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Astragalus adscendens extract shows antidiabetic effects through controlling oxidative stress,inflammation and apoptosis in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第6期13卷 242-249页

作者： Yosra Raziani Kimia Karami hamid reza mohammadi Hossein Mahmoudvand Mohammad Nabi Moradi Javad Ghasemian Yadegari Nursing Department Al-Mustaqbal University College51001 HillahBabylonIraq Razi Herbal Medicines Research Center Lorestan University of Medical SciencesKhorramabadIran Molecular and Cellular Laboratory School of Allied MedicineLorestan University of Medical SciencesKhorramabadIran

Objective:To assess the effect of oral treatment of methanolic extract of the aerial parts of Astragalus adscendens in streptozotocin-induced diabetic ***:In order to induce diabetes,rats intraperitoneally received streptozotocin at 65 mg/*** adult male Wistar rats were allocated into six groups(10 rats per each)including the healthy control group,the diabetic group as well as the diabetic group treated with Astragalus adscendens methanolic extract at 50,100,and 200 mg/kg per day or glibenclamide(0.6 mg/kg/day)for 28 *** effects of Astragalus adscendens methanolic extract on the levels of glucose,insulin,alanine aminotransferase,alkaline phosphatase,aspartate aminotransferase,bilirubin,creatinine,urea,uric acid,total protein,albumin,triglyceride,cholesterol,α-amylase,oxidant/antioxidant enzymes,and inflammatory cytokines were *** time-PCR was also used for measuring the gene expression of caspase-3,Bcl2,and ***:The levels of glucose,cholesterol,triglyceride,creatinine,urea,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,bilirubin,and malondialdehyde considerably declined(P<0.001)in diabetic rats after treatment with Astragalus adscendens methanolic extract especially at a dose of 200 mg/*** addition,treatment with Astragalus adscendens methanolic extract noticeably increased the level of insulin,total protein,and albumin as well as improved the activities of catalase,glutathione peroxidase,and superoxide dismutase,as well as the expression levels of TNF-α,IL-1β,caspase-3,Bcl2 and Bax(P<0.001)compared to the diabetic control *** extract also inhibitedα-amylase in a dose-dependent manner with an IC_(50)value of 19.6μg/***:Astragalus adscendens methanolic extract shows potent antidiabetic,anti-inflammatory,anti-apoptotic,and antioxidant effects in diabetic ***,more studies are needed to verify the underlying mechanism of the effect of this plant extract and test its effica

关键词： Herbal medicines Astragalus adscendens Diabetes Antioxidant Antidiabetes Streptozotocin Antiinflammation

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Influences of adsorptions of some inorganic molecules on electronic, optical, and thermodynamic properties of Mg_(12)O_(12) nanocage: A computational approach

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Chinese Physics B 2018年第8期27卷 280-289页

作者： Asghar mohammadi Hesari hamid reza Shamlouei Chemistry Department Lorestan UniversityI(horram AbadLorestanIraa

According to density functional theory, we investigate the effects of BF3, BF4, BCI3, A1F3, AICI3, A1Br3, 13eF3, GaF3, GaC13, GaBr3, NO3, BS2, BSO, BO2, F2, PFs, PC15, and ASF5 molecules on the geometric, electronic, linear, and nonlinear optical properties of an Mg12012 nanocage. The thermodynamic stability and feasibility of the adsorption process are investigated by analyzing the free energy. It is shown that the adsorptions of almost all molecules on the Mg12OI2 surface are exothermic. The calculations of the polarizability of these nanoclusters show that among the studied molecules, BeF3 has the largest influence on the polarizability value （a≈315 a.u., the unit a.u. is short for atomic unit）. The static first hyperpolarizability （β0） value is increased in the presence of these superhalogens. This increase is greatest for BeF3 and BF4 of which the highest value of the first hyperpolarizability （βO≈ 5775 a.u.） is related to a BeF3_c（e@Mgl2Ol2） nanocluster. The adsorption position is a key to estimating the value of increasing the first hyperpolarizability.

