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Reduced micro RNA 375 in colorectal cancer upregulates metadherin-mediated signaling

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World Journal of Gastroenterology 2019年第44期25卷 6495-6507页

作者： Seol-Hee han Ji-Su Mo Won-Cheol Park Soo-Cheon chae Department of Pathology School of MedicineWonkwang UniversityIksanChonbuk 54538South Korea Digestive Disease Research Institute Wonkwang UniversityIksanChonbuk 54538South Korea

BACKGROUND The human microRNA 375(MIR375)is significantly downregulated in human colorectal cancer(CRC)and we have previously shown that MIR375 is a CRCassociated *** metadherin(MTDH)is a candidate target gene of *** To investigate the interaction and function between MIR375 and MTDH in human *** A luciferase reporter system was used to confirm the effect of MIR375 on MTDH *** expression levels of MIR375 and the target genes were evaluated by quantitative RT-PCR(qRT-PCR),western blotting,or *** MTDH expression was found to be upregulated in human CRC tissues compared to that in healthy *** show that MIR375 regulates the expression of many genes involved in the MTDH-mediated signal transduction pathways[BRAF-MAPK and phosphatidylinositol-4,5-biphosphate-3-kinase catalytic subunit alpha(PIK3CA)-AKT]in CRC *** MTDH expression levels were found to inhibit NF-κB inhibitor alpha,which further upregulated NFKB1 and RELA expression in CRC *** Our findings suggest that suppressing MIR375 expression in CRC regulates cell proliferation and angiogenesis by increasing MTDH ***,MIR375 may be of therapeutic value in treating human CRC.

关键词： MicroRNA 375 Metadherin Mitogen-activated protein kinase Angiogenesis Cell proliferation Colorectal cancer

Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia

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Asian Journal of Andrology 2010年第5期12卷 690-696页

作者： Koo han Yoo Su Kang Kim joo-Ho Chung Sung-Goo Chang Department of Urology School of Medicine Kyung Hee University Seou1130-702 Korea Kohwang Medical Research Institute School of Medicine Kyung Hee University Seoul 130-702 Korea

The precise aetiology of benign prostatic hyperplasia （BPH） remains unclear; however, it is known that immunological inflammatory processes have a role in the pathogenesis of BPH initiation and progression. Nitric oxide synthase 2 （NOS2） inducible expression is closely correlated with prostatic disease, including prostate cancer and BPH. The aim of this study was to investigate the relationship between NOS2 polymorphisms and BPH. With a cohort of 205 controls and 229 BPH subjects, we genotyped three single nucleotide polymorphisms （SNPs） in the NOS2 gene, including rs2779248 （promoter, -278 T/C）, rs 10459953 （5＇-untranslated region） and rs2297518 （exon 16, missense, Ser608Leu）, using direct sequencing and restriction fragment length polymorphism. The genotypic and allelic frequencies between control and BPH subjects were compared, and the associations among the BPH subjects were analyzed. SNPStats, SNPAnalyzer and HelixTree programmes were used to analyze SNPs. There was no association on SNPs between control and BPH subjects. When BPH subjects were analyzed, there was no association on SNPs between the low and high prostate-specific antigen groups. However, one SNP （rs 10459953, odds ratio [OR] = 0.44, 95% confidence interval [CI] = 0.29-0.65, P 〈 0.0001, in codominant model; OR = 0.23, 95% CI = 0.12-0.46, P 〈 0.0001, in dominant model; and OR = 0.46, 95% CI = 0.24-0.86, P = 0.015, in recessive model） was associated with prostatic volume in BPH. We detected a strong association in genotype frequencies of NOS2 SNP （rs10459953） between subjects with small and large prostatic volume in BPH. The result suggests that NOS2 may be associated with prostatic volume in BPH.

