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Food Science and Human Wellness 2024年

作者： han dou Anthony Pius Bassey Jingwen Li Xianming Zeng Keping Ye State Key Laboratory of Meat Quality Control and Cultured Meat Development Jiangsu Collaborative Innovation Center of Meat Production and Processing College of Food Science and Technology Nanjing Agricultural University

Pseudomonas (P.) fragi and P. lundensis have been reported as key spoilage bacteria in aerobically-stored chilled meat. However， the co-spoilage effect of these bacteria has not been effectively evaluated. This study evaluated the spoilage potential of P. fragi， P. lundensis and P. fragi + P. lundensis in vitro and in situ at 4 ℃. The results showed that P. fragi + P. lundensis performed the highest growth rate and displayed larger decomposition zone diameters on Raw-pork juice agar (RJA) plates. P. fragi + P. lundensis inoculants exhibited the strongest proteolytic activity， which resulted in the highest values of trichloroacetic acid (TCA)-soluble peptides， total volatile basic nitrogen (TVB-N) and myofibril fragmentation index (MFI) in chilled pork. Moreover， the inoculated samples showed different pH and sensory changes. Notably， increased amounts of volatile organic compounds (VOCs)， such as octanal， nonanal， 2-nonanone， 1-propanol， 1-octanol， isopropyl acetate， and 2，6-dimethylpyazine， were observed in inoculated P. fragi + P. lundensis samples， hinting their potential use as spoilage markers for spoilage monitoring of co-cultures. This study would provide a deeper understanding of meat spoilage and serve as a reference for future studies to inhibit meat spoilage.

关键词：

人工强化负载锰氧化物滤料去除地下水中氨/锰中试

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中国给水排水 2024年第3期40卷 15-22页

作者：窦韩黄廷林程亚西安建筑科技大学环境与市政工程学院陕西西安710055 陕西省环境工程重点实验室陕西西安710055 西北水资源与环境生态教育部重点实验室陕西西安710055

以人工强化负载锰氧化物滤料为研究对象,考察了在两种不同硬度、碱度地下水环境下活性滤料除氨/锰活性形成,以及滤料表面膜负载量与负载强度随时间的变化规律。结果表明,在低硬度、碱度水质环境下运行的1#滤柱除氨/锰活性形成速度显著... 详细信息

以人工强化负载锰氧化物滤料为研究对象,考察了在两种不同硬度、碱度地下水环境下活性滤料除氨/锰活性形成,以及滤料表面膜负载量与负载强度随时间的变化规律。结果表明,在低硬度、碱度水质环境下运行的1#滤柱除氨/锰活性形成速度显著高于高硬度、碱度环境下的2#滤柱,1#滤柱在第9天时出水氨浓度低于0.5 mg/L,2#滤柱在第21天时氨浓度低于0.5 mg/L。此外,人工强化负载滤料负载强度与表面膜负载量分别为0.07、0.92 g/10 g,均高于传统挂膜(0.02和0.072 g/10 g)。通过SEM与XRD发现,滤料形貌及结构在运行过程中发生了改变,成熟的滤料表面存在大量网状结构,并生成了水钠锰矿型锰氧化物。可见,人工强化负载锰氧化物滤料在低碱度、硬度地下水条件下更易形成除氨/锰活性,能够有效去除进水中2 mg/L的氨/锰,具有一定的工程应用价值。

关键词：催化氧化除氨/锰地下水

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大跨钢桁梁浮拖施工技术

建筑机械 2024年第7期 67-70页

作者：刘海军车元平张波窦晗陈国中铁一局集团有限公司第三工程分公司陕西宝鸡721006 南京林业大学土木工程学院江苏南京210037

京沪高速公路改扩建工程盐河大桥第2联为95m跨径的下承式钢桁梁,全桥分左右2幅,单幅桥面宽20.5m,上跨既有航道,交叉角度为77°。针对钢桁梁的特点,分析了架桥过程中的重难点,提出了以平板船作为浮墩,千斤顶连续顶推的方法将钢桁梁浮运... 详细信息

京沪高速公路改扩建工程盐河大桥第2联为95m跨径的下承式钢桁梁,全桥分左右2幅,单幅桥面宽20.5m,上跨既有航道,交叉角度为77°。针对钢桁梁的特点,分析了架桥过程中的重难点,提出了以平板船作为浮墩,千斤顶连续顶推的方法将钢桁梁浮运至河对岸。介绍了滑移系统、浮拖系统以及施工过程中的控制要点,依靠卷扬机牵引力克服了横向水流所导致的钢桁梁横向偏位。相比膺架法,浮拖法加快了施工进度,大幅减少了封航时间,同时节约了工程造价。

