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Serum Level of Vitamin C in a Sample of Egyptian Patients with multiple Sclerosis

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Neuroscience & medicine 2019年第4期10卷 398-406页

作者： Asmaa Ibrahim Taha K. Alloush Yousry Abo Elnaga mohamed hamdy mohamed m. Fouad Department of Neurology Faculty of Medicine Ain Shams University Cairo Egypt

Background: Antioxidants such as vitamin C can eliminate free radicles responsible for oxidative stress. Objective: To assess the serum level of vitamin C in a sample of multiple sclerosis (mS) patients to investigate a possible role of vitamin C in the pathogenesis of mS. Subjects and methods: Forty patients with mS and twenty healthy controls were included in this study. Vitamin C level was estimated for each participant. Results: Serum vitamin C levels were significantly lower among the patients (ranging from 0.28 mg/dL to 0.75 mg/dL with mean 0.47 ± 0.14 mg/dL and median of 0.46 mg/dL) compared to controls (ranging from 0.60 mg/dL to 2.90 mg/dL with mean 1.87 ± 0.61 mg/dL and median of 1.90 mg/dL) (P Conclusion: Patients with mS tended to have low serum vitamin C levels, and younger patients had lower serum levels.

关键词： Vitamin C multiple Sclerosis

A New model of Drug-Disease Interaction in Rabbits

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Journal of Pharmacy and Pharmacology 2017年第8期5卷 591-605页

作者： Sahar K. Hegazy Noha A. hamdy Ahmed G. Adam Nawal m. Khalafallah Faculty of Pharmacy Tanta University Tanta Egypt Faculty of Pharmacy Pharos University Alexandria Egypt Faculty of medicine Alexandria University Alexandria Egypt Faculty of Pharmacy Alexandria University Alexandria Egypt

Background： Drug-infection interaction should be considered in drug prescribing, particularly if potentiated byco-occuring drug-drug interactions. The effects of Candida and e-coli infections separately, and fluconazole administration weretested on cyclosporine blood level in rabbits. methods： Three study designs were carried out, crossoversingle-dose-fluconazole-cyclosporine study testing fluconazole-cyclosporine interaction, multi-dosecandida-fluconazole-cyclosporine and multi-dose escherichia coli-cyclosporine study designs involving each rabbit acting as itscontrol; cyclosporine was given daily in both studies. Candida and e-coli infections were inoculated on day 5. In themulti-Candida-Fluc-CyA, fluconazole-cyclosporine interaction was also considered, and flueonazole was administered daily fromday 9-18. In all three studies, Cyclosporine trough levels and serum creatinine were measured by CmIA and enzymatic assayrespectively, pre, during, post-infection and after fluconazole administration in the Candida study. Results： Both infections resulted insignificant rise in cyclosporine trough level （p = 0.018） and （p = 0.005） in fungal and bacterial studies, respectively. The median risein CyA level reached 52% （range 9-426%） in the Candida infection and reached 60 - 47.5% （mean） with the e-coli *** also increased mean cyclosporine trough levels in the single-dose study by 70.3 - 45.3 and the concomitant rise inthemulti-dose study reached 76% （median, range 22-665%）. Conclusions： Cyclosporine trough levels increased during Candida ande-coli infections and also during fluconazole administration in the single and multi-dose studies. Fluconazole exerted an additiveeffect to the Candida inhibitory effect. Type of infection and inoculum size affected CyA levels differently. monitoring cyclosporinelevel during episodes of infection as well as in therapy regimen involving interacting drugs is advisable.

关键词： Candida, cyclosporine, CYP450, disease-interaction, e-coli, rabbits.

Role of Transcranial Direct Current Stimulation in the management of Post-Stroke Depression

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Neuroscience & medicine 2020年第1期11卷 1-11页

作者： T. Alloush E. Fayez I. Abd-Allah Al-Azab m. Bouls m. hamdy Neurology and Psychiatry Department Faculty of Medicine Ain Shams University Cairo Egypt Physical Therapy Department for Neuromuscular Disorder and Its Surgery Faculty of Physical Therapy Cairo University Cairo Egypt