关键词： Mg1201 polarizability hyperpolarizability binding energy nanocage DFT calculation

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Influence of alkali metal superoxides on structure,electronic,and optical properties of Be_(12)O_(12) nanocage:Density functional theory study

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Chinese Physics B 2016年第9期25卷 381-387页

作者： Ali Raoof Toosi hamid reza Shamlouei Asghar mohammadi Hesari Lorestan University Chemistry Department

The effect of alkali metal superoxides M_3O（M = Li,Na,K） on the electronic and optical properties of a Be_（12）O_（12） nanocage was studied by density functional theory（DFT） and time-dependent density functional theory（TD-DFT）.The energy gaps（Eg） of all configurations were ***,the adsorption of alkali metal superoxides on the Be_（12）O_（12） nanocage causes a decrease of *** dipole moment μ,polarizability α,and static first hyperpolarizability β were calculated and it was shown that the adsorption of alkali metal superoxides on Be_（12）O_（12） increases its *** was found that the absorption of M_3 O on Be_（12）O_（12） nanocluster improves its nonlinear optical *** highest first hyperpolarizability（β≈ 214000 a.u.） is obtained in the K_3O–Be_（12）O_（12）*** TD-DFT calculations were performed to investigate the origin of the first hyperpolarizabilities and it was shown that a higher first hyperpolarizability belongs to the structure that has a lower transition energy.

关键词： Be_(12)O_(12) alkali metal superoxides hyperpolarizability DFT calculation

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Exponential B-spline collocation method for numerical solution of the generalized regularized long wave equation

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Chinese Physics B 2015年第5期24卷 177-190页

作者： reza mohammadi Department of Mathematics University of Neyshabur

The aim of the present paper is to present a numerical algorithm for the time-dependent generalized regularized long wave equation with boundary conditions. We semi-discretize the continuous problem by means of the Crank-Nicolson finite difference method in the temporal direction and exponential B-spline collocation method in the spatial direction. The method is shown to be unconditionally stable. It is shown that the method is convergent with an order of θ（k2 ＋ h2）. Our scheme leads to a tri-diagonal nonlinear system. This new method has lower computational cost in comparison to the Sinc-collocation method. Finally, numerical examples demonstrate the stability and accuracy of this method.

关键词： solitary waves GRLW equation exponential B-spline collocation

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1-Methylimidazole-catalyzed reaction between tosylmethyl isocyanide and dialkyl acetylenedicarboxylates:An efficient synthesis of functionalized pyrroles

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Chinese Chemical Letters 2011年第3期22卷 314-317页

作者： Mehdi Adib Bagher mohammadi Ehsan Sheikhi hamid reza Bijanzadeh School of Chemistry University College of ScienceUniversity of TehranPO Box 14155-6455TehranIran Department of Chemistry Tarbiat Modarres UniversityPO Box 14115-175TehranIran

An efficient 1-methylimidazole-catalyzed synthesis of dialkyl 2-[（4-methylphenyl）sulfonyl]-1H-pyrrole-3,4-dicarboxylates is *** reactive 1：1 zwitterionic intermediate formed by the addition of 1-methylimidazole to dialkyl acetylenedicarboxylates is trapped by tosylmethyl isocyanide（TOSMIC） to afford the title compounds in excellent yields.

关键词： 1-Methylimidazole Tosylmethyl isocyanide Acetylenic esters Pyrrole synthesis

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Evaluation of the effects of Alkyl Phenolic compounds on kinetic coefficients and biomass activity in MBBR by means of respirometric techniques

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Chinese Journal of Chemical Engineering 2018年第4期26卷 822-829页

作者： Bijan Bina Farzaneh mohammadi Mohammad Mehdi Amin hamid reza Pourzamani Zeynab Yavari Environment Research Center Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences Department of Environmental Health Engineering School of Health Isfahan University of Medical Sciences Student Research Committee Isfahan University of Medical Sciences

