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Seroepidemiology of echovirus 30 in Korean children

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World Journal of Pediatrics 2017年第6期13卷 611-614页

作者： Joo Young Lee Yumi Seo Ui Yoon Choi Jong-Hyun Kim Jin han kang Department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type *** current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus ***:Two hundred and fifty residual serum samples were collected at ***'s *** were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were ***:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) *** rates were 23%,48%,55% and 73% in groups 1-4,*** antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and *** the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,***:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age *** findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years *** 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.

关键词： echovirus 30 Korea seroepidemiology

10 kV电容器组运行异常的原因分析与处理

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电工技术 2024年第10期 145-146,150页

作者：韩康占敏杨刚卢正中邱奕铭张攀国网湖北省电力有限公司孝感供电公司湖北孝感432000

不平衡电压保护是电容器组的主要保护,首先介绍了电容器组故障的基本情况,分析了电容器组不平衡电压保护动作的原因,剖析了2起电容器组开关合闸后故障跳闸的案例,通过试验检查和数据分析找到了故障产生的原因,验证了保护动作原因分析的... 详细信息

不平衡电压保护是电容器组的主要保护,首先介绍了电容器组故障的基本情况,分析了电容器组不平衡电压保护动作的原因,剖析了2起电容器组开关合闸后故障跳闸的案例,通过试验检查和数据分析找到了故障产生的原因,验证了保护动作原因分析的有效性,最后提出了相关防范措施和处理建议。

关键词：电容器组开关跳闸不平衡电压保护原因分析

China's Overseas M&A In Global Economic Crisis

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China's Foreign Trade 2009年第15期 24-25页

作者： han kang from China University of Mining and Technology

Overseas Merger and Acquisition(M&A)is not only the major means for the enterprises to expand rapidly and operate globally,but also the significant strategic tools for acquiring advanced technology from other companie... 详细信息

关键词：海外并购中国收购兼并

Legal response to environmental health risks in a risky society

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Ecological Economy 2021年第3期17卷 218-231页

作者： han kang-ning School of Humanities and Law Northeast Forestry UniversityHarbin 150040CHINA

The protection of public health is one of the legislative purposes of China’s environmental legal *** 39 of the Environmental Protection Law of the People’s Republic of China establishes an environmental and health risk assessment *** health risk assessment system has biases in understanding,and it fails to face up to the functional transformation from the ex-post relief of environmental damage to the pre-prevention prevention of health risks in the environmental legal system;lack of a complete environmental and health legal system,unclear environmental and health risk assessment framework,and unclear environmental and health risk assessment *** risk management capabilities need to be improved,there is a lack of specialized environmental and health risk assessment institutions,and there is a lack of supporting risk assessment technical standard system *** is necessary to combine practical experience with China’s national conditions and actual needs,construct an environmental health risk assessment system with Chinese characteristics from both the entity and the procedure,strengthen legislative support,and improve my country’s environmental and health laws on the basis of objective and scientific protection of the assessment *** system,establish a national environmental health risk assessment expert committee as soon as possible,improve my country’s environmental and health risk assessment framework,strengthen environmental and health management capacity building,improve the environmental and health risk assessment technical system,and promote the development of China’s environmental and health risk assessment system develop and give play to the institutional mission of safeguarding public health.

关键词： environment and health public health risk risk assessment precautionary principle

Co-CRISPR: A valuable toolkit for mutation enrichment in the gene editing of Spodoptera frugiperda

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Insect Science 2023年第3期30卷 625-636页

作者： Wei-kang han Feng-Xian Tang Hao-Li Gao Yan Wang Na Yu Jian-Jun Jiang Ze-Wen Liu Key Laboratory of Integrated Management of Crop Diseases and Pests(Ministry of Education) College of Plant ProtectionNanjing Agricultural UniversityNanjingChina Plant Protection Research Institute Guangxi Academy of Agricultural ScienceGuangxi Key Laboratory of Biology for Crop Diseases and Insect PestsNanningChina