Study Objectives: Stroke is a major neurological disease significantly threatening the human health and life with a high morbidity, disability, and mortality. Post-stroke depression (PSD) is one of the common complications of stroke. PSD has been a major factor hindering the recovery of neurological functions and daily activities in stroke patients and is closely related to the social avoidance and increased mortality of stroke patients. Although antidepressant drug treatment has improved during the last decades, symptoms in about 20% of the patients are not in remission two years after initiation of pharmacological intervention. Nowadays, non-invasive brain stimulation;techniques;transcranial direct current stimulation (tCDS) has gained an important interest in the treatment of many neuropsychiatric disorders which might be of some help in treatment of PSD. The goal of the current study is to evaluate the beneficial short term role of tDCS on post-stroke depression. Study Design: This was a randomized double blind placebo-controlled clinical trial included forty hemiparetic patients with post-stroke depression from outpatient clinic of Faculty of Physical Therapy, Cairo university, in the period between June 2018 to June 2019. All patients diagnosed as having a PSD according to the Diagnostic and Statistical manual of mental Disorders (DSm-5). Depression was evaluated by Hamilton Depression Rating Scale (HAm-D) pre and post treatment and quality of life was evaluated by the Stroke Specific Quality Of Life scale (SS-QOL). Patients were assigned randomly into two groups: the study group A and the control group B. Both groups received antidepressant medication in addition to physical therapy program. Group A received tCDS for 30 minutes, three times per week for one month, while the group B received sham transcranial direct current stimulation. Results: Active tDCS was significantly superior to sham with significant improvement in depression and Stroke Specific Qualit

关键词： Post-Stroke Depression Transcranial Direct Current Stimulation Diagnostic and Statistical manual of mental Disorders

Oral Vinorelbine as Switch maintenance Therapy versus Best Supportive Care in Patients with Advanced Adenocarcinoma Non-Small Cell Lung Cancer EGFR Wild Type

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Journal of Cancer Therapy 2019年第12期10卷 908-914页

作者： Amen hamdy Zaky Ahmed Refaat Abd Elzaher Ola Nabih medical Oncology Department South Egypt Cancer Institute Assuit University Assuit Egypt Clinical Oncology Department Faculty of Medicine Assuit University Assuit Egypt

Background: This study was performed to evaluate the efficacy and safety of switch maintenance therapy with oral vinorelbine in advanced non-small cell lung cancer (NSCLC) with adenocarcinoma limited to epidermal growth factor receptor (EGFR) wild type. materials and methods: In this single randomized trial, patients with advanced stage (IIIB and IV) NSCLC with adenocarcinoma EGFR wild-type status, treated with 6 cycles of platinum based chemotherapy. Patients did not show progression after first-line chemotherapy were randomly assigned to receive switch maintenance with vinorelbine (80 mg/m2, day 1, 8) (group I) or the best supportive care until disease progression (group II). Results: The median progression free survival (PFS) was 9.7 months for group I versus 5.7 months for group II with statistically significant difference between both groups [HR = 1.15;95% CI 1.19 to 1.49;P value = 0.002], while the median overall survival (OS) was 13.2 months for group I versus 11.9 months for group II with no statistically significant differences between both groups [HR = 1.24;95% CI 1.05 to 1.46;P value = 0. 3]. The patients who received oral vinorelbine had tolerable toxicity profile. Conclusion: Switch maintenance therapy with oral vinorelbine, though improve PFS, did not improve OS in patients with NSCLC with adenocarcinoma EGFR wild type.

关键词： Lung Cancer maintenance Chemotherapy Vinorelbine EGFR-Wild Type

Outcome of Laparoscopic Resection for Left Sided Colon and Rectal Cancer

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Journal of Cancer Therapy 2017年第1期8卷 51-63页

作者： hamdy abdelhady Taha A. Esmail mohamed A. Hablus Osama Hassan mahmoud Elsherif mohamed m. Elshheikh General Surgery Department Tanta Faculty of Medicine Tanta Egypt

Background: For many years, traditional surgery for left colon and rectal cancers had developed with variable degrees of morbidity. With the evolution of laparoscopy and by the aid of better visualization and magnification, laparoscopic colorectal surgery had appeared, but technically challenging as it involves almost all advanced laparoscopic techniques, with the benefits of minimal morbidity, less pain, earlier recovery, shorter hospital stay, without compromising oncological results. Aim: The aim of this work was to evaluate laparoscopic resection for left sided colon and rectal cancer as regard feasibility, safety and outcomes. Patients and methods: This prospective study was conducted on 40 patients having left sided colon and rectal cancer, including 29 patients with rectal cancer and 11 patients with left sided colon cancer within the inclusion criteria are evaluated by clinical examination, radiological and colonoscopic study and biopsy and treated by laparoscopic resection and followed ranged from 6 months to 2 years with mean of 20 months. Results: Twenty seven patients (67.5%) underwent laparoscopic anterior resection, 11 patients (27.5%) underwent laparoscopic left hemicolectomy and only 2 patients (5%) underwent laparoscopic abdominoperineal resection, minimal morbidity, no cancer related mortality and no recurrence during the period of follow up either local or systemic. Conclusion: Laparoscopic resection for left sided colon and rectal cancer is technically feasible, oncologically safe and has more benefits on postoperative recovery.

