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Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cells

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Cellular & Molecular Immunology 2016年第1期13卷 119-131页

作者： Rhonda L Taylor Mark N Cruickshank Mahdad Karimi han leng ng Elizabeth Quail Kenneth M Kaufman John B Harley Lawrence J Abraham Betty P Tsao Susan A Boackle Daniela Ulgiati School of Pathology and Laboratory Medicine Centre for Genetic Origins of Health and Disease The University of Western Australia Crawley WA Australia Biochemistry and Molecular Biology School of Chemistry and Biochemistry The University of Western Australia Crawley WA Australia Telethon Kids Institute The University of Western Australia Crawley WA Australia Cincinnati Children's Hospital Medical Center Cincinnati OH USA US Department of Veterans Affairs Medical Center Cincinnati OH USA Division of Rheumatology Department of Medicine University of California at Los Angeles Los Angeles CA USA Division of Rheumatology University of Colorado School of Medicine Aurora CO USA

Complement receptor 2 （CR2/CD21） is predominantly expressed on the surface of mature B cells where it forms part of a coreceptor complex that functions, in part, to modulate B-cell receptor signal strength. CR2/CD21 expression is tightly regulated throughout B-cell development such that CR2/CD21 cannot be detected on pre-B or terminally differentiated plasma cells. CR2/CD21 expression is upregulated at B-cell maturation and can be induced by IL-4 and CD40 signaling pathways. We have previously characterized elements in the proximal promoter and first intron of CR2/CD21 that are involved in regulating basal and tissue-specific expression. We now extend these analyses to the CR2/CD21 core promoter. We show that in mature B cells, CR2/~D21 transcription proceeds from a focused TSS regulated by a non-consensus TATA box, an initiator element and a downstream promoter element. Furthermore, occupancy of the general transcriptional machinery in pre-B versus mature B-cell lines correlate with CR2/CD21 expression level and indicate that promoter accessibility must switch from inactive to active during the transitional B-cell window.

关键词： B cells core promoter CR2/CD21 molecular biology transcription factor

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De Broglie–Bohm Interpretation of Canonical Quantum Cosmology Implies Early Stages of the Universe Dominated by Radiation

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Communications in Theoretical Physics 2013年第12期60卷 691-694页

作者： Ch’ng han Siong Shahidan Radiman School of Applied Physics Faculty of Science and Technology Universiti Kebangsaan Malaysia

The Einstein＇s genera/relativity is formulated in the Hamiltonian form for a spatia/ly Bat, isotropic and homogeneous universe. Subsequently, we perform the canonical quantization procedure to the Hamiltonian to obtain the Wheeler-DeWitt equation. Solving the Wheeler-DeWitt equation and employing the de Broglie-Bohm interpretation to the wave function of the universe, we obtain a new version of spatia/ly fiat Friedmann equation for the early universe where the scale factor of the universe is taken to be sufilcientlv small.

关键词： de Broglie-Bohm interpretation canonical quantum cosmology Friedmann equation Wheeler-DeWitt equation

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Markov branching processes with killing and resurrection

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Science China Mathematics 2016年第3期59卷 573-588页

作者： CHEN An Yue LU Ying ng Kai Wang ZhanG han Jun Department of Financial Mathematics and Financial Engineering South University of Science and Technology of China Department of Mathematical Sciences University of Liverpool Department of Statistics and Actuarial Science University of Hong Kong School of Mathematics and Computational Science Xiangtan University

In this paper, we consider Markov branching processes with killing and resurrection. We first show that the Markov branching process with killing and stable resurrection is just the Feller minimum process which is honest and thus unique. We then further show that this honest Feller minimum process is not only positive recurrent but also strongly ergodic. The generating function of the important stationary distribution is explicitly expressed. For the interest of comparison and completeness, the results of the Markov branching processes with killing and instantaneous resurrection are also briefly stated. A new result regarding strong ergodicity of this difficult case is presented. The birth and death process with killing and resurrection together with another example is also analyzed.

关键词： Markov branching processes killing stable and instantaneous resurrections uniqueness existence limiting and stationary distributions ergodicity strong ergodicity

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Developmental impacts and toxicological hallmarks of silver nanoparticles across diverse biological models

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Environmental Science and Ecotechnology 2024年第3期19卷 60-79页

作者： Yán Wāng Yapeng han De-Xiang Xu Department of Toxicology School of Public Health&Key Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei230032China

Silver nanoparticles(AgNPs),revered for their antimicrobial prowess,have become ubiquitous in a range of products,from biomedical equipment to food ***,amidst their rising popularity,concerns loom over their possible detrimental effects on fetal development and subsequent adult *** review delves into the developmental toxicity of AgNPs across diverse models,from aquatic species like zebrafish and catfish to mammalian rodents and in vitro embryonic stem *** focus encompasses the fate of AgNPs in different contexts,elucidating associated hazardous results such as embryotoxicity and adverse pregnancy ***,we scrutinize the enduring adverse impacts on offspring,spanning impaired neurobehavior function,reproductive disorders,cardiopulmonary lesions,and *** hallmarks of developmental harm are identified,encompassing redox imbalances,inflammatory cascades,DNA damage,and mitochondrial ***,we explore potential explanations,linking immunoregulatory dysfunction and disrupted epigenetic modifications to AgNPsinduced developmental *** substantial progress,our understanding of the developmental risks posed by AgNPs remains incomplete,underscoring the urgency of further research in this critical area.