关键词： benign prostatic hyperplasia nitric oxide synthase 2 single nucleotide polymorphism

Periportal thickening on magnetic resonance imaging for hepatic fibrosis in infantile cholestasis

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World Journal of Gastroenterology 2020年第21期26卷 2821-2830页

作者： Myung Hwan Lee Hyun joo Shin Haesung Yoon Seok joo han Hong Koh Mi-Jung Lee Department of Radiology Severance HospitalSeverance Pediatric Liver Disease Research GroupResearch Institute of Radiological ScienceYonsei University College of MedicineSeoul 03722South Korea Department of Surgery Severance HospitalSeverance Pediatric Liver Disease Research GroupYonsei University College of MedicineSeoul 03722South Korea Division of Gastroenterology Hepatology and NutritionDepartment of PediatricsSeverance Children’s HospitalSeverance Pediatric Liver Disease Research GroupYonsei University College of MedicineSeoul 03722South Korea

BACKGROUND Untreated neonatal cholestasis can progress to liver cirrhosis and end stage liver disease in infancy due to prolonged hepatocyte and biliary tree injury and may require liver ***,non-invasive evaluation of hepatic fibrosis is important in infants with *** To investigate the usefulness of periportal thickening(PT)measured on liver magnetic resonance imaging(MRI)for the assessment of hepatic fibrosis in infants with cholestasis including biliary atresia(BA).METHODS This retrospective study included infants less than 6 mo who underwent liver MRI and biopsy for the evaluation of infantile *** and spleen size were measured on *** assessment was based on aspartate transaminase to platelet ratio index(APRI).The grade of histopathologic fibrosis was assessed by the METAVIR grading *** and diagnostic performance of PT,normalized spleen size ratio(SR,using the upper normal size limit),and APRI for diagnosing hepatic fibrosis were obtained by receiveroperating characteristic(ROC)curve *** A total of 155 patients were included,110 of which were diagnosed with *** age at the time of MRI was 57.6±34.4 *** were positive correlations between fibrosis grade and PT and SR,even after adjusting age(all,Phan 0.741(95%CI:0.664–0.808)for SR and 0.712(95%CI:0.634–0.782)for APRI(both,P<0.001).For the diagnosis of cirrhosis(F4),the area under the ROC curve was the highest with SR as 0.790(95%CI:0.718–0.852).CONCLUSION Liver MRI findings of PT and SR are useful to assess clinically significant hepatic fibrosis(F2 and higher)in infants with cholestasis including BA.

关键词： Infants Cholestasis Biliary atresia Liver Fibrosis Magnetic resonance imaging

Prevalence of coronavirus from diarrheic calves in the Republic of Korea

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Asian Pacific Journal of Tropical Biomedicine 2018年第1期8卷 1-6页

作者： Jinho Park Du-Gyeong han Su Hee Kim Jeong-Byoung chae joon-Seok chae Do-Hyeon Yu Kyoung-Seong Choi College of Veterinary Medicine Chonbuk National University Department of Animal Science and Biotechnology College of Ecology and Environmental Science Kyungpook National University Animal Disease & Biosecurity Team National Institute of Animal Science Rural Development Administration Laboratory of Veterinary Internal Medicine BK21 PLUS Program for Creative Veterinary Science Research Research Institute for Veterinary Science and College of Veterinary Medicine Seoul National University College of Veterinary Medicine Gyeongsang National University

Objective: To investigate the prevalence of bovine coronavirus(BCo V), bovine rotavirus, and bovine viral diarrhea virus in the feces of normal and diarrheic Korean native calves aged 1-81 days between April and October of 2016 in the Republic of Korea. Methods: Samples were obtained from 50 normal and 93 diarrheic(56 semi-formed, 28 loose, and 9 watery feces) calves in six different regions of northern and southern Korea. These fecal samples were tested for BCo V, bovine rotavirus, and bovine viral diarrhea virus by RT-PCR. Results: Among the three pathogens examined, infection with BCo V was especially prominent in relation to diarrhea among calves aged 1-21 days [odds ratio(OR)=9.3, 95% confidence interval(CI): 1.1-78.9; P=0.02). Infection with BCo V alone(OR=2.9; 95% CI: 1.1-7.6; P=0.03) or coinfection of BCo V with bovine viral diarrhea virus(OR=3.6; 95% CI: 1.0-12.4; P=0.04) was significantly associated with the development of loose feces. Grazing and colostrum intake strongly reduced the occurrence of diarrhea as compared to housed calves(OR=0.2; 95% CI: 0.1-0.4; P=0.00) and calves that had not been fed colostrum(OR=0.2; 95% CI: 0.1-0.7; P=0.02), respectively. Conclusions: The present study suggests that BCo V is involved in calf diarrhea in the Republic of Korea. Therefore, grazing and colostrum intake is recommended for preventing and controlling calf diarrhea caused by BCoV.

