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Feasible Method to Assess the Performance of a Lung Cancer CT Screening CAD System in Clinical Practice: Dependence on Nodule Size and Density

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2014年第2期3卷 107-116页

作者： Janaka C. Marasinghe Masaki Ohkubo hajime kobayashi Kohei Murao Toru Matsumoto Shusuke Sone Shinichi Wada Fujitsu Ltd. Tokyo Japan Graduate School of Health Sciences Niigata University Niigata Japan Graduate School of Health Sciences Niigata University Niigata Japan Department of Radiography/Radiotherapy Faculty of Allied Health Sciences University of Peradeniya Peradeniya SriLanka Kensei Clinic Chiba Japan Nagano Health Promotion Corporation Nagano Japan

Detection of small pulmonary nodules is the goal of lung cancer screening. Computer-aided detection (CAD) systems are recommended to use in lung cancer computed tomography (CT) screening to increase the accuracy of nodule detection. Size and density of lung nodules are primary factors in determining the risk of malignancy. Therefore, purpose of this study is to apply computer-simulated virtual nodules based on the point spread function (PSF) measured in same scanner (maintaining spatial resolution condition) to assess the CAD system performance dependence on nodule size and density. Virtual nodules with density differences between lung background and nodule density (ΔCT) values (200, 300 and 400 HU) and different sizes (4 to 8 mm) were generated and fused on clinical images. CAD detection was performed and free-response receiver operating characteristic (FROC) curves were obtained. Results show that both density and size of virtual nodules can affect detection efficiency. Detailed results are possible to use for quantitative analysis of a CAD system performance. This study suggests that PSF-based virtual nodules could be effectively used to assess the lung cancer CT screening CAD system performance dependence on nodule size and density.

关键词： Computed Tomography (CT) Point Spread Function (PSF) Lung Cancer Screening Computer-Aided Detection (CAD) Virtual Nodule

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Effects of Neuroticism on Partial and Whole Body Reactions under Stress

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Journal of Sports Science 2015年第4期3卷 155-164页

作者： Kanaka Yatabe Hiroto Fujiya Naoko Yui Keisuke Tateishi Yuka Murofushi Fumiko Terawaki Atsuhiro Yoshida Hirotaka Yoshioka Koh Terauchi hajime kobayashi Takaaki Kudo Mahiro Ohno Aya Uchino Hisao Miyano Tadasu Oyama Haruki Musha Department of Sports Medicine St. Marianna University School of Medicine Kawasaki 216-8511 Japan Department of Sports Medicine St. Marianna University Graduate School of Medicine Kawasaki 216-8511 Japan Research Division National Center for University Entrance Examinations Tokyo 153-8501 Japan Department of Psychology College of Humanities and Sciences Nihon University Tokyo 156-8550 Japan

Effects of neuroticism on partial and whole body reaction times were investigated under stress, or choking conditions in student participants (N = 127). We measured simple and choice reaction times of parts of the body and choice reaction times of the whole body in the participants with high and low neuroticism such as depression, cyclic tendency, inferiority feelings, and nervousness under the controlled stress scenario of being in front of people. Results indicated significant differences in reaction times of partial body, discriminative decisions and choice reaction times of participants in the high neuroticism group. Results of whole body reaction times were opposite to that of partial body reactions. However, a two-way factorial analysis of variance indicated neither a significant main effect, nor interactions between reaction times and personality traits. Whole body reactions suggest that the effects of stimulus transduction process from motor commands to motor outputs via motor neurons has a greater effect in the central nervous system than recognition and decision-making. However, it is possible that changes in the intracortical mechanisms related to cognitions and emotions could be correlated in partial body movements with nearly no muscular activity. Our findings suggested that delays indiscrimination, decision-making, and choice times could affect the performance of individuals.

关键词：运动科学体育运动训练体育训练

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Excited state calculations using variational quantum eigensolver with spin-restricted ansätze and automatically-adjusted constraints

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npj Computational Materials 2023年第1期9卷 2204-2212页

作者： Shigeki Gocho hajime Nakamura Shu Kanno Qi Gao Takao kobayashi Taichi Inagaki Miho Hatanaka School of Fundamental Science and Technology Faculty of Science and TechnologyKeio UniversityYokohama 223-8522Japan Quantum Computing Center Keio UniversityYokohama 223-8522Japan IBM Quantum–IBM Research Tokyo Tokyo 103-8510Japan Mitsubishi Chemical Corporation Science&Innovation CenterYokohama 227-8502Japan

The ground and excited state calculations at key geometries, such as the Frank–Condon (FC) and the conical intersection (CI)geometries, are essential for understanding photophysical properties. To compute these geometries on noisy intermediate-scalequantum devices, we proposed a strategy that combined a chemistry-inspired spin-restricted ansatz and a new excited statecalculation method called the variational quantum eigensolver under automatically-adjusted constraints (VQE/AC). Unlike theconventional excited state calculation method, called the variational quantum deflation, the VQE/AC does not require the pre-determination of constraint weights and has the potential to describe smooth potential energy surfaces. To validate this strategy,we performed the excited state calculations at the FC and CI geometries of ethylene and phenol blue at the complete active spaceself-consistent field (CASSCF) level of theory, and found that the energy errors were at most 2 kcal mol−1 even on the ibm_kawasakidevice.

