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Analysis and Review of.Downregulated Actin Cytoskeletal Proteins in Non-Small Cell Lung Cancer

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Journal of.Biosciences and medicines 2024年第4期12卷 89-115页

作者： hala m. Abdel mageed Praveen Sahu Raji Sundararajan School of.Engineering Technology Purdue University West Lafayette USA National Institute of.Standards Al Haram Egypt

Actin, a highly conserved protein, plays a dominant role in Non-small cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of.NSCLC pose a signif.cant threat. Studying the clinic pathological properties of.NSCLC proteins is a potential alternative f.r developing treatment strategies. Towards this, 35 downregulated actin cytoskeletal proteins on NSCLC prognosis and treatment were studied by examining their protein-protein interactions, gene ontology enrichment terms, and signaling pathways. Using Pubmed, various proteins in NSCLC were identif.ed. The protein-protein interactions and f.nctional associations of.these proteins were examined using the STRING database. The f.cal adhesion signaling pathway was selected f.om all available KEGG and Wiki pathways because of.its role in regulating gene expression, f.cilitating cell movement and reproduction, and signif.cantly impacting NSCLC. The protein-protein interaction network of.the 35 downregulated actin cytoskeleton proteins revealed that ACTG1, ACTR2, ACTR3, ANXA2, ARPC4, f.NA, TLN1, CalD1, mYL6, mYH9, mYH10, TPm1, TPm3, TPm4, Pf.1, IQGAP1, mSN, and ZXY exhibited the highest number of.interactions. Whereas HSPB1, CTNNA1, KRT17, KRT7, f.NB, SEPT2, and TUBA1B displayed medium interactions, while UTRN, TUBA1B, and DUSP23 had relatively f.wer interactions. It was discovered that f.cal adhesions are critical in connecting membrane receptors with the actin cytoskeleton. In addition, protein kinases, phosphatases, and adapter proteins were identif.ed as key signaling molecules in this process, greatly inf.uencing cell shape, motility, and gene expression. Our analysis shows that the f.cal adhesion pathway plays a crucial role in NSCLC and is essential f.r developing ef.ective treatment strategies and improving patient outcomes.

关键词： Non-Small Cell Lung Cancer NSCLC Actin Actin Cytoskeletal Proteins f.cal Adhesion KEEG Pathway

Octreotide ameliorates gastric lesions in chronically mild stressed rats

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World Journal of.Gastroenterology 2011年第9期17卷 1135-1142页

作者： Noha N Nassar mona f.Schaalan hala f.Zaki Dalaal m Abdallah Department of.Pharmacology and Toxicology Faculty of PharmacyCairo University Department of.Biochemistry Faculty of PharmacyMisr International University

AIm:To evaluate the ef.ect of.chronic mild stress(CmS) on the emergence of.gastric ulcers and possible modulation by octreotide,a synthetic somatostatin analogue. mETHODS:Adult male Wistar rats were subjected to nine dif.erent unpredictable random stress procedures f.r 21 d,a multif.ctorial interactional animal model f.r *** was administered daily f.r 21 d at two dose levels(50 and 90μg/kg)bef.re exposure to stress ***-and microscopical assessments were made,in addition to quantif.cation of.plasma corticosterone and gastric mucosal inf.ammatory,oxidative stress, and apoptotic biomarkers. RESULTS:Exposure to CmS elevated plasma corticosterone(28.3±0.6μg/dL,P=0.002),an event that was accompanied by gastric lesions(6.4±0.16 mm,P=0.01) and conf.rmed ***,the insult elevated gastric mucosal lipid peroxides(13±0.5 nmol/g tissue,P=0.001),tumor necrosis f.ctor-α(3008.6±78.18 pg/g tissue,Pmg protein,P=0.002).Conversely,CmS mitigated interleukin-10(627.9±12.82 pg/g tissue,P= 0.001).f.rthermore,in animals exposed to CmS,octreotide restored plasma corticosterone(61%and 71%f.om CmS,P=0.002)at both dose *** benef.cial ef.ects were associated with a remarkable suppression of.gastric lesions(38%and 9%f.om CmS,P=0.01)and reversal of.derangements in gastric mucosa. CONCLUSION:The current investigation provides evidence that exposure to CmS induces gastric ulceration, which was alleviated by administration of.octreotide possibly possessing antioxidant,anti-inf.ammatory,and anti-apoptotic actions.

