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Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

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Chinese Journal of Cancer Research 2018年第3期30卷 364-372页

作者： Zhiyu Li Xiaolong Wu Xinyu Bi Yefan Zhang Zhen Huang haizhen lu Hong Zhao Jianjun Zhao Jianguo Zhou Muxing Li Jianming Ying Jianqiang Cai Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College

Objective：This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical ***：The clinicopathological data of 114 patients who were diagnosed with histologically proven four subtypes：clear cell carcinoma（CCC）,giant cell carcinoma（GCC）,sarcomatoid carcinoma（SC）,and combined hepatocellular-cholangiocarcinoma（CHC）between October 1998 and August 2015 were *** survival data were compared with those of 908 patients with histologically proven common hepatocellular carcinoma（HCC）（early-and advanced-stage HCC）during the same ***：The outcome of the CCC group was better than that of the other three subgroups,and was similar to that of the early-stage HCC ***,the smallest tumor size and the highest incidence of pseudocapsule formation were observed in the CCC *** SC group had the worst outcome among these four subgroups;the prognosis was much poorer than that of any other subgroups,even poorer than that of the advanced-stage common HCC *** statistical difference was observed between the GCC,CHC and advanced-stage HCC groups on survival *** incidences of tumor vascular emboli,TNM staging and non-radical resection were three risk factors of the ***：CCC is a low-degree malignancy and relatively favorably prognostic subtype of ***,GCC,SC,and CHC are three rare high-degree malignancy subtypes of HCC with poor prognosis.

关键词： Clear cell carcinoma combined hepatocellnlar-cholangiocarcinoma giant cell carcinoma sarcomatoid carcinoma hepatocellular carcinoma

Novel gold nanoparticles targeting somatostatin receptor subtype two with near-infrared light for neuroendocrine tumour therapy

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Nano Research 2022年第10期15卷 9149-9159页

作者： Qichen Chen Zilin Li Jiangyuan Yu Qing Xie haizhen lu Yiqiao Deng Jinghua Chen Wenjia Zhu Li Huo Yizhou Zhang Wei Song Jianqiang Lan Jianqiang Cai Zhen Huang Zixi Wang Hong Zhao Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Nuclear Medicine Key Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationPeking University Cancer Hospital&InstituteBeijing 100142China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17Panjiayuan NanliBeijing 100021China Nuclear Medicine Department State Key Laboratory of Complex Severe and Rare DiseasesCenter for Rare Diseases ResearchBeijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicinePeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Guangdong Research Center of Organoid Engineering and Technology Accurate International Biotechnology Co.Ltd.Guangzhou 510650China

Neuroendocrine tumours(NETs)are rare cancers with positive somatostatin receptor 2(SSTR2)expression,and treatment strategies for NETs are not ***-mediated therapy targeting SSTR2 in NETs is very *** study firstly combined mesoporous silica-coated gold nanorods(AuNRs@mSiO_(2))and targeting-SSTR2 dodecane tetraacetic acidtyrosine3-octreotate(DOTA-TATE)into AuNRs@mSiO_(2)@DOTA-TATE to investigate NETs inhibition under near-infrared ***@mSiO_(2)@DOTA-TATE showed good photothermal conversion *** vitro,under light irradiation,the cell viability significantly decreased with increasing AuNR@mSiO_(2)@DOTA-TATE concentration;in two successfully established neuroendocrine tumour organoids with SSTR2 expression,AuNRs@mSiO_(2)@DOTA-TATE with light inhibited tumours significantly better than AuNRs@mSiO_(2) with *** vivo,the SSTR2-targeting ability and biodistribution of AuNRs@mSiO_(2)@DOTA-TATE were confirmed with AuNRs@mSiO_(2)@64Cu-DOTA-TATE under micro-positron emission tomography/computed tomography(micro-PET/CT);in the AuNRs@mSiO_(2)@DOTA-TATE with laser group,the tumour surface temperature increased rapidly,with tumour volumes similar to those in the octreotide group and significantly lower than those in other *** was no significant difference in mice body weight between the AuNRs@mSiO_(2)@DOTA-TATE with laser group and other *** significant inflammatory lesions or cell necrosis was found in the main *** summary,we presented a feasible strategy to construct AuNRs@mSiO_(2)@DOTA-TATE with good photothermal conversion efficiency,targetingSSTR2 ability,significant antitumour effects,and good biocompatibility,warranting further explorations of AuNRs@mSiO_(2)@DOTA-TATE for NETs therapy applications.

