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Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction

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Bioactive Materials 2023年第5期23卷 353-367页

作者： Ming Pei Yixuan Amy Pei Sheng Zhou Elmira Mikaeiliagah Christopher Erickson Benjamin Giertych halima Akhter Lei Wang Amanda Stewart Joshua Parenti Bin Wang Sijin Wen Sotcheadt Sim Eric Quenneville Kirk C.Hansen Steven Frisch Gangqing Hu Stem Cell and Tissue Engineering Laboratory Department of OrthopaedicsWest Virginia UniversityMorgantownWVUSA WVU Cancer Institute Robert C.Byrd Health Sciences CenterWest Virginia UniversityMorgantownWVUSA Perelman School of Medicine University of PennsylvaniaPhiladelphiaPAUSA Department of Biology Ardabil BranchIslamic Azad UniversityArdabilIran Department of Biochemistry&Molecular Genetics University of Colorado DenverAuroraCOUSA Department of Microbiology Immunologyand Cell BiologyWest Virginia UniversityMorgantownWVUSA Department of Foot and Hand Surgery Clinical Medical College of Yangzhou UniversitySubei People’s Hospital of Jiangsu ProvinceYangzhouJiangsuChina Department of Biostatistics School of Public HealthWest Virginia UniversityMorgantownWVUSA Biomomentum Inc. LavalQuebecCanada Department of Biochemistry West Virginia UniversityMorgantownWVUSA Bioinformatics Core West Virginia UniversityMorgantownWVUSA

Articular cartilage has a limited capacity to self-heal once ***-specific stem cells are a solution for cartilage regeneration;however,ex vivo expansion resulting in cell senescence remains a challenge as a large quantity of high-quality tissue-specific stem cells are needed for cartilage *** previous report demonstrated that decellularized extracellular matrix(dECM)deposited by human synovium-derived stem cells(SDSCs),adipose-derived stem cells(ADSCs),urine-derived stem cells(UDSCs),or dermal fibroblasts(DFs)provided an ex vivo solution to rejuvenate human SDSCs in proliferation and chondrogenic potential,particularly for dECM deposited by *** make the cell-derived dECM(C-dECM)approach applicable clinically,in this study,we evaluated ex vivo rejuvenation of rabbit infrapatellar fat pad-derived stem cells(IPFSCs),an easily accessible alternative for SDSCs,by the abovementioned C-dECMs,in vivo application for functional cartilage repair in a rabbit osteochondral defect model,and potential cellular and molecular mechanisms underlying this *** found that C-dECM rejuvenation promoted rabbit IPFSCs’cartilage engineering and functional regeneration in both ex vivo and in vivo models,particularly for the dECM deposited by UDSCs,which was further confirmed by proteomics ***-Seq analysis indicated that both mesenchymal-epithelial transition(MET)and inflammation-mediated macrophage activation and polarization are potentially involved in the C-dECM-mediated promotion of IPFSCs’chondrogenic capacity,which needs further investigation.

关键词： Decellularized extracellular matrix Tissue-specific stem cell Urine-derived stem cell Rejuvenation Functional cartilage repair

Do We Really Need to Adopt Electronic Banking?

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Do We Really Need to Adopt Electronic Banking?

Comparison of Different Regularized and Shrinkage Regression Methods to Predict Daily Tropospheric Ozone Concentration in the Grand Casablanca Area

International Conference on Machine Learning and Computing（ICMLC 2009）

作者： Zaid Al-Baghdadi S.A.M.Rizvi halima Sadia Rizvi Dept. of Computer Sc. J.M.I.New DelhiIndia Dept. of Economics J.M.I.New DelhiIndia

Today at the beginning of the third millennium with the huge information technology revolution in all life sectors and the banking sector is one of it,many of the banks in world adopted e-banking and convert them ordinary banking services to e-banking services and this growing in e-banking services mostly came from e-commerce growing which it is value estimated in hundreds billions of dollars and all this huge business needs a strong infrastructure of e-banking to manage all the money transactions and support e-commerce so the question is " Do We Really Need to Adopt Electronic Banking?,"in this paper we are trying to answer this question and highlight some of important points of it.

