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Evaluation and projection of marine heatwaves in the South China Sea: insights from CMIP6 multi-model ensemble

Acta Oceanologica Sinica 2024年第7期43卷 15-25页

作者： Kai Liu Kang Xu Tongxin han Congwen Zhu Nina Li Anboyu guo Xiaolu huang National Marine Environmental Forecasting Center Beijing 100081China State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China National Meteorological Center China Meteorological AdministrationBeijing 100081China Inner Mongolia Autonomous Region Meteorological Observatory Huhhot 010051China

This study evaluates the performance of 16 models sourced from the coupled model intercomparison project phase 6(CMIP6)in simulating marine heatwaves(MHWs)in the South China Sea(SCS)during the historical period(1982−2014),and also investigates future changes in SCS MHWs based on simulations from three shared socioeconomic pathway(SSP)scenarios(SSP126,SSP245,and SSP585)using CMIP6 *** demonstrate that the CMIP6 models perform well in simulating the spatial-temporal distribution and intensity of SCS MHWs,with their multi-model ensemble(MME)results showing the best *** reasonable agreement between the observations and CMIP6 MME reveals that the increasing trends of SCS MHWs are attributed to the warming sea surface temperature *** various SSP scenarios,the year 2040 emerges as pivotal juncture for future shifts in SCS MHWs,marked by distinct variations in changing rate and *** is characterized by an accelerated decrease in MHWs frequency and a notably heightened increase in mean intensity,duration,and total days after ***,the projection results for SCS MHWs suggest that the spatial pattern of MHWs remains consistent across future ***,the intensity shows higher consistency only during the near-term period(2021−2050),while notable inconsistencies are observed during the medium-term(2041−2070)and long-term(2071−2100)periods under the three SSP *** the nearterm period,the SCS MHWs are characterized by moderate and strong events with high frequencies and relatively shorter *** contrast,during the medium-term period,MHWs are also characterized by moderate and strong events,but with longer-lasting and more intense events under the SSP245 and SSP585 ***,in the long-term period,extreme MHWs become the dominant feature under the SSP585 scenario,indicating a substantial intensification of SCS MHWs,effectively establishing a near-permanent state.

关键词： marine heatwaves South China Sea global warming future projections CMIP6

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Practical Synthesis of Valbenazine via 1,3-Dipolar Cycloaddition

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Chinese Journal of Chemistry 2024年第8期42卷 841-845页

作者： Yalan Peng Zuming Lin Lili Zhu Shiqing han Sha-Hua huang Ran Hong College of Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjingJiangsu211816 China School of Environmental and Chemical Engineering Shanghai Institute of TechnologyShanghai201418 China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China Innovation Research Institute of Traditional Chinese Medicine(IRI) Shanghai University of Traditional Chinese Medicine1200 Cailun RoadShanghai201203 China

Comprehensive Summary,Valbenazine(Ingrezza),a potent and highly selective inhibitor of vesicular monoamine transporter type 2(VMAT2)through the active metabolite hydrotetrabenazine(HTBZ),has been approved for the treatment of tardive dyskinesia and,very recently,for chorea,which is associated with Huntington's *** numerous synthetic efforts dedicated to the synthesis of HTBZ,the industrial preparation of valbenazine uses dihydroisoquinoline as a starting material and the chiral resolution of racemic HTBZ derived from ketone ***,we present a practical synthesis of HTBZ and valbenazine featuring a highly stereoselective 1,3-dipolar cycloaddition and enzymatic kinetic *** cascade process includes cycloaddition,N—O bond cleavage,and lactamization,which proved to be operationally *** allure of the enzymatic resolution developed in this work offers a rapid access toward affording tetrahydroisoquinoline(THIQ)-fused piperidine in the production of medically significant compounds,such as yohimbine and reserpine.

关键词： Cycloaddition Chemoenzymatic Kinetic resolution Prodrugs VMAT2 inhibitor

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LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2942-2958页