The presence of Alkyl Phenols(APs) in aquatic systems is considered as one of the environmental concerns in recent decades which are generally used as surfactants. APs are endocrine disruptors and estrogen-mimicking,causing harmful effects such as feminization and carcinogenesis on aquatic environment and human *** most commercially important APs are 4-Nonyl Phenol(4-NP) and 4-tert-OctylP henol(4-t-OP). Moving bed biofilm reactor(MBBR), which combined attached and suspended growth advantages, is an advanced biological treatment process for municipal and industrial wastewaters that has drawn considerable attention from many researchers to remove toxic pollutants from wastewater. The aim of this research was to evaluate Bacterial activities and kinetic coefficients in the presence of APs. This study was carried out using laboratory-scale MBBR fed with synthetic wastewater containing 4-NP and 4-t-OP. The reactor was operated at different loads of chemical oxygen demand(COD) and APs and different hydraulic retention time(HRT). The respirometric technique was applied to investigate the effect of APs on heterotrophic and autotrophic activity and kinetic coefficients in biomass obtained from MBBR. Respirometric technique demonstrates a reliable tool in order to assess the biofilm kinetic coefficients and biomass viability to insert in the mathematical models. The calculated kinetic parameters were in the range of conventional and extended aeration activated sludge processes. The results demonstrate that APs have significant inhibitory effects on activity and growth rate of heterotrophic and autotrophic bacteria, heterotrophs have been less affected by the presence of 4-NP and 4-t-OP, and these compounds had greater inhibitory effects on autotrophic bacteria.

关键词： Alkyl Phenols Autotrophs Heterotrophs Kinetic coefficients MBBR Respirometric techniques

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Determination of 4-nonylphenol and 4-tert-octylphenol compounds in various types of wastewater and their removal rates in different treatment processes in nine wastewater treatment plants of Iran

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Chinese Journal of Chemical Engineering 2018年第1期26卷 183-190页

作者： Bijan Bina Farzaneh mohammadi Mohammad Mehdi Amin hamid reza Pourzamani Zeynab Yavari Environment Research Center School of HealthIsfahan University of Medical Sciences Student Research Center School of HealthIsfahan University of Medical Sciences

Alkylphenols(APs), considered as xenoestrogenic compounds, mainly exist as 4-nonylphenol(4-NP) and 4-tertoctylphenol(4-t-OP) in environments. The high stability and accumulation of APs in aquatic systems have caused endocrine disruption. In this study we measured APs in the wastewater influent and effluent samples, from the urban, rural, livestock, commercial and hospital wastewater treatment plants(WWTPs) in Iran. Dispersive liquid–liquid microextraction(DLLME) combined with gas chromatography–mass spectrometry(GC–MS) was used for the extraction and determination of 4-NP and 4-t-OP. In these treatment plants, various processes such as activated sludge, aerated lagoon, moving bed biofilm reactor and activated sludge along with wetland were applied. The highest concentration of 4-NP and 4-t-OP was observed in commercial and livestock sewages. The activated sludge along with wetland and then the MBBR process showed the highest removal rates of pollutants. The rates of biodegradability and accumulation in sludge were determined and also the specific adsorption coefficient Kdand the organic carbon–water partition coefficient kOCof the sludge for APs were calculated.

关键词： Alkylphenols DLLME Full scale WWTP Biodegradation Adsorption

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Effect of metal oxide arrester on the chaotic oscillations in the voltage transformer with nonlinear core loss model using chaos theory

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Chinese Physics B 2014年第1期23卷 480-488页

作者： hamid reza Abbasi habbasi@iust.ac.ir Amirkabir University Electrical Engineering Department Tehran 64540 Iran

In this paper, controlling chaos when chaotic ferroresonant oscillations occur in a voltage transformer with nonlin- ear core loss model is performed. The effect of a parallel metal oxide surge arrester on the ferroresonance oscillations of voltage transformers is studied. The metal oxide arrester （MOA） is found to be effective in reducing ferroresonance chaotic oscillations. Also the multiple scales method is used to analyze the chaotic behavior and different types of fixed points in ferroresonance of voltage transformers considering core loss. This phenomenon has nonlinear chaotic dynamics and includes sub-harmonic, quasi-periodic, and also chaotic oscillations. In this paper, the chaotic behavior and various ferroresonant oscillation modes of the voltage transformer is studied. This phenomenon consists of different types of bifur- cations such as period doubling bifurcation （PDB）, saddle node bifurcation （SNB）, Hopf bifurcation （HB）, and chaos. The dynamic analysis of ferroresonant circuit is based on bifurcation theory. The bifurcation and phase plane diagrams are il- lustrated using a continuous method and linear and nonlinear models of core loss. To analyze ferroresonance phenomenon, the Lyapunov exponents are calculated via the multiple scales method to obtain Feigenbaum numbers. The bifurcation diagrams illustrate the variation of the control parameter. Therefore, the chaos is created and increased in the system.