关键词：高速公路改扩建钢桁梁浮托法同步顶推系统

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大跨钢桁梁快速拼装施工技术研究

建筑机械 2024年第5期 269-271,275页

作者：李海鹏刘海军车元平张波窦晗陈国中铁一局集团有限公司第三工程分公司陕西宝鸡721006 南京林业大学土木工程学院江苏南京210037

京沪高速公路改扩建工程盐河大桥为左右两幅分离式桥梁,结构形式为下承式钢桁梁,主跨长95m,线形控制难度大。本工程的显著特点是桥址距京沪高速铁路较近,场地狭窄,工期紧,给钢桁梁快速拼装带来了极大挑战。文章介绍了钢桁梁拼装的施工... 详细信息

京沪高速公路改扩建工程盐河大桥为左右两幅分离式桥梁,结构形式为下承式钢桁梁,主跨长95m,线形控制难度大。本工程的显著特点是桥址距京沪高速铁路较近,场地狭窄,工期紧,给钢桁梁快速拼装带来了极大挑战。文章介绍了钢桁梁拼装的施工技术难点,确定了由一端(小里程)向另一端(大里程)进行拼装的方式。分析了钢桁梁线形产生误差的原因,提出了减小误差的措施,从而保证了钢桁梁成桥后的线形满足设计要求。

关键词：高速公路改扩建钢桁梁拼装线形

High donor-number and low content electrolyte additive for stabilizing zinc metal anode

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Journal of Energy Chemistry 2024年第8期95卷 626-635页

作者： Yuxin Gong Ruifan Lin Bo Wang Huaizheng Ren Lei Wang han Zhang Jianxin Wang Deyu Li Yueping Xiong Dianlong Wang Huakun Liu Shixue dou MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and Environment School of Chemistry and Chemical Engineering Harbin Institute of Technology Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of Chemistry Nankai University Institute of Energy Material Science University of Shanghai for Science and Technology

The aqueous zinc ion batteries（AZIBs） are thought as promising competitors for electrochemical energy storage,though their wide application is curbed by the uncontrollable dendrite growth and gas evolution side reactions.Herein,to stabilize both zinc anodes and water molecules,we developed a modified electrolyte by adding a trace amount of N,N-diethylformanmide（DEF） into the ZnSO4electrolyte for the first time in zinc ion batteries.The effectiveness of DEF is predicted by the comparison of donor number and its preferential adsorption behavior on the zinc anode is further demonstrated by several spectroscopy characterizations,electrochemical methods,and molecular dynamics simulation.The modified electrolyte with 5% v.t.DEF content can ensure a stable cycling life longer than 3400 h of Zn‖Zn symmetric cells and an ultra-reversible Zn stripping/plating process with a high coulombic efficiency of 99.7%.The Zn‖VO2full cell maintains a capacity retention of 83.5% and a 104 mA h g-1mass capacity after 1000cycles.This work provides insights into the role of interfacial adsorption behavior and the donor number of additive molecules in designing low-content and effective aqueous electrolytes.

关键词： Aqueous zinc ion batteries Donor number Electrolyte additives Zinc anode Zinc dendrites

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磁共振零回波成像应用进展

磁共振成像 2022年第2期13卷 167-170页

作者：窦晗王晓明中国医科大学附属盛京医院放射科沈阳110000

零回波时间(zero echo time,ZTE)成像技术是一种3D容积成像技术,其独特的梯度开启顺序以及K空间径向填充方式,使得射频激励后即可进行梯度编码,从而实现较高的信号采集效率,临床相关研究主要集中在脑血管成像、肺实质结构的显示以及病... 详细信息

零回波时间(zero echo time,ZTE)成像技术是一种3D容积成像技术,其独特的梯度开启顺序以及K空间径向填充方式,使得射频激励后即可进行梯度编码,从而实现较高的信号采集效率,临床相关研究主要集中在脑血管成像、肺实质结构的显示以及病变的检测、骨关节等结构的测量评估。本文重点针对ZTE在以上各方面的主要临床应用进展进行了系统的分析综述。