关键词： neuroendocrine tumours somatostatin receptor 2 nanoparticles photothermal therapy

Clinicopathological practice in the differential diagnosis of mucoepidermoid carcinoma from neoplasms with mucinous component

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Chronic Diseases and Translational Medicine 2023年第1期9卷 29-38页

作者： Yuelu Zhu Yan Li Lei Guo Wenbin Li Jiali Mu Haifeng Zhang Xin Li Jianming Ying haizhen lu Department of Pathology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:The differential diagnosis of mucoepidermoid carcinoma(MEC)from neoplasm undergoing mucinous features brings more pitfalls to *** specific MAML2 gene rearrangement and histological characteristics may be the ***:Twenty-five tumors with mucinous components were selected for differential diagnosis of *** the cases were detected for MAML2 gene *** cases diagnosed as MEC were classified into four variants:classic,oncocytic,Warthin-like,and nonclassified,and they were graded using the Brandwein *** histological characteristics of non-MECs were summarized for differential *** survival analysis was performed on ***:There were 16 MECs;62.5%were MAML2 *** the low-,intermediate-,and high-grade MECs,the rate of rearrangement was 83.3%,100%,and 28.6%,*** the oncocytic and Warthinlike MECs were MAML2 *** the classic and nonclassified MECs without MAML2 rearrangement,non-keratinized squamoid cells and distinctive mucinous cells were essential diagnostic *** survival analysis,all the disease progression occurred in high-grade MECs(p=0.038).Nine cases were diagnosed as non-MECs:pleomorphic adenoma with mucinous metaplasia showed no ex-capsular involvement;metaplastic Warthin tumor appeared with overt keratinization and residual oncocytic bilayered epithelium;mix squamous cell and glandular papilloma showed an endobronchial papillary growing pattern;adenosquamous carcinoma was accompanied by squamous carcinoma in situ of the overlying *** the non-MECs were negative for MAML2 ***:The application of combining MAML2 rearrangement and histological characteristics is helpful in the differential diagnosis between MEC and other tumors with mucinous components.

关键词： differential diagnosis histology MAML2 rearrangement mucinous feature mucoepidermoid carcinoma

Primary Malignant Amelanotic Melanoma in the Female Genital Tract:A Report of Six Cases and a Review of the Literature

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Chinese Journal of Clinical Oncology 2008年第5期5卷 383-386页

作者： Jusheng An Lingying Wu Bin Li haizhen lu Ning Li Shaokang Ma Department of Gynecological Oncology Cancer Hospital Peking Union Medical College Beijing 100021 China Department of Pathology Cancer Hospital Peking Union Medical College Beijing 100021 China

OBJECTIVE To analyze the clinical characteristics,pathologic diagnosis,treatment and prognosis of amelanotic melanoma in the female genital tract(AMFGT).METHODS The medical records of 6 patients with AMFGT between 1991 and 2006 in our hospital were *** Of these cases,4 were preliminarily misdiagnosed as chorioepithelioma,sarcoma,adenocarcinoma or *** patients were determined to have AMFGT preoperatively after positive immunohistochemical staining for both S-100 protein and *** removed from all 6 cases were tested for immunohistochemical staining,as well as H&E histochemical stains.S-100 and vimentin were both positive in all patients,and HMB-45 was positive in 3 out of 5 *** patients recurred(at 6,6,12 and 19 months) a er primary *** patients died(at 13,18 and 19 months) a er the initial *** Because of an absence of pigmentation AMFGT is extremely difficult to *** immunohistochemical staining,such as the S-100 protein,HMB-45 and vimentin etc,is important in the evaluation of *** diagnosis plays a crucial role in the treatment of this disease.

关键词： melanoma ameIanotic female genital tract immunohistochemical staining prognosis.

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单片机在电机测试中的应用

机械管理开发 2007年第1期22卷 103-104页

作者：吕海珍经纬纺机股份有限公司榆次分公司山西晋中030601

分析了单片机的特点及其在电机测试中的应用。采用单片机的电机测试系统,在测试功能和测量精度等指标上,都远远超过传统测试方法,是电机测试的一大进步。

关键词：电机测试单片机应用

BRAF V600E突变与甲状腺乳头状癌临床病理特征的关系

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中华病理学杂志 2014年第12期43卷 794-798页

作者：鲁海珍邱田应建明郭嫦媛吕宁中国医学科学院肿瘤医院病理科北京100021

目的：检测BRAF V600E基因在甲状腺乳头状癌中的突变，评价与各项临床病理指标的关系。方法收集中国医学科学院肿瘤医院2010年12月至2012年12月原发性甲状腺乳头状癌292例，复阅病理切片，收集临床病理信息。石蜡包埋肿瘤组织提取DNA，... 详细信息

目的：检测BRAF V600E基因在甲状腺乳头状癌中的突变，评价与各项临床病理指标的关系。方法收集中国医学科学院肿瘤医院2010年12月至2012年12月原发性甲状腺乳头状癌292例，复阅病理切片，收集临床病理信息。石蜡包埋肿瘤组织提取DNA，经PCR扩增后直接测序。应用SPSS 16软件对比BRAF基因突变与各项临床病理指标关系。结果292例原发性甲状腺乳头状癌，男性87例，女性205例，男女比为1．0∶2．4。年龄范围13～84岁，平均年龄43．1岁。 BRAF基因突变率为65．1％（190／292），与就诊时患者年龄≥45岁、肿瘤直径＞1 cm、甲状腺被膜外侵犯、组织亚型（经典型和高细胞型）及肿瘤分期呈显著相关（ P＜0．05）。与患者性别、肿瘤的解剖部位、多灶性发生及淋巴结转移无相关性（P＞0．05）。结论 BRAF基因突变与多项高危的临床病理指标相关，提示其可能是甲状腺乳头状癌预后相关因子之一，为预后判断提供依据。