关键词： properties quantum variational

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Applications of quantum computing for investigations of electronic transitions in phenylsulfonyl-carbazole TADF emitters

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npj Computational Materials 2021年第1期7卷 619-627页

作者： Qi Gao Gavin O.Jones Mario Motta Michihiko Sugawara Hiroshi CWatanabe Takao kobayashi Eriko Watanabe Yu-ya Ohnishi hajime Nakamura Naoki Yamamoto Mitsubishi Chemical Corporation Science&Innovation CenterYokohamaJapan Quantum Computing Center Keio UniversityYokohamaJapan IBM Quantum IBM Research-AlmadenSan JoseCAUSA Materials Informatics Initiative Yokkaichi Research CenterJSR CorporationYokkaichiMieJapan IBM Research-Tokyo TokyoJapan Department of Applied Physics and Physico-Informatics Keio UniversityYokohamaJapan

A quantum chemistry study of the first singlet(S_(1))and triplet(T_(1))excited states of phenylsulfonyl-carbazole compounds,proposed as useful thermally activated delayed fluorescence(TADF)emitters for organic light emitting diode(OLED)applications,was performed with the quantum Equation-Of-Motion Variational Quantum Eigensolver(qEOM-VQE)and Variational Quantum Deflation(VQD)algorithms on quantum simulators and *** quantum simulations were performed with double zeta quality basis sets on an active space comprising the highest occupied and lowest unoccupied molecular orbitals(HOMO,LUMO)of the TADF *** differences in energy separations between S_(1) and T_(1)(ΔEST)predicted by calculations on quantum simulators were found to be in excellent agreement with experimental *** of 17 and 88 mHa with respect to exact energies were found for excited states by using the qEOM-VQE and VQD algorithms,respectively,to perform simulations on quantum devices without error *** utilizing state tomography to purify the quantum states and correct energy values,the large errors found for unmitigated results could be improved to differences of,at most,4 mHa with respect to exact ***,excellent agreement could be found between values ofΔEST predicted by quantum simulations and those found in experiments.

关键词： quantum excited occupied

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Direct Production of High Pressure Hydrogen at Great Rate from Glycerol/Water/Metal Mixture

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Green and Sustainable Chemistry 2016年第3期6卷 136-142页

作者： Seiichi Deguchi Norifumi Isu Noriyuki kobayashi hajime Ohtani Department of Energy Engineering and Science Nagoya University Nagoya Japan Kitchen and Bathroom Technology Research Institute LIXIL Corporation Tokoname Japan Department of Chemical Engineering Nagoya University Nagoya Japan Department of Life Science and Applied Chemistry Nagoya Institute of Technology Nagoya Japan

One of the key issues facing the global society today is to find renewable and sustainable energy sources. Hydrogen has gained much attention in recent years since it is one of fuels for fuel cells. It emits no carbon dioxide when it is used and so on. In this study, a great rate production of high pressure hydrogen rich gas from glycerol/water/metal mixtures was developed since glycerol has become one of the enormous industrial by-products, especially from biodiesel processing plants. It was found that cobalt was the optimum metal additive among tested metals of aluminum, cobalt, magnesium and nickel in terms of a hydrogen producing rate, a hydrogen partial pressure and a conversion ratio from 50 mol% glycerol/water mixtures under an operating temperature of 723 K. Concretely, hydrogen rich gas with concentration about 64%H2 and high partial pressure about 4 MPaN,H2 could be produced at the great producing rate of 42.9 LN,H2 dm-2min-1 and high conversion ratio about 60%H2. All the produced hydrogen rich gases from glycerol/water/metal mixtures were by no means inferior to pure hydrogen as a fuel for the polymer elec-trolyte fuel cell.

