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Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice

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Asian Journal of Andrology 2021年第3期23卷 281-287页

作者： Fathiah abdullah Mohamed Noor Khan Nor-Ashikin Renu Agarwal Yuhaniza Shafinie Kamsani Mastura abd Malek Nor Salmah Bakar Aqila-Akmal Mohammad Kamal Mimi-Sophia Sarbandi Nor-Shahida abdul rahman Nurul Huda Musa Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah CampusTapah Road 35400PerakMalaysia Faculty of Medicine Universiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam 42300SelangorMalaysia Centre of Foundation Studies Universiti Teknologi MARASelangor BranchDengkil CampusDengkil 43800SelangorMalaysia

Diabetes mellitus(DM)is known to cause reproductive *** men,it has been linked to altered sperm quality and testicular *** stress(OS)plays a pivotal role in the development of DM ***(GSH)is a part of a nonenzymatic antioxidant defense system that protects lipid,protein,and nucleic acids from oxidative ***,the protective effects of exogenous GSH on the male reproductive system have not been comprehensively *** study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac *** at the doses of 15 mg kg^(-1)and 30 mg kg^(-1)was given intraperitoneally to mice weekly for 6 consecutive *** mice were then weighed,euthanized,and had their reproductive organs *** diabetic(D Group)showed significant impairment of sperm quality and testicular histology compared with the nondiabetic(ND Group).Diameters of the seminiferous lumen in diabetic mice treated with 15 mg kg^(-1) GSH(DGSH15)were decreased compared with the D *** motility was also significantly increased in the DGSH15 *** in testicular morphology might be an early indication of the protective roles played by the exogenous GSH in protecting sperm quality from effects of untreated type 1 DM or diabetic *** investigation using different doses and different routes of GSH is necessary to confirm this suggestion.

关键词： diabetes mellitus glutathione mice sperm quality testis histology

Vitamin E supplementation may negatively affect preimplantation development and mitochondrial ultrastructure of vitrified murine embryos

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Asian pacific Journal of Reproduction 2021年第3期10卷 137-144页

作者： Mimi-Sophia Sarbandi Nor-Ashikin Mohamed Noor Khan Nor-Shahida abdul rahman Zolkapli Eshak Fathiah abdullah Mastura abd Malek Aqila-Akmal Mohammad Kamal Maternofetal and Embryo Research Group Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah Campus35400 Tapah RoadPerakMalaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam42300 Kuala SelangorSelangorMalaysia Faculty of Pharmacy Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam42300 Kuala SelangorSelangorMalaysia

Objective:To observe the effects of vitamin E on post-vitrification preimplantation development,gross morphology as well as mitochondrial distribution and ***:Twenty-four female C57BL/6NTac mice,aged 12-16 weeks,were randomly divided into four *** A did not receive any treatment and served as the control *** B was treated with corn oil stripped of tocopherols and served as the vehicle *** C was treated with 60 mg/kg body weight of tocotrienol-rich-fraction with corn oil stripped of *** D was treated with 60 mg/kg body weight of alpha-tocopherol with corn oil stripped of *** treatments were administered orally for 7 consecutive *** superovulation and mating with fertile males,2-cell stage embryos were harvested for *** vitrification development in vitro,gross morphology and ultrastructure were compared between ***:The number of 2 and 8-cell embryo,and blastocysts in the treatment and control groups were not significantly different(P>0.05).Following vitrification,all 2-cell embryos had equal-sized blastomeres and intact zona *** aggregation toward the perinuclear region was seen in all of the treatment *** groups C and D had vacuolated mitochondria,which was reflected in the trend of preimplantation development ***:Vitamin E supplementation of 60 mg/kg body weight does not improve the viability of healthy embryos according to this *** a result,the most effective dose of vitamin E supplementation may be determined by the initial quality of the embryos.