关键词： Gastric ulcer Chronic mild stress Octreotide Inf.ammation Oxidative stress Apoptosis Histopathology

The expressional level of.tankyrase-1 gene and its regulation in colorectal cancer in a Saudi population

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BIOCELL 2019年第2期43卷 51-57页

作者： hala ABDULAZIZ m alWARTHAN mOHAmmAD SAUD al ANAZI NARASImHA RPARINE RAmESA SHAf. BHAT GHADAH alAmRO f.OON alJARBOU SOOAD K al-DAIHAN Department of.Biochemistry College of ScienceKing Saud UniversityP.O.Box 22452Zip code 11495RiyadhSaudi Arabia

Tankyrase1(TNKS1)plays an essential role in cancer progression by regulating telomere *** study aimed to determine expression of.TNKS1 and its regulation in colorectal cancer(CRC)in 20 samples f.om Saudi *** expression of.TNKS1 in CRC and paired normal tissues was measured by *** modif.cation of.TNKS1 promoter was determined by methylation-specif.c PCR while somatic mutation was analyzed by Sanger sequencing in exon 10 of.the *** cancerous and normal tissues expressed TNKS1,but level of.expression in CRC tissues was signif.cantly associated with tumor stage though no other parameters;age,gender,and tumor location,showed any *** of.TNKS1 was markedly higher in earlier(I,II)than in later(Ⅲ,Ⅳ)stages of.CRC *** cancerous and healthy tissues had unmethylated *** sequencing of.exon 10 masked any somatic mutation in the *** f.ndings suggest that up-regulation of.TNKS1 was inversely correlated with cancer progression in CRC,indicating that TNKS1 participates in the initiation of.CRC by stabilizing telomere length in the f.rst phase of.cancer *** other than TNKS1 might play a role in malignant tumor progression and telomere maintenance in the late stages of.CRC.

关键词： Gene expression TNKS1 cancer progression telomeres

Preliminary Study of.a Hybrid Helicon-ECR Plasma Source

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Plasma Science and Technology 2016年第8期18卷 832-836页

作者： A.m.hala L.OKSUZ ZHU Ximing The National Center f.r Applied Physics Material Science Research InstituteKing Abdul Aziz City for Science and Technology(KACST) Süleyman Demirel University Science and Literature FacultyPhysics Department Institute f.r Plasma and Atomic Physics Ruhr University

A new type of.hybrid discharge is experimentally investigated in this work. A helicon source and an electron cyclotron resonance（ECR） source were combined to produce plasma. As a preliminary study of.this type of.plasma, the optical emission spectroscopy（OES） method was used to obtain values of.electron temperature and density under a series of.typical conditions. Generally,it was observed that the electron temperature decreases and the electron density increases as the pressure increased. When increasing the applied power at a certain pressure, the average electron density at certain positions in the discharge does not increase signif.cantly possibly due to the high degree of.neutral depletion. Electron temperature increased with power in the hybrid *** mechanisms of.these preliminary observations are discussed.

关键词： helicon plasma ECR hybrid discharge

Receiving antenatal care via mobile clinic: Lived experiences of.Jordanian mothers

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International Journal of.Nursing Sciences 2023年第2期10卷 230-237页

作者： hala A.Bawadi Asma’a S.Abu Abed Zaid m.al-Hamdan Saf. m.alzubi maternal and Child Health Department School of Nursing the University of JordanAmmanJordan National Women Health Center(resigned) Royal Medical ServicesAmmanJordan f.culty of.Nursing Jordan University of.Science and Technology IrbidJordan Royal medical Services AmmanJordan

Objective To understand the perceptions of.pregnant Jordanian women who received antenatal care via mobile clinic,and to contribute new insights into the experiences of.these mothers and how they evaluated the services that were *** Ten Jordanian mothers who had received antenatal care at a mobile clinic discussed their experiences in semi-structured,audiotaped interviews in a study that adopted a qualitative research *** analysis was done using interpretative phenomenological *** Three main themes were identif.ed:Being inf.rmed about the medical campaign or missing the opportunity of.being inf.rmed;The experience of.receiving antenatal care was wonderf.l,although there was only one thing lacking;and they saf.guard our lif. and take any opportunity to educate *** Data indicate that the mothers were largely satisf.ed with most f.cets of.the antenatal care services they had received at the mobile ***,while services are generally well received,there are clear opportunities f.r ameliorating the quality of.services *** mothers living in remote,deprived areas,outreach is not just an‘optional extra’but rather an essential service.