关键词： Laparoscopic Colorectal Surgery

Assessment of Sleep Pattern in Egyptian Elderly with Vascular Dementia

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Neuroscience & medicine 2019年第2期10卷 82-100页

作者： A. Alloush H. Sweed A. abdelnaser R. El Akkad m. A. Tork m. mortada m. hamdy Department of Geriatrics and Gerontology Faculty of Medicine Ain Shams University Cairo Egypt Department of Neurology and Psychiatry Faculty of Medicine Ain Shams University Cairo Egypt

Study Objectives: Growing evidence suggests that sleep disturbances is common in vascular dementia (VaD). The goal of the current study is to assess the disturbance in sleep pattern in patients with VaD, and compare it to healthy normally cognitive elderly individuals. We next studied whether there are meaningful differences in the Subjective sleep assessment: Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI) and sleep measurements by polysomnography (PSG) in VaD patients. Study design: Case control study. Subject and methods: Overnight PSG recordings and self-reported sleep measures were obtained from 20 healthy elderly subjects and 20 VaD patients at the sleep laboratory. Results: This study showed abnormal subjective sleep quality in all patients and revealed that the most common sleep complaints among VaD patients were: excessive daytime sleepiness (EDS), sleep disordered breathing (SDB), insomnia, restless leg syndrome (RLS), periodic limb movements (PLmS) and REm behavioral disordered (RBD) respectively. moreover, patients spent more time in stage I sleep, but less time in slow wave sleep (SWS) and REm sleep compared to control populations, with delayed REmL and less 1st REmL. Also, increased sleep fragmentation;wakefulness after sleep onset (WASO) & sleep fragmentation index (SFI), increased arousal index (AI) & PLmS index were detected in VaD patients. Finally, VaD patients had significant high Apnea, Hypopnea and Respiratory Distress Index (RDI) score with high average SpO2 Desaturation. Conclusions: Sleep is significantly impaired in patients with VaD at both the objective and subjective level, which may be used as a diagnostic marker of VaD. SDB is a common feature of VaD and leads to fragmented sleep, increased nocturnal confusion, and excessive daytime sleepiness. Subjective sleep assessment questionnaire (ESS and PSQI) can be used in VaD patients when objective sleep assessment by PSG recordings is difficult to be done. The PSG stud

关键词： REm and NREm Sleep Disturbances Vascular Dementia Alzheimer Dementia Vascular Cognitive Impairment Subjective Sleep Assessment Polysomnography Brain magnetic Resonance Imaging

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汉阿条件复句对比研究

汉阿条件复句对比研究

作者：穆子晖（m.hamdy）山东师范大学

学位级别：硕士

中国是个伟大的国家。近年来中国的发展速度日趋加快，国际地位也不断提升。随着中国跟阿拉伯国家的关系日益增近,语言的差异逐渐成了不可小觑的障碍。因此阿拉伯语国家许多学习者开始学汉语。语言是表达思想的手段，复句作为一种语言手... 详细信息

中国是个伟大的国家。近年来中国的发展速度日趋加快，国际地位也不断提升。随着中国跟阿拉伯国家的关系日益增近,语言的差异逐渐成了不可小觑的障碍。因此阿拉伯语国家许多学习者开始学汉语。语言是表达思想的手段，复句作为一种语言手段,在社会交际中具有很重要的使用价值。同时复句是语言最重要语法点之一，其使用频率很高，如果想表达比较复杂的思想，往往得使用复句。复句可分为诸多种类，本文研究的是条件复句。本文探讨的内容是汉阿条件复句的对比分析。汉语和阿语条件复句在很多方面都具有共同点,当然也存在许多不同点。论文在前人研究的基础上,通过查阅大量相关资料,运用对比分析法,总结了汉阿条件复句的特点与分类,研究汉阿条件复句的句法、语义、语用方面并对两种语言的条件复句进行对比。本文分为六章。第一章是绪论，主要介绍本文选题的理由与意义、研究目标、研究方法、研究内容和国内外学界对条件复句的研究成果。第二章主要介绍汉语条件复句的定义、分类以及每个分类的主要特征与最常用的关联词语。第三章主要介绍阿拉伯语的条件复句，包括定义，构成的成分，最常用的条件工具词。第四章的主要内容是汉阿条件复句的对比，包括相同点与不同点。第五章主要给汉语条件复句学习者提出一些有用的建议。最后第六章是结束语,对全文进行概括和总结,并指出论文不足之处。