关键词： ferroresonance chaos theory metal oxide arrester Lyapunov exponent

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Application of consistent geometric decomposition theorem to dynamic finite element of 3D composite beam based on experimental and numerical analyses

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Frontiers of Structural and Civil Engineering 2020年第3期14卷 675-689页

作者： Iman FATTAHI hamid reza MIRDAMADI hamid ABDOLLAHI Department of Mechanical Engineering Isfahan University of TechnologyIsfahan ***Iran

Analyzing static and dynamic problems including composite structures has been of high significance in research efforts and industrial *** this article,equivalent single layer approach is utilized for dynamic finite element procedures of 3D composite beam as the building block of numerous composite *** this model,both displacement and strain fields are decomposed into cross-sectional and longitudinal components,called consistent geometric decomposition ***,the model is discretized using finite clement *** local coordinate systems and a global one are defined to decouple mechanical degrees of ***,from the viewpoint of consistent geometric decomposition theorem,the transformation and element mass matrices for those systems are introduced here for the first *** same decomposition idea can be used for developing element stiffiness ***,comprehensive validations are conducted for the theory against experimental and numerical results in two case studies and for various conditions.

关键词： composite beam dynamic finite element degrees of freedom coupling experimental validation numerical validation

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Functionalized Graphene Oxide with Bismuth and Titanium Oxide Nanoparticles for Efficiently Removing Formaldehyde from the Air by Photocatalytic Degradation-Adsorption Process

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Journal of Analysis and Testing 2023年第4期7卷 444-458页

作者： Mohsen mohammadi Asl hamid Shirkhanloo Nabiollah Mansouri Seyed Ali reza Haji Seyed Mirzahosseini Farideh Atabi Department of Environmental Engineering Faculty of Natural Resource and EnvironmentScience and Research BranchIslamic Azad UniversityTehran 14778-93855Iran Research Institute of Petroleum Industry(RIPI) West BoulevardOlympic VillageTehran 14857-33111Iran

Formaldehyde(HCHO)is formed through the oxidation of volatile organic compounds(VOCs)and can cause human *** oxide and titanium oxide nanoparticles-functionalized nanographene oxide(Bi_(2)O_(3)/TiO_(2)@NGO)were used to rapidly remove the HCHO from the air by a photocatalytic degradation-adsorption process(PC-DAP).The formaldehyde vapor in pure air was generated in a dynamic system within a chamber,and flowed over Bi_(2)O_(3)/TiO_(2)@NGO adsorbent inside a fixed-bed quartz reactor(FBQR)under UV irradiation at optimized conditions(250C).At atmospheric pressure,the flow rate and gas hourly space velocity(GHSV)were adjusted to 300 mL/min and 100-450 L/h,*** radicals of HCHO and nanographene oxide(NGO)were generated through the UV-photochemical process,enhancing the chemical adsorption through the radicals’*** the other hand,the semi-degradation process by catalytic oxidation process converted some HCHO into raw materials of CO_(2)and H_(2)O,while the unconverted HCHO was physically absorbed by ***,the HCHO concentration in the outlet system was measured by gas chromatography with a flame ionization detector(GC-FID)after derivatizing formaldehyde with 2,4-dinitrophenylhydrazine(DNPH)and ***,efficient removal of HCHO from the air,the removal efficiency of more than 95%,was achieved through physical/chemical adsorption and the *** mean removal efficiencies for HCHO with Bi_(2)O_(3)-TiO_(2)@NGO,TiO_(2)@NGO,Bi_(2)O_(3)@NGO,and NGO were 98.7%,73.6%,61.8%,and 11.4%,respectively(n=10,RSD<5%).The methodology was validated by spiking different concentrations of standard HCHO into pure air.

关键词： Formaldehyde removal Air Functionalized graphene oxide UV radiation Photocatalytic degradation-adsorption process

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