关键词：甲状腺肿瘤病理学,临床预后

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无创自然分娩模式在基层医院的应用研究

国际医药卫生导报 2019年第10期25卷 1621-1624页

作者：鲁海珍鹤山市妇幼保健院产科 529700

目的探讨将无创自然分娩模式在基层专科医院逐步开展。方法选择2017年4月至2019年1月在本院计划生育服务中心产科经阴道分娩的580例正常初产妇,随机将其分为两组,各290例。对照组按常规当胎头拨露使阴唇后联合紧张时,开始保护会阴。观... 详细信息

目的探讨将无创自然分娩模式在基层专科医院逐步开展。方法选择2017年4月至2019年1月在本院计划生育服务中心产科经阴道分娩的580例正常初产妇,随机将其分为两组,各290例。对照组按常规当胎头拨露使阴唇后联合紧张时,开始保护会阴。观察组则采用无创接生技术,助产士在产妇分娩过程中用单手控制胎头娩出速度,用拉玛泽呼吸法指导产妇进行屏气和哈气,合理控制好胎头下降速度,使胎头下降对阴道产生的压力均匀分布,待会阴充分扩张后,胎儿便会顺利娩出。比较两组产妇在会阴情况、新生儿窒息、产后出血、产后尿潴留、产妇满意度等情况。结果观察组会阴侧切率28.6%,低于对照组50.0%,会阴Ⅰ°裂伤率47.6%,高于对照组24.1%,差异均有统计学意义(均P0.05)。结论无创自然分娩降低了会阴侧切率、提升了产妇满意度,加快了产妇产后康复,提高产妇生活质量,提升本院产科质量,值得推广,由于本院刚刚开展这项业务,技术不是很成熟,产后尿潴留发生率较高,在今后的工作中进一步改进。

关键词：无创自然分娩产科质量应用研究

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肝细胞肝癌微血管侵犯病理解读

肝癌电子杂志 2018年第2期5卷 13-15页

作者：鲁海珍国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院/肿瘤医院病理科北京100021

微血管侵犯(microvascular invasion, MVI)是肝细胞肝癌预后不良的重要危险因素,是患者个体化治疗策略制定的重要参考指标之一。MVI的检出率会随着肿瘤体积的增大、分化程度的降低而增加。根据MVI与主瘤体的距离、检出数目及与血管壁的... 详细信息

微血管侵犯(microvascular invasion, MVI)是肝细胞肝癌预后不良的重要危险因素,是患者个体化治疗策略制定的重要参考指标之一。MVI的检出率会随着肿瘤体积的增大、分化程度的降低而增加。根据MVI与主瘤体的距离、检出数目及与血管壁的关系而进行的组织学分型,则对MVI的危险度又进行了分层。MVI的发生机制复杂,而未完全被揭示,目前学术界比较关注的研究也在此做一介绍。

关键词：肝细胞肝癌微血管侵犯病理分型

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分娩镇痛与新生儿窒息的相关性调查

国际医药卫生导报 2017年第20期23卷 3269-3270页

作者：鲁海珍鹤山市妇幼保健计划生育服务中心 529700

目的对比采用连续硬膜外分娩镇痛与按产科常规不采用分娩镇痛的两组新生儿窒息情况，调查分娩镇痛与新生儿窒息的相关性，为临床合理实施分娩镇痛提供参考。方法选取2014年10月至2016年9月在本院产科分娩的产妇1100例，随机分成观察组... 详细信息

目的对比采用连续硬膜外分娩镇痛与按产科常规不采用分娩镇痛的两组新生儿窒息情况，调查分娩镇痛与新生儿窒息的相关性，为临床合理实施分娩镇痛提供参考。方法选取2014年10月至2016年9月在本院产科分娩的产妇1100例，随机分成观察组和对照组各550例。观察组在产程中实施连续硬膜外镇痛；对照组按产科常规处理未行分娩镇痛。对比两组新生儿窒息发生率。结果观察组发生急性胎儿窘迫率4．72％、新生儿出生后1minApgar评分呼吸〈2分为4．36％、出生后1minApgar评分〈7分为4．00％，均明显高于对照组0．73％、0，55％、0．36％，差异均有统计学意义（均P〈0．01）。结论采用连续硬膜外分娩镇痛发生新生儿窒息的情况显著高于未采用分娩镇痛的产妇，因此在产程中要严格掌握分娩镇痛的适应症和禁忌症，合理安排产程中实施分娩镇痛的时机，降低新生儿窒息的发生率。

关键词：分娩镇痛新生儿窒息相关性