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Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus(MRSA)-infected wounds in rabbits

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Asian Pacific Journal of Tropical Biomedicine 2023年第11期13卷 488-496,I0002页

作者： Muhammad Asif Ayesha Safdar Chaudhry Ambreen Ashar hamad bin rashid Muhammad Hassan Saleem Hassaan bin Aslam Abdul Aziz Department of Veterinary Surgery University of Veterinary and Animal SciencesLahorePunjabPakistan TECS Department Wilson College of TextilesNC State UniversityRaleigh 27606USA Department of Veterinary Medicine University of Veterinary and Animal SciencesLahorePunjabPakistan Institute of Microbiology University of Veterinary and Animal SciencesLahorePunjabPakistan Department of Veterinary Clinical Sciences University of PoonchRawalakot 12350Pakistan

Objective:To synthesize zinc oxide nanoparticles(ZnONPs)and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus(MRSA).Methods:ZnONPs were prepared by sol-gel method and characterized by X-ray diffraction(XRD)analysis and scanning electron microscopy(SEM).A total of 18 rabbits were divided into three groups:the ZnONPs group,the gentamicin group and the control group.A wound of 3 cm^(2) was inflicted on each rabbit and contaminated with MRSA *** was started from the fourth day *** healing,microbiological analysis,and histopathological analysis were performed to assess the efficacy of ZnONPs ***:XRD analysis confirmed the hexagonal wurtzite structure of the ZnONPs with an average crystallite size of 29.23 *** revealed discoid-shaped ZnONPs with a rough surface and an average size of 48.36 ***-dispersive X-ray analysis confirmed the purity of ***,the particle size ranged from 100-700 nm with a high agglomeration *** with ZnONPs promoted MRSA-infected wound *** addition,ZnONPs showed a good antibacterial effect as evidenced by a dose-dependent increase in the zone of ***:ZnONPs accelerate the healing of MRSA-infected ***,it can be explored for the treatment of MRSA infection.

关键词： MRSA Wound healing ZnO Nanoparticles Ointment

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Flexible pavement longitudinal joint quality evaluation using non-destructive testing

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Journal of Road Engineering 2024年第2期4卷 189-202页

作者： hamad bin Muslim Syed Waqar Haider Lev Khazanovich Department of Civil and Environmental Engineering Michigan State UniversityEast LansingMI 48824USA Department of Civil and Environmental Engineering University of PittsburghPittsburghPA 15261USA

Longitudinal joint construction quality is critical to the life of flexible *** deteriorated longitudinal joints has become a challenge for many highway *** the joint's quality through better compaction during construction can help achieve flexible pavements with longer service lives and less *** quality control(QC)and quality assurance(QA)plans provide limited ***,the risk of missing areas with poor joint compaction is significant.A density profiling system(DPS)is a non-destructive alternative to conventional destructive evaluation *** can provide quick and continuous real-time coverage of the compaction during construction in *** paper presents several case studies comparing various types of longitudinal joints and demonstrating the use of DPS to evaluate the joint's compaction *** paper shows that dielectric measurements can provide valuable insight into the ability of various construction techniques to achieve adequate levels of compaction at the longitudinal *** paper proposes a dielectric-based longitudinal joint quality index(LJQI)to evaluate the relative compaction of the joint during *** also shows that adopting DPS for assessing the compaction of longitudinal joints can minimize the risk of agencies accepting poorly constructed joints,identify locations of poor quality during construction,and achieve better-performing flexible pavements.

关键词： Sustainable pavements Dielectric/density profiling system Quality assurance Non-destructive testing Asphalt longitudinal joint

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Nodule Detection Using Local binary Pattern Features to Enhance Diagnostic Decisions

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Computers, Materials & Continua 2024年第3期78卷 3377-3390页

作者： Umar rashid Arfan Jaffar Muhammad rashid Mohammed S.Alshuhri Sheeraz Akram Faculty of Computer Science and Information Technology The Superior UniversityLahore54600Pakistan Intelligent Data Visual Computing Research(IDVCR) Lahore54600Pakistan Department of Computer Science National University of TechnologyIslamabad45000Pakistan Department of Radiological Sciences and Medical Imaging College of AppliedMedical SciencesPrince Sattam Bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Information Systems Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh12571Saudi Arabia