关键词： Jordan mobile health units Pregnancy Pregnant women Prenatal care Qualitative research

Antioxidative, cytotoxic, and anti-metastatic potentials of.Laurencia obtusa and Ulva lactuca seaweeds

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Asian Pacif.c Journal of.Tropical Biomedicine 2021年第7期11卷 308-316页

作者： Reem al monla Yahya Salma Achraf.Kouzayha hala Gali-muhtasib Zeina Dassouki Hiba mawlawi Laboratory of.Applied Biotechnology(LBA3B) AZM Center for Research in Biotechnology and its ApplicationsDoctoral School for Sciences and TechnologyLebanese UniversityTripoliLebanon Department of.Biology American University of BeirutLebanon Center f.r Drug Discovery American University of BeirutRiad El Solh 11072020BeirutLebanon

Objective:To investigate the antioxidant and cytotoxic properties of.the most active extracts f.om Ulva lactuca and Laurencia obtusa against colon and cervical cancer cell ***:The antioxidant radical scavenging activity of.the algal extracts was estimated using the 2,2-diphenyl-1-picrylhydrazyl colorimetric ***,the cytotoxic potential of.these bioactive extracts was studied against HCT-116 and HeLa cells by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide *** healing analysis was adopted to evaluate the antimetastatic ef.ects of.protein extracts f.om both *** cycle analysis was perf.rmed by f.ow cytometry,and apoptotic bodies were detected using 4′,6-diamidino-2-phenylindole f.uorescent *** acids of.hydrolyzed protein extract were separated and identif.ed chromatographically by high perf.rmance liquid ***:The green algae Ulva lactuca had higher lipid content than Laurencia obtusa,whereas the latter had higher protein content with high antioxidant *** extracts had signif.cant dose-and time-dependent cytotoxicity and anti-metastatic activity against HCT-116 *** b extracts of.both algae obtained f.om the chlorof.rm:hexane solvent lipid-f.ee residue caused morphological changes and induced apoptosis of.HCT-116 *** analysis revealed that apoptosis induced upon Laurencia obtusa protein b treatment was triggered via the ROS pathway,causing a signif.cant increase in the sub-G_(1) *** and arginine(5.94 and 5.47μm,respectively)were the most common amino acids in Laurencia obtusa protein b ***:Proteins of.Laurencia obtusa and Ulva lactuca could be considered as an adjuvant nutraceutical source of.pro-apoptotic and anti-metastatic biomolecules against colon cancer.

关键词： macroalgae Laurencia obtusa Ulva lactuca Reactive oxygen species Apoptosis

Consensus statement on the epidemiology,diagnosis,prevention,and management of.cow's milk protein allergy in the middle East:a modif.ed Delphi-based study

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World Journal of.Pediatrics 2021年第6期17卷 576-589页

作者： moustaf. A.El-Hodhod mortada H.f.El-Shabrawi Ahmed AIBadi Ahmed Hussein Am almehaidib Basil Nasrallah Ebtsam mohammed AIBassam hala El f.ghali Hasan m.Isa Khaled al Saraf.maroun Sokhn mehdi Adeli Najwa mohammed mousa al-Sawi Pierre Hage Suleiman al-Hammadi Department of.Pediatrics Faculty of MedicineAin Shams UniversityCairoEgypt f.culty of.medicine October 6 UniversityGizaEgypt f.culty of.medicine Cairo UniversityCairoEgypt International Pediatric Association(IPA) MarengoUSA International Society of.Tropical Pediatrics(ISTP) ManilaPhilippines DRC Hospital MuscatOman al Amiri and al Adan Hospitals KuwaitKuwait Pediatric Gastroenterology Department of PediatricsKing Faisal Specialist Hospital and Research Center RiyadhRiyadhSaudi Arabia American Hospital Dubai DubaiUnited Arab Emirates Nutrition Service Department King Faisal Specialist and Research Center RiyadhRiyadhSaudi Arabia CHU Notre Dame de Secours ByblosLebanon Pediatric Department Salmaniya Medical ComplexManamaBahrain Pediatric department Arabian Gulf UniversityManamaBahrain Pediatrics Department Dar Al Shifa HospitalKuwaitKuwait Pediatric Gastroenterology Hepatologyand Nutrition DepartmentSaint George University Medical CenterUniversity of BalamandBeirutLebanon Sidra medicine DohaQatar Department of.Pediatrics Doctor Sulaiman Alhabib Medical GroupAlrryan BranchRiyadhSaudi Arabia Pediatric Pulmonology and allergology University of BalamandBeirutLebanon College of.medicine Mohanuned Bin Rashid University of Medicine and Health SciencesBuilding 14505055 DubaiUnited Arab Emirates

