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Synthetic high-density lipoprotein(sHDL):a bioinspired nanotherapeutics for managing periapical bone inflammation

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International Journal of Oral Science 2024年第3期16卷 460-470页

作者： Renan Dal-Fabbro Minzhi Yu Ling Mei hajime Sasaki Anna Schwendeman Marco C.Bottino Department of Cariology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUSA Department of Pharmaceutical Sciences College of Pharmacy and Biointerfaces InstituteUniversity of MichiganAnn ArborMIUSA Department of Biomedical Engineering College of EngineeringUniversity of MichiganAnn ArborMIUSA

Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affecting 50%of the worldwide population,with more than 15 million root canals performed annually in the United *** treatment involves cleaning and decontaminating the infected tissue with chemo-mechanical approaches and materials introduced years ago,such as calcium hydroxide,zinc oxide–eugenol,or even formalin ***,we present,for the first time,a nanotherapeutics based on using synthetic highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone *** application in concentrations ranging from 25μg to 100μg/mL decreases nuclear factor Kappa B(NF-κB)activation promoted by an inflammatory stimulus(lipopolysaccharide,LPS).Moreover,sHDL at 500μg/mL concentration markedly decreases in vitro osteoclastogenesis(P<0.001),and inhibits IL-1α(P=0.027),TNF-α(P=0.004),and IL-6(P<0.001)production in an inflammatory ***,sHDL strongly dampens the Toll-Like Receptor signaling pathway facing LPS stimulation,mainly by downregulating at least 3-fold the pro-inflammatory genes,such as Il1b,Il1a,Il6,Ptgs2,and *** vivo,the lipoprotein nanoparticle applied after NaOCl reduced bone resorption volume to(1.3±0.05)mm^(3) and attenuated the inflammatory reaction after treatment to(1090±184)cells compared to non-treated animals that had(2.9±0.6)mm^(3)(P=0.0123)and(2443±931)cells(P=0.004),thus highlighting its promising clinical potential as an alternative therapeutic for managing dental bone inflammation.

关键词： inflammation lipoprotein markedly

Skull metastasis from hepatocellular carcinoma with chronic hepatitis B

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World Journal of Gastrointestinal Oncology 2010年第3期2卷 165-168页

作者： Takashi Goto Takahiro Dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama Tomomi Shibuya Ei Kataoka Daisuke Segawa Wataru Sato Yumiko Anezaki hajime ishii Daigo Kon Ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi Department of Gastroenterology Akita University School of Medicine

A 56-year-old male visited our hospital for evaluation of an occipital *** computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the *** resonance imaging showed bone metastasis in the thoracic *** for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade *** diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis *** was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for *** he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and *** showed HCC with multiple bone *** liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular *** the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting *** necrosis was not *** fibrosis was *** 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial *** lesion was osteolytic and showed invasion into the dura *** the subdural cavity nor the brain showed involvement from the metastatic ***,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of ***,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC.

关键词： Hepatocellular carcinoma Skull metastasis Bone metastasis Osteolytic change Chronic hepatitis B

Evaluation of bacterial contamination and medium-term oncological outcomes of intracorporeal anastomosis for colon cancer:A propensity score matching analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 670-680页

作者： hajime Kayano Nana Mamuro Yutaro Kamei Takashi Ogimi Hiroshi Miyakita Toshio Nakagohri Kazuo Koyanagi Masaki Mori Seiichiro Yamamoto Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

BACKGROUND Although intracorporeal anastomosis(IA)for colon cancer requires longer operative time than extracorporeal anastomosis(EA),its short-term postoperative results,such as early recovery of bowel movement,have been reported to be equal or *** IA requires opening the intestinal tract in the abdominal cavity under pneumoperitoneum,there are concerns about intraperitoneal bacterial infection and recurrence of peritoneal dissemination due to the spread of bacteria and tumor ***,intraperitoneal bacterial contamination and medium-term oncological outcomes have not been *** cavity in *** Of 127 patients who underwent laparoscopic colon resection for colon cancer from April 2015 to December 2020,75 underwent EA(EA group),and 52 underwent IA(IA group).After propensity score matching,the primary endpoint was 3-year disease-free survival rates,and secondary endpoints were 3-year overall survival rates,type of recurrence,surgical site infection(SSI)incidence,number of days on antibiotics,and postoperative biological *** Three-year disease-free survival rates did not significantly differ between the IA and EA groups(87.2%and 82.7%,respectively,P=0.4473).The 3-year overall survival rates also did not significantly differ between the IA and EA groups(94.7%and 94.7%,respectively;P=0.9891).There was no difference in the type of recurrence between the two *** addition,there were no significant differences in SSI incidence or the number of days on antibiotics;however,postoperative biological responses,such as the white blood cell count(10200 vs 8650/mm^(3),P=0.0068),C-reactive protein(6.8 vs 4.5 mg/dL,P=0.0011),and body temperature(37.7 vs 37.5℃,P=0.0079),were significantly higher in the IA *** IA is an anastomotic technique that should be widely performed because its risk of intraperitoneal bacterial contamination and medium-term oncological outcomes are comparable to those of EA.