关键词： Internet Banking Electronic Banking Banking Technology

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Advances in Pure Mathematics 2018年第10期8卷 793-812页

作者： halima Oufdou Lise Bellanger Amal Bergam Angélina El Ghaziri Kenza Khomsi El Mostafa Qannari Laboratory MAE2D University of Abdelmalek Essaadi Larache Morocco Laboratory of Mathematics Jean Leray UMR CNRS 6629 University of Nantes Nantes France Maison des Sciences de l’Homme Ange Guépin USR 3491 University of Nantes Nantes France National Meteorological Office Casablanca Morocco StatSC ONIRIS INRA Nantes France

Tropospheric ozone (O3) is one of the pollutants that have a significant impact on human health. It can increase the rate of asthma crises, cause permanent lung infections and death. Predicting its concentration levels is therefore important for planning atmospheric protection strategies. The aim of this study is to predict the daily mean O3 concentration one day ahead in the Grand Casablanca area of Morocco using primary pollutants and meteorological variables. Since the available explanatory variables are multicollinear, multiple linear regressions are likely to lead to unstable models. To counteract the multicollinearity problem, we compared several alternative regression methods: 1) Continuum Regression;2) Ridge & Lasso Regressions;3) Principal component regression (PCR);4) Partial least Square regression & sparse PLS and;5) Biased Power Regression. The aim is to set up a good prediction model of the daily ozone in the Grand Casablanca area. These models are fitted on a training data set (from the years 2013 and 2014), tested on a data set (from 2015) and validated on yet another data set data (from 2015). The Lasso model showed a better performance for the prediction of ozone concentrations compared to multiple linear regression and its other alternative methods.

关键词： Multiple Linear Regression Multicollinearity Penalized Regression Statistical Forecasting Tropospheric Ozone

Chromosomal aberrations and nucleic acids systems affected by some Egyptian medicinal plants used in treating female pregnant diabetic rats

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American Journal of Molecular Biology 2011年第1期1卷 26-32页

作者： halima S . Abdou Sherifa H. Salah Amira Abd El Raouf E.A. Abdel-Rahim Dep. Biochem. Fac. Agric. Cairo. University Department of cell biology National Research Center Dokki Egypt

The influences of medicinal plants Juniperus Phoenicea (Araar), Hyphaene thebaica (Doum), An-astatica hierochuntica (Kafta) and Cleome droserifolia (Sammo) as antidiabetic agents were investigated using female pregnant albino rats. Female rats were injected with 60 mg/kg b.w. alloxan to induce diabe-tes. Diabetic rats treated orally with the methanol extracts of tested plants till the 19 day of gestation. The present studies include the frequencies of chro-mosomal aberrations and nucleic acid system of liver in the female pregnant rats and their embryos. The results showed that injection of alloxan caused highly significant increase in chromosomal aberrations as well as in blood glucose levels as a result of diabetes in pregnant females. It also caused a high incidence of chromosomal deviation in embryos and decreased the liver soluble protein contents of female rats and their embryos. These effects in alloxanized animals were treated and improved by ingestion of the methanol extracts of the tested plants (Araar, Doum, Kafta and Somma) in which under their treatments, the inceased level of blood glu-cose of diabetic rats was deceased. Ingestion with the plants methanolic extracts improved and normalized the effects of diabetes in nucleic acids values of liver tissues. These were accompanied with nucleases (RNAase and DNAase) activities. The inhibited ac-tivities of both DNA ase and RNA ase of pregnant rats and their embryos were stimulated and read-justed around the normal values. Also administration of the plants methanol extracts decreased the per-centage of chromosomal aberrations in the female rats and embryos. It is concluded that there are some biochemical dynamics which might occur in the metabo-lism of glucose, nucleic acids and proteins in order to prevent or to reduce the oxidative stress of diabetes by flavonoides treatment.

关键词： Tested Plants: Cleome Droserfolia (Sommo) Jumiperus Phoenicia (Araar) Anostatica Hierochuntica (Kafta) And Hyphened Thebaica (Doum) Alloxan Pregnant Females Albino Rats Diabetes Mellitus

Evaluation of an ＂Attract and Kill＂ System to Combat Ceratitis capitata on Peach Trees in Tunisia

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Journal of Agricultural Science and Technology(A) 2014年第7期4卷 612-619页

