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参桃软肝颗粒抑制肝癌的分子机制及调控RBPJ的探索

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中医肿瘤学杂志 2024年第1期6卷 49-56页

作者：周瑞生吴岱琳高天琦黄丹唐莹周岱翰广州中医药大学第一附属医院广东广州510405 广州中医药大学第一临床医学院广东广州510405 广州中医药大学肿瘤研究所广东广州510405 广州中医药大学科技创新中心广东广州510405

目的肝细胞癌(hepatocellular carcinoma,HCC)是全球第四大常见癌症,严重威胁着国民健康。参桃软肝颗粒(STR)是国医大师周岱翰教授治疗肝癌的临床经验方,在临床实践中取得了良好的疗效,阐明其抑制肝癌生长和转移的机制是亟需解决的问题... 详细信息

目的肝细胞癌(hepatocellular carcinoma,HCC)是全球第四大常见癌症,严重威胁着国民健康。参桃软肝颗粒(STR)是国医大师周岱翰教授治疗肝癌的临床经验方,在临床实践中取得了良好的疗效,阐明其抑制肝癌生长和转移的机制是亟需解决的问题。方法Transwell侵袭迁移实验检测STR对HepG2细胞侵袭能力的影响,蛋白质印迹法(Western blot,WB)检测STR对Huh7细胞株RBPJ蛋白的表达影响。观察STR对Huh7荷瘤小鼠移植瘤生长的影响。RNA-seq鉴定STR处理的Huh7移植瘤组织中差异表达基因(differentially expressed genes,DEGs)。结果STR可显著抑制HepG2细胞的迁移和侵袭能力,STR可通过蛋白泛素化降解的途径减少RBPJ蛋白的表达;STR给药后,肝癌模型小鼠移植瘤体积以及瘤体重量均下降,肿瘤生长明显受到抑制。在对照组和STR给药组组间共发现2961个DEGs,其中上调和下调基因分别为1884和1077个。基因本体论(gene ontology,GO)、京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)和疾病本体论(disease ontology,DO)通路富集分析分别展示了STR可能作用的信号通路。结论Notch信号在肝癌中频繁发生异常表达及激活突变,转录因子RBPJ是Notch信号通路主要的下游靶基因,可以增强Notch信号通路中下游基因的表达。STR对肝细胞癌的抑制作用显著,其分子机制可能与抑制RBPJ的蛋白表达相关。

关键词：参桃软肝颗粒肝细胞癌 RBPJ RNA-seq测序分子机制

Observation of flat-band localized state in a one-dimensional diamond momentum lattice of ultracold atoms

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Chinese Physics B 2024年第1期33卷 212-217页

作者：曾超石悦然毛一屹武菲菲谢岩骏苑涛戴汉宁陈宇翱 Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Shanghai Research Center for Quantum Sciences and CAS Center for Excellence Quantum Information and Quantum Physics University of Science and Technology of ChinaShanghai 201315China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Physics Renmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Constructuion and Manipulation Renmin University of ChinaBeijing 100872China

We investigated the one-dimensional diamond ladder in the momentum lattice platform. By inducing multiple twoand four-photon Bragg scatterings among specific momentum states, we achieved a flat band system based on the diamond model, precisely controlling the coupling strength and phase between individual lattice sites. Utilizing two lattice sites couplings, we generated a compact localized state associated with the flat band, which remained localized throughout the entire time evolution. We successfully realized the continuous shift of flat bands by adjusting the corresponding nearest neighbor hopping strength, enabling us to observe the complete localization process. This opens avenues for further exploration of more complex properties within flat-band systems, including investigating the robustness of flat-band localized states in disordered flat-band systems and exploring many-body localization in interacting flat-band systems.

关键词： diamond lattice flat band momentum lattice localized state

Technology portfolio assessment for near-zero emission iron and steel industry in China

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Advances in Climate Change Research 2023年第3期14卷 469-478页

作者： Wei-Yi JIANG Tae Yong JUNG han-Cheng dai Pian-Pian XIANG Graduate School of International Studies Yonsei UniversitySeoul 03722South Korea College of Environmental Science and Engineering Peking UniversityBeijing 100871China Faculty of Environment and Life Beijing University of TechnologyBeijing 100124China

China aims to peak CO_(2)emissions before 2030 and to achieve carbon neutrality before 2060;hence,industrial sectors in China are keen to figure out appropriate pathways to support the national target of carbon *** objective of this study is to explore near-zero emission pathways for the steel industry of China through a detailed technology *** innovative technology development has been simulated using the AIM-China/steel model,developed by including material-based technologies and optimal cost *** scenarios have been given in terms of different levels of production output,emission reduction and carbon ***-zero emission and carbon tax scenarios have shown that China's steel industry can achieve near-zero emission using electric furnaces and hydrogen-based direct reduction iron technologies with policy *** on these technologies,minimised production costs have been calculated,revealing that the steel produced by these technologies is ***,the feedstock cost can play a key role in these technology portfolios,especially the cost of scrap,iron ore and *** addition,the feedstock supply can have strong regional effects and can subsequently impact the allocation of steelmaking in the ***,China can achieve near-zero emissions in the steel industry,and electric furnace and hydrogen-based direct reduction iron technologies are crucial to achieving them.

