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Boundary slip and lubrication mechanisms of organic friction modifiers with effect of surface moisture

Friction 2024年第7期12卷 1483-1498页

作者： Xiaobin YI haiyu xu Ge JIN Yang LU Biqiang CHEN Shaofeng xu Junqin SHI Xiaoli FAN State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072China Xi’an Thermal Power Research Institute Co. Ltd.Xi’an 710054China NingboTech University Ningbo 315000China

Surface moisture or humidity impacting the lubrication property is a ubiquitous phenomenon in tribological systems,which is demonstrated by a combination of molecular dynamics(MD)simulation and experiment for the organic friction modifier(OFM)-containing *** stearic acid and poly-α-olefin 4cSt(PAO4)were chosen as the OFM and base oil molecules,*** physical adsorption indicates that on the moist surface water molecules are preferentially adsorbed on friction surface,and even make OFM adsorption film thoroughly leave surface and mix with base *** shear process,the adsorption of water film and desorption OFM film are further enhanced,particularly under higher shear *** simulated friction coefficient(that is proportional to shear rate)increases firstly and then decreases with thickening water film,in good agreement with experiments,while the slip length shows a contrary *** wear increases with humidity due to tribochemistry revealing the continuous formation and removal of Si–O–Si *** tribological discrepancy of OFM-containing lubricant in dry and humid conditions is attributed to the slip plane’s transformation from the interface between OFM adsorption film and lubricant bulk to the interface between adsorbed water *** work provides a new thought to understand the boundary lubrication and failure of lubricant in humid environments,likely water is not always harmful in oil lubrication systems.

关键词： organic friction modifier(OFM) boundary lubrication boundary slip surface moisture

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Effect of linear friction welding process on microstructure evolution,mechanical properties and corrosion behavior of GH4169 superalloy

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Chinese Journal of Aeronautics 2024年第6期37卷 504-520页

作者： Yu SU Xiawei YANG Tingxi MENG Dong WU Rui xu haiyu xu Wenya LI Shuo YIN State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Manufacturing&Biomedical EngineeringParsons BuildingTrinity College DublinThe University of DublinDublin 2Ireland

Linear Friction Welding(LFW)technology was used to realize the welding of GH4169 superalloy,and the effect of welding parameters on the microstructure,mechanical properties and corrosion behavior of the joint was *** results show that there is a positive correlation between the weld hardness and the tensile *** the gradual increase of heat input and welding pressure,the joint quality is gradually improved,but the heat affected zone is not significantly *** smaller the grain size of the weld,the higher the strength and plasticity of the *** the increase of the joint shortening amount,the corrosion resistance of the weld first gradually ***,when the shortening reaches a certain level,the corrosion resistance of the joint becomes little *** the increase of solution temperature,the corrosion current density increases and the polarization impedance *** higher the corrosion temperature,the worse the corrosion resistance of the *** is no significant correlation between the joint strength and the corrosion *** corrosion resistance of the joint can be enhanced without changing the joint mechanical properties by reducing the welding frequency and amplitude or increasing the welding pressure.

关键词： Linear Friction Welding(LFW) GH4169 superalloy Microstructure Mechanical properties Corrosion behavior

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Summer maize LAI retrieval based on multi-source remote sensing data

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International Journal of Agricultural and Biological Engineering 2023年第2期16卷 179-186页

作者： Fangjiang Pan Jinkai Guo Jianchi Miao haiyu xu Bingquan Tian Daocai Gong Jing Zhao Yubin Lan School of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255000ShandongChina National Sub-center for International Collaboration Research on Precision Agricultural Aviation Pesticide Spraying Technology Shandong University of TechnologyZibo 255000ShandongChina Research of Institute of Ecological Unmanned Farm Shandong University of TechnologyZibo 255000ShandongChina

Leaf Area of Index(LAI)refers to half of the total leaf area of all crops per unit *** is an important index to represent the photosynthetic capacity and biomass of *** obtain LAI conditions of summer maize in different growth stages quickly and accurately,further guiding field fertilization and *** Unmanned aerial vehicles(UAV)multispectral data,growing degree days,and canopy height model of 2020-2021 summer maize were used to carry out LAI *** vegetation index was constructed by the ground hyperspectral data and multispectral data of the same range of *** correlation analysis was conducted to verify the accuracy of the multispectral *** include many bands as possible,four vegetation indices which included R,G,B,and NIR bands were selected in this study to test the spectral *** were nine vegetation indices calculated with UAV multispectral data which were based on the red band and the near-infrared *** correlation analysis of LAI and the vegetation index,vegetation indices with a higher correlation to LAI were selected to construct the LAI inversion *** addition,the Canopy Height Model(CHM)and Growing degree days(GDD)of summer maize were also calculated to build the LAI inversion *** LAI inversion of summer maize was carried out based on multi-growth stages by using the general linear regression model(GLR),Multivariate nonlinear regression model(MNR),and the partial least squares regression(PLSR)models.R²and RMSE were used to assess the accuracy of the *** results show that the correlation between UAV multispectral data and hyperspectral data was greater than 0.64,which was *** Wide Dynamic Range Vegetation Index(WDRVI),Normalized Difference Vegetation Index(NDVI),Ratio Vegetation Index(RVI),Plant Biochemical Index(PBI),Optimized Soil-Adjusted Vegetation Index(OSAVI),CHM and GDD have a higher correlation with *** comparing the models constructed by the three methods,it was f