The CRISPR/Cas9 system has been successfully applied in dozens of diverse species;although the screening of successful CRISPR/Cas9 editing events remains particularly laborious,especially for those that occur at relatively low ***,a co-CRISPR strategy was proved to enrich the desired CRISPR ***,the co-CRISPR strategy was developed in the Fall armyworm,Spodoptera frugiperda,with kynurenine 3-monooxygenase gene(kmo)as a *** kmo mosaics induced by single-guide RNAs(sgRNAs)/Cas9 displayed the darker green color phenotype in larvae,compared with wild type(brown),and mosaic-eye adults were significantly acquired from the mosaic larvae *** the kmo knockout strain,no significant difference was observed in larval development and adult *** 2(ace2)and Wntl were selected as target genes to construct the co-CRISPR strategy using kmo *** coinjection of kmo and ace2 sgRNAs,the mutant efficiency of ace2 was significantly increased in the kmo mosaic(larvae or adults)***,more malformed pupae with Wntl mutations were observed in the darker green larvae *** together,these results demonstrated that kmo was a suitable visible marker gene for the application and extension of co-CRISPR strategy in Fall *** darker green color in larvae or mosaic-eye in adults from kmo knockout as a marker,the mutant efficiency of a target gene could be enriched in a Fall armyworm group consisting of marked *** co-CRISPR strategy is helpful for gene function studies by the knockout technique with no or lethal phenotypes.

关键词： co-CRISPR kmo mutation enrichment Spodoptera frugiperda Wnt1

Comprehensive applicability evaluation of four precipitation products at multiple spatiotemporal scales in Northwest China

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Journal of Arid Land 2024年第9期16卷 1232-1254页

作者： WANG Xiangyu XU Min kang Shichang LI Xuemei han Haidong LI Xingdong School of Mathematics Lanzhou Jiaotong UniversityLanzhou 730070China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Faculty of Geomatics Lanzhou Jiaotong UniversityLanzhou 730070China

Precipitation plays a crucial role in the water cycle of Northwest *** accurate precipitation data is crucial for regional water resource management,hydrological forecasting,flood control and drought ***,the applicability of multi-source precipitation products for long time series in Northwest China has not been thoroughly *** this study,precipitation data from 183 meteorological stations in Northwest China from 1979 to 2020 were selected to assess the regional applicability of four precipitation products(the fifth generation of European Centre for Medium-Range Weather Forecasts(ECMWF)atmospheric reanalysis of the global climate(ERA5),Global Precipitation Climatology Centre(GPCC),Climatic Research Unit gridded Time Series Version 4.07(CRU TS v4.07,hereafter CRU),and Tropical Rainfall Measuring Mission(TRMM))based on the following statistical indicators:correlation coefficient,root mean square error(RMSE),relative bias(RB),mean absolute error(MAE),probability of detection(POD),false alarm ratio(FAR),and equitable threat score(ETS).The results showed that precipitation in Northwest China was generally high in the east and low in the west,and exhibited an increasing trend from 1979 to *** with the station observations,ERA5 showed a larger spatial distribution difference than the other *** overall overestimation of multi-year average precipitation was approximately 200.00 mm and the degree of overestimation increased with increasing precipitation *** multi-year average precipitation of GPCC and CRU was relatively close to that of station *** trend of annual precipitation of TRMM was overestimated in high-altitude regions and the eastern part of Lanzhou with more *** the monthly scale,GPCC performed well but underestimated precipitation in the Tarim Basin(RB=-4.11%),while ERA5 and TRMM exhibited poor accuracy in high-altitude ***5 had a large bias(RB≥120.00%)in winter months

关键词： precipitation products the fifth generation of European Centre for Medium-Range Weather Forecasts(ECMWF)atmospheric reanalysis of the global climate(ERA5) Global Precipitation Climatology Centre(GPCC) Climatic Research Unit gridded Time Series(CRU TS) Tropical Rainfall Measuring Mission(TRMM) applicability evaluation Northwest China

谷子SiPHYA和SiPHYB基因对光质、光周期和非生物胁迫的响应

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农业生物技术学报 2024年第5期32卷 983-994页