Pulmonary nodules are small, round, or oval-shaped growths on the lungs. They can be benign (noncancerous) or malignant (cancerous). The size of a nodule can range from a few millimeters to a few centimeters in diameter. Nodules may be found during a chest X-ray or other imaging test for an unrelated health problem. In the proposed methodology pulmonary nodules can be classified into three stages. Firstly, a 2D histogram thresholding technique is used to identify volume segmentation. An ant colony optimization algorithm is used to determine the optimal threshold value. Secondly, geometrical features such as lines, arcs, extended arcs, and ellipses are used to detect oval shapes. Thirdly, Histogram Oriented Surface Normal Vector (HOSNV) feature descriptors can be used to identify nodules of different sizes and shapes by using a scaled and rotation-invariant texture description. Smart nodule classification was performed with the XGBoost classifier. The results are tested and validated using the Lung Image Consortium Database (LICD). The proposed method has a sensitivity of 98.49% for nodules sized 3–30 mm.

关键词： Pulmonary nodules segmentation histogram thresholding

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Influence of erbium on structural,and charged particles,photons,and neutrons shielding properties of Ba_(1-x)Er_(x)SnO_(3) perovskite ceramics

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Journal of Rare Earths 2024年第4期42卷 724-732页

作者： M.K.h.hamad Nidal Dwaikat M.H.A.Mhareb M.I.Sayyed R.M.hamad Y.S.M.Alajerami M.A.Almessiere Gameel Saleh Ahmad Hussein Alomari K.A.Ziq Department of Basic Sciences School of Social and Basics SciencesAl Hussein Technical UniversityKing Abdullah II St 242Amman11831Jordan Department of Physics College of Engineering and PhysicsInterdisciplinary Research Center for Advanced MaterialsKing Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Department of Physics College of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Basic and Applied Scientific Research Center Imam Abdulrahman Bin Faisal UniversityP0.Box 1982Dammam31441Saudi Arabia Department of Physics Faculty of ScienceIsra UniversityAmman11622Jordan Department of Nuclear Medicine Research Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityPo.Box 1982Dammam31441Saudi Arabia Medical Imaging Department Applied Medical Sciences FacultyAl Azhar University-Gaza CityPo.Box 1277Palestine Department of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityPo.Box1982Dammam 31441Saudi Arabia Department of Biomedical Engineering College of EngineeringImam Abdulrahman Bin Faisal UniversityPo.Box 1982Dammam31441Saudi Energy&Minerals Regulatory Commission Amman11821Jordan

Five perovskite ceramics samples of Ba_(1-x)Er_(x)SnO_(3) with x=0.00,0.05,0.10,0.15,and 0.20 were synthesized using the conventional solid-state reaction *** prepared samples were characterized by X-ray diffraction(XRD),Fourier transforms infrared(FTIR),and UV-Vis *** shielding properties against ionizing radiation were also *** XRD analysis shows the perovskite cubic structure as the major phase in all *** FTIR reveals a distinctive band around 614-620 cm^(-1) ascribed to the antisymmetric O-Sn-O ***-Vis spectroscopy was used to determine the bandgap according to diffuse reflectance,and the results display a fixed enhancement in the bandgap from 3.2 to 3.3 eV for all ***-ray shielding properties of the synthesized samples were experimentally measured and compared with XCOM computational *** relative differences(Δ,%)between experimental and theo retical values are low and fall within the 0.446%-7.10%*** addition of Er leads to the enhanced density,neutron,and gamma shielding *** contrast,charged particles’shielding parameters gradually reduce with rising Er *** results suggest that Ba_(1-x)Er_(x)SnO_(3) samples can be used in different radiation shielding applications.