关键词：汉语条件复句阿拉伯语条件复句对比研究关联词语

1961～2015年黑龙江省西部半干旱区气候变化评估

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1961～2015年黑龙江省西部半干旱区气候变化评估

作者： mahmoud mohammed Ahmed hamdy Hassanien 扬州大学

学位级别：硕士

1.绪论1.1背景和意义研究干旱变化对区域生态环境保护和可持续发展具有重要意义。根据世界气象组织(WmO)的统计,全球气象灾害约占所有自然灾害的70%,而干旱占所有气象灾害的比例达50%。干旱带来的损失也是自然灾害中最大的。近几十年来... 详细信息

1.绪论1.1背景和意义研究干旱变化对区域生态环境保护和可持续发展具有重要意义。根据世界气象组织(WmO)的统计,全球气象灾害约占所有自然灾害的70%,而干旱占所有气象灾害的比例达50%。干旱带来的损失也是自然灾害中最大的。近几十年来,全球干旱情况变得更加严重,影响也更为广泛。干旱也是我国农业面临的主要挑战性自然灾害之一,位于黑龙江省西部半干旱区的松嫩平原是我国重要的商品粮基地。该区处于我国东北高纬度寒区,半干旱季风气候显著,年降水量时空分布不均,冬季积雪少,春季干旱频发,气象条件对农业生产非常不利。开展该地区干旱变化特性与评估的研究,可为该地区防治和减轻干旱的影响,科学评价气候演变特征以及实现水资源的科学管理提供基础数据。对保障黑龙江省西部粮食产能和农业的可持续发展以及实现生态安全具有重要意义。1.2研究内容和技术路线1.2.1主要研究内容(1)黑龙江省西部半干旱区干旱特性评估选取具有黑龙江省西部半干旱气候特性的典型研究区,采用不同的单位时间间隔(1、3、6、12、24个月),推求研究区各时间间隔的标准化降水指数(Standardized Precipitation Index,SPI)和标准化降水-蒸散指数(Standardized Precipitation Evapotranspiration Index,SPEI),通过对不同时间间隔SPI和SPEI结果的分析,评价研究区各时间尺度的气象干旱特征及趋势。(2)主要气象因子的时间变异性分析采用变异系数法,计算研究区研究时段内各主要气象因子如降水量、气温、湿度、日照时数等年平均值序列的变异系数,通过对各气象因子变异系数的分析,对研究区各因子的变异性进行评价。(3)主要气象因子对降水的影响程度分析以年降水量为因变量,气温、相对湿度、日照时数和风速为自变量,构建多元线性回归模型,评价各因子对年降水量的线性相关程度以及影响的大小。(4)SPI和SPEI相关性分析针对不同的时间尺度(1、3、6、12和24个月)建立线性回归模型,以SPEI为因变量,SPI为自变量构建线性预测模型,验证各时间尺度SPEI和SPI值之间的差异性以及评价SPI和SPEI之间的线性关系。1.2.2技术路线根据研究的主要内容、所采用的研究方法和手段,拟采用的技术路线图如图1所示。2.材料和方法2.1研究区简介研究区位于黑龙江省西部(46°14’24"22°2624"25°31’48"E)(见图2),该区主要位于齐齐哈尔地区境内,处于松嫩平原腹地,冬季漫长寒冷,夏季短暂凉爽,年均气温2.0.5°C;多年平均降雨量450mm左右,降雨季节性分布不均,超过80%集中在6月的雨季;年潜在蒸散发量超过1000 mm,年降雨蒸发比在0.2.5之间,为半干旱区。研究区位置如图2所示。2.2气象数据收集在国家气象科学数据中心获取了研究区1961015年6个气象站的逐日气象数据(降水量、温度、相对湿度、太阳辐射和风速),气象站的分布如图2所示。2.3研究方法2.3.1 SPI和SPEI SPI是由美国科学家mcKee等于1993年提出的一种多时间尺度干旱指数,采用Gamma函数来描述降水量的变化,只需降水量即可计算,通过SPI值可判别所评价的时间尺度内是否发生了干旱及其对应的等级,计算过程见文献。1月尺度SPI(SPI1)和3月尺度SPI(SPI3)能够反映短期气象旱涝特征,与农业干旱关系密切;6月尺度SPI(SPI6)和12月尺度SPI(SPI12)可以清楚地反映长期的旱涝变化特征,其中,SPI2对长期旱涝影响及持续时段具有显著的标识功能,通常与河流水位,水库水位,甚至地下水位相关度较高,因此,多种时间尺度的SPI综合应用可实现对旱涝的综合监测评估。SPEI的计算是基于月降水与同期潜在蒸散量的差值D=P-PET(D为月降水量与潜在蒸散量的差值;P为月降水量,为月潜在蒸散发量,单位均为mm),采用Log-logistic分布函数对A数据序列求累积概率,进行正态化,最终可得到不同时间尺度如1、3、6、9、12、24月等的SPEI值,计算过程可参考文献。mcKee等(1993)基于SPI值对干旱进行了分级。在某些同类研究中,对mackee(1993)基于SPI值的干旱分级标准进行了拓展,并包含了湿润分级,也有研究采用SPEI值对干旱(含湿润)进行分级,丰富和发展了干旱分级方法。本文在参考同类研究对干旱(含湿润)分级方法的基础上,采用不同SPI和SPEI值对干旱等级进行划分(见表1)。PET的计算方法有很多种,FAO-56推荐的彭曼-蒙蒂斯(P-m)公式(式1)综合考虑了温度、太阳辐射量、风速和相对湿度对蒸散发的影响,因此,本文采用P-m公式推求尸五r。(?)式中:为潜在蒸散发量,rrmrd;A为不同温度下饱和水汽压曲线上的斜率,