关键词： Calf diarrhea Bovine coronavirus Bovine viral diarrhea virus Loose feces Grazing

Effects of TiN film coating on electrochemical behaviors of nanotube formed Ti-xHf alloys

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中国有色金属学会会刊：英文版 2009年第4期19卷 857-861页

作者： Kang LEE Won-Gi KIM joo-Young CHO Sang-Won EUN han-Cheol CHOE Department of Dental Materials & Research Center of Nano-Interface Activation for Biomaterials College of DentistryChosun University Department of Applied Advanced Materials Korea Polytechnic Ⅴ Colleges

Ti-xHf(x=10%,20%,30% and 40%,mass fraction) alloys were prepared by arc melting,and the microstructure was controlled for 24 h at 1 000 ℃ in argon *** formation of nanotube was conducted by anodizing on Ti-Hf alloys in 1.0 mol/L H3PO4 electrolytes with small amounts of NaF at room *** then TiN coatings were coated by DC-sputtering on the anodized *** and nanotube morphology of the alloys were examined by field emission scanning electron microscopy(FE-SEM) and X-ray diffractometry(XRD).The corrosion properties of the specimens were examined through potentiodynamic test(potential range from -1 500 to 2 000 mV) in 0.9 % NaCl solution by *** microstructure shows the acicular phase and α' phase with Hf *** amorphous oxide surface is transformed to crystalline anatase *** coated nanotube surface has a good corrosion resistance.

关键词：氮化钛涂层合金制备纳米管电化学行为薄膜包衣 0.9%NaCl溶液扫描电子显微镜微观结构

Electrochemical behavior of dental implant system before and after clinical use

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中国有色金属学会会刊：英文版 2009年第4期19卷 846-851页

作者： chae-Heon CHUNG Hee-Jung KIM Yong-Tae JEONG Mee-Kyoung SON Yong-Hoon JEONG han-Cheol CHOE Department of Prosthodontics College of DentistryChosun University Department of Dental Materials & Research Center of Nano-Interface Activation for Biomaterials College of DentistryChosun University

Electrochemical behavior of dental implant system before and after clinical use(in vivo and in vitro) was researched by using abutment and titanium *** simulate an oral environment,the samples of clinically used and non-used implant systems as a working electrode were exposed to artificial saliva at(36.5±1) ℃.Electrochemical tests were carried out using a *** electrochemical test,the corrosion morphology of each sample was investigated by FE-SEM and *** corrosion potential and pitting potential of clinically used implant system are lower than those of non-used implant system,and clinically used implant system exhibits a lower range of passivation,indicating a less degree of inherent resistance against chloride *** polarization resistance decreases in the case of clinically used implant system,whereas,Rp for clinically non-used implant system increases compared with clinically used implant system.

关键词：电化学行为种植制度临床应用使用制度临床使用电化学测试夹具系统腐蚀形态

Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fibrosis in children

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World Journal of Gastroenterology 2018年第27期24卷 3013-3020页

作者： Hyun joo Shin Haesung Yoon Myung-joon Kim Seok joo han Hong Koh Seung Kim Mi-Jung Lee Department of Radiology Severance Hospital Severance Pediatric Liver Disease Research Group Research Institute of Radiological Science Yonsei University College of Medicine Department of Surgery Severance Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Severance Children's Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine

AIM To evaluate the correlation between intravoxel incoherent motion(IVIM) diffusion-weighted imaging(DWI) parameters and the degree of hepatic steatosis and fibrosis in *** This retrospective study was approved by the institutional review board. The children(≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver(FAT), and fibrotic liver(FIB) groups. The slow diffusion coefficient(D), fast diffusion coefficient(D*), perfusion fraction(f), and apparent diffusion coefficient(ADC) were measured. MR proton density fat fraction(PDFF), MR elastography(MRE), and IVIM values were *** A total of 123 children(median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D* values were lower in the FIB group compared with those of the normal(P = 0.015) and FAT(P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group(P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value(β = 3.194, P < 0.001), and MRE value was negatively correlated with D* value(β =-7.031, P = 0.032). The D and ADC values were not influenced by PDFF or MRE *** In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffness and endovascular blood flow velocity, while diffusion-related parameters were not affected.

关键词： Intravoxel incoherent motion Diffusionweighted imaging Fibrosis Fatty liver Pediatrics

Predicting gastroesophageal varices through spleen magnetic resonance elastography in pediatric liver fibrosis

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World Journal of Gastroenterology 2019年第3期25卷 367-377页

作者： Haesung Yoon Hyun joo Shin Myung-joon Kim Seok joo han Hong Koh Seung Kim Mi-Jung Lee Department of Radiology Severance Hospital Severance Pediatric Liver Disease Research Group Research Institute of Radiological Science Yonsei University College of Medicine Department of Surgery Severance Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Severance Children's Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine

BACKGROUND A recent retrospective study confirmed that hepatic stiffness and splenic stiffness measured with magnetic resonance elastography(MRE) are strongly associated with the presence of esophageal varices. In addition, strong correlations have been reported between splenic stiffness values measured with MRE and hepatic venous pressure gradients in animal models. However, most studies have been conducted on adult populations, and previous pediatric MRE studies have only demonstrated the feasibility of MRE in pediatric populations, while the actual clinical application of spleen MRE has been *** To assess the utility of splenic stiffness measurements by MRE to predict gastroesophageal varices in *** We retrospectively reviewed abdominal MRE images taken on a 3 T system in pediatric patients. Patients who had undergone Kasai operations for biliary atresia were selected for the Kasai group, and patients with normal livers and spleens were selected for the control group. Two-dimensional spin-echo echoplanar MRE acquisition centered on the liver, with a pneumatic driver at 60 Hz and a low amplitude, was performed to obtain hepatic and splenic stiffness values. Laboratory results for aspartate aminotransferase to platelet ratio index(APRI) were evaluated within six months of MRE, and the normalized spleen size ratio was determined with the upper normal size limit. All Kasai group patients underwent gastroesophageal endoscopy during routine follow-up. The MannWhitney U test, Kendall's tau b correlation and diagnostic performance analysis using the area under the curve(AUC) were performed for statistical *** The median spleen MRE value was 5.5 kPa in the control group(n = 9, age 9-18 years, range 4.7-6.4 kPa) and 8.6 kPa in the Kasai group(n = 22, age 4-18 years,range 5.0-17.8 kPa). In the Kasai group, the APRI, spleen size ratio and spleen MRE values were higher in patients with portal hypertension(n = 11) than in patients without(n =

关键词： Biliary atresia Magnetic resonance elastography Kasai operation Splenic stiffness Portal hypertension

Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice

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World Journal of Gastroenterology 2014年第45期20卷 17084-17091页

作者： Mi Na Kim Seong-joon Koh Jung Mogg Kim Jong Pil Im Hyun chae Jung joo Sung Kim Seoul National University Healthcare System Gangnam Center Seoul National University Hospital Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Microbiology Hanyang University College of Medicine Department of Internal Medicine Liver Research Institute Seoul National University College of Medicine

AIM: To investigate the effect of Clostridium difficile (C. difficile) infection in an interleukin 10-deficient (IL-10-/-) mouse model of inflammatory bowel disease.

关键词： Clostridium difficile Inflammatory bowel disease Interleukin 10-deficient mice Interferon-γ Colitis