关键词： Mitochondria Preimplantation Embryo Vitrification Vitamin E Alpha-tocopherol Tocotrienol-richfraction,Transmission electron microscopy

Tracing ancient continental crust beneath juvenile oceanic arc in northern Arabian-Nubian Shield,Egypt

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Tracing ancient continental crust beneath juvenile oceanic a...

Power Conversion Efficiency of Schottky Diode Fabricated on AIGaAs/GaAs Heterostructure

2017中国地球科学联合学术年会

作者：李献华 Yasser abd El-rahman 中国科学院地质与地球物理研究所

The intra-oceanic arc(IOA)is generated by partial melting of mantle wedge where one oceanic plate subducts beneath another,contamination of the ascending IOA magmas by continental crustal materials is ***,accretion of... 详细信息

关键词： IOA Tracing ancient continental crust beneath juvenile oceanic arc in northern Arabian-Nubian Shield,Egypt

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材料科学与工程（中英文版） 2010年第6期4卷 60-65页

作者： Parimon Norfarariyanti Mustafa Farahiyah Hashim abdui Manaf abd rahman Shaharin Fadzli abdul rahman abdul Rahim Osman Mohd Nizam abd Aziz Azlan Hashim Md. Roslan Material Innovations and Nanoelectronics Research Group Faculty of Electrical Engineering Universiti Teknologi MalaysiaSkudai 81310 Johor Malaysia Telekom Research ＆ Development TM Innovation Centre Cyberjaya 63000 Malaysia Nano-Optoelectronics Research Faculty of Physics Universiti Sains Malaysia Minden 11800 Penang Malaysia

Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions

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World Journal of Gastroenterology 2018年第11期24卷 1228-1238页

作者： abdel-rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa abd Elkader Molecular Virology and Immunology Unit Department of Cancer BiologyNational Cancer InstituteCairo University Department of Zoology Faculty of ScienceCairo University Department of Pathology National Cancer InstituteCairo University Medical Biochemistry and Molecular Biology Department of Cancer BiologyNational Cancer InstituteCairo University Department of Hepatology and Tropical Medicine Faculty of MedicineCairo University Department of Biochemistry Misr University for Science and Technology

AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic *** Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow *** levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by *** Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other *** p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC *** was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC *** was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC.

关键词： Hepatocellular carcinoma Hepatitis C virus NKG2D CD40 interleukin-2 interleukin-10 myeloid dendritic cells plasmacytoid cells natural killer cell Cytokines

Analytical Model of Nonlinear Semi-rigid Frames Using Finite Element Method

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Journal of Architectural Environment & Structural Engineering Research 2020年第4期3卷 22-27页

作者： Shahrin Mohammad Ahmad Baharuddin abd rahman Cher Siang Tan Yeong Huei Lee School of Civil Engineering Faculty of EngineeringUniversiti Teknologi Malaysia81310 Johor BahruJohorMalaysia Department of Civil and Construction Engineering Faculty of Engineering and ScienceCurtin University MalaysiaCDT25098009 MiriSarawakMalaysia

Performance-based design for a constructional steel frame in nonlinear-plastic region requires an improvement in order to achieve a reliable structural *** need to explicitly consider the nonlinear behaviour of structures makes the numerical modelling approach much more favourable than expensive and potentially dangerous experimental *** parameters considered in the analysis are not limited to the linear change of geometry and material yielding,but also include the effect of large deformations,geometrical imperfections,load eccentricities,residual stresses,strain-unloading,and the nonlinear boundary *** analysis requires the use of accurate mathematical modelling and effective numerical procedures for solving equations of *** that in mind,this paper presents the mathematical formulations and finite element procedures of nonlinear inelastic steel frame analysis with quasi-static semi-rigid *** and validation of the developed analytical procedures are conducted and good agreements are *** is an approach that enables the structural behaviour of constructional steel frames to be traced throughout the entire range of loading until *** also provides information on the derivation of the structural analysis by using finite element method.