关键词： Perovskite Ceramics Gamma ray shielding Mass stopping power Rare earths

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Congenital absence of the lateral meniscus:A case report

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World Journal of Orthopedics 2024年第5期15卷 477-482页

作者： hamad Ali Alkhunayfir Abdulaziz Ali AlQahtani Abdulrahman Jalwi Korkoman Department of Orthopedic Surgery Prince Muhammed bin Abdulaziz HospitalRiyadh 61422Saudi Arabia Department of Orthopedic Surgery Prince Sultan Military Medical CityRiyadh 12233Saudi Arabia Department of Orthopedic Surgery University of BishaBisha 67714Saudi Arabia

BACKGROUND Congenital absence of the menisci is a rare anatomical variation characterized by the absence or underdevelopment of one or both menisci in the knee *** menisci are crucial in load distribution,joint stability,and shock *** the clinical presentation,diagnosis,and management of this condition is important for optimal patient *** SUMMARY A 27-year-old male with a long-standing history of knee pain underwent diagnostic arthroscopy,revealing a congenital absence of the *** patient's clinical findings,imaging results,surgical procedures,and pertinent images are *** case presents a unique aspect with the congenital absence of the meniscus,contributing valuable insights to the literature on rare anatomical *** This case of congenital absence of the menisci highlights the diagnostic challenges posed by rare *** diagnostic arthroscopy played a crucial role in identifying the absence of the meniscus and providing an explanation for the patient's persistent knee *** case underscores the importance of individualized treatment approaches,including physical therapy,for optimal management of rare meniscal *** research is warranted to explore effective management strategies for the aforementioned cases and to expand our knowledge of these rare conditions.

关键词： Lateral meniscus Arthroscopy Knee joint Menisci reformation Magnetic resonance imaging Case report

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Endoscopic Transcanal Excision of Glomus Tympanicum: A Case Report and Literature Review

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第5期13卷 305-310页

作者： Mohammed Atiah Alzahrani Yahia Dhafer Alahmari Ali Jaber Asiry Ibrahem hamad Erwe Ghada Ahmed bin Abbas Department of Otorhinolaryngology Aseer Central Hospital Abha Saudi Arabia College of Medicine University of King Khalid Abha Saudi Arabia

Glomus tumors are extremely rare tumors that arise from paraganglionic cells, which are derived from neural crest cells. These tumors are benign, slow-growing, locally invasive, and destructive. Glomus tumors are the most common tumor of the middle ear cavity and the second most common tumor of the temporal bone. We present a case of a 49-year-old healthy female who, following diagnostic tools, received surgical intervention resulting in an excellent outcome. Our case report includes a comprehensive analysis of published cases in the literature.

关键词： Glomus Tympanicum Paragangliomas Endoscopic Transcanal

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Machine Learning Empowered Security and Privacy Architecture for IoT Networks with the Integration of Blockchain

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Intelligent Automation & Soft Computing 2024年第2期39卷 353-379页

作者： Sohaib Latif M.Saad bin Ilyas Azhar Imran hamad Ali Abosaq Abdulaziz Alzubaidi Vincent Karovic Jr. Department of Computer Science The University of ChenabGujrat50700Pakistan Department of Creative Technologies Air UniversityIslamabad42000Pakistan Computer Science Department College of Computer Science and Information SystemsNajran UniversityNajran66244Saudi Arabia Department of Computer Science Umm Alqura UniversityAlQunfudah28821Saudi Arabia Department of Information Systems Faculty of ManagementComenius University in BratislavaBratislava82005Slovakia

The Internet of Things(IoT)is growing rapidly and impacting almost every aspect of our lives,fromwearables and healthcare to security,traffic management,and fleet management *** has generated massive volumes of data and security,and data privacy risks are increasing with the advancement of technology and network *** access control solutions are inadequate for establishing access control in IoT systems to provide data protection owing to their vulnerability to single-point OF ***,conventional privacy preservation methods have high latency costs and overhead for resource-constrained *** machine learning approaches were also unable to detect denial-of-service(DoS)*** study introduced a novel decentralized and secure framework for blockchain *** avoid single-point OF failure,an accredited access control scheme is incorporated,combining blockchain with local peers to record each transaction and verify the signature to ***-based attribute-based cryptography is implemented to protect data storage privacy by generating threshold parameters,managing keys,and revoking users on the *** innovative contract-based DOS attack mitigation method is also incorporated to effectively validate devices with intelligent contracts as trusted or untrusted,preventing the server from becoming *** proposed framework effectively controls access,safeguards data privacy,and reduces the risk of *** results depict that the suggested framework outperforms the results in terms of accuracy,precision,sensitivity,recall,and F-measure at 96.9%,98.43%,98.8%,98.43%,and 98.4%,respectively.