关键词： Great-Rate Hydrogen Production High Pressure Hydrogen Glycerol Reforming Sustainable Energy

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Molecular pathogenesis of sporadiccolorectal cancers

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Chinese Journal of Cancer 2016年第1期35卷 12-19页

作者： Hidetsugu Yamagishi hajime Kuroda Yasuo Imai Hideyuki Hiraishi Department of Diagnostic Pathology Dokkyo Medical University880 Kita‑KobayashiMibuShimotsugaTochigi 321‑0293Japan Department of Pathology International University of Health and Welfare Hospital537‑3 IguchiNasushiobaraTochigi 329‑2763Japan Department of Diagnostic Pathology Ota Memorial HospitalFuji Heavy Industries Health Insurance Society455‑1 OshimaOtaGunma 373‑8585Japan Department of Gastroenterology Dokkyo Medical University880 Kita‑KobayashiMibuShimotsugaTochigi 321‑0293Japan.

Colorectal cancer(CRC)results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to *** 75%of CRCs are sporadic and occur in people without genetic predisposition or family history of *** the past two decades,sporadic CRCs were classified into three major groups according to frequently altered/mutated *** genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate genes selected on the basis of functional *** the first half of this review,we describe the genetic pathways of sporadic CRCs and their clinicopathologic ***,large-scale genome analyses have detected many infrequently mutated genes as well as a small number of frequently mutated *** infrequently mutated genes are likely described in a limited number of ***-oriented models of CRC progression are being replaced by pathway-oriented *** the second half of this review,we summarize the present knowledge of this research field and discuss its prospects.

关键词： Sporadic colorectal cancer, Pathogenesis, Morphology, Large-scale genome analysis, Genetic pathway

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Complete withdrawal of glucocorticoids after dupilumab therapy in allergic bronchopulmonary aspergillosis:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6922-6928页

作者： Tadashi Nishimura Tomohito Okano Masahiro Naito Chikashi Tsuji Soichi Iwanaka Yasumasa Sakakura Taro Yasuma hajime Fujimoto Corina N D'Alessandro-Gabazza Yasuhiro Oomoto Tetsu kobayashi Esteban C Gabazza Hidenori Ibata Department of Pulmonary Medicine Mie Chuo Medical CenterTsu 514-1101MieJapan Department of Pulmonary and Critical Care Medicine Mie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan Department of Pulmonary and Critical Care Medicine Graduate School of Medicine MieMie UniversityTsu 514-8507MieJapan

BACKGROUND Allergic bronchopulmonary aspergillosis(ABPA)is an allergic reaction to Aspergillus species that aggravates bronchial *** studies demonstrated the glucocorticoid-sparing effect of dupilumab in patients with *** is no report of complete withdrawal of glucocorticoids after *** SUMMARY The patient was a 54-year-old woman with bronchial asthma treated with inhaled corticosteroids and a long-acting beta-2 *** consulted our institution for productive cough and fever in March *** computed tomography scan revealed mucoid impaction,and the bronchial lavage fluid culture was positive for Aspergillus *** diagnosis was *** patient was treated with oral glucocorticoids from April 2017 to November *** January 2019,she had bronchial asthma exacerbation,and a chest computed tomography scan showed recurrent mucoid *** was treated with oral glucocorticoids and *** February 2020,during tapering of oral glucocorticoid,she had the third episode of bronchial asthma exacerbation and a mucoid *** patient was treated with dupilumab in addition to oral glucocorticoid and *** clinical response improved,and oral glucocorticoid was discontinued in June *** This is the first case of ABPA in which complete withdrawal of glucocorticoid was possible after treatment with dupilumab.

关键词： Allergic bronchopulmonary aspergillosis Dupilumab Asthma Interleukin-13 Interleukin-4 Case report

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First cases of MPV17 related mitochondrial DNA depletion syndrome with compound heterozygous mutations in p.R50Q/p.R50W:a case report

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Hepatoma Research 2020年第1期6卷 1-10页

作者： Shuichiro Umetsu Ayano Inui Sohya kobayashi Masaru Shimura Tomoko Uehara hajime Uchida Rie Irie Tsuyoshi Sogo Haruki Komatsu Takako Yoshioka Kei Murayama Kenjiro Kosaki MureoKasahara Tomoo Fujisawa Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama City Tobu HospitalKanagawa 230-0012Japan Department of Metabolism Chiba Children’s HospitalChiba 266-0007Japan Center for Medical Genetics Keio University School of MedicineTokyo 160-8582Japan Department of Transplantation Surgery National Center for Child Health and DevelopmentTokyo 157-8535Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Department of Pediatrics Toho University Sakura Medical CenterChiba 285-8741Japan Department of Pathology National Center for Child Health and DevelopmentTokyo 157-8535Japan