作者： Shishi He guowei huang Rong Lei Rurong Jia Zhanghai He Jiewen Chen Hongyan huang Zixian huang Ailifeire Yilihamu Xun Li Zilin Zhuang Mengjia han Xueman Chen Di huang Yan Nie guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Pathology Shantou University Medical CollegeShantou 515041China School of Basic Medical Science Southern Medical UniversityGuangzhou 510515China Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Breast Medicine Affiliated Foshan Maternity and Child Healthcare HospitalSouthern Medical UniversityFoshan 528000China Department of Breast Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Oral and Maxillofacial Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Breast phyllodes tumor(PT)is a rare fibroepithelial neoplasm with potential malignant *** non-coding RNAs(lncRNAs)play multifaceted roles in various cancers,but their involvement in breast PT remains largely *** this study,microarray was leveraged for the first time to investigate the role of lncRNA in *** identified lncRNA ZFPM2-AS1 was significantly upregulated in malignant PT,and its overexpression endowed PT with high tumor grade and adverse ***,we elucidated that ZFPM2-AS1 promotes the proliferation,migration,and invasion of malignant PT in *** ZFPM2-AS1 through nanomaterial-mediated siRNA delivery in patient-derived xenograft(PDX)model could effectively inhibit tumor progression in ***,our findings showed that ZFPM2-AS1 is competitively bound to CDC42,inhibiting ACK1 and STAT1 activation,thereby launching the transcription of *** conclusion,our study provides evidence that ZFPM2-AS1 plays a pivotal role in the pathogenesis of breast PT,and suggests that ZFPM2-AS1 could serve as a prognostic indicator for patients with PT as well as a promising novel therapeutic target.

关键词： LncRNA Phyllodes tumor ZFPM2-AS1 Cell division cycle 42 Activated cdc42 kinase 1 Signal transducer and activator of transcription 1 TNF receptor superfamily member 19 Nano particles

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Rationally construction of atomic-precise interfacial charge transfer channel and strong build-in electric field in nanocluster-based Zscheme heterojunctions with enhanced photocatalytic hydrogen production

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Nano Research 2024年第6期17卷 5002-5010页

作者： Qingtao Zhu Honglei Shen Chao han Liu huang Yanting Zhou Yuanxin Du Xi Kang Manzhou Zhu Department of Materials Science and Engineering Centre for Atomic Engineering of Advanced MaterialsKey Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationKey Laboratory of Functional Inorganic Material Chemistry of Anhui ProvinceAnhui UniversityHefei 230601China

The lack of effective charge transfer driving force and channel limits the electron directional migration in nanoclusters(NC)-based heterostructures,resulting in poor photocatalytic ***,a Z-scheme NC-based heterojunction(Pt1Ag28-BTT/CoP,BTT=1,3,5-benzenetrithiol)with strong internal electric field is constructed via interfacial Co-S bond,which exhibits an absolutely superiority in photocatalytic performance with 24.89 mmol·h^(−1)·g−1 H_(2)production rate,25.77%apparent quantum yield at 420 nm,and~100%activity retention in stability,compared with Pt1Ag28-BDT/CoP(BDT=1,3-benzenedithiol),Ag29-BDT/CoP,and *** enhanced catalytic performance is contributed by the dual modulation strategy of inner core and outer shell of NC,wherein,the center Pt single atom doping regulates the band structure of NC to match well with CoP,builds internal electric field,and then drives photogenerated electrons steering;the accurate surface S modification promotes the formation of Co-S atomic-precise interface channel for further high-efficient Z-scheme charge directional *** work opens a new avenue for designing NC-based heterojunction with matchable band structure and valid interfacial charge transfer.

关键词： atomically precise metal nanocluster Z-scheme heterojunction interfacial charge transfer build-in electric field photocatalytic hydrogen production

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Interface catalytic reduction of alumina by nickle for the aluminum nanowire growth: Dynamics observed by in situ TEM

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Nano Research 2024年第3期17卷 1225-1231页

作者： Zichun Wang Dan Wang Ang Li Lizhuo Wang Xiaodong han Yijiao Jiang Jianfeng Chen Jun huang Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic–Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029China Laboratory for Catalysis Engineering School of Chemical and Biomolecular EngineeringThe University of SydneyNew South Wales 2006Australia Beijing Key Laboratory of Microstructure and Property of Advanced Materials Beijing University of TechnologyBeijing 100024China Department of Engineering Macquarie UniversitySydneyNew South Wales 2109Australia

Metal nanowires show promise in a broad range of applications and can be fabricated via a number of methods,such as vapor–liquid–solid process and template-based ***,the synthesis of Al nanowires(NWs)is still challenging from the stable alumina *** this work,the Ni-catalyzed fabrication of Al NWs has been realized using various Al_(2)O_(3) *** growth dynamics of Al NWs on Ni/Al_(2)O_(3) was studied using in situ transmission electron microscopy(TEM).The effect of alumina structures,compositions,and growth temperature were *** growth of Al NWs correlates with the Na addition to the alumina *** no eutectic mixture of nickel aluminide was formed,a mechanism of Ni-catalyzed reduction of Al_(2)O_(3) for Al NWs growth has been proposed instead of the vapor–liquid–solid *** key insights reported here are not restricted to Ni-catalyzed Al NWs growth but can be extended to understanding the dynamic change and catalytic performance of Ni/Al_(2)O_(3) under working conditions.