关键词：黒龙江省西部半干旱区气候变化标准化降水指数标准化降水-蒸散指数多元线性回归分析

Small for size syndrome difficult dilemma: Lessons from 10 years single centre experience in living donor liver transplantation

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World Journal of Hepatology 2017年第21期9卷 930-944页

作者： Hany Shoreem Emad hamdy Gad Hosam Soliman Osama Hegazy Sherif Saleh Hazem Zakaria Eslam Ayoub Yasmin Kamel Kalid Abouelella Tarek Ibrahim Ibrahim marawan Hepatobiliary Surgery Department National Liver InstituteMenoufiya Univer-sity Anesthesia Department National Liver InstituteMenoufiya University

AIm To analyze the incidence, risk factors, prevention, treatment and outcome of small for size syndrome(SFSS) after living donor liver transplantation(LDLT). mETHODS Through-out more than 10 years: During the period from April 2003 to the end of 2013, 174 adult-to-adults LDLT(A-ALDLT) had been performed at National Liver Institute, menoufiya university, Shibin Elkoom, Egypt. We collected the data of those patients to do this cohort study that is a single-institution retrospective analysis of a prospectively collected database analyzing the incidence, risk factors, prevention, treatment and outcome of SFSS in a period started from the end of 2013 to the end of 2015. The median period of follow-up reached 40.50 m, range(0-144 m). RESULTS SFSS was diagnosed in 20(11.5%) of our recipients. While extra-small graft [small for size graft(SFSG)], portal hypertension, steatosis and left lobe graft were significant predictors of SFSS in univariate analysis(P = 0.00, 0.04, 0.03, and 0.00 respectively); graft size was the only independent predictor of SFSS on multivariate analysis(P = 0.03). On the other hand, there was lower incidence of SFSS in patients with SFSG who underwent splenectomy [4/10(40%) SFSS vs 3/7(42.9%) no SFSS] but without statistical significance, However, there was none significant lower incidence of the syndrome in patients with right lobe(RL) graft when drainage of the right anterior and/or posterior liver sectors by middle hepatic vein, V5, V8, and/or right inferior vein was done [4/10(28.6%) SFSS vs 52/152(34.2%) no SFSS]. The 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients with SFSS were 30%, 30%, 25%, 25%, 25% and 25% respectively, while, the 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients without SFSS were 70.1%, 65.6%, 61.7%, 61%, 59.7%, and 59.7% respectively, with statistical significant difference(P = 0.00). CONCLUSION SFSG is the independent and main factor for occurrence of SFSS after A-ALDLT leading to poor outcome. However, the mana

关键词： Living donor liver transplantation Outcome after living donor liver transplantation Small for size syndrome Small for size graft Portal inflow Venous outflow