关键词： Colon cancer Intracorporeal anastomosis 3-year disease-free survival Recurrence Surgical site infection Postoperative biological response

Using GIS to develop a mobile communications network for disaster-damaged areas

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International Journal of Digital Earth 2014年第4期7卷 279-293页

作者： Youhei Kawamura Ashraf MDewan Bert Veenendaal Masahiro Hayashi Takeshi Shibuya Itaru Kitahara hajime Nobuhara Kento ishii Department of Mining Engineering Curtin UniversityKalgoorlieAustralia Department of Spatial Sciences Curtin UniversityPerthAustralia Graduate School of System and Information Engineering University of TsukubaTsukubaJapan

Communications network damage resulting from a large disaster causes difficulties in the ability to rapidly understand the current situation and thus make appropriate decisions towards mitigating problems,such as where to send and dispense emergency *** research outlined in this paper focuses on the rapid construction of a network after a disaster *** study suggests ZigBee and geographic information systems(GIS)technologies to resolve these problems and provide an effective communication *** experimental results of the ZigBee network system are presented,examples are provided of the mapping and analysis undertaken using GIS for the disaster-stricken area of Tsukuba City,Japan,and the communications node arrangements are determined for this *** results demonstrate the effectiveness of establishing such a communications system for supporting efforts to relieve disaster-damaged areas.

关键词： ZigBee GIS disaster network

Cell surface protein engineering for high-performance whole-cell catalysts

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Frontiers of Chemical Science and Engineering 2017年第1期11卷 46-57页

作者： hajime Nakatani Katsutoshi Hori Department of Biotechnology Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan

Cell surface protein engineering facilitated by accumulation of information on genome and protein structure involves heterologous production and modifica- tion of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts. In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a cartier protein. The target proteins are fused to the carrier proteins that transport and tether them to the cell surface, as well as to a secretion signal. This paper reviews cell surface display systems for prokaryotic and eukaryotic cells from the perspective of carrier proteins, which determine the number of displayed molecules, and the localization, size, and direction （N- or C-terminal anchoring） of the passengers. We also discuss advanced methods for displaying multiple enzymes and a new method for the immobilization of whole-cell catalysts using adhesive surface proteins.

关键词： cell surface engineering surface display,whole-cell catalysts bioprocess

EXPERIMENTAL STUDY ON THE RELATION OF BED MORPHOLOGY WITH SURFACE FLOW IN MEANDER CHANNELS

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International Journal of Sediment Research 2006年第1期21卷 1-12页

作者： hajime MIWA Faculty of Agriculture Iwate University Japan Prof.

Alternate bars have the property that they migrate downstream whenever floods occur. However, in meander channels whose bend angles are larger than a critical value, the migration of bars can be suppressed, and the positions of bank erosion and flood attack also will be steady. In this study, the bed morphology in flume channels with bends of various lengths and angles is investigated at various flow discharges, and the relation of bed morphology to surface flow is investigated in detail using fluid measuring software. An effort is made to obtain guidelines for the plane shape design of meander channels. Based on the experimental results of bed topography and measurement of surface flow direction and velocity distribution, from the viewpoint of bank erosion and the concentration and dispersion of flood flow the most suitable plane shape for meandering channels is suggested through which the migration of alternate bars is suppressed.