关键词： in situ transmission electron microscopy(TEM) Al nanowires alumina reduction nanowire growth

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Synthesis of tetrahedrally coordinated CoO for higher alcohol synthesis directly from syngas

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Frontiers of Chemical Science and Engineering 2024年第8期18卷 99-109页

作者： Zhuoshi Li han Yang Xiaofeng Pei Jiahui Li Jing Lv Shouying huang Yue Wang Xinbin Ma Key Laboratory for green Chemical Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Higher alcohol synthesis directly from syngas is highly desirable as one of the efficient non-petroleum energy conversion ***0–Co^(O)catalysts showed great potential for this reaction,but the alcohol selectivity still needs to be improved and the crystal structure effect of Co^(O)on catalytic behaviors lacks ***,a series of tetrahedrally coordinated Co^(O)polymorphs were prepared by a thermal decomposition method,which consisted of wurtzite CoO and zinc blende CoO with varied *** diluting with SiO_(2),the catalyst showed excellent performance for higher alcohol synthesis with ROH selectivity of 45.8%and higher alcohol distribution of 84.1 wt%under the CO conversion of 38.0%.With increasing the content of wurtzite CoO,the Co^(0)/Co^(2+)ratio gradually increased in the spent catalysts,while the proportion of highly active hexagonal close packed cobalt in Co^(0)decreased,leading to first decreased then increased CO ***,the higher content of zinc blende CoO in fresh catalyst facilitated the retention of more Co^(2+)sites in spent catalysts,promoting the ROH selectivity but slightly decreasing the distribution of higher *** catalyst with 40%wurtzite CoO obtained the optimal performance with a space time yield toward higher alcohols of 7.9 mmol·gcat^(-1)·h^(-1).

关键词： higher alcohol synthesis CO hydrogenation wurtzite CoO zinc blende CoO hexagonal-closest-packed Co

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Photoelectrocatalytic hydrogen evolution and synchronous degradation of organic pollutants by pg-C_(3)N_(4)/β-FeOOH S-scheme heterojunction

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Science China(Technological Sciences) 2024年第4期67卷 1238-1252页

作者： LI XiBao han Tao ZHOU YingTang XIE Yu LUO YiDan huang JunTong CHEN Zhi DENg Fang School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang 330063China National-Local Joint Engineering Research Center of Heavy Metal Pollutants Control and Resource Utilization Nanchang Hangkong UniversityNanchang 330063China Zhejiang Key Laboratory of Petrochemical Environmental Pollution Control National Engineering Research Center for Marine AquacultureMarine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316022China

Crafting photoelectrocatalytic materials with robust oxidation-reduction properties for simultaneous hydrogen evolution and pollutant degradation poses a formidable *** this study,a pg-C_(3)N_(4)/β-FeOOH S-scheme heterostructure with a special energy band structure was developed by anchoring porous pg-C_(3)N_(4)on needle shapedβ-*** as a hole extraction layer,needle-leaf-likeβ-FeOOH can facilitate efficient hole migration and enhance charge ***,the optimized 0.2-pg-C_(3)N_(4)/β-FeOOH could degrade 78%of ofloxacin(OFLO)in 90 *** organic pollutants could absorb a large number of holes,which prompted a greater proportion of photogenerated electrons to actively participate in the hydrogen evolution reaction at the ***,the hydrogen production of 0.2-pg-C_(3)N_(4)/β-FeOOH reached 1452.88μmol cm^(-2)h^(-1),exhibiting a notable increase of 61.81-165.12μmol cm^(-2)h^(-1)compared with that in the absence of *** and theoretical calculation results underscore that this investigation is grounded in a distinctive electron and hole dual channel transfer *** findings offer novel insights for the future development of S-scheme heterojunction photoelectrocatalytic materials capable of concurrently degrading pollutants and promoting hydrogen evolution.