关键词：零回波时间磁共振成像三维成像中枢神经系统胸部成像临床应用

DENND1A desensitizes granulosa cells to FSH by arresting intracellular FSHR transportation

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Science China Life Sciences 2024年第8期 1620-1634页

作者： Yunde dou Rusong Zhao han Wu Zhiheng Yu Changjian Yin Jie Yang Chaoyan Yang Xiaohua Luan Yixiao Cheng Tao Huang Yuehong Bian Shan han Yuqing Zhang Xin Xu Zi-Jiang Chen han Zhao Shigang Zhao National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital Nanjing Medical University Gusu School Nanjing Medical University Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory Institute of Women Guangdong Second Provincial General Hospital Reproductive Medicine Center Guangdong Second Provincial General Hospital Research Unit of Gametogenesis and Health of ART-Offspring Chinese Academy of Medical Sciences (No.2021RU001) Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Center for Reproductive Medicine Renji Hospital School of Medicine Shanghai Jiao Tong University Children and Reproductive Health Shandong University State Key Laboratory of Reproductive Medicine and Offspring Health Key laboratory of Reproductive Endocrinology of Ministry of Education Shandong University Shandong Key Laboratory of Reproductive Medicine Shandong University Shandong Provincial Clinical Research Center for Reproductive Health

Polycystic ovary syndrome(PCOS) is a complex disorder.Genome-wide association studies(GWAS) have identified several genes associated with this condition,including DENND1A.DENND1A encodes a clathrin-binding protein that functions as a guanine nucleotide exchange factor involved in vesicular transport.However,the specific role of DENND1A in reproductive hormone abnormalities and follicle development disorders in PCOS remain poorly understood.In this study,we investigated DENND1A expression in ovarian granulosa cells(GCs)from PCOS patients and its correlation with hormones.Our results revealed an upregulation of DENND1A expression in GCs from PCOS cases,which was positively correlated with testosterone levels.To further explore the functional implications of DENND1A,we generated a transgenic mouse model overexpressing Dennd1a(TG mice).These TG mice exhibited subfertility,irregular estrous cycles,and increased testosterone production following PMSG stimulation.Additionally,the TG mice displayed diminished responsiveness to FSH,characterized by smaller ovary size,less well-developed follicles,and abnormal expressions of FSH-priming genes.Mechanistically,we found that Dennd1a overexpression disrupted the intracellular trafficking of follicle stimulating hormone receptor(FSHR),promoting its internalization and inhibiting recycling.These findings shed light on the reproductive role of DENND1A and uncover the underlying mechanisms,thereby contributing valuable insights into the pathogenesis of PCOS and providing potential avenues for drug design in PCOS treatment.

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基于智能手机APP的运动干预方案在糖尿病前期病人中的应用

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护理研究 2022年第1期36卷 128-132页

作者：韩豆王晓云山西医科大学护理学院山西030001 山西省人民医院

目的:探讨基于计划行为理论的智能手机APP运动干预方案在糖尿病前期人群中的应用效果。方法:采用便利抽样法选取在太原市某三级甲等医院体检中心或内分泌门诊诊断为糖尿病前期的120例病人,随机分为对照组和试验组各60例,对照组建立微信... 详细信息

目的:探讨基于计划行为理论的智能手机APP运动干预方案在糖尿病前期人群中的应用效果。方法:采用便利抽样法选取在太原市某三级甲等医院体检中心或内分泌门诊诊断为糖尿病前期的120例病人,随机分为对照组和试验组各60例,对照组建立微信群管理并进行电话随访,试验组在对照组的基础上实施基于计划行为理论的智能手机APP的运动干预方案,比较两组干预前后的空腹血糖、餐后2 h血糖、糖化血红蛋白、三酰甘油、总胆固醇和运动自我效能。结果:干预12周后,试验组空腹血糖、餐后2 h血糖、糖化血红蛋白均低于对照组(P<0.05),试验组运动自我效能总分高于对照组(P<0.05)。结论:基于计划行为理论的智能手机APP的运动干预有利于改善糖尿病前期人群的糖代谢状况,提高病人的运动效能。

关键词：计划行为理论糖尿病糖尿病前期延续护理自我效能智能手机

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia:a prospective,single arm,phase I trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2250-2259页