关键词： Steel industry Near-zero emission Cost optimisation Climate change Carbon neutrality Technology learning

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证本质研究对中医肿瘤学临床研究意义的探讨

中医肿瘤学杂志 2024年第2期6卷 1-7,41页

作者：甄宏德李兵蓝翎周岱翰广州中医药大学第一临床医学院广东广州510405 广州中医药大学第一附属医院肿瘤中心广东广州510405

证本质是困扰中医辨证论治研究的核心问题。本文回顾了辨证论治的历史源流,并审视古人对中医证认识的由来,认为证本质是病机的概括。20世纪50年代开始的一系列证本质研究,将证的“规律性”与“物质基础”等同,鲜有找到具有特异性的微观... 详细信息

证本质是困扰中医辨证论治研究的核心问题。本文回顾了辨证论治的历史源流,并审视古人对中医证认识的由来,认为证本质是病机的概括。20世纪50年代开始的一系列证本质研究,将证的“规律性”与“物质基础”等同,鲜有找到具有特异性的微观指标。由此可见,证应是纯理论的概念,量表是量化证的适宜工具。以病统证,从中医四诊出发,严格遵循规范制定肿瘤的证候量表,既可用于寻找方剂的敏感人群,也可用于肿瘤的疗效评估。

关键词：证证本质量表敏感人群症状体征负荷

FgHAT2 is involved in regulating vegetative growth, conidiation, DNA damage repair, DON production and virulence in Fusarium graminearum

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Journal of Integrative Agriculture 2020年第7期19卷 1813-1824页

作者： LU Wu-yun YANG Nan XU Zhe dai han TANG Shuai WANG Zheng-yi State Key Laboratory of Rice Biology&Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang UniversityHangzhou 310029P.R.China

Histone lysine acetylation is catalyzed by acetyltransferases(HATs), which is important in regulating gene expression and physiological function in eukaryotic cells. HATs can be classified into two main types: A-and B-type HATs. Recently, in Fusarium graminearum, it has been reported that A-type HATs are involved in hyphal development, conidiation, sexual reproduction and virulence. However, the biological roles of B-type HATs are unknown. Here we report the identification and characterization of two B-type HATs(FgHat1 and FgHat2) in F. graminearum. Targeted deletion of FgHAT1 did not result in any detectable phenotypes. However, ΔFghat2 mutants were severely defective in vegetative growth, conidia production and morphogenesis, deoxynivalenol(DON) biosynthesis and virulence. Interestingly, deletion of Fg HAT2 resulted in significantly increased sensitivity to the DNA-damaging agent methyl methanesulfonate(MMS). Furthermore, double deletion mutants(ΔFghat1ΔFghat2) displayed similar phenotypes to the ΔFghat2 mutants. Taken together, we conclude that FgHat2 but not FgHat1 plays essential roles in regulating morphogenesis, DNA damage repair, DON production and virulence in F. graminearum.

关键词： Fusarium graminearum acetyltransferases FgHA T2 pathogenicity

The Influence of Different Solar System Planetary Ephemerides on Pulsar Timing

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Research in Astronomy and Astrophysics 2024年第8期24卷 85-99页

作者： Jian-Peng dai Wei han Na Wang School of Physical Science and Technology Xinjiang UniversityUrumqi 830046China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China

Pulsar timing offers a comprehensive avenue for exploring diverse topics in physics and *** solar system planetary ephemeris is crucial for pulsar timing as it provides the positions and velocities of solar system planets including the ***,it is inevitable that inherent inconsistencies exist in these *** between various ephemerides can significantly impact pulsar timing and parameter ***,pulsar timing highly depends on the JPL DE ephemeris,for instance,the Pulsar Timing Array data analysis predominantly utilizes *** this study,we examine inconsistencies across various ephemeris series,including JPL DE,EPM,and ***,discrepancies emerge particularly between the current ephemeris DE436 and the earliest released ephemeris DE200,as well as the most recent ephemerides,e.g.,DE440,INPOP21A,and *** detailed analysis of the effects of ephemeris on geometric correction procedures for the conversion of measured topocentric times of arrival is presented in this *** researches reveal that variations in the Roemer delays across different ephemerides lead to distinct *** timing residuals and the fact that these discrepancies can be readily incorporated into the subsequent pulsar parameters,leading to inconsistent fitting estimates,suggest that the influence of errors in the ephemeris on the timing process might currently be underappreciated.