Mutations in MPV17 lead to severe mitochondrial DNA depletion syndrome(MTDPS).All known p.R50W variants in MPV17 are *** homozygous variant p.R50Q in MPV17 among patients with Navajo neurohepatopathy is known to allow longer survival,although heterozygous variants p.R50Q have not been *** is the first clinical report in compound heterozygosity MPV17 mutation(p.R50W/p.R50Q).Three siblings were admitted due to multiple hepatic nodules;none presented neurological ***,they suffered from severe hypoglycemia and cyclic *** diagnosis of MPV17-related MTDPS was confirmed by detection of a compound heterozygous MPV17 mutation(p.R50W/p.R50Q),and striking reduction of hepatic mitochondrial *** patient developed pediatric-onset of hepatocellular ***,all patients survived for extended periods,including two patients who received liver transplantation,which contrasted the high mortality rate associated with p.R50W mutations,as previously *** p.R50Q mutation might be associated with longer survival and improved liver transplantation outcomes.

关键词： Mitochondrial DNA depletion syndrome MPV17 compound heterozygous mutation liver transplantation

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STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line,GIST-T1

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World Journal of Gastroenterology 2006年第5期12卷 703-708页

作者： Toufeng Jin hajime Nakatani Takahiro Taguchi Takumi Nakano Takehiro Okabayashi Takeki Sugimoto Michiya kobayashi Keijiro Araki Department of Tumor Surgery Kochi Medical School Kochi University Nankoku Kochi 783-8505 Japan and Department of General Surgery College of Medical Yanbian University 119 Juzijie Yanji Jilin Province China Department of Tumor Surgery Kochi-Medical School Kochi University Nankoku Kochi 783-8505 Japan Department of Human Health and Medical Science Graduate school of Kuroshio Science Kochi UniversityNankoku Kochi 783-8503 Japan

AIM:To estimate whether STI571 inhibits the expressionof vascular endothelial growth factor(VEGF)in thegastrointestinal stromal tumor(GIST)***:We used GIST cell line,*** hasa heterogenic 57-bp deletion in exon 11 to produce amutated c-KIT,which results in constitutive activationof *** were treated with/without STI571 orstem cell factor(SCF).Transcription and expression ofVEGF were determined by RT-PCR and flow cytometryor Western blotting,*** c-KIT wasestimated by immunoprecipitation *** viabilitywas determined by MTT ***:Activation of c-KIT was inhibited bySTI571 *** was suppressed at both thetranscriptional and translational levels in a temporal anddose-dependent manner by *** upregulatedthe expression of VEGF and it was inhibited by ***571 also reduced the cell viability of the GIST-T1cells,as determined by MTT ***:Activation of c-KIT in the GIST-T1regulated the expression of VEGF and it was inhibited ***571 has antitumor effects on the GIST cellswith respect to not only the inhibition of cell growth,butalso the suppression of VEGF expression.

关键词：内皮生长因子基因表达 ST1571 胃肠肿瘤肿瘤血管

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Further Stabilization and Power Density Improvement of Stack-Type Thermoelectric Power Generating Module with Biphasic Medium by Using Various Flexible Metals as Electrodes

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Journal of Power and Energy Engineering 2018年第11期6卷 78-86页

作者： Seiichi Deguchi Shoichiro Imaizumi hajime Arimura Keisuke Sawada Noriyuki kobayashi Norifumi Isu Kenji Sakai Kentaro Kimoto Department of Energy Engineering and Science Nagoya University Nagoya Japan Kitchen and Bathroom Technology Research Institute LIXIL Corporation Tokoname Japan Materials System Division Toshima Manufacturing Corporation Ltd. Saitama Japan

In order to realize further stability of a stack-type thermoelectric power generating module (i.e. no electrical connections inside), flexible materials of metal springs and/or rods having restoring forces were installed between lower-temperature-sides of thermoelectric elements. These flexible materials were expected to play three important roles of interpolating different thermal expansions of the module components, enlarging heat removal area and penetration of any media through themselves. Then, a low-boiling-point medium (i.e. NOVEC manufactured by 3M Japan Ltd.) was also applied for a high-speed direct heat removal via its phase change from the lower-temperature-sides of the thermoelectric elements in the proposing stack-type thermoelectric power generating module. No electrical disconnections inside the module were confirmed for more than 9 years of use, indicating further module stability. The power generating density was improved to about 120 mW·m-2 with SUS304 springs having 0.7 mm diameter. Increasing power generating density can be expected in terms of suitable selection of flexible metal with high Vickers hardness, cavities control on the spring surface, more vigorous multiphase flow with adding powders to the medium and optimization of the module configurations according to numerical simulations.

关键词： Thermoelectric Power Generation Stack-Type Module Flexible Section Biphasic Medium Phase Change Multi-Phase Flow Heat Transfer Enhancement Module Stabilization

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