关键词： photoelectrocatalysis hydrogen evolution degradation synchronous S-scheme heterojunction

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Weakly supervised point cloud segmentation via deep morphological semantic information embedding

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 695-708页

作者： Wenhao Xue Yang Yang Lei Li Zhongling huang Xinggang Wang Junwei han Dingwen Zhang School of Automation Northwestern Polytechnical UniversityXi'anChina Institute of Mechanical and Electrical Engineering BeijingChina School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhanChina

Segmenting the semantic regions of point clouds is a crucial step for intelligent agents to understand 3D *** supervised point cloud segmentation is highly desirable because entirely labelling point clouds is highly time-consuming and *** the low-costing labelling of 3D point clouds,the scene-level label is one of the most effortless label ***,due to the limitation of classifier discriminative capability and the orderless and structurless nature of the point cloud data,existing scene-level method is hard to transfer the semantic information,which usually leads to the under-activated or over-activated *** this end,a local semantic embedding network is introduced to learn local structural patterns and semantic ***,the proposed network contains graph convolution-based dilation and erosion embedding modules to implement‘inside-out’and‘outside-in’semantic information dissemination ***,the proposed weakly supervised learning framework could achieve the mutual propagation of semantic information in the foreground and *** experiments on the widely used ScanNet benchmark demonstrate the superior capacity of the proposed approach when compared to the current alternatives and baseline models.

关键词： artificial intelligence computer vision deep learning

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Computational tools for plant genomics and breeding

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Science China(Life Sciences) 2024年第8期67卷 1579-1590页

作者： Hai Wang Mengjiao Chen Xin Wei Rui Xia Dong Pei Xuehui huang Bin han State Key Laboratory of Maize Bio-breeding Frontiers Science Center for Molecular Design BreedingJoint International Research Laboratory of Crop Molecular BreedingNational Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Sanya Institute of China Agricultural University Sanya 572025China Hainan Yazhou Bay Seed Laboratory Sanya 572025China State Key Laboratory of Tree genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of the State Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China College of Horticulture South China Agricultural UniversityGuangzhou 510640China National Center for gene Research CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200233China

Plant genomics and crop breeding are at the intersection of biotechnology and information *** by a combination of highthroughput sequencing,molecular biology and data science,great advances have been made in omics technologies at every step along the central dogma,especially in genome assembling,genome annotation,epigenomic profiling,and transcriptome *** advances further revolutionized three directions of *** is genetic dissection of complex traits in crops,along with genomic prediction and *** second is comparative genomics and evolution,which open up new opportunities to depict the evolutionary constraints of biological sequences for deleterious variant *** third direction is the development of deep learning approaches for the rational design of biological sequences,especially proteins,for synthetic *** three directions of development serve as the foundation for a new era of crop breeding where agronomic traits are enhanced by genome design.

关键词： bioinformatics plant genomics breeding by design

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A pH-responsive nanoparticle delivery system containing dihydralazine and doxorubicin-based prodrug for enhancing antitumor efficacy

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Aggregate 2024年第1期5卷 436-450页

作者： Lianxue Zhang Jianxiang huang Damiano Buratto Panli han Zaixing Yang Ruhong Zhou Institute of Quantitative Biology Shanghai Institute for Advanced StudyCollege of Life SciencesZhejiang UniversityHangzhouChina State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversitySuzhouChina Cancer Center Zhejiang UniversityHangzhouChina Department of Chemistry Columbia UniversityNew YorkNew YorkUSA

The efficacy of nanoparticle(NP)-based drug delivery technology is hampered by aberrant tumor stromal microenvironments(TSMs)that hinder NP ***,the promotion of NP permeation into deep tumor sites via the regulation of tumor microenvironments is of critical ***,we propose a potential solution using a dihydralazine(HDZ)-loaded nanoparticle drug delivery system containing a pH-responsive,cyclic RgD peptide-modified prodrug based on doxorubicin(cRgD-Dex-DOX).With a combined experimental and theoretical approach,we find that the designed NP system can recognize the acid tumor environments and precisely release the encapsulated HDZ into tumor *** can notably downregulate the expression levels of hypoxia-inducible factor 1α(HIF1α),α-smooth muscle actin,and fibronectin through the dilation of tumor blood *** changes in the TSMs enhance the enrichment and penetration of NPs and also unexpectedly promote the infiltration of activated T cells into tumors,suggesting that such a system may offer an effective“multifunctional therapy”through both improving the chemotherapeutic effect and enhancing the immune response to *** vivo experiments on 4T1 breast cancer bearing mice indeed validate that this therapy has the most outstanding antitumor effects over all the other tested control regimens,with the lowest side effects as well.

关键词： antitumor dihydralazine drug delivery system tumor stromal microenvironment vasculature

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