关键词： maize UAV multispectral leaf area of index growing degree day canopy height model vegetation index

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A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1379-1399页

作者： haiyu xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Shaanxi Institute of International Trade&Commerce Xianyang 7120462China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin 300193China

Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its ***,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in *** review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of ***,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in ***,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,*** that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental ***,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very.

关键词： Integrative pharmacology-based traditional Chinese medicine PK-PD correlations Big data Mathematical modeling Multidimensional association network

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Biomolecular network-based synergistic drug combination discovery:a combination of paeoniflorin and liquiritin alleviates neuropathic pain by inhibiting neuroinflammation via suppressing the chemokine signaling pathway

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1804-1806页

作者： Qiuyan Guo Weijie Li Chao Wang Xia Mao Xiaoyue Wang Wenjia Chen haiyu xu Qian Wang Yanqiong Zhang Na Lin Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University100191 BeijingChina

Dear Editor,Neuropathic pain(NP)resulting from injuries or diseases affecting the somatosensory nervous system is highly prevalent in various pathological conditions.1 Since NP is debilitating and impacts health and the quality of life,there is an urgent need for effective non-addictive new *** Chinese medicine(TCM)has been increasingly used for its benefits in relieving pain in ***-Tou Decoction(WTD),which was first described by the famous TCM classic“Jin Gui Yao Lue”,is one of the most effective TCM herbal prescriptions for pain management.A growing body of clinical evidence shows that WTD markedly alleviates different types of NP,such as trigeminal neuralgia,inflammatory pain,and cancer-induced pain,with a total effectiveness of~80%.2 Our previous data demonstrated the analgesic effects of WTD via suppression of glial cell activation and neuroinflammation and further revealed that WTD attenuated NP partially by inhibiting spinal astrocytic IL-1R1/TRAF6/JNK signaling and regulating the glutamatergic system in CA3 in spinal nerve ligation(SNL)-induced NP in vivo.3,4 However,the bioactive compounds(BACs)of WTD that have an effect on NP and the underlying mechanisms remain unclear.

关键词： pain inflammation inhibiting

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ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2559-2571页

作者： Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang haiyu xu Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China State Key Laboratory of Drug Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China National Resource Center for Chinese Materia Medica Chinese Academy of Chinese Medical SciencesBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Shaanxi Academy of Traditional Chinese Medicine Xi'an 710003China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Provincial Key Laboratory of PharmaceuticsGuizhou Medical UniversityGuiyang 550004China China Academy of Chinese Medical Sciences Beijing 100700China

Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated ***,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://***/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 *** facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding ***,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal ***,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological *** v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases.

关键词： Traditional Chinese medicine Database Target identification Network visualization New drug research and development Molecular mechanism Quality marker Drug repurposing

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Protective effects of Yindanxinnaotong capsule in a rat model of myocardial ischemia/reperfusion injury

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Journal of Traditional Chinese Medicine 2014年第6期34卷 699-709页

作者： Wandan Wang Lan Wang Hongjun Yang Jianlu Wang Xiaojie Yin haiyu xu Long Cheng Rixin Liang Pharmacology and Pharmacokinetics Laboratory Institute of Chinese MaterialMedical China Academy of Chinese Medical Sciences Institute of Medical Plant Development Chinese Academy of Medical Sciences