Background This study aimed to develop an expert consensus regarding the epidemiology,diagnosis,and management of.cow’s milk protein allergy(CmPA)in the middle *** A three-step modif.ed Delphi method was utilized to develop the *** specialized pediatricians participated in the development of.this *** statement was considered a consensus if.it achieved an agreement level of.80%.Results The experts agreed that the double-blind placebo-controlled oral challenge test(OCT)should be perf.rmed f.r 2-A weeks using an amino acid f.rmula(AAf.in f.rmula-f.d inf.nts or children with suspected ***-f.d inf.nts with conf.rmed CmPA should be of.ered a therapeutic *** panel stated that an extensively hydrolyzed f.rmula(eHf.is indicated in the absence of.red f.ag *** the same time,the AAf.is of.ered f.r inf.nts with red f.ag signs,such as severe anaphylactic *** panel agreed that inf.nts on an eHf.with resolved symptoms within 2-4 weeks should continue the eHf.with particular attention to the growth and nutritional *** the other hand,an AAf.should be considered f.r inf.nts with persistent symptoms;the AAf.should be continued if.the symptoms resolve within 2-4 weeks,with particular attention to the growth and nutritional *** cases with no symptomatic improvements af.er the introduction of.an *** measures should be *** panel developed a management algorithm,which achieved an agreement level of.90.9%.Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of.CmPA in the middle East.

关键词： Consensus Cow's milk protein allergy Inf.nt f.rmula middle East milk hypersensitivity

Inf.rmation security through controlled quantum teleportation networks

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Digital Communications and Networks 2020年第4期6卷 463-470页

作者： hala Hamdoun alaa Sagheer Center f.r Artif.cial Intelligence and RObotics(CAIRO) Department of Computer ScienceAswan UniversityAswanEgypt Department of.Computer Science College of Computer Science and Information TechnologyKing Faisal UniversitySaudi Arabia

Inf.rmation security is the backbone of.current intelligent systems,such as the Internet of.Things(IoT),smart grids,and machine-to-machine(m2m)*** increasing threat of.inf.rmation security requires new models to ensure the saf. transmission of.inf.rmation through such ***,quantum systems have drawn much attention since they are expected to have a signif.cant impact on the research in inf.rmation *** paper proposes a quantum teleportation scheme based on controlled multi-users to ensure the secure inf.rmation transmission among *** teleportation is an original key element in a variety of.quantum inf.rmation tasks as well as quantum-based technologies,which plays a pivotal role in the current progress of.quantum computing and *** the proposed scheme,the sender transmits the inf.rmation to the receiver under the control of.a third user or ***,we show that the ef.iciency of.the proposed scheme depends on the properties of.the transmission channel and the honesty of.the *** with various teleportation scheme presented recently in the literature,the most important dif.erence in the proposed scheme is the possibility of.suspicion about the honesty of.the controller and,consequently,taking proper precautions.

关键词： Inf.rmation security machine-to-machine communication Intelligent secure systems Quantum teleportation Quantum networks

Reviving f.rtility:Phytochemicals as Natural allies in the f.ght against Non-genetic male Inf.rtility

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Clinical Complementary medicine and Pharmacology 2024年第1期4卷 112-128页

作者： Vivek P.Chavda Shreya S Sonak Pankti C.Balar Krupa Vyas Pranali Palandurkar Komal mule Krishna Patel Vivek hala Dixa A.Vaghela Devarshi Acharya Akta Vaishnav Jimil Gandhi Vasso Apostolopoulos Department of.Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabadGujarat 380008India Bharati Vidyapeeth University’s Poona College of.Pharmacy ErandwaneKothrudPune 411038India Pharmacy section L M College of PharmacyAhmedabadGujarat 380008India University Department of.Pharmaceutical Sciences R.T.m Nagpur 440033India Department of.Pharmaceutics Khyati College of PharmacyAhmedabad 380009India IICISST Sardar Patel UniversityVallabh Vidyanagar 388120India Institute f.r Health and Sport Immunology and Translational ResearchVictoria UniversityMelbourneVIC 3030Australia Immunology Program Australian Institute for Musculoskeletal ScienceMelbourneVIC 3021Australia

Background:male inf.rtility poses a growing challenge to the healthcare system,with its prevalence on the *** lif.style,f.od,and addictions such as smoking,alcoholism,*** the *** several approaches are being investigated to prevent and treat this condition,each therapeutic approach has its *** medications continue to play a crucial role in the healthcare *** recent years,there has been a shif. towards determining the ef.icacy of.phytochemicals(or,herbal drugs)as ***:To evaluate the ef.ect of.various herbs,plant,metabolites,or a part of.plant in management of.non-genetic male ***:The male inf.rtility-associated keywords were searched in Pubmed,excluding those non-English writen papers.A total of.146 pertinent and closely connected records were included f.r f.ll reading and inclusion in the systemic ***:The manuscript f.cuses on individual herbal drug components,their active ingredients,their role in improving the condition and quality of.lif.,and decreasing the prevalence of.male ***:Herbal medicinal plants show promising outcomes to treat male *** alternatives are appealing and have regained *** f.ture holds promise f.r some of.these herbal treatments to advance with many showing improved outcomes in males with inf.rtility issues.

关键词： male inf.rtility Plant-based management Phytochemical Herbal drug Traditional Chinese medicine