher than that of NC(41%),with the current density of CO at 3.1 mA/cm^(2).The interaction between the metal oxide and carbon allowed the effi cient formation of defect sites,especially imine-type nitrogen,strengthening the adsorption of the key reaction intermediate CO_(2)^(•−) and thus promoting the CO_(2) reduction reaction.

关键词： Metal oxide Nitrogen-doped carbon Interface eff ect CO_(2)reduction reaction

UNSTEADY FLOW OF POLYMER FLUID BETWEEN COAXIAL CYLINDERS

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Journal of Hydrodynamics 1993年第2期5卷 52-62页

作者： han, shi-fang Roesner, K.G. Academia Sinica Chengdu China

In the present paper an unsteady flow of polymer fluid, i.e. non-Newtonian fluid is studied. The constitutive equation of upper-convected Maxwell fluid is used. The variational approach due to Kantorovich is used for the unsteady problem of the fluid. A special computer program `MACSYMA' is used to get the different approximation of the method of Kantorovich. The present method developed is called Computational Analytical Method which is available for the scientific research.

关键词： Computational methods Computer aided analysis Computer software Cylinders (shapes) Fluid structure interaction Mathematical models Non Newtonian liquids Polymers

Parametric Research of Experiments on a Carangiform Robotic Fish

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Journal of Bionic Engineering 2008年第2期5卷 95-101页

作者： Qin Yan Zhen han shi-wu Zhang Jie Yang Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei 230026 P R. China

In this paper, a carangiform robotic fish with 4-DoF （degree of freedom） tail has been developed. The robotic fish has capability of swimming under two modes that are radio control and autonomous swimming. Experiments were conducted to investigate the influences of characteristic parameters including the frequency, the amplitude, the wave length, the phase difference and the coefficient on forward velocity. The experimental results shown that the swimming performance of the robotic fish is affected mostly by the characteristic parameters observed.

关键词： biomimetic robotic fish experimental parameter matrix undulation equation body length velocity

Prediction of the Conductance of Strong Electrolytes and the Calculation of the Ionization Constant of Weak Electrolytes in a Dilute Solution by a New Equation

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Chemical Research in Chinese Universities 2000年第3期16卷 230-235页

作者： NI Liang JIANG Wen-hua han shi-jun Department of Chemistry Zhejiang UniversityHangzhou 310027P.R.China

In order to predict the conductance for dilute 1 1 valent electrolyte solutions, a new conductance equation was proposed based on the Onsager and Onsagar Fuoss Chen conductance equation. It has only one parameter A , which can be obtained directly from the data of ionic limiting molar conductivity Λ ∞ m, and its expression is very simple. The new equation has been verified by the experimental molar conductivities of some single strong electrolyte and mixed electrolyte solutions at 298.15 K reported in literatures. The results are in good agreement with the experimental data. Meanwhile the ionization constants of some weak electrolyte solutions were calculated by a modified equation of this new equation, and it was also found that the calculation results are in good agreement with the data in the literature.

关键词： Electrolyte Prediction Conductance equation Constant of ionization

Semantic composition of distributed representations for query subtopic mining

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Frontiers of Information Technology & Electronic Engineering 2018年第11期19卷 1409-1419页

作者： Wei SONG Ying LIU Li-zhen LIU han-shi WANG Information and Engineering College Capital Normal University

Inferring query intent is significant in information retrieval tasks. Query subtopic mining aims to find possible subtopics for a given query to represent potential intents. Subtopic mining is challenging due to the nature of short queries. Learning distributed representations or sequences of words has been developed recently and quickly, making great impacts on many fields. It is still not clear whether distributed representations are effective in alleviating the challenges of query subtopic mining. In this paper, we exploit and compare the main semantic composition of distributed representations for query subtopic mining. Specifically, we focus on two types of distributed representations: paragraph vector which represents word sequences with an arbitrary length directly, and word vector composition. We thoroughly investigate the impacts of semantic composition strategies and the types of data for learning distributed representations. Experiments were conducted on a public dataset offered by the National Institute of Informatics Testbeds and Community for Information Access Research. The empirical results show that distributed semantic representations can achieve outstanding performance for query subtopic mining, compared with traditional semantic representations. More insights are reported as well.

关键词： Subtopic mining Query intent Distributed representation Semantic composition

A CA-LBM model for simulating dendrite growth with forced convection

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Journal of Iron and Steel Research International 2021年第8期28卷 997-1008页

作者： Xiang-ning Meng Lei Cui Yi-han shi Miao-yong Zhu Key Laboratory for Ecological Metallurgy of Multi-Metallic Ores Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

A two-dimensional coupled model of the cellular automaton(CA)and the lattice Boltzmann method(LBM)was developed to simulate the solute dendrite growth of Fe-C-Mn-S alloy in the presence of forced *** model describes the transport phenomenon by the evolution of moving pseudo-particles distribution functions and utilizes the LBM to solve fluid flow and solute transport under forced convection *** on the solute field calculated by the CA technique,the dynamics of dendrite growth were determined by the previously proposed local solute balance *** accuracy of the forced convection dendrite growth model was verified by comparing the CA-LBM model with Lipton-Glicksman-Kurz analytical *** is revealed that the dendrite symmetry structure is destroyed compared to free diffusion,and the upstream arm is more developed than the downstream arm of the *** enriched solute segregates more at the downstream side than at the upstream side of the *** length of the upstream dendrite arm increases firstly and then becomes stable with the increase in the flow velocity,the dendrite necking is restrained,and the vertical dendrite arm becomes longer.

关键词： Two-dimensional coupled model Cellular automaton Lattice Boltzmann method Dendrite growth Forced convection

Simulation and control strategy for the variational influent of WWTP

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Journal of Environmental Sciences 2006年第1期18卷 62-68页

作者： LIU Yan-chen FAN Long shi han-chang WANG Zhi-qiang State Key Joint Laboratory of Environment Simulation and Pollution Control Department of Environmental Science and Engineering TsinghuaUniversity Beijing 100084 China

With the development of activated sludge model, the simulation software for the design and operation of wastewater treatment plant （WWTP） was produced and has been widely used. The dynamic change of the quality and flow of influent are major factors causing the unstable operation of wastewater treatment process. As a basic model, ASMI model was used for the simulation of activated sludge process, and double exponential model was selected for the simulation of secondary sedimentation tank. The influences of influent change to the aeration tank and secondary sedimentation tank were investigated, and the relationship among influent change, the quality of effluent and the level of sludge blanket in secondary sedimentation tank was established. On the basis of the simulation results, the operation of the WWTP could be adjusted under the dynamic change of the influent. Furthermore, the controlling strategy combined the feed-forward on the influent flow and the feedback on the level of sludge blanket in the secondary sedimentation tank was studied.

关键词： modeling dynamic simulation static simulation controlling strategy influent