关键词： (stars)pulsars general-Planetary Systems-time-ephemerides

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从两例验案探讨中医治疗肝癌的临床优势

中医肿瘤学杂志 2024年第4期6卷 41-45,72页

作者：潘艳丽周瑞生唐莹周岱翰固生堂中医门诊部广东广州518112 广州中医药大学第一附属医院广东广州510405 广州中医药大学广东广州510405

通过报道治疗两例肝癌的成功案例,探讨肝癌的中医辨证论治特色与临床疗效优势。周岱翰教授认为“肝火盛、脾气虚、肾水亏”是肝癌的核心病机,临床论治强调“熄肝火、益脾气、养肝阴、滋肾水”。“验案一”中医辨证为肝肾阴虚证,初期治... 详细信息

通过报道治疗两例肝癌的成功案例,探讨肝癌的中医辨证论治特色与临床疗效优势。周岱翰教授认为“肝火盛、脾气虚、肾水亏”是肝癌的核心病机,临床论治强调“熄肝火、益脾气、养肝阴、滋肾水”。“验案一”中医辨证为肝肾阴虚证,初期治疗予滋水涵木,攻补兼施;病程中期肝肾阴津得充,增加活血化瘀药,侧重攻邪;后期减少攻邪药物,中病即止,预防复发。“验案二”中医辨证为肝热血瘀证,治以清肝凉血,兼以健脾益气;同时予清肝祛瘀利胆法治疗门静脉高压以及滋阴补阳法缓解双乳疼痛。周岱翰教授结合“辨证论治”的原则,按照肝癌发病规律实施中医治疗全病程管理,应用“异法方宜,杂合以治”的理论,充分发挥中医治疗肝癌的独特优势,获得较好的临床疗效。

关键词：原发性肝癌辨证论治全病程管理异法方宜

Solidification behavior and elimination of undissolved Al_(2)CuMg phase during homogenization in Ce-modified Al–Zn–Mg–Cu alloy

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Rare Metals 2020年第11期39卷 1279-1287页

作者： Xin-Xiang Yu Jie Sun Zhu-Tie Li han dai Hong-Jie Fang Jun-Feng Zhao Deng-Feng Yin School of Engineering Yantai Nanshan UniversityYantai 265713China Testing and Analysis Center Shandong Nanshan Aluminum Co.Ltd.Yantai 264006China

The solidification behavior and intermetallic phase evolution during homogenization annealing of an Al-Zn-Mg-Cu alloy with 0.12 wt%Ce addition were *** residual Al_(2)CuMg phase is completely dissolved after homogenization and is replaced by a large number of dispersed micro/nanoscaled AlCuCe enrichment phases within Al *** change occurs because of the formation of a large number of finer lamellar eutectic network structures which are more easily dissolved into Al matrix during the homogenization *** addition,the trapping of Cu atoms in the stable AlCuCe phase also prevents the formation of Al_(2)CuMg phase,leading to the complete dissolution of Al_(2)CuMg phase in the Al-Zn-MgCu *** grain refinement behavior in Al alloy with Ce addition is similar to that in alloys with the addition of Sc,because of the formation of primary Ce-enriched Al_(11)Ce_(3)phase as the nucleation agent ofα(Al)during solidification.

关键词： Al–Zn–Mg–Cu alloy Al_(2)CuMg phase Homogenization Grain refinement

Study on the optimal incident proton energy of ^(7)Li(p,n)^(7)Be neutron source for boron neutron capture therapy

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Nuclear Science and Techniques 2024年第3期35卷 170-180页

作者： Yi-Nan Zhu Zuo-Kang Lin Hai-Yan Yu Ye dai Zhi-Min dai Xiao-han Yu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Science Beijing 100049China

Boron neutron capture therapy(BNCT)is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the^(10)B(n,α)^(7)Li nuclear *** various neutron sources,accelerator-based sources have emerged as particularly promising for BNCT ***^(7)Li(p,n)^(7)Be reaction is highly regarded as a potential neutron source for BNCT,owing to its low threshold energy for the reaction,significant neutron yield,appropriate average neutron energy,and additional *** study utilized Monte Carlo simulations to model the physical interactions within a lithium target subjected to proton bombardment,including neutron moderation by an MgF_(2)moderator and subsequent BNCT dose analysis using a Snyder head *** study focused on calculating the yields of epithermal neutrons for various incident proton energies,finding an optimal energy at 2.7 ***,the Snyder head phantom was employed in dose simulations to validate the effectiveness of this specific incident energy when utilizing a^(7)Li(p,n)^(7)Be neutron source for BNCT purposes.

关键词： Boron neutron capture therapy ^(7)Li(p,n)7Be neutron source Incident proton energy Monte Carlo simulation