作者： Yunfei Chen Yanmei Xu Ying Chi Ting Sun Yuchen Gao Xueqing dou Zhibo han Feng Xue Huiyuan Li Wei Liu Xiaofan Liu Huan Dong Rongfeng Fu Mankai Ju Xinyue Dai Wentian Wang Yueshen Ma Zhen Song Jundong Gu Wei Gong Renchi Yang Lei Zhang State Key Laboratory of Experimental Hematology National Clinical Research Centre for Blood DiseasesHaihe Laboratory of Cell EcosystemTianjin Key Laboratory of Gene Therapy for Blood DiseasesCAMS Key Laboratory of Gene Therapy for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhou 215006China National Engineering Research Centre of Cell Products Tianjin Key Laboratory of Engineering Technologies for Cell PharmaceuticalAmCellGene Engineering Co.LtdTianjin 300457China School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College100730 BeijingChina

Patients with refractory immune thrombocytopenia(ITP)frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies.Umbilical cord-derived mesenchymal stem cells(UC-MSCs)present a promising alternative,capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune disorders.This prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory ITP.The research design included administering UC-MSCs at escalating doses of 0.5×10^(6)cells/kg,1.0×10^(6)cells/kg,and 2.0×10^(6)cells/kg weekly for four consecutive weeks across three cohorts during the dose-escalation phase,followed by a dose of 2.0×10^(6)cells/kg weekly for the dose-expansion phase.Adverse events,platelet counts,and changes in peripheral blood immunity were monitored and recorded throughout the administration and follow-up period.Ultimately,12(with an addition of three patients in the 2.0×10^(6)cells/kg group due to dose-limiting toxicity)and six patients were enrolled in the dose-escalation and dose-expansion phase,respectively.Thirteen patients(13/18,72.2%)experienced one or more treatment emergent adverse events.Serious adverse events occurred in four patients(4/18,22.2%),including gastrointestinal hemorrhage(2/4),profuse menstruation(1/4),and acute myocardial infarction(1/4).The response rates were 41.7%in the dose-escalation phase(5/12,two received 1.0×10^(6)cells/kg per week,and three received 2.0×10^(6)cells/kg per week)and 50.0%(3/6)in the dose-expansion phase.The overall response rate was 44.4%(8/18)among all enrolled patients.To sum up,UC-MSCs are effective and well tolerated in treating refractory ITP(ClinicalTrials.gov ID:NCT04014166).

关键词： doses immunity treatment

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精准温控对冰温贮藏生鲜猪肉保鲜效果的影响

南京农业大学学报 2023年第1期46卷 150-158页

作者：郭依萍栗婧文窦晗叶可萍南京农业大学国家肉品质量安全控制工程技术研究中心/江苏省肉类生产与加工质量安全控制协同创新中心江苏南京210095

[目的]本文模拟不同温度波动条件[-1℃、(-1±3)℃、(-1±5)℃],探究精准温控对冰温贮藏生鲜猪肉的保鲜效果的影响。[方法]选取猪背最长肌作为研究对象,测定其菌落总数、挥发性盐基氮、感官评价及挥发性有机化合物等指标,研究精准温控... 详细信息

[目的]本文模拟不同温度波动条件[-1℃、(-1±3)℃、(-1±5)℃],探究精准温控对冰温贮藏生鲜猪肉的保鲜效果的影响。[方法]选取猪背最长肌作为研究对象,测定其菌落总数、挥发性盐基氮、感官评价及挥发性有机化合物等指标,研究精准温控下冰温贮藏生鲜猪肉品质的变化。[结果]冰温贮藏条件下生鲜猪肉的品质及货架期显著受贮藏温度波动影响。贮藏12 d后,2个波动组的微生物数量显著增长,TVB-N含量显著高于-1℃组,感官评分显著降低,气味与-1℃组存在明显差异。GC-IMS结果表明,波动组中丁醛、2-庚酮、2-戊酮、乙酸乙酯、乙酸异戊酯、乙酸异丙酯、α-蒎烯、苯乙烯、2-甲基吡嗪含量显著增加。贮藏中后期,(-1±3)℃与(-1±5)℃2个波动组的细菌总数、TVB-N及感官等指标之间无显著差异。[结论](-1±3)℃与(-1±5)℃2个波动组的生鲜猪肉货架期比-1℃组缩短2~3 d,稳定的-1℃冰温贮藏更有利于保持生鲜猪肉的品质。

关键词：冰温贮藏温度波动生鲜猪肉保鲜挥发性有机化合物