关键词： Silver nanoparticles(AgNPs) Developmental toxicity Maternal exposure Fetal development Redox imbalance Mitochondrial dysfunction

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Chylous ascites in colorectal surgery:A systematic review

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World Journal of Gastrointestinal Surgery 2021年第6期13卷 585-596页

作者： Zi Qin ng Margaret han han Nien Beh Simon Keelan Department of General Surgery St John of God Midland HospitalMidland 6056Western AustraliaAustralia Department of General Surgery Joondalup Health CampusJoondalup 6027Western AustraliaAustralia

BACKGROUND Chylous ascites is a rare complication in colorectal surgery with limited *** To systematically review all available evidence to describe the incidence,clinical presentation,risk factors and management *** The systematic review was performed through PubMed,MEDLINE,EMBASE and Cochrane and cross-checked up to November *** data collated included:Demographics,indications(benign vs malignant),site of disease,surgical approach,extent of lymphadenectomy,day to and method of diagnosis of chylous ascites and management *** A total of 28 studies were included in the final analysis(426 cases).Patient age ranged from 31 to 89 *** except one case were performed for *** the 426 cases,195 were right-colonic,121 left-colonic,103 pelvic surgeries and 7 *** majority were diagnosed during the same inpatient stay by recognition of typical drain appearance and increased *** cases were diagnosed during outpatient visits with increased abdominal distention and subsequently underwent *** cases were managed successfully non-operatively(fasting with prolonged drainage,total parenteral nutrition,somatostatin analogues or a combination of these).Only three cases required surgical intervention after failing conservative management and subsequently resolved *** factors identified include:Right-colonic surgery/tumour location,extent of lymphadenectomy and number of lymph nodes *** Chylous ascites after colorectal surgery is a relatively rare *** the majority of cases resolved without surgical intervention,preventative measures should be undertaken such as meticulous dissection and clipping of lymphatics during lymphadenectomy to prevent morbidity.

关键词： Chylous Chyle Ascites Leak Colon Rectum Lymphadenectomy

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Reproductive medicine gets a new tool

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Journal of Molecular Cell Biology 2011年第6期3卷 320-321页

作者： Wei-Xia Ang Cheng-Xu Delon Toh Huck-Hui ng Yuin-han Loh Epigenetics and Cell Fates Laboratory A*STAR Institute of Medical BiologySingapore 138648Singapore NUS Graduate School for Integrative Sciences and Engineering Singapore 117597Singapore Department of Biological Sciences National University of SingaporeSingapore 117543Singapore Gene Regulation Laboratory Genome Institute of SingaporeSingapore 138672Singapore Department of Biochemistry National University of SingaporeSingapore 117597Singapore School of Biological Sciences Nanyang Technological UniversitySingapore 639798Singapore

Infertility is a problem faced by millions *** a recent paper published in Cell,Hayashi et al.(2011)provided a potential solution for male infertility through the generation of functional spermatozoa that can give ris... 详细信息

关键词： infertility offspring

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The Transport Properties of Concrete under the Simultaneous Coupling of Fatigue Load and Environment Factors

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Journal of Wuhan University of Technology(Materials Science) 2012年第1期27卷 181-186页

作者： WAng Caihui SUN Wei JIng Jinyang han Jiande R0ng Hui School of Materials Science and Engineering Southeast University Jiangsu Key Laboratory of Construction Materials

A set of coupling experimental instrument was designed to study the transport properties of chloride ion in concrete under simultaneous coupling action of fatigue load and environmental factors. Firstly the water-saturated performance of modem concrete was investigated, then diffusion performance of chloride ion under different stress levels and different temperature were studied respectively; meanwhile, the time- dependent behavior of the chloride ion diffusion in concrete was also researched. The results showed that the saturation degree of concrete can reach as high as 99%. Besides, diffusion coefficient of chloride ion increased with increasing of the stress level and temperature, and when the stress level and temperature are at 0.6 and 60 ℃ respectively, the diffusion coefficient is 6.3 ×10 -14 m2/s, moreover the diffusion coefficient of chloride ion in concrete decreased with time under the simultaneous coupling action of fatigue load and environment factors.