OBJECTIVE: To investigate the effects of Yindanxinnaotong capsule(YDXNTC) and main components compatibility and ratios on myocardium against ischemia/reperfusion injury and the effect's underlying ***: Myocardial ischemia/reperfusion injury(MIRI) was induced by ischemia for 30 min and reperfusion for 30 min. Electrocardiogram data and coronary flow were recorded, and superoxide dismutase(SOD), malondialdehyde(MDA), lactate dehydrogenase, creatine kinase-MB, cardiac troponin T and I(cT nT, cT n I) and interleukin-1β, interleukin-8,interleukin-18(IL-1β, IL-8, IL-18) in myocardium were measured. Hypoxia/reoxygenation and hydrogen peroxide(H2O2) injury were induced by hypoxia for 3 h/reoxygenation for 2 h, and 100 μM H2O2 for 1 h, respectively, in vitro rat myocardial cells(H9c2). Cell viability, SOD, MDA, cT nT and inflamma-tory factors(IL-1β, IL-8 and IL-18) were determined,and Toll-like receptor 4(TLR-4) expression was measured by western ***: In the isolated heart experiment, elevated heart function, coronary flow and SOD levels,and decreased MDA levels and inflammatory factors were noted in the YDXNTC, main components and main components compatibility groups. Ventricular tachycardia/ventricular fibrillation occurrence decreased in the ginkgo biloba extract(GBE),and GBE and salvia miltiorrhiza ethanol extract compatibility(SM-E, GSEC) groups. Lactic dehydrogenase levels decreased in the YDXNTC and aqueous extract of salvia miltiorrhiza(SM-H) groups. Creatine kinase-MB decreased with GBE, SM-E, SM-H and GSEC treatment, and cT n I and cT nT levels decreased with GSEC. In the in vitro cell study,YDXNTC and main components ratios improved cell viability and SOD levels, and suppressed MDA,cT nT and inflammatory factors. TLR-4 expression was ***: YDXNTC and main components compatibility showed protective effects on MIRI in this rat model and in vitro study. Regulating the Toll-like receptor signaling pathway may affect the

关键词： Myocardial ischemia Reperfusion Components compatibility Yindanxinnaotong cap-sule

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通气超空化流域径向尺度影响

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西北工业大学学报 2020年第3期38卷 478-484页

作者：许海雨罗凯黄闯左振浩西北工业大学航海学院陕西西安710072

为研究流域尺度对阵泄气通气超空化的影响,基于分相流模型和SST湍流模型,考虑通气可压缩性,建立了通气超空泡流动的三维数值模型,通过水洞实验对数值方法进行了验证,研究了流域径向尺度对通气超空泡尺度和压力分布特性的影响。计算结果... 详细信息

为研究流域尺度对阵泄气通气超空化的影响,基于分相流模型和SST湍流模型,考虑通气可压缩性,建立了通气超空泡流动的三维数值模型,通过水洞实验对数值方法进行了验证,研究了流域径向尺度对通气超空泡尺度和压力分布特性的影响。计算结果表明:流域径向尺度对通气超空泡流型及压力分布影响显著。流域径向尺度比小于6.5时,无法形成完全包裹航行器的超空泡,随着流域径向尺度增加,超空泡尺寸增大,空泡内压力和外流场压力均减小;当径向尺度比大于54.0时,空泡尺寸和内部压力达到稳定收敛,计算结果与经验公式吻合,研究结果为模拟阵泄气通气超空泡自由流场空泡形态提供了流域径向尺度的选择标准,可用于指导工程实践。

关键词：通气空化泡流场空泡尺寸压力分布多相流 SST湍流模型水下航行器

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BNC Protects H9c2 Cardiomyoblasts from H2O2-Induced Oxidative Injury through ERK1/2 Signaling Pathway

BNC Protects H9c2 Cardiomyoblasts from H2O2-Induced Oxidativ...

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2014中国医师协会中西医结合医师大会

作者： Fangbo Zhang Bin Huang Ye Zhao Shihuan Tang haiyu xu Lan Wang Rixin Liang Hongjun Yang Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Buchang naoxintong capsule(BNC)is a traditional Chinese medicine approved for the treatment of cerebrovascular and cardiovascular ***,little is known about the specific protective function or mechanism by which BNC protects against myocardial *** research was designed to investigate the cardioprotective effects of BNC in vitro model of hydrogen peroxide(H202)-induced H9c2

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低弗劳德数通气超空泡初生及发展演变特性

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上海交通大学学报 2021年第8期55卷 934-941页

作者：许海雨罗凯黄闯左振浩古鉴霄西北工业大学航海学院西安710072

为了研究通气超空泡初生及发展过程中空泡形态及泄气模式的演变特性,采用分相流模型和SST湍流模型,考虑通气压缩性和重力效应,建立了通气超空化三维数值计算模型,并通过试验数据进行了校核和验证,研究了在通气率和弗劳德数大范围变化下... 详细信息

为了研究通气超空泡初生及发展过程中空泡形态及泄气模式的演变特性,采用分相流模型和SST湍流模型,考虑通气压缩性和重力效应,建立了通气超空化三维数值计算模型,并通过试验数据进行了校核和验证,研究了在通气率和弗劳德数大范围变化下的通气超空泡生成及发展过程.结果表明:回射流模式超空泡发展过程非常不稳定,空泡初生时伴随空泡的断裂及分离,空泡发展过程中存在气/水混合物回流现象,超空泡形态难以预估.双涡管模式超空泡先以回射流模式发展,当超空泡充分发展后,空泡闭合模式转变为双涡管方式,空泡形态及泡内压力相对比较稳定.接近超空泡泄气转变临界时,超空泡闭合模式在双涡管和回射流之间相互转变,导致超空化流动及超空泡形态变化更加复杂.

关键词：通气超空泡空泡泄气模式空泡生成及发展多相流

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