作者：杜晓芬沈蒙蒙王智兰韩康妮李颜方成锴李禹欣连世超王军山西农业大学谷子研究所/山西省后稷实验室山西农业大学农学院

光敏色素是一类红光/远红光受体，调控植物种子萌发、株高、开花和避荫性。为探究谷子(Setaria italica)光敏色素A (phytochromes A, PHYA)和光敏色素B (PHYB)基因对光质、光周期和非生物胁迫的响应模式，本研究采用RT-PCR克隆得到SiPHY... 详细信息

光敏色素是一类红光/远红光受体，调控植物种子萌发、株高、开花和避荫性。为探究谷子(Setaria italica)光敏色素A (phytochromes A, PHYA)和光敏色素B (PHYB)基因对光质、光周期和非生物胁迫的响应模式，本研究采用RT-PCR克隆得到SiPHYA (Seita.9G113600)和SiPHYB (Seita.9G427800)的c DNA序列，SiPHYA编码区长度为3 396 bp，编码1 131个氨基酸；SiPHYB编码区长度为3 507 bp，编码1 169个氨基酸。利用MEGA-X软件构建多物种进化树，谷子SiPHYA和SiPHYB分别与玉米(Zea mays)ZmPHYA和ZmPHYB亲缘关系最近。通过在线网站植物转录调控图谱(plant transcriptional regulatory map, PlantRegMap, http://***/***)预测SiPHYA和SiPHYB启动子区结合转录因子情况，结果显示，29个家族共计109个转录因子可结合到SiPHYA启动子区，27个家族共计93个转录因子可结合到SiPHYB启动子区。最后利用qRT-PCR研究其在谷子不同组织器官及不同光质、光周期和逆境处理下的表达模式。结果表明，SiPHYA和SiPHYB在谷子的根、茎、叶和幼穗中均有表达，且都在旗叶中表达量最高；不同光质处理下，SiPHYA和SiPHYB在'衡谷12号'和'长农35号'中响应模式有所不同。其中，'衡谷12号'中SiPHYA在黑暗下表达量最高，而'长农35号'中SiPHYA在远红光下表达量最高，SiPHYB在'衡谷12号'和'长农35号'中均表现为白光下表达量最高，红光下表达量最低；长日照条件下，SiPHYA在'衡谷12号'和'长农35号'中均表现出相似的昼夜节律变化，SiPHYB在'长农35号'中表现出昼夜节律变化，但在'衡谷12号'中无昼夜节律变化；短日照条件下，SiPHYA和SiPHYB在'衡谷12号'和'长农35号'中均无昼夜节律变化；SiPHYA和SiPHYB对高盐、高热、低温和干旱均有响应，但响应模式有所不同。本研究为深入挖掘SiPHYA和SiPHYB在谷子生长发育和非生物胁迫中的功能机制提供线索，并为其在谷子分子遗传改良中的应用提供依据。

关键词：谷子光敏色素光质光周期逆境胁迫表达分析

Interferon-α induced severe thrombocytopenia:A case report and review of the literature

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World Journal of Gastroenterology 2010年第11期16卷 1414-1417页

作者： Li Li,Da-kang han,Jun Lu,Tumor Biotherapy Ward of Beijing Youan Hospital,Capital Medical University,Beijing 100069,China Tumor Biotherapy Ward of Beijing Youan Hospital Capital Medical University Beijing 100069 China.

We report a case of severe thrombocytopenia following pegylated interferon-α 2a(Peg-IFN-α 2a)treatment of hepatitis C virus infection and summarize the clinical characteristics of 16 cases of IFN-α induced severe thrombocytopenia and its immune-mediated *** of IFN-α and early administration of immunosuppressants are the effective therapy for IFN-αinduced severe thrombocytopenia.

关键词： Interferon-α Severe thrombocytopenia Chronic hepatitis C

The way in the connotation development of colleges and universities of science technology

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中国国际财经（中英文版） 2015年第9期 5-6页

作者： kang han month yingkou institute of technology

the connotation development of colleges and universities is the necessary requirement of times development, is the scale of higher education under the con dition of relatively stable, to adjust structure, improve education quality and increase the efficiency of *** universities in China should focus on the cultural construction,team construction, subject construction, system construction, environment construction, seize the opportunity, to form core competitive power as soon as possible.

关键词：内涵发展科学技术核心竞争力相对稳定教育规模调整结构教育质量文化建设