关键词： Machine learning internet of things blockchain data privacy security Industry 4.0

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Mixed plastics waste valorization to high-added value products via thermally induced phase separation and spin-casting

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Green Energy & Environment 2024年第10期9卷 1627-1640页

作者： Junaid Saleem Moghal Zubair Khalid Baig Usman bin Shahid Rafael Luque Gordon McKay Division of Sustainable Development College of Science and EngineeringHamad Bin Khalifa University Center for Advanced Materials Qatar University Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Universidad ECOTEC

Plastic waste is an underutilized resource that has the potential to be transformed into value-added ***,its chemical diversity leads to cost-intensive sorting techniques,limiting recycling and upcycling ***,we report an open-loop recycling method to produce graded feedstock from mixed polyolefins waste,which makes up 60%of total plastic *** method uses heat flow scanning to quantify the composition of plastic waste and resolves its compatibility through controlled *** resulting feedstock is then used to synthesize blended pellets,porous sorbents,and superhydrophobic coatings via thermally induced phase separation and *** hybrid approach broadens the opportunities for reusing plastic waste,which is a step towards creating a more circular economy and better waste management practices.

关键词： Plastic waste Valorization Superhydrophobic coatings Blended pellets Porous materials Sorbents

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Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in Saudi Arabia:A multicenter retrospective study

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World Journal of Diabetes 2024年第3期15卷 440-454页

作者： Saleh Fahad Alqifari Aya K Esmail Dalal M Alarifi Ghalya Y Alsuliman Maram M Alhati May R Mutlaq Mohammed Aldhaeefi Shaden A Alshuaibi Palanisamy Amirthalingam Abrar Abdallah Afaf S Wasel Heba R hamad Shoroq Alamin Tasneem H Atia Tariq Alqahtani Department of Pharmacy Practice University of TabukTabuk 71491Saudi Arabia Department of Clinical Sciences Sulaiman Alrajhi UniversityQassim 52726Saudi Arabia Department of Family Medicine International Medical CenterJeddah 23214Saudi Arabia Clinical and Administrative Pharmacy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Pharmacology King Saud Bin Abdulaziz University for Health SciencesKing Abdullah International Medical Research CenterRiyadh 11481Saudi Arabia

BACKGROUND Patients with diabetes mellitus(DM)are predisposed to an increased risk of infection signifying the importance of vaccination to protect against its potentially severe *** Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices(CDC/ACIP)issued immunization recommendations to protect this patient *** To assess the adherence of patients with DM to the CDC/ACIP immunization recommendations in Saudi Arabia and to identify the factors associated with the vaccine adherence *** An observational retrospective study conducted in 2023 was used to collect data on the vaccination records from 13 diabetes care centers in Saudi Arabia with 1000 eligible patients in phase I with data collected through chart review and 709 patients in phase II through online *** Among participants,10.01%(n=71)had never received any vaccine,while 85.89%(n=609)received at least one dose of the coronavirus disease 2019(COVID-19)vaccine,and 34.83%(n=247)had received the annual influenza *** 2.96%(n=21),2.11%(n=15),and 1.12%(n=8)received herpes zoster,tetanus,diphtheria,and pertussis(Tdap),and human papillomavirus(HPV)vaccines,*** patients with DM in Saudi Arabia,the rate of vaccination for annual influenza and COVID-19 vaccines was higher compared to other vaccinations such as herpes zoster,Tdap,pneumococcal,and *** such as vaccine recommendations provided by family physicians or specialists,site of care,income level,DM-related hospitalization history,residency site,hemoglobin A1c(HbA1c)level,and health sector type can significantly influence the vaccination rate in patients with *** non-vaccinated patients with DM,the most reported barriers were lack of knowledge and fear of side *** signifies the need for large-scale research in this area to identify additional factors that might facilitate adherence to CDC/ACIP vaccine recommendations in patients with *** In S

关键词： Diabetes mellitus Vaccine recommendation COVID-19 vaccine Influenza vaccine Pneumococcal vaccine Immunization Retrospective study

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Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.Baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

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