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CD44 and CD221 directed magnetic cubosomes for the targeted delivery of helenalin to rhabdomyosarcoma cells

Nano Research 2023年第2期16卷 2915-2926页

作者： hakmin mun Yuriy Chaban Tanveer A.Tabish Nanasaheb Thorat Nathan Cowieson CDavid Owen Helen E.Townley Nuffield Department of Women’s and Reproductive health University of OxfordOxford OX39DUUK Electron Bio-Imaging Centre Diamond Light SourceDidcot OX110DEUK Radcliffe Department of Medicine University of OxfordOxford OX37BNUK B21 Diamond Light SourceDidcot OX110DEUK Department of Engineering Science University of OxfordOxford OX13PJUK

Confining chemotherapy to tumour sites by means of active targeting nanoparticles(NPs)may increase the treatment effectuality while reducing potential side *** are one of the next-generation drug delivery nanocarriers by virtue of their biocompatibility and bioadhesion,sizeable payload encapsulation and high ***,an active tumour targeting system towards rhabdomyosarcoma(RMS)cells was *** were loaded with helenalin(a secondary metabolite from Arnica plants),which we have previously shown to induce apoptosis in RMS *** functionalization of the cubosomes was accomplished to enable binding to membrane receptors and translocation under a magnetic *** cells overexpress CD44 and CD221 on their membrane surface and,therefore,hyaluronic acid(HA,a ligand for CD44)and antibodies(Abs)against CD221 were coupled to cubosomes via electrostatic attraction and the thiol-Michael reaction,*** of the cubic phase NPs was achieved by embedding superparamagnetic iron oxide NPs(SPIONPs)into the cubic ***-function and multi-function cubosomes had Im3m cubic phase structures with well-organized lattice *** with 2%HA or anti-CD221 half Abs and/or 1%SPIONPs showed significantly higher uptake into RMS cells compared to unfunctionalized ***44 and CD221 directed magnetic(triple-function)cubosomes were capable of internalizing into RMS cells in an energy-independent ***-laden triple functionalized cubosomes showed limited impact on the viability of control fibroblast cells,while they induced a high degree cytotoxicity against RMS *** tumour cell death was observed in both two-dimensional(2D)culture and three-dimensional(3D)tumour spheroids.

关键词： cubosome active targeting rhabdomyosarcoma helenalin nanoparticle functionalization

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