关键词： chloride diffusion fatigue load concrete stress level temperature time dependent

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Dual Phase Renewable Fuel Combustion in an Atmospheric Gas Turbine Burner

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Journal of Thermal Science 2023年第3期32卷 1278-1291页

作者： AGWU Ogbonnaya RUNYON Jon GOKTEPE Burak CHOng TUng Cheng ng Jo-han GILES Anthony VALERA-MEDINA Agustin School of Engineering Cardiff UniversityWales CF243AAUK China-UK Low Carbon College Shanghai Jiao Tong UniversityLin'gang 201306China Faculty of Engineering and Physical Sciences University of Southampton MalaysiaIskandar Puteri 79100Malaysia

Expanding the fuel flexibility of continuous combustion systems to include multiphase fuel combustion offers additional support to combat the problem of energy security and,potentially,environmental *** this study,apart from establishing stability limits and measuring post-combustion emissions,flames generated from simultaneous combustion of biodiesel and syngas were examined using C_(2)*and CH*chemiluminescence imaging to capture changes in the reaction *** proportion of syngas in the fuel mix was varied from 0 to 30%content(by energy contribution)while maintaining a total power output of 15 *** overall equivalence ratio was held at 0.7 in cases other than for determining the flammability *** results indicate a reduction of stability limits as gas proportion in fuel blend ***,chemiluminescence imaging of the two targeted species suggest a general reduction in reaction rate as well as reaction zone area and length with increase in gas ratio in the dual phase ***,emissions performance in the context of NOxand CO was investigated as liquid-to-gas ratios were ***,the study demonstrates the feasibility,limitations and potential benefits of multiphase renewable fuel combustion in a swirl-stabilised burner.

关键词： dual fuel gas turbine multiphase combustion

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Agglutination of Helicobacter pylori coccoids by lectins

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World Journal of Gastroenterology 2000年第2期6卷 202-209页

作者： Mar Mar Khin Jie Song Hua han Cong ng Torkel Wadstrm Bow Ho Departments of Microbiology Faculty of MedicineNational University of Singapore5Science Drive 2Singapore 117597Republic of Singapore Department of Medical Microbiology Lund UniversitySolvegatan 23S 223 62 LundSweden

AIM To study the agglutination pattern ofHelicobacter pylori coccoid and spiral *** Assays of agglutination andagglutination inhibition were applied usingfifteen commercial *** Strong agglutination was observedwith mannose-specific Concanavalin A(Con A),fucose-specific Tetragonolobus purpureas(Lotus A)and N-acetyl glucosamine-specificTriticum vulgaris(WGA)*** andfucose specific lectins were reactive with allstrains of *** coccoids as compared to *** carbohydrates,glycoproteinsand mucin were shown to inhibit ***-agglutination ***-treatment ofthe bacterial cells with formalin and sulphuricacid did not alter the agglutination patterns ***,sodium periodate treatment ofbacterial cells were shown to inhibitagglutination reaction with Con A,Lotus A andWGA *** the contrary,enzymatictreatment of coccoids and spirals did not showmarked inhibition of ***,heating of *** cells at 60℃ for 1 hour was shown toaugment the agglutination with all of the *** The considerable differences inlectin agglutination patterns seen among the twodifferentiated forms of *** might beattributable to the structural changes during theevents of morphological transformation,resulting in exposing or masking some of the sugar residues on the cell *** ofvarious sugar residues on the cell wall of thecoccoids may allow them to bind to differentcarbohydrate receptors on gastric mucus andepithelial *** coccoids with adherencecharacteristics like the spirals could aid in thepathogenic process of Helicobacter *** may probably lead to different clinicaloutcome of *** associated gastroduodenaldisease.

关键词： Helicobacter pylori coccoids lectin gastric mucosa

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A monolithic InP/SOI platform for integrated photonics

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Light(Science & Applications) 2021年第11期10卷 2143-2152页

作者： Zhao Yan Yu han Liying Lin Ying Xue Chao Ma Wai Kit ng Kam Sing Wong Kei May Lau Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Physics and William Mong Institute of Nano Science and Technology Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

The deployment of photonic integrated circuits(PICs)necessitates an integration platform that is scalable,high-throughput,cost-effective,and *** we present a monolithic InP on SOI platform to synergize the advantages of two mainstream photonic integration platforms:Si photonics and InP *** monolithic InP/SOI platform is realized through the selective growth of both InP sub-micron wires and large dimension InP membranes on industry-standard(001)-oriented silicon-on-insulator(SOI)*** epitaxial InP is in-plane,dislocation-free,site-controlled,intimately positioned with the Si device layer,and placed right on top of the buried oxide layer to form“InP-on-insulator”.These attributes allow for the realization of various photonic functionalities using the epitaxial InP,with efficient light interfacing between the III-V devices and the Si-based *** exemplify the potential of this InP/SOI platform for integrated photonics through the demonstration of lasers with different cavity designs including subwavelength wires,square cavities,and *** results here mark a critical step forward towards fully-integrated Si-based PICs.

关键词： SOI monolithic integration

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