作者： Bouagga Sarra Hassan Nayem Kamel Ben halima Monia Jammazi Adel Djelouah Khaled Al-Zaidi Skaker Department of Plant Protection Mediterranean Agronomic Institute MAI Bari Via Ceglie 9 70010 Valenzano Bari Italy Russell IPM Ltd. Unit 45 First Avenue Deeside Industrial Park Deeside CH5 2NU United Kingdom Higher Agronomic Institute of Chott Mariem Sousse 4042 Tunisia Department of Entomology Ministry of Agricultural General Direction of Plant Protection and Control of Food Quality Tunis1002 Tunisia

Attract and kill （AK） technology was evaluated against the Mediterranean fruit fly （Med-fly）, Ceratitis capitata W.. Treatment was carried out in two peach orchards of four hectares each; first one located in Borj-Touil and the second in El-Kssibi Mornag, Northern Tunisia during the 2012 field season. AK is a specialized system based on hydrolyzed proteins and alpha-cypermethrin. During this study, 400 AK bait stations were placed in every hectare, four weeks before fruits color changes. The tested AK system was found effective in reducing the number of C. capitata population to 70% comparing to the untreated orchards. Fruit damages assessment showed significant differences between treatments in respect of decreasing infestation onto fruits Study results indicated that AK baited treatments were able to reduce dropped and soften fruits infestation seven times than that of control plots. Fruit damages were restricted to 4%-5% in treated areas with AK system in compare to 31%-35% recorded in control plots. This novel AK system showed good performance to combat Med-fly and can successfully used to combat various fruit fly species when applied for an area wide application program.

关键词： Ceratitis capitata AK system peach fruit damages Tunisia.

Status of multielement in water of the river Buriganga, Bangladesh: Aquatic chemistry of metal ions in polluted river water

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Emerging Contaminants 2021年第1期7卷 99-115页

作者： Aklima Nargis Ahsan Habib Harun-Or-Rashid halima Binte Harun Md Shafiqul Islam Sarker Rong Jin Guorui Liu Wenbin Liu A.N.M.Al-Razee Kai Chen Minggang Cai Coastal and Ocean Management Institute Xiamen UniversityXiamenPR China Department of Chemistry University of DhakaDhaka1000Bangladesh Central Chemical Laboratory Department of Narcotics ControlMinistry of Home AffairsDhaka1204Bangladesh Sate Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental ScienecsChinese Academy of SciencesBeijing100085PR China Department of Analytical Chemistry&Environmental Science Training Institute for Chemical IndustriesPolashBangladesh

The peripheral rivers of Dhaka city became highly polluted because of industrialization and urbanization to a greater extent in the last few ***,an attempt has been taken to measure 48 elements in water of the river Buriganga using the ICP-MS method for the first ***,it could be the reference values for future research in *** of the 48 elements,the following metals are given more attention because of their detrimental effects on living organisms and for discussing their aquatic chemistry in polluted water body:Be,Na,Al,Cr,Mn,Fe,Ni,Cu,Zn,Cd,Ba,Hg,Pb,Bi and *** revealed that metals’concentrations in water in the monsoon were less than that of the winter,however,Cr and Fe were found at below detection limits in the winter that is *** parameters of the river water such as pH,dissolved oxygen play vital roles for hydrolysis reactions in the stagnant water *** products of metal ions having low values of solubility products(K sp),for example,iron(III)hydroxide,chromium(III)hydroxide,phase out through precipitation *** study also detects and quantifies total concentrations of Hg and U in water of the river Buriganga for the first *** and correlation matrix results provided potential sources of the relevant *** of hydrolysis and precipitation reactions for metal ions in the polluted river water are also discussed.

关键词： hydrolysis winter river

Enthalpy of Dissolution and Dehydration of Two Moroccan Clays

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World Journal of Engineering and Technology 2018年第1期6卷 119-127页

作者： Jabrane Maissara halima Karym Mohammed El Mahi Chbihi Mohammed Moutaabbid Mohamed Abatal Said Benmokhtar Department of Chemistry Faculty of Sciences Laboratory of Chemistry and Physics of Materials LCPM Faculty of Sciences Ben M’Sik University of Casablanca Casablanca Morocco Laboratory of Investigation of Advanced Materials Faculty of Engineering in Autonomous University El Carmen Mexico

This work aims to characterize and determine the dehydroxylation enthalpy variations of two natural Moroccan clays from the Nador region (denoted K1) and the Settat region (denoted by K2). The variations of dissolution enthalpies were determined by dissolving clays in hydrofluoric acid. They have a minimum value for dehydroxylation of clays made between 600°C and 700°C. The analysis of the two clays shows that they consist of kaolinite in significant proportion. The optimum calcination parameters, for which dehydroxylation is total, are 700°C with a heating time of 6 H. The conversion of the kaolinite to metakaolinite was confirmed by IR analyses of the starting and thermally treated kaolin samples. The result confirms previous observations about obtaining metakaolinite with optimum reactivity when hydrated with calcium hydroxide as chemical activator.