关键词： Finite element method Nonlinearity Steel frame Semi-rigid connection

Plasmas Created in the Interaction of Antiprotons with Atomic and Ionized Hydrogen Isotopes. Suggested Fuels for Space Engines

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Journal of High Energy Physics, Gravitation and Cosmology 2022年第1期8卷 14-24页

作者： Mohamed Assaad abdel-Raouf abdelfattah T. Elgendy Amr abd Al-rahman Youssef Physics Department Faculty of Science Ain Shams University Cairo Egypt Mathematics Department Faculty of Science Al-Azhar University Cairo Egypt

The main objective of the present work is to investigate the properties of plasmas created by injecting a thermalized beam of antiprotons in two types of media. The first is hydrogen, deuterium, or tritium atoms localized in palladium crystals. The second medium is composed of protons, deuterons, or tritons localized in a magnetic cavity. Particularly, it is demonstrated that huge amounts of energy are released in both cases which could be used as fuels for space shuttle engines. A novel mathematical scheme is employed to calculate the energy yields in real space at different incident energies of the antiprotons.

关键词： Antiprotons Antiprotonic Hydrogens Antiprotonic Plasma Fuel for Space Engines Plasmas in Molecular Crystals Palladium as Host for Neutral Plasma Antiprotons-Ionized Hydrogen Isotopes Plasma

Investigation on the performance of DI-BSCCO superconducting electric motor

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Natural Science 2011年第1期3卷 36-41页

作者： Chin Kat Meng Nasri A. Hamid Mohd. Yusri abd. rahman 不详

Superconducting electrical devices have been developed in various fields especially in industrial energy over a decade. Superconducting motor is one of the electrical devices that attracted the attention of engineers and researchers from the universities and industries due to its distinctive energy efficiency. This paper describes the performance of superconducting electric motor and its performance was compared with conventional copper electric motor. Direct current (DC) synchronous single- phase series motor has been chosen as the base for development of both motors. Two prototypes of electric motor fabricated using conventional copper coil and superconducting coil were developed with similar motor type, design, dimension, and features. The superconducting motor coil was wound using Bi-2223 (DI-BSCCO) Type H wires developed by Sumitomo Electric Industries Limited, Japan. A finite element analysis was performed to get a clear view on flux plots of the magnetic induction. Features of the superconducting motor and the special coil frame designed to protect the superconducting wire was also presented in this paper. In addition, the torque performances for both types of motor were measured. The superconducting electric motor was found to consume lower power to produce the same output compared with the conventional copper-wound motor.

关键词： Superconductor Magnetic flux Finite Element Analysis Electric Motor

Cold Fusion Based on Matter-Antimatter Plasma Formed in Molecular Crystals

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Journal of High Energy Physics, Gravitation and Cosmology 2022年第1期8卷 56-66页

The main purpose of this work is to shed light on the possibility of producing huge amount of energy based on the construction matter-antimatter plasma in a molecular crystal. It is assumed that two beams of isothermal hydrogen and antihydrogen are injected into a palladium crystal leading to a plasma state composed of particles and antiparticles. The collapse of this state releases a huge amount of energy which can be used as fuel for space shuttles. Thus, the novel system of isothermal pressure interaction enhances the energy power carried out by the quantum ion acoustic soliton (QIAS). In addition to the energy power released from the particle-antiparticle annihilation. The probability of merging the energy from these two cases is available at certain condition. The released energy may be a significant step in solving the energy scape of Tokomak to produce fusion energy. The study starting from the one-dimensional quantum hydrodynamic model (in which the term of electron-positron and proton-antiproton for hydrogen-antihydrogen is included), a Korteweg de Vries equation (kdv) is derived, the QIAS energy experiences and the annihilation energy power are calculated. It is found that the total energy of QIAS and the energy resulting from hydrogen-antihydrogen annihilation are important step towards the establishment of a cold fusion power station.

关键词： Cold Fusion Annihilation Energy Plasma Energy Ion-Acoustic Plasma Cold and Hot Plasma Matter-Antimatter Plasma in Molecular Crystals Fuel for Space Shuttles in Palladium Crystals