关键词： Meander channel Alternate bars Particle Tracking Velocimetry (PTV) Particle Image Velocimetry (PIV)

Numerical prediction of colloidal phase separation by direct computation of Navier–Stokes equation

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npj Computational Materials 2019年第1期5卷 806-814页

作者： Michio Tateno hajime Tanaka Department of Fundamental Engineering Institute of Industrial ScienceUniversity of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan

Numerical prediction of out-of-equilibrium processes in soft and bio matter containing liquids is highly ***,it is quite challenging primarily because the motions of the components at different hierarchical levels(e.g.,large colloids and small solvent molecules)are spatio-temporally coupled in a complicated manner via momentum *** we critically examine the predictability of numerical simulations for colloidal phase separation as a prototype example of self-organization of soft materials containing a *** use coarse-grained hydrodynamic simulations to tackle this problem,and succeed in almost perfectly reproducing the structural and topological evolution experimentally observed by three-dimensional confocal microscopy without any adjustable ***,comparison with non-hydrodynamic simulations shows the fundamental importance of many-body hydrodynamic interactions in colloidal phase *** predictive power of our computational approach may significantly contribute to not only the basic understanding of the dynamical behavior and self-organization of soft,bio and active matter but also the computer-aided design of colloidal materials.

关键词： materials. separation hydrodynamic

Motor tract reorganization after acute central nervous system injury: a translational perspective

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Neural Regeneration Research 2021年第6期16卷 1144-1149页

作者： hajime Takase Robert W.Regenhardt Department of Neurosurgery Yokohama City University Graduate School of MedicineYokohamaJapan Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA Department of Neurology Massachusetts General Hospital and Harvard Medical SchoolBostonMAUSA

Acute central nervous system injuries are among the most common causes of disability worldwide,with widespread social and economic *** tract injury accounts for the majority of this disability;therefore,there is impetus to understand mechanisms underlying the pathophysiology of injury and subsequent reorganization of the motor tract that may lead to *** acute central nervous system injury,there are changes in the microenvironment and structure of the motor *** example,ischemic stroke involves decreased local blood flow and tissue death from lack of oxygen and *** injury,in contrast,causes stretching and shearing injury to microstructures,including myelinated axons and their surrounding *** involve blood-brain barrier dysfunction,which is an important initial *** acute central nervous system injury,motor tract reorganization occurs in the form of cortical remapping in the gray matter and axonal regeneration and rewiring in the white *** remapping involves one cortical region taking on the role of ***-response-element binding protein is a key transcription factor that can enhance plasticity in the peri-infarct *** regeneration and rewiring depend on complex cell-cell interactions between axons,oligodendrocytes,and other *** RhoA/Rho-associated coiled-coil containing kinase signaling pathway plays a central role in axon growth/regeneration through interactions with myelin-derived axonal growth inhibitors and regulation of actin cytoskeletal *** and their precursors play a role in myelination,and neurons are involved through their voltage-gated calcium *** the pathophysiology of injury and the biology of motor tract reorganization may allow the development of therapies to enhance recovery after acute central nervous system *** include targeted rehabilitation,novel pharmacotherapies,such as growth factors and axonal growt

关键词： corticospinal tract myelin-axon interaction recovery remapping reorganization RhoA/ROCK translation

A Fine-Grained Runtime Power/Performance Optimization Method for Processors with Adaptive Pipeline Depth

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Journal of Computer Science & Technology 2011年第2期26卷 292-301页

作者：姚骏 Shinobu Miwa hajime Shimada Shinji Tomita Graduate School of Information Science Nara Institute of Science and Technology School of Engineering Tokyo University of Agriculture and Technology Graduate School of Informatics Kyoto University Institute for Integrated Cell-Material Sciences Kyoto University

Recently, a method known as pipeline stage unification （PSU） has been proposed to alleviate the increasing energy consumption problem in modern microprocessors. PSU achieves a high energy efficiency by employing a changeable pipeline depth and its working scheme is eligible for a fine control method. In this paper, we propose a dynamic method to study fine-grained program interval behaviors based on some easy-to-get runtime processor metrics. Using this method to determine the proper PSU configurations during the program execution, we are able to achieve an averaged 13.5% energydelay-product （EDP） reduction for SPEC CPU2000 integer benchmarks, compared to the baseline processor. This value is only 0.14% larger than the theoretically idealized controlling. Our hardware synthesis result indicates that the proposed method can largely decrease the hardware overhead in both area and delay costs, as compared to a previous program study method which is based on working set signatures.

关键词： dynamic optimization energy saving fine-grained pipeline stage unification workload analysis