关键词： Clay Characterization Dissolution Calorimetry IR

Evaluate All the Order of Every Element in the Higher Order of Group for Addition and Multiplication Composition

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International Journal of Modern Nonlinear Theory and Application 2022年第2期11卷 11-30页

作者： Md. Abdul Mannan Nazmun Nahar halima Akter Momtaz Begum Md. Amanat Ullah Shabnam Mustari Department of Mathematics Uttara University Dhaka Bangladesh Department of Computer Science & Engineering Prime University Dhaka Bangladesh Department of Computer Science & Engineering Uttara University Dhaka Bangladesh Department of Mechanical Engineering Sonargaon University Dhaka Bangladesh

This paper aims at treating a study on the order of every element for addition and multiplication composition in the higher order of groups for different algebraic structures as groups;order of a group and order of element of a group in real numbers. Here we discuss the higher order of groups in different types of order which will give us practical knowledge to see the applications of the addition and multiplication composition. If G is a finite group, n is a positive integer and a ⋴G, then the order of the products na. When G is a finite group, every element must have finite order. However, the converse is false: there are infinite groups where each element has finite order. For example, in the group of all roots of unity in C× each element has finite order. Finally, we find out the order of every element of a group in different types of higher order of group.

关键词： Order of Element of a Group Addition Composition Multiplication Composition Modulo

Evaluation of 3D-CRT and VMAT Radiotherapy Plans for Left Breast Cancer with Regional Lymph Nodes Irradiation

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Journal of Cancer Therapy 2023年第8期14卷 345-352页

作者： Houda Benmessaoud Hasnae Bouhia halima Ahmut Sanaa El Majjaoui Hanane El Kacemi Khalid Hassouni Tayeb Kebdani Department of Radiotherapy National Institute of Oncology of Rabat Faculty of Medicine and Pharmacy of Rabat Rabat Morocco

Introduction: Radiation therapy after breast surgery is an integral part of the treatment of early breast cancer. The goal of radiation therapy is to achieve the best possible coverage of the planning target volume (PTV), while reducing the dose to organs at risk (OARs) which are normal tissues whose sensitivity to irradiation could cause damage that can lead to modification of the treatment plan. In the last decade, radiation oncologist started to use the Intensity Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) for irradiating the breast, in order to achieve better dose distribution and target dose to the PTV and OAR. The aim of this study is to compare 2 external radiotherapy techniques (VMAT vs 3D) for patients with node-positive left breast cancer. Patients and Methods: We randomly selected 10 cases of postoperative radiotherapy for breast cancer in our hospital. The patients are all female, the average age was 45.4 years old, and the primary lesions are left breast. The ANOVA test was used to compare the mean difference between subgroups, and the p value Results: Dose volume histogram (DVH) was used to analyze each evaluation dose of clinical target volume (CTV) and organs at risk (OARs). Compared to 3DCRT plans, VMAT provided more uniform coverage to the breast and regional lymph nodes. The max point dose for tVMAT was lower on average (106.4% for VMAT versus 109% for 3DCRT). OAR sparing was improved with tVMAT, with a lower average V17Gy for the left lung (27.91% for VMAT versus 30.04% for 3DCRT, p and lower for V28Gy (13.75% for VMAT versus 22.34% for 3DCRT, p = 0.01). We also found a lower V35Gy for the heart on VMAT plan (p = 0.02). On the contrary, dose of contralateral breast was lower in 3DCRT than VMAT (0.59 Gy vs 3.65 Gy, p = 0.00). Conclusion: The both types of plans can meet the clinical dosimetry demands of postoperative radiotherapy for left breast cancer. The VMAT plan has a better conformity, but 3CDRT can provide a lo

关键词： Volumetric-Modulated arc Therapy 3D-Conformal Radiation Therapy Left Breast Cancer Target Volumes Treatment Plan