Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

作     者：Zhiyu Li Xiaolong Wu Xinyu Bi Yefan Zhang Zhen Huang Haizhen Lu Hong Zhao Jianjun Zhao Jianguo Zhou Muxing Li Jianming Ying Jianqiang Cai 

作者机构：Department of Hepatobiliary SurgeryNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of PathologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2018年第30卷第3期

页      面：364-372页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：financially supported by the State Key Project on Infection Diseases of China (No.2018ZX10723204-005) the National Natural Science Foundation of China (No.81672461) the National Hightech R&D (863) Program of China (No.2015AA020408) the Capital Health Research and Development of Special(No.2018-1-4021) the CAMS Innovation Fund for Medical Sciences (CIFMS) (No.2016-I2M-1-001) the CAMS Innovation Fund for Medical Sciences (CIFMS) (No.2017-12M-4-002) 

主　　题：Clear cell carcinoma combined hepatocellnlar-cholangiocarcinoma giant cell carcinoma sarcomatoid carcinoma hepatocellular carcinoma 

摘      要：Objective：This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical ***：The clinicopathological data of 114 patients who were diagnosed with histologically proven four subtypes：clear cell carcinoma（CCC）,giant cell carcinoma（GCC）,sarcomatoid carcinoma（SC）,and combined hepatocellular-cholangiocarcinoma（CHC）between October 1998 and August 2015 were *** survival data were compared with those of 908 patients with histologically proven common hepatocellular carcinoma（HCC）（early-and advanced-stage HCC）during the same ***：The outcome of the CCC group was better than that of the other three subgroups,and was similar to that of the early-stage HCC ***,the smallest tumor size and the highest incidence of pseudocapsule formation were observed in the CCC *** SC group had the worst outcome among these four subgroups;the prognosis was much poorer than that of any other subgroups,even poorer than that of the advanced-stage common HCC *** statistical difference was observed between the GCC,CHC and advanced-stage HCC groups on survival *** incidences of tumor vascular emboli,TNM staging and non-radical resection were three risk factors of the ***：CCC is a low-degree malignancy and relatively favorably prognostic subtype of ***,GCC,SC,and CHC are three rare high-degree malignancy subtypes of HCC with poor prognosis.